| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MILLENNIUM MANAGEMENT LLC | 709,953 | 3,434,654 | +2,724,701 | 0.05 | 0.20 | 0.00 | buy |
| SAMLYN CAPITAL, LLC | 3,504,540 | 4,400,226 | +895,686 | 2.96 | 3.44 | +0.48 | buy |
| Avidity Partners Management LP | 432,900 | 899,000 | +466,100 | 0.74 | 1.60 | +0.87 | buy |
| D. E. Shaw & Co., Inc. | 1,102,347 | 713,979 | +388,368 | 0.10 | 0.06 | 0.00 | sell |
| FIRST TRUST ADVISORS LP | 660,813 | 380,608 | +280,205 | 0.04 | 0.02 | 0.00 | sell |
| Tri Locum Partners LP | 52,964 | 274,795 | +221,831 | 0.96 | 3.90 | +2.94 | buy |
| GILDER GAGNON HOWE & CO LLC | 849,622 | 1,064,131 | +214,509 | 0.57 | 0.72 | +0.15 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 744,785 | 536,197 | +208,588 | 0.11 | 0.07 | 0.00 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 554,423 | 713,113 | +158,690 | 0.34 | 0.41 | +0.07 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 1,470,565 | 1,590,790 | +120,225 | 0.05 | 0.05 | 0.00 | buy |
| Kynam Capital Management, LP | 2,900,000 | 3,003,668 | +103,668 | 21.63 | 22.09 | +0.47 | buy |
| Magnetar Financial LLC | 396,621 | 490,468 | +93,847 | 0.42 | 0.56 | +0.13 | buy |
| Eversept Partners, LP | 2,413,787 | 2,492,636 | +78,849 | 12.40 | 12.25 | -0.16 | buy |
| Rhenman & Partners Asset Management AB | 200,000 | 266,769 | +66,769 | 1.03 | 1.27 | +0.25 | buy |
| BEACONLIGHT CAPITAL, LLC | 198,157 | 259,865 | +61,708 | 4.67 | 5.85 | +1.18 | buy |
| C WorldWide Group Holding A/S | 425,000 | 475,000 | +50,000 | 0.27 | 0.29 | +0.02 | buy |
| PURA VIDA INVESTMENTS, LLC | 200,094 | 248,131 | +48,037 | 4.04 | 5.39 | +1.35 | buy |
| RTW INVESTMENTS, LP | 2,611,783 | 2,651,783 | +40,000 | 2.42 | 2.48 | +0.06 | buy |
| Polar Asset Management Partners Inc. | 163,600 | 201,100 | +37,500 | 0.16 | 0.21 | +0.06 | buy |
| Capital World Investors | 363,000 | 396,421 | +33,421 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 19,900 | 51,815 | +31,915 | 0.13 | 0.29 | +0.16 | buy |
| Allspring Global Investments Holdings, LLC | 591,721 | 560,167 | +31,554 | 0.05 | 0.04 | 0.00 | sell |
| ZEVENBERGEN CAPITAL INVESTMENTS LLC | 407,607 | 432,892 | +25,285 | 0.47 | 0.49 | +0.02 | buy |
| Bellevue Group AG | 232,775 | 257,686 | +24,911 | 0.16 | 0.18 | +0.02 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 62,689 | 84,688 | +21,999 | 0.25 | 0.34 | +0.09 | buy |
| TCW GROUP INC | 36,495 | 57,513 | +21,018 | 0.02 | 0.03 | +0.01 | buy |
| PICTON MAHONEY ASSET MANAGEMENT | 70,693 | 85,812 | +15,119 | 0.17 | 0.18 | +0.01 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 196,216 | 210,964 | +14,748 | 0.04 | 0.04 | -0.00 | buy |
| Keebeck Wealth Management | 8,695 | 22,233 | +13,538 | 0.06 | 0.17 | +0.11 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,655,231 | 1,643,669 | +11,562 | 0.01 | 0.01 | 0.00 | sell |
| K.J. Harrison & Partners Inc | 5,900 | 16,700 | +10,800 | 0.05 | 0.17 | +0.11 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 129,443 | 119,065 | +10,378 | 0.01 | 0.01 | -0.00 | sell |
