| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| LORD, ABBETT & CO. LLC | 8,511,000 | 17,609,000 | +9,098,000 | 0.05 | 0.14 | +0.09 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 441,024 | 2,248,665 | +1,807,641 | 0.01 | 0.06 | +0.05 | buy |
| AMERIPRISE FINANCIAL INC | 2,283,903 | 3,441,930 | +1,158,027 | 0.04 | 0.09 | +0.04 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,520,333 | 2,639,254 | +1,118,921 | 0.09 | 0.20 | +0.11 | buy |
| Duquesne Family Office LLC | 893,030 | 1,929,380 | +1,036,350 | 1.80 | 4.74 | +2.94 | buy |
| FIRST TRUST ADVISORS LP | 114,925 | 1,130,572 | +1,015,647 | 0.01 | 0.10 | +0.10 | buy |
| LORD, ABBETT & CO. LLC | 799,489 | 1,796,310 | +996,821 | 0.18 | 0.53 | +0.35 | buy |
| MAVERICK CAPITAL LTD | 0 | 798,682 | +798,682 | 0.00 | 1.42 | +1.42 | buy |
| CITADEL ADVISORS LLC | 1,663,344 | 2,341,611 | +678,267 | 0.10 | 0.21 | +0.10 | buy |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 0 | 622,498 | +622,498 | 0.00 | 2.72 | +2.72 | buy |
| First Light Asset Management, LLC | 165,886 | 656,708 | +490,822 | 0.84 | 4.60 | +3.76 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 3,474,883 | 3,927,683 | +452,800 | 1.36 | 2.11 | +0.75 | buy |
| Invesco Ltd. | 2,816,142 | 3,210,099 | +393,957 | 0.04 | 0.06 | +0.02 | buy |
| Sumitomo Mitsui Trust Group, Inc. | 0 | 371,271 | +371,271 | 0.00 | 0.02 | +0.02 | buy |
| Nikko Asset Management Americas, Inc. | 0 | 371,271 | +371,271 | 0.00 | 0.34 | +0.34 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 706,083 | 1,064,966 | +358,883 | 0.53 | 0.97 | +0.44 | buy |
| ARK Investment Management LLC | 0 | 322,384 | +322,384 | 0.00 | 0.20 | +0.20 | buy |
| NOMURA HOLDINGS INC | 0 | 272,221 | +272,221 | 0.00 | 0.20 | +0.20 | buy |
| JENNISON ASSOCIATES LLC | 212,811 | 472,147 | +259,336 | 0.01 | 0.03 | +0.02 | buy |
| Point72 Asset Management, L.P. | 6,920 | 263,746 | +256,826 | 0.00 | 0.07 | +0.07 | buy |
| Ensign Peak Advisors, Inc | 36,900 | 273,425 | +236,525 | 0.00 | 0.05 | +0.04 | buy |
| Mirae Asset Global Investments Co., Ltd. | 86,199 | 307,716 | +221,517 | 0.01 | 0.05 | +0.03 | buy |
| FRANKLIN RESOURCES INC | 235,563 | 448,387 | +212,824 | 0.01 | 0.01 | +0.01 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 209,433 | +209,433 | 0.00 | 0.07 | +0.07 | buy |
| MARSHALL WACE, LLP | 436,901 | 623,753 | +186,852 | 0.05 | 0.09 | +0.04 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 963,228 | 1,144,333 | +181,105 | 0.61 | 0.98 | +0.37 | buy |
| MPM BioImpact LLC | 0 | 172,413 | +172,413 | 0.00 | 2.54 | +2.54 | buy |
| Castle Hook Partners LP | 0 | 158,512 | +158,512 | 0.00 | 0.52 | +0.52 | buy |
| Chevy Chase Trust Holdings, LLC | 0 | 158,183 | +158,183 | 0.00 | 0.05 | +0.05 | buy |
| D. E. Shaw & Co., Inc. | 685,315 | 841,457 | +156,142 | 0.06 | 0.10 | +0.04 | buy |
| BANK OF AMERICA CORP /DE/ | 195,568 | 343,789 | +148,221 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 55,400 | 200,183 | +144,783 | 0.01 | 0.03 | +0.02 | buy |
