| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| NEA Management Company, LLC | 2,144,261 | 3,535,561 | +1,391,300 | 5.81 | 17.98 | +12.17 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 733,530 | 1,714,000 | +980,470 | 0.55 | 2.18 | +1.63 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 598,156 | 1,240,281 | +642,125 | 0.00 | 0.01 | +0.01 | buy |
| Soleus Capital Management, L.P. | 1,178,860 | 1,808,258 | +629,398 | 3.11 | 7.65 | +4.54 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 88,686 | 375,132 | +286,446 | 0.63 | 5.41 | +4.78 | buy |
| PERCEPTIVE ADVISORS LLC | 2,956,319 | 3,160,200 | +203,881 | 4.22 | 5.62 | +1.40 | buy |
| Boxer Capital Management, LLC | 90,000 | 225,000 | +135,000 | 1.42 | 4.91 | +3.49 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 162,256 | 250,055 | +87,799 | 0.06 | 0.17 | +0.11 | buy |
| Candriam S.C.A. | 390,924 | 476,370 | +85,446 | 0.10 | 0.24 | +0.14 | buy |
| Rafferty Asset Management, LLC | 8,053 | 57,128 | +49,075 | 0.00 | 0.02 | +0.02 | buy |
| Sofinnova Investments, Inc. | 253,375 | 299,417 | +46,042 | 0.68 | 1.29 | +0.60 | buy |
| Granahan Investment Management, LLC | 49,281 | 87,032 | +37,751 | 0.10 | 0.37 | +0.27 | buy |
| TD ASSET MANAGEMENT INC | 72,796 | 97,526 | +24,730 | 0.00 | 0.01 | +0.00 | buy |
| Patient Square Capital LP | 100,000 | 120,000 | +20,000 | 1.32 | 2.56 | +1.24 | buy |
| Hennion & Walsh Asset Management, Inc. | 171,354 | 190,933 | +19,579 | 0.31 | 0.66 | +0.35 | buy |
| ALPS ADVISORS INC | 20,050 | 37,894 | +17,844 | 0.01 | 0.02 | 0.00 | buy |
| Harvest Investment Services, LLC | 28,878 | 42,485 | +13,607 | 0.29 | 0.80 | +0.51 | buy |
| Atle Fund Management AB | 37,157 | 41,831 | +4,674 | 0.72 | 1.33 | +0.61 | buy |
| SummitTX Capital, L.P. | 9,837 | 13,449 | +3,612 | 0.02 | 0.04 | +0.02 | buy |
| HighVista Strategies LLC | 13,680 | 16,543 | +2,863 | 0.17 | 0.42 | +0.26 | buy |
| NEOS Investment Management LLC | 25,790 | 28,233 | +2,443 | 0.01 | 0.02 | +0.01 | buy |
| TEMA ETFS LLC | 25,790 | 27,818 | +2,028 | 0.11 | 0.22 | +0.11 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 8,071 | 6,293 | +1,778 | 0.03 | 0.05 | 0.00 | sell |
| ORBIMED ADVISORS LLC | 84,020 | 85,664 | +1,644 | 0.10 | 0.17 | +0.08 | buy |
| WoodTrust Financial Corp | 5,600 | 6,207 | +607 | 0.03 | 0.07 | +0.04 | buy |
| Aristides Capital LLC | 15,000 | 15,303 | +303 | 0.11 | 0.27 | +0.16 | buy |
| OGOREK ANTHONY JOSEPH /NY/ /ADV | 553 | 662 | +109 | 0.01 | 0.02 | +0.01 | buy |
| Inscription Capital, LLC | 4,682 | 4,717 | +35 | 0.02 | 0.05 | +0.02 | buy |
| GREAT VALLEY ADVISOR GROUP, INC. | 5,215 | 5,230 | +15 | 0.01 | 0.01 | +0.00 | buy |
| Avanza Fonder AB | 1,604 | 1,532 | -72 | 0.00 | 0.00 | +0.00 | sell |
| GAGNON SECURITIES LLC | 53,955 | 53,401 | -554 | 0.53 | 1.08 | +0.55 | sell |
| JNBA Financial Advisors | 37,753 | 36,753 | -1,000 | 0.17 | 0.32 | +0.15 | sell |
| NorthRock Partners, LLC | 5,954 | 4,854 | -1,100 | 0.01 | 0.01 | +0.00 | sell |
| Focus Financial Network, Inc. | 10,691 | 9,334 | -1,357 | 0.02 | 0.03 | +0.01 | sell |
| PERKINS CAPITAL MANAGEMENT INC | 7,900 | 6,400 | -1,500 | 0.34 | 0.51 | +0.16 | sell |
| Murphy Pohlad Asset Management LLC | 9,000 | 6,600 | -2,400 | 0.17 | 0.25 | +0.08 | sell |
| Red Door Wealth Management, LLC | 7,875 | 5,175 | -2,700 | 0.04 | 0.05 | +0.01 | sell |
| Roundview Capital LLC | 6,857 | 2,778 | -4,079 | 0.02 | 0.02 | -0.00 | sell |
| Virtus Investment Advisers, LLC | 9,059 | 2,528 | -6,531 | 0.13 | 0.07 | -0.06 | sell |
| STEMPOINT CAPITAL LP | 136,710 | 118,333 | -18,377 | 1.36 | 2.03 | +0.66 | sell |
| Clearbridge Investments, LLC | 134,220 | 106,931 | -27,289 | 0.00 | 0.01 | +0.00 | sell |
| Artisan Partners Limited Partnership | 585,892 | 546,641 | -39,251 | 0.04 | 0.08 | +0.04 | sell |
| Informed Momentum Co LLC | 87,292 | 48,034 | -39,258 | 0.49 | 0.53 | +0.05 | sell |
| LORD, ABBETT & CO. LLC | 247,874 | 181,485 | -66,389 | 0.04 | 0.06 | +0.02 | sell |
| J. Goldman & Co LP | 102,707 | 4,642 | -98,065 | 0.13 | 0.01 | -0.12 | sell |
| TANG CAPITAL MANAGEMENT LLC | 1,150,000 | 1,050,000 | -100,000 | 2.19 | 5.17 | +2.99 | sell |
| Saturn V Capital Management LP | 473,828 | 317,095 | -156,733 | 5.13 | 5.80 | +0.67 | sell |
| APIS CAPITAL ADVISORS, LLC | 776,000 | 602,000 | -174,000 | 8.47 | 10.46 | +1.99 | sell |
| Sio Capital Management, LLC | 786,526 | 477,067 | -309,459 | 9.83 | 7.48 | -2.35 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,088,799 | 313,679 | -775,120 | 0.88 | 0.49 | -0.40 | sell |