| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MILLENNIUM MANAGEMENT LLC | 3,434,654 | 1,520,333 | +1,914,321 | 0.20 | 0.12 | 0.00 | sell |
| PERCEPTIVE ADVISORS LLC | 218,178 | 850,225 | +632,047 | 0.32 | 1.19 | +0.87 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 832,742 | 595,743 | +236,999 | 0.05 | 0.05 | -0.01 | sell |
| Avidity Partners Management LP | 899,000 | 1,110,000 | +211,000 | 1.60 | 2.66 | +1.06 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 536,197 | 327,359 | +208,838 | 0.07 | 0.06 | 0.00 | sell |
| LORD, ABBETT & CO. LLC | 618,127 | 799,489 | +181,362 | 0.10 | 0.18 | +0.07 | buy |
| Allspring Global Investments Holdings, LLC | 560,167 | 720,160 | +159,993 | 0.04 | 0.08 | 0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,643,669 | 1,771,062 | +127,393 | 0.01 | 0.01 | 0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 6,956,186 | 7,076,651 | +120,465 | 1.77 | 2.39 | +0.62 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 1,590,790 | 1,703,615 | +112,825 | 0.05 | 0.07 | 0.00 | buy |
| Eagle Health Investments LP | 595,694 | 690,862 | +95,168 | 5.81 | 8.79 | +2.99 | buy |
| AMERIPRISE FINANCIAL INC | 2,197,190 | 2,283,903 | +86,713 | 0.03 | 0.05 | +0.01 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 72,577 | 145,996 | +73,419 | 0.01 | 0.03 | +0.02 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 6,072 | 47,000 | +40,928 | 0.00 | 0.01 | +0.01 | buy |
| TWINBEECH CAPITAL LP | 361,509 | 398,299 | +36,790 | 0.31 | 0.40 | +0.10 | buy |
| LOOMIS SAYLES & CO L P | 555,135 | 590,612 | +35,477 | 0.04 | 0.06 | +0.01 | buy |
| ORBIMED ADVISORS LLC | 920,581 | 954,481 | +33,900 | 0.87 | 1.20 | +0.32 | buy |
| D. E. Shaw & Co., Inc. | 713,979 | 685,315 | +28,664 | 0.06 | 0.07 | 0.00 | sell |
| GCM Grosvenor Holdings, LLC | 190,000 | 217,157 | +27,157 | 1.67 | 2.40 | +0.73 | buy |
| Integral Health Asset Management, LLC | 200,000 | 225,000 | +25,000 | 1.23 | 1.92 | +0.69 | buy |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 131,881 | 155,343 | +23,462 | 0.04 | 0.07 | +0.02 | buy |
| Granite Investment Partners, LLC | 92,948 | 112,194 | +19,246 | 0.17 | 0.27 | +0.10 | buy |
| Gotham Asset Management, LLC | 38,013 | 52,184 | +14,171 | 0.04 | 0.06 | +0.03 | buy |
| BANK OF HAWAII | 41,687 | 53,044 | +11,357 | 0.11 | 0.18 | +0.07 | buy |
| Investors Towarzystwo Funduszy Inwestycyjnych Spolka Akcyjna | 2,800 | 13,600 | +10,800 | 0.07 | 0.36 | +0.29 | buy |
| TCW GROUP INC | 57,513 | 67,237 | +9,724 | 0.03 | 0.05 | +0.01 | buy |
| Crestline Management, LP | 56,073 | 65,070 | +8,997 | 0.29 | 0.35 | +0.06 | buy |
| ALGERT GLOBAL LLC | 64,904 | 73,195 | +8,291 | 0.14 | 0.19 | 0.00 | buy |
| OSTERWEIS CAPITAL MANAGEMENT INC | 80,480 | 87,850 | +7,370 | 0.26 | 0.35 | +0.09 | buy |
| GSA CAPITAL PARTNERS LLP | 26,304 | 19,903 | +6,401 | 0.11 | 0.11 | 0.00 | sell |
| Keebeck Wealth Management | 22,233 | 27,956 | +5,723 | 0.17 | 0.29 | +0.12 | buy |
| K.J. Harrison & Partners Inc | 16,700 | 21,700 | +5,000 | 0.17 | 0.23 | +0.06 | buy |
