| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| LORD, ABBETT & CO. LLC | 8,511,000 | 17,609,000 | +9,098,000 | 0.05 | 0.14 | +0.09 | buy |
| VANGUARD GROUP INC | 10,971,895 | 11,044,743 | +72,848 | 0.02 | 0.02 | +0.00 | buy |
| JPMORGAN CHASE & CO | 7,954,212 | 7,357,916 | -596,296 | 0.05 | 0.06 | +0.01 | sell |
| FRED ALGER MANAGEMENT, LLC | 7,076,651 | 6,546,927 | -529,724 | 2.39 | 2.97 | +0.58 | sell |
| FARALLON CAPITAL MANAGEMENT LLC | 3,474,883 | 3,927,683 | +452,800 | 1.36 | 2.11 | +0.75 | buy |
| AMERIPRISE FINANCIAL INC | 2,283,903 | 3,441,930 | +1,158,027 | 0.04 | 0.09 | +0.04 | buy |
| Invesco Ltd. | 2,816,142 | 3,210,099 | +393,957 | 0.04 | 0.06 | +0.02 | buy |
| STATE STREET CORP | 3,185,683 | 2,722,993 | -462,690 | 0.01 | 0.01 | +0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 1,520,333 | 2,639,254 | +1,118,921 | 0.09 | 0.20 | +0.11 | buy |
| ALLIANCEBERNSTEIN L.P. | 2,990,416 | 2,619,459 | -370,957 | 0.07 | 0.08 | +0.01 | sell |
| RTW INVESTMENTS, LP | 2,593,323 | 2,593,323 | 0 | 2.54 | 3.50 | +0.96 | hold |
| CITADEL ADVISORS LLC | 1,663,344 | 2,341,611 | +678,267 | 0.10 | 0.21 | +0.10 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 441,024 | 2,248,665 | +1,807,641 | 0.01 | 0.06 | +0.05 | buy |
| Kynam Capital Management, LP | 2,400,000 | 2,000,000 | -400,000 | 17.01 | 20.35 | +3.33 | sell |
| SAMLYN CAPITAL, LLC | 3,874,801 | 1,984,579 | -1,890,222 | 5.27 | 3.15 | -2.12 | sell |
| Duquesne Family Office LLC | 893,030 | 1,929,380 | +1,036,350 | 1.80 | 4.74 | +2.94 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,771,062 | 1,841,557 | +70,495 | 0.01 | 0.02 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 1,870,496 | 1,827,603 | -42,893 | 0.08 | 0.11 | +0.02 | sell |
| LORD, ABBETT & CO. LLC | 799,489 | 1,796,310 | +996,821 | 0.18 | 0.53 | +0.35 | buy |
| Eversept Partners, LP | 2,251,588 | 1,778,051 | -473,537 | 13.83 | 12.15 | -1.68 | sell |
| Sofinnova Investments, Inc. | 1,550,280 | 1,550,280 | 0 | 5.44 | 8.37 | +2.93 | hold |
| PRINCIPAL FINANCIAL GROUP INC | 1,703,615 | 1,376,413 | -327,202 | 0.07 | 0.07 | +0.01 | sell |
| FMR LLC | 1,879,329 | 1,350,227 | -529,102 | 0.01 | 0.01 | -0.00 | sell |
| NORGES BANK | 1,340,514 | 1,249,248 | -91,266 | 0.01 | 0.02 | +0.00 | sell |
| MORGAN STANLEY | 1,299,600 | 1,235,494 | -64,106 | 0.01 | 0.01 | +0.00 | sell |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 963,228 | 1,144,333 | +181,105 | 0.61 | 0.98 | +0.37 | buy |
| FIRST TRUST ADVISORS LP | 114,925 | 1,130,572 | +1,015,647 | 0.01 | 0.10 | +0.10 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 706,083 | 1,064,966 | +358,883 | 0.53 | 0.97 | +0.44 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 997,909 | 1,034,545 | +36,636 | 0.02 | 0.02 | +0.01 | buy |
| GILDER GAGNON HOWE & CO LLC | 1,055,021 | 1,030,474 | -24,547 | 0.91 | 1.18 | +0.27 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 1,064,676 | 931,824 | -132,852 | 0.07 | 0.08 | +0.01 | sell |
| ORBIMED ADVISORS LLC | 954,481 | 899,431 | -55,050 | 1.20 | 1.51 | +0.31 | sell |