| Allspring Global Investments Holdings, LLC | 720,160 | 863,406 | +143,246 | 0.07 | 0.12 | +0.05 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 548,152 | 669,961 | +121,809 | 0.00 | 0.01 | +0.00 | buy |
| Portolan Capital Management, LLC | 92,426 | 201,218 | +108,792 | 0.51 | 1.40 | +0.90 | buy |
| NATIONAL BANK OF CANADA /FI/ | 51,800 | 160,575 | +108,775 | 0.01 | 0.03 | +0.02 | buy |
| Blue Water Life Science Advisors, LP | 397,436 | 503,094 | +105,658 | 21.81 | 43.28 | +21.47 | buy |
| DIMENSIONAL FUND ADVISORS LP | 98,150 | 195,278 | +97,128 | 0.00 | 0.00 | +0.00 | buy |
| Soleus Capital Management, L.P. | 0 | 87,000 | +87,000 | 0.00 | 0.70 | +0.70 | buy |
| Qube Research & Technologies Ltd | 13,111 | 91,443 | +78,332 | 0.00 | 0.02 | +0.01 | buy |
| Handelsbanken Fonder AB | 18,800 | 94,600 | +75,800 | 0.01 | 0.04 | +0.03 | buy |
| CASTLEARK MANAGEMENT LLC | 0 | 74,630 | +74,630 | 0.00 | 0.28 | +0.28 | buy |
| VANGUARD GROUP INC | 10,971,895 | 11,044,743 | +72,848 | 0.02 | 0.02 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,771,062 | 1,841,557 | +70,495 | 0.01 | 0.02 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 26,109 | 90,406 | +64,297 | 0.00 | 0.01 | +0.01 | buy |
| AGF MANAGEMENT LTD | 0 | 61,885 | +61,885 | 0.00 | 0.03 | +0.03 | buy |
| Magnetar Financial LLC | 115,829 | 176,643 | +60,814 | 0.18 | 0.36 | +0.18 | buy |
| ZEVENBERGEN CAPITAL INVESTMENTS LLC | 437,014 | 487,631 | +50,617 | 0.63 | 0.95 | +0.32 | buy |
| Tri Locum Partners LP | 141,847 | 190,114 | +48,267 | 4.36 | 6.03 | +1.67 | buy |
| HSBC HOLDINGS PLC | 27,014 | 71,926 | +44,912 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 72,047 | 116,538 | +44,491 | 0.01 | 0.01 | +0.01 | buy |
| NEXT CENTURY GROWTH INVESTORS LLC | 80,897 | 123,976 | +43,079 | 0.49 | 0.98 | +0.49 | buy |
| HRT FINANCIAL LP | 23,961 | 66,545 | +42,584 | 0.01 | 0.04 | +0.03 | buy |
| BANK OF MONTREAL /CAN/ | 3,699 | 45,678 | +41,979 | 0.00 | 0.00 | +0.00 | buy |
| Vestmark Advisory Solutions, Inc. | 0 | 41,462 | +41,462 | 0.00 | 0.16 | +0.16 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 39,433 | +39,433 | 0.00 | 0.17 | +0.17 | buy |
| PRUDENTIAL FINANCIAL INC | 4,410 | 42,187 | +37,777 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 997,909 | 1,034,545 | +36,636 | 0.02 | 0.02 | +0.01 | buy |
| Allianz Asset Management GmbH | 0 | 36,394 | +36,394 | 0.00 | 0.01 | +0.01 | buy |
| Sivik Global Healthcare LLC | 0 | 35,000 | +35,000 | 0.00 | 1.16 | +1.16 | buy |
| Aberdeen Group plc | 51,308 | 85,386 | +34,078 | 0.01 | 0.02 | +0.01 | buy |
| Hood River Capital Management LLC | 0 | 30,844 | +30,844 | 0.00 | 0.06 | +0.06 | buy |
| Bayesian Capital Management, LP | 5,580 | 34,300 | +28,720 | 0.04 | 0.30 | +0.26 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 157,602 | 185,290 | +27,688 | 0.00 | 0.01 | +0.00 | buy |
