| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Avoro Capital Advisors LLC | 0 | 3,590,000 | +3,590,000 | 0.00 | 3.43 | +3.43 | buy |
| VANGUARD GROUP INC | 5,381,904 | 7,785,724 | +2,403,820 | 0.00 | 0.01 | +0.01 | buy |
| FMR LLC | 15,004,340 | 16,347,292 | +1,342,952 | 0.02 | 0.09 | +0.07 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 38,440 | 1,076,688 | +1,038,248 | 0.00 | 0.09 | +0.09 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 994,098 | +994,098 | 0.00 | 1.44 | +1.44 | buy |
| Perpetual Ltd | 0 | 958,368 | +958,368 | 0.00 | 0.77 | +0.77 | buy |
| CITADEL ADVISORS LLC | 71,567 | 901,749 | +830,182 | 0.00 | 0.07 | +0.07 | buy |
| BRAIDWELL LP | 0 | 713,100 | +713,100 | 0.00 | 1.88 | +1.88 | buy |
| Pictet Asset Management Holding SA | 694,724 | 1,378,036 | +683,312 | 0.01 | 0.12 | +0.11 | buy |
| Hood River Capital Management LLC | 0 | 671,928 | +671,928 | 0.00 | 1.23 | +1.23 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 0 | 662,131 | +662,131 | 0.00 | 0.29 | +0.29 | buy |
| Clearbridge Investments, LLC | 0 | 597,189 | +597,189 | 0.00 | 0.04 | +0.04 | buy |
| Invesco Ltd. | 137,563 | 695,934 | +558,371 | 0.00 | 0.01 | +0.01 | buy |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 0 | 514,693 | +514,693 | 0.00 | 6.51 | +6.51 | buy |
| JPMORGAN CHASE & CO | 567,592 | 1,040,158 | +472,566 | 0.00 | 0.01 | +0.01 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 467,216 | +467,216 | 0.00 | 0.19 | +0.19 | buy |
| AMERIPRISE FINANCIAL INC | 77,041 | 450,414 | +373,373 | 0.00 | 0.01 | +0.01 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 11,114 | 360,839 | +349,725 | 0.00 | 0.02 | +0.02 | buy |
| LORD, ABBETT & CO. LLC | 0 | 349,074 | +349,074 | 0.00 | 0.09 | +0.09 | buy |
| FRANKLIN RESOURCES INC | 15,058 | 340,511 | +325,453 | 0.00 | 0.01 | +0.01 | buy |
| Granahan Investment Management, LLC | 0 | 318,893 | +318,893 | 0.00 | 0.92 | +0.92 | buy |
| EMERALD ADVISERS, LLC | 0 | 311,007 | +311,007 | 0.00 | 1.03 | +1.03 | buy |
| BOONE CAPITAL MANAGEMENT LLC | 0 | 310,462 | +310,462 | 0.00 | 5.15 | +5.15 | buy |
| MARSHALL WACE, LLP | 102,855 | 371,686 | +268,831 | 0.00 | 0.05 | +0.05 | buy |
| Rock Springs Capital Management LP | 0 | 261,000 | +261,000 | 0.00 | 0.54 | +0.54 | buy |
| Artal Group S.A. | 0 | 253,863 | +253,863 | 0.00 | 0.54 | +0.54 | buy |
| BLAIR WILLIAM & CO/IL | 58,372 | 299,235 | +240,863 | 0.00 | 0.08 | +0.07 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 0 | 240,437 | +240,437 | 0.00 | 1.03 | +1.03 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,128,343 | 2,326,779 | +198,436 | 0.00 | 0.02 | +0.01 | buy |
| BAMCO INC /NY/ | 310,067 | 493,259 | +183,192 | 0.02 | 0.11 | +0.09 | buy |
| CI INVESTMENTS INC. | 0 | 171,129 | +171,129 | 0.00 | 0.06 | +0.06 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 0 | 165,409 | +165,409 | 0.00 | 0.13 | +0.13 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 37,500 | 191,959 | +154,459 | 0.00 | 0.02 | +0.01 | buy |
