| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BAKER BROS. ADVISORS LP | 7,915,792 | 7,915,792 | 0 | 2.83 | 4.62 | +1.80 | hold |
| NEA Management Company, LLC | 2,144,261 | 3,535,561 | +1,391,300 | 5.81 | 17.98 | +12.17 | buy |
| PERCEPTIVE ADVISORS LLC | 2,956,319 | 3,160,200 | +203,881 | 4.22 | 5.77 | +1.56 | buy |
| Avoro Capital Advisors LLC | 0 | 3,111,111 | +3,111,111 | 0.00 | 3.05 | +3.05 | buy |
| BlackRock, Inc. | 2,246,447 | 2,540,377 | +293,930 | 0.00 | 0.00 | +0.00 | buy |
| VANGUARD GROUP INC | 2,059,047 | 2,279,433 | +220,386 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 1,178,860 | 1,808,258 | +629,398 | 3.11 | 7.65 | +4.54 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 733,530 | 1,714,000 | +980,470 | 0.56 | 2.19 | +1.64 | buy |
| STATE STREET CORP | 722,800 | 1,637,687 | +914,887 | 0.00 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 1,512,852 | 1,398,970 | -113,882 | 0.00 | 0.01 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 598,156 | 1,240,281 | +642,125 | 0.00 | 0.01 | +0.01 | buy |
| TANG CAPITAL MANAGEMENT LLC | 1,150,000 | 1,050,000 | -100,000 | 2.19 | 5.17 | +2.99 | sell |
| BANK OF AMERICA CORP /DE/ | 539,527 | 977,118 | +437,591 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 766,471 | 830,684 | +64,213 | 0.00 | 0.01 | +0.00 | buy |
| Polar Capital Holdings Plc | 0 | 750,000 | +750,000 | 0.00 | 0.01 | +0.01 | buy |
| Holocene Advisors, LP | 0 | 695,340 | +695,340 | 0.00 | 0.15 | +0.15 | buy |
| GOLDMAN SACHS GROUP INC | 422,938 | 652,827 | +229,889 | 0.00 | 0.01 | +0.01 | buy |
| APIS CAPITAL ADVISORS, LLC | 776,000 | 602,000 | -174,000 | 8.47 | 10.46 | +1.99 | sell |
| RTW INVESTMENTS, LP | 0 | 550,160 | +550,160 | 0.00 | 0.55 | +0.55 | buy |
| Artisan Partners Limited Partnership | 585,892 | 546,641 | -39,251 | 0.04 | 0.08 | +0.04 | sell |
| Nearwater Capital Markets, Ltd | 0 | 520,200 | +520,200 | 0.00 | 0.89 | +0.89 | buy |
| Sio Capital Management, LLC | 786,526 | 477,067 | -309,459 | 9.83 | 7.89 | -1.94 | sell |
| Candriam S.C.A. | 390,924 | 476,370 | +85,446 | 0.10 | 0.24 | +0.14 | buy |
| ALLIANCEBERNSTEIN L.P. | 652,649 | 472,938 | -179,711 | 0.01 | 0.01 | +0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 88,686 | 375,132 | +286,446 | 0.63 | 5.41 | +4.78 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 111,281 | 371,139 | +259,858 | 0.00 | 0.01 | +0.01 | buy |
| PFIZER INC | 349,406 | 349,406 | 0 | 3.95 | 14.74 | +10.79 | hold |
| Saturn V Capital Management LP | 473,828 | 317,095 | -156,733 | 5.13 | 5.80 | +0.67 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,088,799 | 313,679 | -775,120 | 0.88 | 0.49 | -0.40 | sell |
| Sofinnova Investments, Inc. | 253,375 | 299,417 | +46,042 | 0.77 | 1.29 | +0.52 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 268,749 | 292,315 | +23,566 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 276,161 | 287,746 | +11,585 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 162,256 | 250,055 | +87,799 | 0.06 | 0.17 | +0.11 | buy |
| Focus Partners Wealth | 234,843 | 234,807 | -36 | 0.02 | 0.03 | +0.01 | sell |
| JENNISON ASSOCIATES LLC | 0 | 229,704 | +229,704 | 0.00 | 0.01 | +0.01 | buy |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 0 | 226,469 | +226,469 | 0.00 | 0.08 | +0.08 | buy |
| Boxer Capital Management, LLC | 90,000 | 225,000 | +135,000 | 1.42 | 4.91 | +3.49 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 221,595 | +221,595 | 0.00 | 0.04 | +0.04 | buy |
| Qube Research & Technologies Ltd | 6,665 | 208,505 | +201,840 | 0.00 | 0.03 | +0.03 | buy |
| Hennion & Walsh Asset Management, Inc. | 171,354 | 190,933 | +19,579 | 0.31 | 0.66 | +0.35 | buy |
| LORD, ABBETT & CO. LLC | 247,874 | 181,485 | -66,389 | 0.04 | 0.06 | +0.02 | sell |
| Walleye Capital LLC | 298,901 | 153,289 | -145,612 | 0.12 | 0.09 | -0.03 | sell |
| Ensign Peak Advisors, Inc | 0 | 148,994 | +148,994 | 0.00 | 0.03 | +0.03 | buy |
| Invesco Ltd. | 141,010 | 147,938 | +6,928 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 178,851 | 142,203 | -36,648 | 0.01 | 0.01 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 22,327 | 138,435 | +116,108 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 0 | 130,943 | +130,943 | 0.00 | 0.05 | +0.05 | buy |
| AMERIPRISE FINANCIAL INC | 61,418 | 123,251 | +61,833 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 51,801 | 122,854 | +71,053 | 0.00 | 0.00 | +0.00 | buy |