| BANQUE PICTET & CIE SA | 133,095 | 142,850 | +9,755 | 0.06 | 0.07 | +0.02 | buy |
| SWS Partners | 79,456 | 88,204 | +8,748 | 1.40 | 1.44 | +0.05 | buy |
| Holocene Advisors, LP | 1,208,612 | 1,216,329 | +7,717 | 0.26 | 0.24 | -0.02 | buy |
| Nebula Research & Development LLC | 7,859 | 15,067 | +7,208 | 0.29 | 0.35 | +0.06 | buy |
| LOOMIS SAYLES & CO L P | 548,342 | 555,135 | +6,793 | 0.04 | 0.04 | -0.00 | buy |
| Thematics Asset Management | 81,259 | 87,494 | +6,235 | 0.19 | 0.19 | +0.00 | buy |
| PARADIGM CAPITAL MANAGEMENT INC/NY | 93,600 | 99,800 | +6,200 | 0.26 | 0.25 | -0.01 | buy |
| INTREPID FAMILY OFFICE LLC | 15,000 | 20,000 | +5,000 | 1.39 | 1.53 | +0.14 | buy |
| Crestline Management, LP | 51,073 | 56,073 | +5,000 | 0.27 | 0.30 | +0.03 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 46,841 | 42,169 | +4,672 | 0.01 | 0.01 | 0.00 | sell |
| Swiss National Bank | 234,300 | 238,700 | +4,400 | 0.01 | 0.01 | +0.00 | buy |
| ALGERT GLOBAL LLC | 68,829 | 64,904 | +3,925 | 0.15 | 0.14 | 0.00 | sell |
| HighVista Strategies LLC | 7,255 | 10,066 | +2,811 | 0.16 | 0.21 | +0.04 | buy |
| GSA CAPITAL PARTNERS LLP | 28,842 | 26,304 | +2,538 | 0.15 | 0.11 | 0.00 | sell |
| OPPENHEIMER ASSET MANAGEMENT INC. | 10,062 | 12,115 | +2,053 | 0.01 | 0.01 | 0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 43,313 | 45,111 | +1,798 | 0.02 | 0.02 | 0.00 | buy |
| ELEVATION POINT WEALTH PARTNERS, LLC | 15,016 | 16,792 | +1,776 | 0.08 | 0.08 | +0.00 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 70,970 | 72,577 | +1,607 | 0.01 | 0.01 | -0.00 | buy |
| OSTERWEIS CAPITAL MANAGEMENT INC | 78,955 | 80,480 | +1,525 | 0.25 | 0.26 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 831,950 | 832,742 | +792 | 0.06 | 0.05 | -0.00 | buy |
| TORRAY INVESTMENT PARTNERS LLC | 20,026 | 20,775 | +749 | 0.17 | 0.16 | -0.01 | buy |
| Bank Pictet & Cie (Europe) AG | 9,226 | 9,899 | +673 | 0.02 | 0.02 | +0.00 | buy |
| Treasurer of the State of North Carolina | 45,239 | 45,469 | +230 | 0.01 | 0.01 | 0.00 | buy |
| Knights of Columbus Asset Advisors LLC | 1,853 | 1,969 | +116 | 0.01 | 0.01 | -0.00 | buy |
| CI INVESTMENTS INC. | 1,249 | 1,232 | +17 | 0.00 | 0.00 | 0.00 | sell |
| OLIVER LAGORE VANVALIN INVESTMENT GROUP | 345 | 356 | +11 | 0.01 | 0.01 | -0.00 | buy |
| MONTAG A & ASSOCIATES INC | 14 | 16 | +2 | 0.00 | 0.00 | +0.00 | buy |
| Itau Unibanco Holding S.A. | 506 | 504 | -2 | 0.00 | 0.00 | -0.00 | sell |
| EFG Asset Management (Americas) Corp. | 7,553 | 7,514 | -39 | 0.09 | 0.08 | -0.01 | sell |
| KING LUTHER CAPITAL MANAGEMENT CORP | 15,811 | 15,706 | -105 | 0.00 | 0.00 | -0.00 | sell |
| GW&K Investment Management, LLC | 97,385 | 97,270 | -115 | 0.04 | 0.04 | -0.00 | sell |
| Silicon Valley Community Foundation | 6,800 | 6,670 | -130 | 0.04 | 0.04 | -0.00 | sell |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 132,014 | 131,881 | -133 | 0.05 | 0.04 | -0.00 | sell |
| Lagoda Investment Management, L.P. | 165,715 | 165,465 | -250 | 5.69 | 4.81 | -0.88 | sell |