| MACQUARIE GROUP LTD | 330,100 | 476,935 | +146,835 | 0.01 | 0.04 | +0.04 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 149,282 | 285,917 | +136,635 | 0.00 | 0.04 | +0.03 | buy |
| Point72 Asset Management, L.P. | 0 | 133,990 | +133,990 | 0.00 | 0.03 | +0.03 | buy |
| First Turn Management, LLC | 0 | 128,064 | +128,064 | 0.00 | 1.57 | +1.57 | buy |
| KEYSTONE INVESTORS PTE LTD | 0 | 111,597 | +111,597 | 0.00 | 0.79 | +0.79 | buy |
| TANG CAPITAL MANAGEMENT LLC | 0 | 100,000 | +100,000 | 0.00 | 0.85 | +0.85 | buy |
| COMERICA BANK | 324 | 91,543 | +91,219 | 0.00 | 0.03 | +0.03 | buy |
| Russell Investments Group, Ltd. | 256,633 | 344,825 | +88,192 | 0.01 | 0.04 | +0.04 | buy |
| Altium Capital Management LLC | 0 | 85,000 | +85,000 | 0.00 | 3.11 | +3.11 | buy |
| NORGES BANK | 0 | 81,699 | +81,699 | 0.00 | 0.00 | +0.00 | buy |
| Nicholas Investment Partners, LP | 0 | 80,010 | +80,010 | 0.00 | 0.67 | +0.67 | buy |
| BIT Capital GmbH | 0 | 77,614 | +77,614 | 0.00 | 0.56 | +0.56 | buy |
| Vestal Point Capital, LP | 0 | 75,000 | +75,000 | 0.00 | 0.51 | +0.51 | buy |
| FORA Capital, LLC | 0 | 73,911 | +73,911 | 0.00 | 0.50 | +0.50 | buy |
| State of New Jersey Common Pension Fund D | 0 | 72,456 | +72,456 | 0.00 | 0.02 | +0.02 | buy |
| CANADA LIFE ASSURANCE Co | 8,759 | 76,636 | +67,877 | 0.00 | 0.01 | +0.01 | buy |
| HAP Trading, LLC | 0 | 65,357 | +65,357 | 0.00 | 1.66 | +1.66 | buy |
| Woodline Partners LP | 0 | 65,308 | +65,308 | 0.00 | 0.05 | +0.05 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 775,699 | 838,984 | +63,285 | 0.00 | 0.02 | +0.01 | buy |
| Park West Asset Management LLC | 0 | 60,000 | +60,000 | 0.00 | 0.37 | +0.37 | buy |
| Pier Capital, LLC | 0 | 59,659 | +59,659 | 0.00 | 0.67 | +0.67 | buy |
| Allspring Global Investments Holdings, LLC | 0 | 58,236 | +58,236 | 0.00 | 0.01 | +0.01 | buy |
| SIMPLEX TRADING, LLC | 0 | 57,999 | +57,999 | 0.00 | 0.14 | +0.14 | buy |
| MOODY ALDRICH PARTNERS LLC | 0 | 55,735 | +55,735 | 0.00 | 0.78 | +0.78 | buy |
| CASTLEARK MANAGEMENT LLC | 0 | 55,689 | +55,689 | 0.00 | 0.19 | +0.19 | buy |
| ROYAL BANK OF CANADA | 70,766 | 126,392 | +55,626 | 0.00 | 0.00 | +0.00 | buy |
| AGF MANAGEMENT LTD | 0 | 52,405 | +52,405 | 0.00 | 0.02 | +0.02 | buy |
| STEADFAST CAPITAL MANAGEMENT LP | 0 | 52,000 | +52,000 | 0.00 | 0.10 | +0.10 | buy |
| GROUP ONE TRADING LLC | 22,925 | 74,245 | +51,320 | 0.01 | 0.22 | +0.20 | buy |
| Artia Global Partners LP | 383,580 | 433,580 | +50,000 | 2.82 | 8.72 | +5.90 | buy |
| Steward Partners Investment Advisory, LLC | 38,746 | 84,273 | +45,527 | 0.01 | 0.08 | +0.07 | buy |
| Eagle Health Investments LP | 0 | 45,000 | +45,000 | 0.00 | 0.70 | +0.70 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 41,154 | +41,154 | 0.00 | 0.06 | +0.06 | buy |
