| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Soleus Capital Management, L.P. | 1,245,387 | 2,565,087 | +1,319,700 | 1.54 | 2.54 | +1.00 | buy |
| BAKER BROS. ADVISORS LP | 1,874,978 | 2,678,553 | +803,575 | 0.29 | 0.37 | +0.08 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 648,118 | +648,118 | 0.00 | 0.00 | +0.00 | buy |
| BlackRock, Inc. | 1,810,448 | 2,179,064 | +368,616 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 0 | 263,590 | +263,590 | 0.00 | 0.02 | +0.02 | buy |
| AMERIPRISE FINANCIAL INC | 306,529 | 447,171 | +140,642 | 0.00 | 0.00 | +0.00 | buy |
| Saturn V Capital Management LP | 946,335 | 1,063,783 | +117,448 | 5.04 | 5.45 | +0.41 | buy |
| Artisan Partners Limited Partnership | 415,677 | 491,507 | +75,830 | 0.01 | 0.01 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 73,026 | 144,032 | +71,006 | 0.05 | 0.09 | +0.03 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 630,369 | 692,372 | +62,003 | 0.00 | 0.00 | -0.00 | buy |
| CITADEL ADVISORS LLC | 774,928 | 836,023 | +61,095 | 0.01 | 0.01 | -0.00 | buy |
| J. Goldman & Co LP | 0 | 43,345 | +43,345 | 0.00 | 0.02 | +0.02 | buy |
| NORTHERN TRUST CORP | 257,890 | 300,076 | +42,186 | 0.00 | 0.00 | -0.00 | buy |
| VANGUARD GROUP INC | 1,627,552 | 1,651,981 | +24,429 | 0.00 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 21,316 | +21,316 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 19,435 | 38,808 | +19,373 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 19,235 | +19,235 | 0.00 | 0.02 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 100,703 | 117,759 | +17,056 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 16,649 | +16,649 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 221,671 | 237,706 | +16,035 | 0.00 | 0.00 | -0.00 | buy |
| Shay Capital LLC | 0 | 14,300 | +14,300 | 0.00 | 0.05 | +0.05 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 12,721 | +12,721 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 0 | 11,640 | +11,640 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 51,611 | 62,776 | +11,165 | 0.00 | 0.00 | +0.00 | buy |
| Bleakley Financial Group, LLC | 0 | 11,159 | +11,159 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 277,352 | 288,259 | +10,907 | 0.00 | 0.00 | -0.00 | buy |
| Bank of New York Mellon Corp | 53,297 | 64,125 | +10,828 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 0 | 10,826 | +10,826 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 73,283 | 83,914 | +10,631 | 0.00 | 0.00 | -0.00 | buy |
| DEUTSCHE BANK AG\ | 13,668 | 22,842 | +9,174 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 8,539 | 15,515 | +6,976 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 13,715 | 20,384 | +6,669 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 7,995 | 14,646 | +6,651 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 32,130 | 38,755 | +6,625 | 0.00 | 0.00 | +0.00 | buy |
| CAPTRUST FINANCIAL ADVISORS | 461,794 | 468,096 | +6,302 | 0.02 | 0.02 | -0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 22,036 | 26,377 | +4,341 | 0.00 | 0.00 | -0.00 | buy |
| Aquatic Capital Management LLC | 0 | 3,840 | +3,840 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 24,709 | 28,391 | +3,682 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 53,605 | 57,199 | +3,594 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 16,969 | 19,725 | +2,756 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 12,007 | 14,683 | +2,676 | 0.00 | 0.00 | +0.00 | buy |
| Corebridge Financial, Inc. | 14,398 | 16,256 | +1,858 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,289 | 3,421 | +1,132 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 2,853 | 3,490 | +637 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 10,366 | 10,924 | +558 | 0.00 | 0.00 | -0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,977 | 2,413 | +436 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 184 | +184 | 0.00 | 0.00 | +0.00 | buy |
| GeoWealth Management, LLC | 0 | 148 | +148 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 23 | +23 | 0.00 | 0.00 | 0.00 | buy |