| PERKINS CAPITAL MANAGEMENT INC | 62,200 | 61,925 | -275 | 2.64 | 2.72 | +0.08 | sell |
| FORMULA GROWTH LTD | 55,205 | 54,589 | -616 | 0.86 | 0.82 | -0.03 | sell |
| Silvant Capital Management LLC | 15,844 | 15,109 | -735 | 0.04 | 0.04 | -0.00 | sell |
| E Fund Management Co., Ltd. | 9,232 | 8,437 | -795 | 0.04 | 0.03 | -0.01 | sell |
| SIRIOS CAPITAL MANAGEMENT L P | 12,438 | 11,589 | -849 | 0.10 | 0.10 | -0.01 | sell |
| SEGALL BRYANT & HAMILL, LLC | 142,057 | 141,119 | -938 | 0.07 | 0.07 | -0.00 | sell |
| SYNOVUS FINANCIAL CORP | 37,998 | 36,904 | -1,094 | 0.02 | 0.02 | -0.00 | sell |
| Pearl River Capital, LLC | 16,307 | 14,927 | -1,380 | 0.13 | 0.10 | -0.02 | sell |
| HWG Holdings LP | 1,876 | 458 | -1,418 | 0.04 | 0.01 | -0.03 | sell |
| BANK OF HAWAII | 43,927 | 41,687 | -2,240 | 0.12 | 0.11 | -0.01 | sell |
| BRANDYWINE MANAGERS, LLC | 21,534 | 18,534 | -3,000 | 0.69 | 1.38 | +0.69 | sell |
| Virtus Investment Advisers, LLC | 10,758 | 7,679 | -3,079 | 0.36 | 0.23 | -0.12 | sell |
| PROFUND ADVISORS LLC | 30,487 | 26,969 | -3,518 | 0.08 | 0.07 | -0.01 | sell |
| Granite Investment Partners, LLC | 97,751 | 92,948 | -4,803 | 0.19 | 0.17 | -0.02 | sell |
| E. Ohman J:or Asset Management AB | 417,470 | 412,570 | -4,900 | 0.73 | 0.69 | -0.04 | sell |
| Polar Capital Holdings Plc | 14,800 | 9,126 | -5,674 | 0.00 | 0.00 | -0.00 | sell |
| EFG Asset Management (North America) Corp. | 130,051 | 124,259 | -5,792 | 1.36 | 1.31 | -0.05 | sell |
| Gotham Asset Management, LLC | 43,964 | 38,013 | -5,951 | 0.05 | 0.04 | -0.01 | sell |
| Rafferty Asset Management, LLC | 171,717 | 164,277 | -7,440 | 0.05 | 0.04 | -0.00 | sell |
| B. Metzler seel. Sohn & Co. AG | 21,552 | 11,607 | -9,945 | 0.01 | 0.01 | -0.01 | sell |
| Granahan Investment Management, LLC | 391,004 | 376,704 | -14,300 | 0.59 | 0.59 | +0.01 | sell |
| Candriam S.C.A. | 305,014 | 289,990 | -15,024 | 0.11 | 0.09 | -0.02 | sell |
| Artisan Partners Limited Partnership | 156,387 | 139,849 | -16,538 | 0.01 | 0.01 | -0.00 | sell |
| Bayesian Capital Management, LP | 25,980 | 9,380 | -16,600 | 0.14 | 0.05 | -0.09 | sell |
| Parkman Healthcare Partners LLC | 75,039 | 50,751 | -24,288 | 0.63 | 0.41 | -0.22 | sell |
| Artemis Investment Management LLP | 562,550 | 532,449 | -30,101 | 0.35 | 0.33 | -0.02 | sell |
| TWINBEECH CAPITAL LP | 395,970 | 361,509 | -34,461 | 0.38 | 0.31 | -0.07 | sell |
| ORBIMED ADVISORS LLC | 973,581 | 920,581 | -53,000 | 0.86 | 0.87 | +0.01 | sell |
| Blue Water Life Science Advisors, LP | 881,436 | 797,436 | -84,000 | 28.95 | 33.31 | +4.36 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 725,879 | 630,413 | -95,466 | 0.00 | 0.00 | -0.00 | sell |
| Soleus Capital Management, L.P. | 168,800 | 61,377 | -107,423 | 0.91 | 0.27 | -0.64 | sell |
| KORNITZER CAPITAL MANAGEMENT INC /KS | 476,864 | 367,494 | -109,370 | 0.46 | 0.34 | -0.12 | sell |
| BRAIDWELL LP | 1,152,851 | 1,012,145 | -140,706 | 1.83 | 1.42 | -0.42 | sell |
| AMERIPRISE FINANCIAL INC | 2,341,168 | 2,197,190 | -143,978 | 0.04 | 0.03 | -0.00 | sell |