| Patient Square Capital LP | 100,000 | 120,000 | +20,000 | 1.32 | 2.56 | +1.24 | buy |
| RAYMOND JAMES FINANCIAL INC | 120,884 | 119,561 | -1,323 | 0.00 | 0.00 | +0.00 | sell |
| STEMPOINT CAPITAL LP | 136,710 | 118,333 | -18,377 | 1.36 | 2.03 | +0.66 | sell |
| Clearbridge Investments, LLC | 134,220 | 106,931 | -27,289 | 0.00 | 0.01 | +0.00 | sell |
| Ikarian Capital, LLC | 0 | 105,545 | +105,545 | 0.00 | 1.36 | +1.36 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 43,423 | 104,986 | +61,563 | 0.00 | 0.01 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 72,796 | 97,526 | +24,730 | 0.00 | 0.01 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 91,895 | +91,895 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 84,819 | 88,623 | +3,804 | 0.00 | 0.00 | +0.00 | buy |
| Granahan Investment Management, LLC | 49,281 | 87,032 | +37,751 | 0.10 | 0.37 | +0.27 | buy |
| Russell Investments Group, Ltd. | 108,020 | 85,773 | -22,247 | 0.01 | 0.01 | +0.00 | sell |
| ORBIMED ADVISORS LLC | 84,020 | 85,664 | +1,644 | 0.10 | 0.17 | +0.08 | buy |
| Atom Investors LP | 0 | 85,583 | +85,583 | 0.00 | 0.68 | +0.68 | buy |
| Nuveen, LLC | 191,323 | 85,298 | -106,025 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 526,615 | 82,243 | -444,372 | 0.02 | 0.01 | -0.01 | sell |
| UBS Group AG | 854,483 | 81,571 | -772,912 | 0.01 | 0.00 | -0.01 | sell |
| NAN FUNG TRINITY (HK) Ltd | 0 | 80,775 | +80,775 | 0.00 | 0.64 | +0.64 | buy |
| Integral Health Asset Management, LLC | 0 | 80,000 | +80,000 | 0.00 | 0.40 | +0.40 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 56,955 | 71,653 | +14,698 | 0.00 | 0.01 | +0.00 | buy |
| Man Group plc | 0 | 62,507 | +62,507 | 0.00 | 0.01 | +0.01 | buy |
| CAPTRUST FINANCIAL ADVISORS | 67,535 | 61,530 | -6,005 | 0.01 | 0.01 | +0.00 | sell |
| D. E. Shaw & Co., Inc. | 371,944 | 57,654 | -314,290 | 0.01 | 0.00 | -0.01 | sell |
| Rafferty Asset Management, LLC | 8,053 | 57,128 | +49,075 | 0.00 | 0.02 | +0.02 | buy |
| Squarepoint Ops LLC | 0 | 57,053 | +57,053 | 0.00 | 0.01 | +0.01 | buy |
| GAGNON SECURITIES LLC | 53,955 | 53,401 | -554 | 0.53 | 1.08 | +0.55 | sell |
| BI Asset Management Fondsmaeglerselskab A/S | 0 | 51,155 | +51,155 | 0.00 | 0.05 | +0.05 | buy |
| JPMORGAN CHASE & CO | 52,045 | 51,059 | -986 | 0.00 | 0.00 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 47,704 | 48,704 | +1,000 | 0.00 | 0.01 | +0.00 | buy |
| Informed Momentum Co LLC | 87,292 | 48,034 | -39,258 | 0.49 | 0.53 | +0.05 | sell |
| CITADEL ADVISORS LLC | 15,022 | 47,037 | +32,015 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 68,780 | 45,705 | -23,075 | 0.06 | 0.13 | +0.07 | sell |
| Harvest Investment Services, LLC | 28,878 | 42,485 | +13,607 | 0.29 | 0.80 | +0.51 | buy |
| Atle Fund Management AB | 37,157 | 41,831 | +4,674 | 0.72 | 1.33 | +0.61 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 39,311 | 41,507 | +2,196 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 58,827 | 39,959 | -18,868 | 0.04 | 0.04 | +0.00 | sell |
| PRUDENTIAL FINANCIAL INC | 4,215 | 38,690 | +34,475 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 41,440 | 38,104 | -3,336 | 0.00 | 0.00 | +0.00 | sell |
| ALPS ADVISORS INC | 20,050 | 37,894 | +17,844 | 0.01 | 0.02 | +0.02 | buy |
| JNBA Financial Advisors | 37,753 | 36,753 | -1,000 | 0.17 | 0.32 | +0.15 | sell |
| Exome Asset Management LLC | 0 | 34,289 | +34,289 | 0.00 | 1.69 | +1.69 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 30,335 | +30,335 | 0.00 | 0.08 | +0.08 | buy |
| NEOS Investment Management LLC | 25,790 | 28,233 | +2,443 | 0.01 | 0.02 | +0.01 | buy |
| TEMA ETFS LLC | 25,790 | 27,818 | +2,028 | 0.11 | 0.22 | +0.11 | buy |
| Accredited Investors Inc. | 27,115 | 27,115 | 0 | 0.07 | 0.14 | +0.07 | hold |
| FMR LLC | 3,007 | 26,651 | +23,644 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 0 | 25,100 | +25,100 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 25,000 | +25,000 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 19,270 | 23,525 | +4,255 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 21,220 | +21,220 | 0.00 | 0.06 | +0.06 | buy |
| SEI INVESTMENTS CO | 24,612 | 21,181 | -3,431 | 0.00 | 0.00 | +0.00 | sell |
| Creative Planning | 17,199 | 20,972 | +3,773 | 0.00 | 0.00 | +0.00 | buy |