| ELEVATION POINT WEALTH PARTNERS, LLC | 16,792 | 21,194 | +4,402 | 0.08 | 0.13 | +0.05 | buy |
| ZEVENBERGEN CAPITAL INVESTMENTS LLC | 432,892 | 437,014 | +4,122 | 0.49 | 0.63 | +0.14 | buy |
| SIRIOS CAPITAL MANAGEMENT L P | 11,589 | 15,089 | +3,500 | 0.10 | 0.19 | +0.10 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 42,169 | 44,984 | +2,815 | 0.01 | 0.01 | 0.00 | buy |
| Thematics Asset Management | 87,494 | 90,232 | +2,738 | 0.19 | 0.25 | +0.06 | buy |
| PROFUND ADVISORS LLC | 26,969 | 24,362 | +2,607 | 0.07 | 0.07 | 0.00 | sell |
| Dynamic Technology Lab Private Ltd | 9,930 | 12,262 | +2,332 | 0.04 | 0.08 | +0.04 | buy |
| Treasurer of the State of North Carolina | 45,469 | 47,639 | +2,170 | 0.01 | 0.01 | 0.00 | buy |
| KING LUTHER CAPITAL MANAGEMENT CORP | 15,706 | 17,579 | +1,873 | 0.00 | 0.01 | +0.00 | buy |
| OPPENHEIMER ASSET MANAGEMENT INC. | 12,115 | 13,659 | +1,544 | 0.01 | 0.01 | 0.00 | buy |
| B. Metzler seel. Sohn & Co. AG | 11,607 | 13,028 | +1,421 | 0.01 | 0.01 | +0.00 | buy |
| TORRAY INVESTMENT PARTNERS LLC | 20,775 | 21,762 | +987 | 0.16 | 0.22 | +0.06 | buy |
| Annis Gardner Whiting Capital Advisors, LLC | 2,500 | 3,230 | +730 | 0.06 | 0.09 | +0.03 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 119,065 | 118,390 | +675 | 0.01 | 0.01 | +0.00 | sell |
| GUGGENHEIM CAPITAL LLC | 45,111 | 44,448 | +663 | 0.02 | 0.02 | 0.00 | sell |
| OLIVER LAGORE VANVALIN INVESTMENT GROUP | 356 | 745 | +389 | 0.01 | 0.02 | +0.01 | buy |
| Utah Retirement Systems | 5,600 | 5,900 | +300 | 0.00 | 0.00 | +0.00 | buy |
| GW&K Investment Management, LLC | 97,270 | 97,450 | +180 | 0.04 | 0.06 | +0.01 | buy |
| SYNOVUS FINANCIAL CORP | 36,904 | 37,034 | +130 | 0.02 | 0.03 | +0.01 | buy |
| CI INVESTMENTS INC. | 1,232 | 1,214 | +18 | 0.00 | 0.00 | 0.00 | sell |
| HWG Holdings LP | 458 | 467 | +9 | 0.01 | 0.01 | +0.00 | buy |
| PERKINS CAPITAL MANAGEMENT INC | 61,925 | 61,875 | -50 | 2.72 | 3.31 | +0.59 | sell |
| Itau Unibanco Holding S.A. | 504 | 424 | -80 | 0.00 | 0.00 | -0.00 | sell |
| Silicon Valley Community Foundation | 6,670 | 6,558 | -112 | 0.04 | 0.04 | +0.01 | sell |
| Knights of Columbus Asset Advisors LLC | 1,969 | 1,853 | -116 | 0.01 | 0.01 | -0.00 | sell |
| PICTON MAHONEY ASSET MANAGEMENT | 85,812 | 85,636 | -176 | 0.11 | 0.15 | +0.03 | sell |
| E Fund Management Co., Ltd. | 8,437 | 8,260 | -177 | 0.03 | 0.03 | +0.00 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 8,504 | 8,205 | -299 | 0.11 | 0.13 | +0.02 | sell |
| Headlands Technologies LLC | 316 | 3 | -313 | 0.01 | 0.00 | -0.01 | sell |
| Bank Pictet & Cie (Europe) AG | 9,899 | 9,539 | -360 | 0.02 | 0.02 | +0.00 | sell |
| SEGALL BRYANT & HAMILL, LLC | 141,119 | 140,747 | -372 | 0.07 | 0.17 | +0.10 | sell |
| EFG Asset Management (Americas) Corp. | 7,514 | 6,440 | -1,074 | 0.08 | 0.09 | +0.01 | sell |
| BRANDYWINE MANAGERS, LLC | 18,534 | 17,444 | -1,090 | 1.38 | 1.20 | -0.19 | sell |
| Bellevue Group AG | 257,686 | 256,584 | -1,102 | 0.18 | 0.25 | +0.06 | sell |
| SWS Partners | 88,204 | 86,697 | -1,507 | 1.44 | 1.77 | +0.33 | sell |