| Bank of New York Mellon Corp | 966,106 | 889,309 | -76,797 | 0.01 | 0.02 | +0.00 | sell |
| Allspring Global Investments Holdings, LLC | 720,160 | 863,406 | +143,246 | 0.07 | 0.12 | +0.05 | buy |
| D. E. Shaw & Co., Inc. | 685,315 | 841,457 | +156,142 | 0.06 | 0.10 | +0.04 | buy |
| Avidity Partners Management LP | 1,110,000 | 803,300 | -306,700 | 2.66 | 2.61 | -0.05 | sell |
| MAVERICK CAPITAL LTD | 0 | 798,682 | +798,682 | 0.00 | 1.42 | +1.42 | buy |
| PERCEPTIVE ADVISORS LLC | 850,225 | 757,225 | -93,000 | 1.19 | 1.22 | +0.03 | sell |
| Holocene Advisors, LP | 1,075,274 | 710,232 | -365,042 | 0.26 | 0.24 | -0.02 | sell |
| GOLDMAN SACHS GROUP INC | 812,941 | 686,240 | -126,701 | 0.01 | 0.01 | +0.00 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 548,152 | 669,961 | +121,809 | 0.00 | 0.01 | +0.00 | buy |
| First Light Asset Management, LLC | 165,886 | 656,708 | +490,822 | 0.84 | 4.60 | +3.76 | buy |
| Eagle Health Investments LP | 690,862 | 632,714 | -58,148 | 8.79 | 11.03 | +2.23 | sell |
| MARSHALL WACE, LLP | 436,901 | 623,753 | +186,852 | 0.05 | 0.09 | +0.04 | buy |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 0 | 622,498 | +622,498 | 0.00 | 2.72 | +2.72 | buy |
| Pictet Asset Management Holding SA | 911,250 | 586,768 | -324,482 | 0.06 | 0.06 | -0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 595,743 | 576,679 | -19,064 | 0.05 | 0.06 | +0.01 | sell |
| NORTHERN TRUST CORP | 545,108 | 541,977 | -3,131 | 0.01 | 0.01 | +0.00 | sell |
| Amundi | 647,055 | 532,579 | -114,476 | 0.02 | 0.02 | +0.00 | sell |
| LOOMIS SAYLES & CO L P | 590,612 | 525,778 | -64,834 | 0.06 | 0.07 | +0.01 | sell |
| Blue Water Life Science Advisors, LP | 397,436 | 503,094 | +105,658 | 21.81 | 43.28 | +21.47 | buy |
| ZEVENBERGEN CAPITAL INVESTMENTS LLC | 437,014 | 487,631 | +50,617 | 0.63 | 0.95 | +0.32 | buy |
| JENNISON ASSOCIATES LLC | 212,811 | 472,147 | +259,336 | 0.01 | 0.03 | +0.02 | buy |
| FRANKLIN RESOURCES INC | 235,563 | 448,387 | +212,824 | 0.01 | 0.01 | +0.01 | buy |
| C WorldWide Group Holding A/S | 475,000 | 435,000 | -40,000 | 0.40 | 0.45 | +0.05 | sell |
| FEDERATED HERMES, INC. | 527,200 | 423,269 | -103,931 | 0.08 | 0.09 | +0.01 | sell |
| Capital World Investors | 396,421 | 396,421 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Sumitomo Mitsui Trust Group, Inc. | 0 | 371,271 | +371,271 | 0.00 | 0.02 | +0.02 | buy |
| Nikko Asset Management Americas, Inc. | 0 | 371,271 | +371,271 | 0.00 | 0.34 | +0.34 | buy |
| SEI INVESTMENTS CO | 352,230 | 368,942 | +16,712 | 0.04 | 0.05 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 195,568 | 343,789 | +148,221 | 0.00 | 0.00 | +0.00 | buy |
| ARK Investment Management LLC | 0 | 322,384 | +322,384 | 0.00 | 0.20 | +0.20 | buy |
| AXA S.A. | 418,129 | 320,342 | -97,787 | 0.08 | 0.09 | +0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 86,199 | 307,716 | +221,517 | 0.01 | 0.05 | +0.03 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 296,731 | 296,731 | 0 | 0.11 | 0.13 | +0.03 | hold |
| KORNITZER CAPITAL MANAGEMENT INC /KS | 336,329 | 294,684 | -41,645 | 0.41 | 0.49 | +0.08 | sell |
