| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Avoro Capital Advisors LLC | 0 | 3,111,111 | +3,111,111 | 0.00 | 3.05 | +3.05 | buy |
| NEA Management Company, LLC | 2,144,261 | 3,535,561 | +1,391,300 | 5.81 | 17.98 | +12.17 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 733,530 | 1,714,000 | +980,470 | 0.56 | 2.19 | +1.64 | buy |
| STATE STREET CORP | 722,800 | 1,637,687 | +914,887 | 0.00 | 0.01 | +0.00 | buy |
| Polar Capital Holdings Plc | 0 | 750,000 | +750,000 | 0.00 | 0.01 | +0.01 | buy |
| Holocene Advisors, LP | 0 | 695,340 | +695,340 | 0.00 | 0.15 | +0.15 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 598,156 | 1,240,281 | +642,125 | 0.00 | 0.01 | +0.01 | buy |
| Soleus Capital Management, L.P. | 1,178,860 | 1,808,258 | +629,398 | 3.11 | 7.65 | +4.54 | buy |
| RTW INVESTMENTS, LP | 0 | 550,160 | +550,160 | 0.00 | 0.55 | +0.55 | buy |
| Nearwater Capital Markets, Ltd | 0 | 520,200 | +520,200 | 0.00 | 0.89 | +0.89 | buy |
| BANK OF AMERICA CORP /DE/ | 539,527 | 977,118 | +437,591 | 0.00 | 0.01 | +0.01 | buy |
| BlackRock, Inc. | 2,246,447 | 2,540,377 | +293,930 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 88,686 | 375,132 | +286,446 | 0.63 | 5.41 | +4.78 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 111,281 | 371,139 | +259,858 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 422,938 | 652,827 | +229,889 | 0.00 | 0.01 | +0.01 | buy |
| JENNISON ASSOCIATES LLC | 0 | 229,704 | +229,704 | 0.00 | 0.01 | +0.01 | buy |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 0 | 226,469 | +226,469 | 0.00 | 0.08 | +0.08 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 221,595 | +221,595 | 0.00 | 0.04 | +0.04 | buy |
| VANGUARD GROUP INC | 2,059,047 | 2,279,433 | +220,386 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 2,956,319 | 3,160,200 | +203,881 | 4.22 | 5.77 | +1.56 | buy |
| Qube Research & Technologies Ltd | 6,665 | 208,505 | +201,840 | 0.00 | 0.03 | +0.03 | buy |
| Ensign Peak Advisors, Inc | 0 | 148,994 | +148,994 | 0.00 | 0.03 | +0.03 | buy |
| Boxer Capital Management, LLC | 90,000 | 225,000 | +135,000 | 1.42 | 4.91 | +3.49 | buy |
| Woodline Partners LP | 0 | 130,943 | +130,943 | 0.00 | 0.05 | +0.05 | buy |
| WELLS FARGO & COMPANY/MN | 22,327 | 138,435 | +116,108 | 0.00 | 0.00 | +0.00 | buy |
| Ikarian Capital, LLC | 0 | 105,545 | +105,545 | 0.00 | 1.36 | +1.36 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 91,895 | +91,895 | 0.00 | 0.01 | +0.01 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 162,256 | 250,055 | +87,799 | 0.06 | 0.17 | +0.11 | buy |
| Atom Investors LP | 0 | 85,583 | +85,583 | 0.00 | 0.68 | +0.68 | buy |
| Candriam S.C.A. | 390,924 | 476,370 | +85,446 | 0.10 | 0.24 | +0.14 | buy |
| NAN FUNG TRINITY (HK) Ltd | 0 | 80,775 | +80,775 | 0.00 | 0.64 | +0.64 | buy |
| Integral Health Asset Management, LLC | 0 | 80,000 | +80,000 | 0.00 | 0.40 | +0.40 | buy |
| BARCLAYS PLC | 51,801 | 122,854 | +71,053 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 766,471 | 830,684 | +64,213 | 0.00 | 0.01 | +0.00 | buy |
| Man Group plc | 0 | 62,507 | +62,507 | 0.00 | 0.01 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 61,418 | 123,251 | +61,833 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 43,423 | 104,986 | +61,563 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 0 | 57,053 | +57,053 | 0.00 | 0.01 | +0.01 | buy |
| BI Asset Management Fondsmaeglerselskab A/S | 0 | 51,155 | +51,155 | 0.00 | 0.05 | +0.05 | buy |
| Rafferty Asset Management, LLC | 8,053 | 57,128 | +49,075 | 0.00 | 0.02 | +0.02 | buy |
| Sofinnova Investments, Inc. | 253,375 | 299,417 | +46,042 | 0.77 | 1.29 | +0.52 | buy |
| Granahan Investment Management, LLC | 49,281 | 87,032 | +37,751 | 0.10 | 0.37 | +0.27 | buy |
| PRUDENTIAL FINANCIAL INC | 4,215 | 38,690 | +34,475 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 0 | 34,289 | +34,289 | 0.00 | 1.69 | +1.69 | buy |
| CITADEL ADVISORS LLC | 15,022 | 47,037 | +32,015 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 30,335 | +30,335 | 0.00 | 0.08 | +0.08 | buy |
| Swiss National Bank | 0 | 25,100 | +25,100 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 25,000 | +25,000 | 0.00 | 0.01 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 72,796 | 97,526 | +24,730 | 0.00 | 0.01 | +0.00 | buy |