| OSTRUM ASSET MANAGEMENT | 2,918 | 1,056 | -1,862 | 0.01 | 0.01 | -0.01 | sell |
| Silvant Capital Management LLC | 15,109 | 13,045 | -2,064 | 0.04 | 0.04 | +0.00 | sell |
| Polar Capital Holdings Plc | 9,126 | 5,600 | -3,526 | 0.00 | 0.00 | -0.00 | sell |
| Bayesian Capital Management, LP | 9,380 | 5,580 | -3,800 | 0.05 | 0.04 | -0.01 | sell |
| Virtus Investment Advisers, LLC | 7,679 | 3,566 | -4,113 | 0.23 | 0.17 | -0.06 | sell |
| Pearl River Capital, LLC | 14,927 | 10,677 | -4,250 | 0.10 | 0.11 | +0.00 | sell |
| EFG Asset Management (North America) Corp. | 124,259 | 118,812 | -5,447 | 1.31 | 1.41 | +0.11 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 713,113 | 706,083 | -7,030 | 0.41 | 0.53 | +0.12 | sell |
| NOMURA ASSET MANAGEMENT CO LTD | 210,964 | 202,632 | -8,332 | 0.04 | 0.05 | +0.01 | sell |
| GILDER GAGNON HOWE & CO LLC | 1,064,131 | 1,055,021 | -9,110 | 0.72 | 0.91 | +0.19 | sell |
| Rafferty Asset Management, LLC | 164,277 | 154,404 | -9,873 | 0.04 | 0.04 | -0.00 | sell |
| FORMULA GROWTH LTD | 54,589 | 44,489 | -10,100 | 0.82 | 0.89 | +0.07 | sell |
| BANQUE PICTET & CIE SA | 142,850 | 128,389 | -14,461 | 0.07 | 0.07 | -0.01 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 84,688 | 68,567 | -16,121 | 0.34 | 0.38 | +0.03 | sell |
| Artisan Partners Limited Partnership | 139,849 | 123,704 | -16,145 | 0.01 | 0.01 | +0.00 | sell |
| Swiss National Bank | 238,700 | 222,100 | -16,600 | 0.01 | 0.01 | +0.00 | sell |
| Rhenman & Partners Asset Management AB | 266,769 | 245,000 | -21,769 | 1.27 | 1.53 | +0.26 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 51,900 | 24,600 | -27,300 | 0.12 | 0.07 | -0.05 | sell |
| Lagoda Investment Management, L.P. | 165,465 | 136,845 | -28,620 | 4.81 | 5.72 | +0.91 | sell |
| SOROS FUND MANAGEMENT LLC | 180,000 | 150,000 | -30,000 | 0.11 | 0.12 | +0.01 | sell |
| KORNITZER CAPITAL MANAGEMENT INC /KS | 367,494 | 336,329 | -31,165 | 0.34 | 0.41 | +0.07 | sell |
| Cinctive Capital Management LP | 51,569 | 12,725 | -38,844 | 0.11 | 0.05 | -0.06 | sell |
| PDT Partners, LLC | 51,815 | 12,093 | -39,722 | 0.29 | 0.08 | -0.21 | sell |
| Candriam S.C.A. | 289,990 | 241,987 | -48,003 | 0.09 | 0.10 | +0.01 | sell |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 1,017,126 | 963,228 | -53,898 | 0.49 | 0.61 | +0.11 | sell |
| BEACONLIGHT CAPITAL, LLC | 259,865 | 202,001 | -57,864 | 4.97 | 5.13 | +0.16 | sell |
| RTW INVESTMENTS, LP | 2,651,783 | 2,593,323 | -58,460 | 2.48 | 2.54 | +0.06 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 630,413 | 548,152 | -82,261 | 0.00 | 0.00 | +0.00 | sell |
| Skandinaviska Enskilda Banken AB (publ) | 396,502 | 296,731 | -99,771 | 0.12 | 0.11 | -0.01 | sell |
| Tri Locum Partners LP | 274,795 | 141,847 | -132,948 | 3.90 | 4.36 | +0.46 | sell |
| Holocene Advisors, LP | 1,216,329 | 1,075,274 | -141,055 | 0.24 | 0.26 | +0.03 | sell |
| Artemis Investment Management LLP | 532,449 | 390,991 | -141,458 | 0.33 | 0.35 | +0.02 | sell |
| PURA VIDA INVESTMENTS, LLC | 248,131 | 93,000 | -155,131 | 2.08 | 0.89 | -1.19 | sell |