| Resolute Capital Asset Partners LLC | 0 | 40,000 | +40,000 | 0.00 | 1.71 | +1.71 | buy |
| PURA VIDA INVESTMENTS, LLC | 0 | 39,868 | +39,868 | 0.00 | 2.22 | +2.22 | buy |
| Prosight Management, LP | 0 | 39,046 | +39,046 | 0.00 | 0.89 | +0.89 | buy |
| Calamos Advisors LLC | 0 | 38,680 | +38,680 | 0.00 | 0.02 | +0.02 | buy |
| Caption Management, LLC | 1,504 | 39,047 | +37,543 | 0.00 | 0.35 | +0.35 | buy |
| NORTHERN TRUST CORP | 916,380 | 952,857 | +36,477 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 178,823 | 214,071 | +35,248 | 0.00 | 0.02 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 35,171 | +35,171 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 33,649 | +33,649 | 0.00 | 0.02 | +0.02 | buy |
| PFM Health Sciences, LP | 0 | 32,827 | +32,827 | 0.00 | 0.13 | +0.13 | buy |
| WELLS FARGO & COMPANY/MN | 28,801 | 60,261 | +31,460 | 0.00 | 0.00 | +0.00 | buy |
| Lighthouse Investment Partners, LLC | 0 | 30,831 | +30,831 | 0.00 | 0.12 | +0.12 | buy |
| Parkman Healthcare Partners LLC | 0 | 30,298 | +30,298 | 0.00 | 0.30 | +0.30 | buy |
| Janney Montgomery Scott LLC | 0 | 29,086 | +29,086 | 0.00 | 0.01 | +0.01 | buy |
| Tidal Investments LLC | 0 | 28,873 | +28,873 | 0.00 | 0.04 | +0.04 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 0 | 28,418 | +28,418 | 0.00 | 0.01 | +0.01 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 0 | 27,448 | +27,448 | 0.00 | 0.00 | +0.00 | buy |
| Shay Capital LLC | 0 | 26,300 | +26,300 | 0.00 | 0.63 | +0.63 | buy |
| OSTERWEIS CAPITAL MANAGEMENT INC | 0 | 24,845 | +24,845 | 0.00 | 0.12 | +0.12 | buy |
| ArrowMark Colorado Holdings LLC | 15,931 | 39,931 | +24,000 | 0.00 | 0.04 | +0.03 | buy |
| Cetera Investment Advisers | 0 | 23,041 | +23,041 | 0.00 | 0.00 | +0.00 | buy |
| Eversept Partners, LP | 0 | 22,818 | +22,818 | 0.00 | 0.14 | +0.14 | buy |
| Quinn Opportunity Partners LLC | 0 | 21,000 | +21,000 | 0.00 | 0.19 | +0.19 | buy |
| SEI INVESTMENTS CO | 25,786 | 45,809 | +20,023 | 0.00 | 0.01 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 20,000 | +20,000 | 0.00 | 0.46 | +0.46 | buy |
| Concentric Capital Strategies, LP | 0 | 19,724 | +19,724 | 0.00 | 0.10 | +0.10 | buy |
| Belvedere Trading LLC | 16,332 | 36,041 | +19,709 | 0.03 | 0.21 | +0.19 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 0 | 19,679 | +19,679 | 0.00 | 0.00 | +0.00 | buy |
| Formidable Asset Management, LLC | 0 | 19,588 | +19,588 | 0.00 | 0.26 | +0.26 | buy |
| EFG Asset Management (North America) Corp. | 0 | 18,816 | +18,816 | 0.00 | 0.27 | +0.27 | buy |
| OPPENHEIMER & CO INC | 30,857 | 48,944 | +18,087 | 0.01 | 0.07 | +0.06 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 0 | 17,340 | +17,340 | 0.00 | 0.00 | +0.00 | buy |
| Silvant Capital Management LLC | 0 | 17,231 | +17,231 | 0.00 | 0.07 | +0.07 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 39,321 | 56,312 | +16,991 | 0.00 | 0.01 | +0.01 | buy |