| FMR LLC | 3,007 | 26,651 | +23,644 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 268,749 | 292,315 | +23,566 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 21,220 | +21,220 | 0.00 | 0.06 | +0.06 | buy |
| Patient Square Capital LP | 100,000 | 120,000 | +20,000 | 1.32 | 2.56 | +1.24 | buy |
| Hennion & Walsh Asset Management, Inc. | 171,354 | 190,933 | +19,579 | 0.31 | 0.66 | +0.35 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 19,304 | +19,304 | 0.00 | 0.01 | +0.01 | buy |
| ALPS ADVISORS INC | 20,050 | 37,894 | +17,844 | 0.01 | 0.02 | +0.02 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 15,278 | +15,278 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 56,955 | 71,653 | +14,698 | 0.00 | 0.01 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 14,368 | +14,368 | 0.00 | 0.00 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 13,718 | +13,718 | 0.00 | 0.06 | +0.06 | buy |
| Harvest Investment Services, LLC | 28,878 | 42,485 | +13,607 | 0.29 | 0.80 | +0.51 | buy |
| NORGES BANK | 0 | 13,205 | +13,205 | 0.00 | 0.00 | +0.00 | buy |
| Artia Global Partners LP | 0 | 12,900 | +12,900 | 0.00 | 0.21 | +0.21 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 11,757 | +11,757 | 0.00 | 0.00 | +0.00 | buy |
| Blackstone Inc. | 0 | 11,668 | +11,668 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 1,787 | 13,379 | +11,592 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 276,161 | 287,746 | +11,585 | 0.00 | 0.00 | +0.00 | buy |
| HSBC HOLDINGS PLC | 0 | 10,636 | +10,636 | 0.00 | 0.00 | +0.00 | buy |
| LEVEL FOUR ADVISORY SERVICES, LLC | 0 | 9,802 | +9,802 | 0.00 | 0.03 | +0.03 | buy |
| Legal & General Group Plc | 3,165 | 12,827 | +9,662 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 8,931 | +8,931 | 0.00 | 0.07 | +0.07 | buy |
| GUGGENHEIM CAPITAL LLC | 0 | 7,708 | +7,708 | 0.00 | 0.01 | +0.01 | buy |
| WINTON GROUP Ltd | 0 | 7,654 | +7,654 | 0.00 | 0.03 | +0.03 | buy |
| Jefferies Financial Group Inc. | 0 | 7,051 | +7,051 | 0.00 | 0.01 | +0.01 | buy |
| Invesco Ltd. | 141,010 | 147,938 | +6,928 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 0 | 6,719 | +6,719 | 0.00 | 0.32 | +0.32 | buy |
| Trexquant Investment LP | 0 | 6,459 | +6,459 | 0.00 | 0.01 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 6,200 | +6,200 | 0.00 | 0.00 | +0.00 | buy |
| Polymer Capital Management (US) LLC | 0 | 6,142 | +6,142 | 0.00 | 0.08 | +0.08 | buy |
| Simplicity Wealth,LLC | 0 | 5,818 | +5,818 | 0.00 | 0.03 | +0.03 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 5,521 | +5,521 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 2,637 | 8,055 | +5,418 | 0.00 | 0.00 | +0.00 | buy |
| Atle Fund Management AB | 37,157 | 41,831 | +4,674 | 0.72 | 1.33 | +0.61 | buy |
| POLEN CAPITAL MANAGEMENT LLC | 0 | 4,660 | +4,660 | 0.00 | 0.00 | +0.00 | buy |
| INTEGRITY ALLIANCE, LLC. | 0 | 4,522 | +4,522 | 0.00 | 0.02 | +0.02 | buy |
| State of New Jersey Common Pension Fund D | 0 | 4,344 | +4,344 | 0.00 | 0.00 | +0.00 | buy |
| Sequoia Financial Advisors, LLC | 0 | 4,265 | +4,265 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 19,270 | 23,525 | +4,255 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 14,123 | 18,269 | +4,146 | 0.00 | 0.00 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 4,000 | +4,000 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 84,819 | 88,623 | +3,804 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 17,199 | 20,972 | +3,773 | 0.00 | 0.00 | +0.00 | buy |
| MERCER GLOBAL ADVISORS INC /ADV | 0 | 3,773 | +3,773 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 6,869 | 10,618 | +3,749 | 0.00 | 0.00 | +0.00 | buy |
| SummitTX Capital, L.P. | 9,837 | 13,449 | +3,612 | 0.02 | 0.04 | +0.02 | buy |
| Arizona State Retirement System | 0 | 3,604 | +3,604 | 0.00 | 0.00 | +0.00 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 0 | 3,557 | +3,557 | 0.00 | 0.08 | +0.08 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 3,504 | +3,504 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 0 | 3,360 | +3,360 | 0.00 | 0.00 | +0.00 | buy |
| Cambridge Investment Research Advisors, Inc. | 0 | 3,260 | +3,260 | 0.00 | 0.00 | +0.00 | buy |