| Pathstone Holdings, LLC | 4,928 | 28,930 | +24,002 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 48,007 | 71,504 | +23,497 | 0.01 | 0.01 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 158,800 | 182,196 | +23,396 | 0.02 | 0.03 | +0.01 | buy |
| SEGALL BRYANT & HAMILL, LLC | 140,747 | 163,436 | +22,689 | 0.17 | 0.28 | +0.11 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 22,341 | +22,341 | 0.00 | 0.02 | +0.02 | buy |
| Polar Asset Management Partners Inc. | 142,700 | 163,281 | +20,581 | 0.24 | 0.40 | +0.16 | buy |
| Schonfeld Strategic Advisors LLC | 15,665 | 35,691 | +20,026 | 0.01 | 0.03 | +0.02 | buy |
| BAMCO INC /NY/ | 23,600 | 41,000 | +17,400 | 0.00 | 0.01 | +0.01 | buy |
| SEI INVESTMENTS CO | 352,230 | 368,942 | +16,712 | 0.04 | 0.05 | +0.01 | buy |
| Cetera Investment Advisers | 3,204 | 19,700 | +16,496 | 0.00 | 0.00 | +0.00 | buy |
| KING LUTHER CAPITAL MANAGEMENT CORP | 17,579 | 33,688 | +16,109 | 0.01 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 19,273 | 34,978 | +15,705 | 0.00 | 0.00 | +0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 0 | 15,222 | +15,222 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 16,810 | 30,904 | +14,094 | 0.01 | 0.02 | +0.01 | buy |
| VAN ECK ASSOCIATES CORP | 98,601 | 112,499 | +13,898 | 0.01 | 0.02 | +0.00 | buy |
| Semanteon Capital Management, LP | 0 | 13,867 | +13,867 | 0.00 | 0.81 | +0.81 | buy |
| Bellevue Group AG | 256,584 | 269,832 | +13,248 | 0.25 | 0.38 | +0.13 | buy |
| Lisanti Capital Growth, LLC | 0 | 13,005 | +13,005 | 0.00 | 0.29 | +0.29 | buy |
| Simplify Asset Management Inc. | 0 | 12,669 | +12,669 | 0.00 | 0.11 | +0.11 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 202,632 | 215,181 | +12,549 | 0.05 | 0.07 | +0.02 | buy |
| COMERICA BANK | 2,664 | 14,866 | +12,202 | 0.00 | 0.01 | +0.01 | buy |
| SIT INVESTMENT ASSOCIATES INC | 3,150 | 15,200 | +12,050 | 0.00 | 0.03 | +0.03 | buy |
| Penserra Capital Management LLC | 466 | 11,263 | +10,797 | 0.00 | 0.01 | +0.01 | buy |
| Cinctive Capital Management LP | 12,725 | 23,262 | +10,537 | 0.06 | 0.11 | +0.05 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 39,345 | 49,698 | +10,353 | 0.08 | 0.13 | +0.04 | buy |
| Russell Investments Group, Ltd. | 64,679 | 74,460 | +9,781 | 0.01 | 0.01 | +0.00 | buy |
| Gotham Asset Management, LLC | 52,184 | 61,671 | +9,487 | 0.06 | 0.09 | +0.02 | buy |
| STRS OHIO | 0 | 9,398 | +9,398 | 0.00 | 0.00 | +0.00 | buy |
| Artisan Partners Limited Partnership | 123,704 | 132,731 | +9,027 | 0.01 | 0.02 | +0.01 | buy |
| Scientech Research LLC | 0 | 8,902 | +8,902 | 0.00 | 0.43 | +0.43 | buy |
| GTS SECURITIES LLC | 0 | 8,901 | +8,901 | 0.00 | 0.02 | +0.02 | buy |
| Entropy Technologies, LP | 0 | 8,617 | +8,617 | 0.00 | 0.08 | +0.08 | buy |
| FORA Capital, LLC | 0 | 8,387 | +8,387 | 0.00 | 0.06 | +0.06 | buy |
| GSA CAPITAL PARTNERS LLP | 19,903 | 28,222 | +8,319 | 0.10 | 0.21 | +0.10 | buy |
| NATIXIS | 0 | 8,283 | +8,283 | 0.00 | 0.00 | +0.00 | buy |
| WINTON GROUP Ltd | 0 | 8,133 | +8,133 | 0.00 | 0.05 | +0.05 | buy |