| Ensign Peak Advisors, Inc | 36,900 | 273,425 | +236,525 | 0.00 | 0.05 | +0.04 | buy |
| NOMURA HOLDINGS INC | 0 | 272,221 | +272,221 | 0.00 | 0.20 | +0.20 | buy |
| Bellevue Group AG | 256,584 | 269,832 | +13,248 | 0.25 | 0.38 | +0.13 | buy |
| Point72 Asset Management, L.P. | 6,920 | 263,746 | +256,826 | 0.00 | 0.07 | +0.07 | buy |
| Man Group plc | 400,846 | 258,069 | -142,777 | 0.07 | 0.06 | -0.01 | sell |
| MACQUARIE GROUP LTD | 300,079 | 250,810 | -49,269 | 0.02 | 0.03 | +0.00 | sell |
| Rhenman & Partners Asset Management AB | 245,000 | 240,000 | -5,000 | 1.53 | 2.08 | +0.55 | sell |
| Artemis Investment Management LLP | 390,991 | 234,096 | -156,895 | 0.36 | 0.28 | -0.08 | sell |
| Candriam S.C.A. | 241,987 | 228,008 | -13,979 | 0.10 | 0.13 | +0.03 | sell |
| Swiss National Bank | 222,100 | 225,400 | +3,300 | 0.01 | 0.01 | +0.00 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 202,632 | 215,181 | +12,549 | 0.05 | 0.07 | +0.02 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 209,433 | +209,433 | 0.00 | 0.07 | +0.07 | buy |
| Squarepoint Ops LLC | 409,162 | 206,947 | -202,215 | 0.10 | 0.08 | -0.03 | sell |
| Portolan Capital Management, LLC | 92,426 | 201,218 | +108,792 | 0.51 | 1.40 | +0.90 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 55,400 | 200,183 | +144,783 | 0.01 | 0.03 | +0.02 | buy |
| Bank of New York Mellon Corp | 200,000 | 200,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DIMENSIONAL FUND ADVISORS LP | 98,150 | 195,278 | +97,128 | 0.00 | 0.00 | +0.00 | buy |
| Tri Locum Partners LP | 141,847 | 190,114 | +48,267 | 4.36 | 6.03 | +1.67 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 327,359 | 189,357 | -138,002 | 0.06 | 0.04 | -0.01 | sell |
| ENVESTNET ASSET MANAGEMENT INC | 157,602 | 185,290 | +27,688 | 0.00 | 0.01 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 158,800 | 182,196 | +23,396 | 0.02 | 0.03 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 176,872 | 177,069 | +197 | 0.00 | 0.01 | +0.00 | buy |
| Magnetar Financial LLC | 115,829 | 176,643 | +60,814 | 0.18 | 0.36 | +0.18 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 183,375 | 175,297 | -8,078 | 0.02 | 0.02 | -0.00 | sell |
| THRIVENT FINANCIAL FOR LUTHERANS | 170,467 | 173,642 | +3,175 | 0.02 | 0.03 | +0.01 | buy |
| CITIGROUP INC | 216,845 | 173,604 | -43,241 | 0.02 | 0.02 | -0.00 | sell |
| MPM BioImpact LLC | 0 | 172,413 | +172,413 | 0.00 | 2.54 | +2.54 | buy |
| GCM Grosvenor Holdings, LLC | 217,157 | 166,125 | -51,032 | 2.40 | 2.32 | -0.09 | sell |
| SEGALL BRYANT & HAMILL, LLC | 140,747 | 163,436 | +22,689 | 0.17 | 0.28 | +0.11 | buy |
| Polar Asset Management Partners Inc. | 142,700 | 163,281 | +20,581 | 0.24 | 0.40 | +0.16 | buy |
| NATIONAL BANK OF CANADA /FI/ | 51,800 | 160,575 | +108,775 | 0.01 | 0.03 | +0.02 | buy |
| Castle Hook Partners LP | 0 | 158,512 | +158,512 | 0.00 | 0.52 | +0.52 | buy |
| Chevy Chase Trust Holdings, LLC | 0 | 158,183 | +158,183 | 0.00 | 0.05 | +0.05 | buy |
| Neuberger Berman Group LLC | 290,747 | 156,694 | -134,053 | 0.02 | 0.01 | -0.00 | sell |