| Sterling Capital Management LLC | 28 | 38 | +10 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 9 | +9 | 0.00 | 0.00 | +0.00 | buy |
| BVF INC/IL | 3,466,000 | 3,466,000 | 0 | 1.51 | 1.54 | +0.03 | hold |
| ALLIANCEBERNSTEIN L.P. | 23,680 | 23,680 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PERCEPTIVE ADVISORS LLC | 2,362,279 | 2,362,279 | 0 | 0.76 | 0.86 | +0.11 | hold |
| NEA Management Company, LLC | 1,250,001 | 1,250,001 | 0 | 1.02 | 0.92 | -0.09 | hold |
| Accredited Investors Inc. | 29,115 | 29,115 | 0 | 0.02 | 0.02 | -0.00 | hold |
| Focus Partners Wealth | 58,000 | 58,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JNBA Financial Advisors | 38,091 | 38,091 | 0 | 0.06 | 0.05 | -0.01 | hold |
| Cunning Capital Partners, LP | 52,465 | 52,465 | 0 | 1.40 | 2.90 | +1.50 | hold |
| IFP Advisors, Inc | 0 | 0 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Vivo Capital, LLC | 610,500 | 610,500 | 0 | 0.75 | 0.90 | +0.14 | hold |
| Russell Investments Group, Ltd. | 14 | 14 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BFSG, LLC | 300 | 300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GPS Wealth Strategies Group, LLC | 658 | 658 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BRAIDWELL LP | 884,306 | 884,306 | 0 | 0.37 | 0.34 | -0.03 | hold |
| Pale Fire Capital SE | 17,458 | 17,458 | 0 | 0.04 | 0.05 | +0.01 | hold |
| GAMMA Investing LLC | 99 | 99 | 0 | 0.00 | 0.00 | -0.00 | hold |
| US BANCORP \DE\ | 548 | 548 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| AMALGAMATED BANK | 581 | 581 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NATIONAL BANK OF CANADA /FI/ | 1 | 0 | -1 | 0.00 | 0.00 | -0.00 | sell |
| Corton Capital Inc. | 11,782 | 11,773 | -9 | 0.09 | 0.09 | +0.00 | sell |
| EARNED WEALTH ADVISORS, LLC | 10 | 0 | -10 | 0.00 | 0.00 | -0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 944 | 917 | -27 | 0.00 | 0.00 | -0.00 | sell |
| EntryPoint Capital, LLC | 20,875 | 20,847 | -28 | 0.18 | 0.11 | -0.06 | sell |
| ALPS ADVISORS INC | 30,093 | 30,028 | -65 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 1,583 | 1,495 | -88 | 0.00 | 0.00 | -0.00 | sell |
| Arax Advisory Partners | 104 | 0 | -104 | 0.00 | 0.00 | -0.00 | sell |
| GAGNON SECURITIES LLC | 52,793 | 52,479 | -314 | 0.16 | 0.14 | -0.02 | sell |
| VIRTUS ADVISERS, LLC | 6,006 | 5,638 | -368 | 0.04 | 0.03 | -0.01 | sell |
| Venturi Wealth Management, LLC | 413 | 0 | -413 | 0.00 | 0.00 | -0.00 | sell |
| Trust Point Inc. | 18,395 | 17,847 | -548 | 0.02 | 0.02 | -0.00 | sell |
| CIBC Private Wealth Group LLC | 810 | 0 | -810 | 0.00 | 0.00 | -0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 30,600 | 29,740 | -860 | 0.00 | 0.00 | -0.00 | sell |
| Tower Research Capital LLC (TRC) | 1,680 | 531 | -1,149 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 10,507 | 9,219 | -1,288 | 0.00 | 0.00 | -0.00 | sell |
| nVerses Capital, LLC | 2,200 | 0 | -2,200 | 0.02 | 0.00 | -0.02 | sell |
| FOURPATH CAPITAL MANAGEMENT, LLC | 2,350 | 0 | -2,350 | 0.01 | 0.00 | -0.01 | sell |
| ADAR1 Capital Management, LLC | 3,000 | 0 | -3,000 | 0.01 | 0.00 | -0.01 | sell |
| TWO SIGMA ADVISERS, LP | 55,000 | 51,200 | -3,800 | 0.00 | 0.00 | -0.00 | sell |
| Values First Advisors, Inc. | 5,762 | 0 | -5,762 | 0.05 | 0.00 | -0.05 | sell |
| Jump Financial, LLC | 29,872 | 20,122 | -9,750 | 0.01 | 0.01 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 11,045 | 0 | -11,045 | 0.00 | 0.00 | -0.00 | sell |
| AlphaQuest LLC | 18,962 | 7,894 | -11,068 | 0.03 | 0.01 | -0.01 | sell |
| PROFUND ADVISORS LLC | 11,267 | 0 | -11,267 | 0.01 | 0.00 | -0.01 | sell |
| MARSHALL WACE, LLP | 11,877 | 0 | -11,877 | 0.00 | 0.00 | -0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 13,722 | 0 | -13,722 | 0.01 | 0.00 | -0.01 | sell |
| Verition Fund Management LLC | 39,916 | 25,991 | -13,925 | 0.00 | 0.00 | -0.00 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 17,478 | 0 | -17,478 | 0.00 | 0.00 | -0.00 | sell |