| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 16,619,430 | 16,715,438 | +96,008 | 0.06 | 0.04 | -0.02 | buy |
| VANGUARD GROUP INC | 10,167,614 | 10,172,441 | +4,827 | 0.01 | 0.01 | -0.00 | buy |
| BlackRock, Inc. | 5,380,323 | 5,872,978 | +492,655 | 0.01 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 4,674,067 | 4,925,490 | +251,423 | 0.01 | 0.01 | -0.00 | buy |
| MORGAN STANLEY | 1,874,845 | 2,593,615 | +718,770 | 0.01 | 0.01 | -0.00 | buy |
| JPMORGAN CHASE & CO | 2,116,438 | 2,157,543 | +41,105 | 0.01 | 0.01 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,863,667 | 1,880,713 | +17,046 | 0.01 | 0.01 | -0.00 | buy |
| CITADEL ADVISORS LLC | 1,472,676 | 1,485,079 | +12,403 | 0.10 | 0.06 | -0.04 | buy |
| BRAIDWELL LP | 1,156,977 | 1,479,666 | +322,689 | 2.08 | 1.77 | -0.31 | buy |
| AMERIPRISE FINANCIAL INC | 450,471 | 1,479,596 | +1,029,125 | 0.01 | 0.02 | +0.01 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 248,269 | 1,357,241 | +1,108,972 | 0.00 | 0.02 | +0.01 | buy |
| NORGES BANK | 1,270,341 | 1,278,928 | +8,587 | 0.01 | 0.01 | -0.00 | buy |
| Pictet Asset Management Holding SA | 1,361,510 | 1,237,093 | -124,417 | 0.09 | 0.05 | -0.04 | sell |
| ALLIANCEBERNSTEIN L.P. | 1,033,885 | 1,115,068 | +81,183 | 0.02 | 0.02 | -0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 1,115,105 | 1,033,409 | -81,696 | 0.12 | 0.06 | -0.06 | sell |
| PERCEPTIVE ADVISORS LLC | 1,699,987 | 995,894 | -704,093 | 2.31 | 1.12 | -1.19 | sell |
| Invesco Ltd. | 876,222 | 872,846 | -3,376 | 0.01 | 0.01 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 860,449 | +860,449 | 0.00 | 0.08 | +0.08 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 715,597 | 728,652 | +13,055 | 0.01 | 0.01 | -0.00 | buy |
| Clearbridge Investments, LLC | 738,574 | 640,118 | -98,456 | 0.04 | 0.02 | -0.02 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 593,528 | 628,764 | +35,236 | 0.02 | 0.01 | -0.01 | buy |
| UBS Group AG | 328,959 | 618,148 | +289,189 | 0.01 | 0.01 | -0.00 | buy |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 581,418 | 597,739 | +16,321 | 0.35 | 0.23 | -0.12 | buy |
| AQR CAPITAL MANAGEMENT LLC | 463,529 | 537,239 | +73,710 | 0.04 | 0.03 | -0.01 | buy |
| NORTHERN TRUST CORP | 481,113 | 535,984 | +54,871 | 0.00 | 0.00 | -0.00 | buy |
| MACQUARIE GROUP LTD | 568,400 | 517,408 | -50,992 | 0.04 | 0.03 | -0.01 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 472,244 | 463,332 | -8,912 | 0.01 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 421,564 | 462,964 | +41,400 | 0.00 | 0.00 | -0.00 | buy |
| Man Group plc | 12,919 | 448,732 | +435,813 | 0.00 | 0.05 | +0.05 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 452,969 | 442,697 | -10,272 | 0.49 | 0.32 | -0.17 | sell |
| Ensign Peak Advisors, Inc | 452,011 | 412,656 | -39,355 | 0.05 | 0.03 | -0.02 | sell |
| JANE STREET GROUP, LLC | 338,807 | 407,679 | +68,872 | 0.03 | 0.03 | -0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 674,139 | 390,140 | -283,999 | 0.04 | 0.02 | -0.03 | sell |
| BAMCO INC /NY/ | 474,644 | 385,472 | -89,172 | 0.08 | 0.04 | -0.04 | sell |
| Connor, Clark & Lunn Investment Management Ltd. | 158,349 | 375,222 | +216,873 | 0.05 | 0.07 | +0.02 | buy |
| BANK OF AMERICA CORP /DE/ | 422,833 | 361,551 | -61,282 | 0.00 | 0.00 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 328,124 | 334,509 | +6,385 | 0.01 | 0.00 | -0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 120,000 | 320,000 | +200,000 | 0.54 | 0.85 | +0.31 | buy |
| ROYAL BANK OF CANADA | 395,893 | 307,830 | -88,063 | 0.01 | 0.00 | -0.00 | sell |
| Granahan Investment Management, LLC | 325,287 | 305,586 | -19,701 | 0.81 | 0.51 | -0.30 | sell |
| AMERICAN CENTURY COMPANIES INC | 275,758 | 301,582 | +25,824 | 0.01 | 0.01 | -0.00 | buy |
| 683 Capital Management, LLC | 320,000 | 280,000 | -40,000 | 2.06 | 1.11 | -0.95 | sell |
| BLAIR WILLIAM & CO/IL | 226,954 | 271,869 | +44,915 | 0.04 | 0.03 | -0.01 | buy |
| Rafferty Asset Management, LLC | 253,753 | 271,163 | +17,410 | 0.06 | 0.04 | -0.02 | buy |
| Fiera Capital Corp | 291,318 | 269,555 | -21,763 | 0.06 | 0.03 | -0.02 | sell |
| Parallax Volatility Advisers, L.P. | 0 | 268,879 | +268,879 | 0.00 | 0.24 | +0.24 | buy |
| Nationale-Nederlanden Powszechne Towarzystwo Emerytalne S.A. | 493,950 | 267,464 | -226,486 | 4.34 | 1.30 | -3.04 | sell |
| Squarepoint Ops LLC | 34,254 | 267,305 | +233,051 | 0.01 | 0.03 | +0.02 | buy |
| GROUP ONE TRADING LLC | 264,108 | 266,753 | +2,645 | 0.66 | 0.36 | -0.30 | buy |
| Russell Investments Group, Ltd. | 406,017 | 262,163 | -143,854 | 0.04 | 0.01 | -0.02 | sell |
| WELLS FARGO & COMPANY/MN | 192,280 | 261,635 | +69,355 | 0.00 | 0.00 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 263,159 | 235,503 | -27,656 | 0.17 | 0.10 | -0.07 | sell |
| Steward Partners Investment Advisory, LLC | 158,051 | 224,409 | +66,358 | 0.09 | 0.08 | -0.01 | buy |
| BOONE CAPITAL MANAGEMENT LLC | 192,889 | 209,853 | +16,964 | 3.17 | 2.85 | -0.32 | buy |
| Aquatic Capital Management LLC | 0 | 209,134 | +209,134 | 0.00 | 0.23 | +0.23 | buy |
| Swiss National Bank | 193,800 | 196,200 | +2,400 | 0.01 | 0.01 | -0.00 | buy |
| 5AM Venture Management, LLC | 237,560 | 189,593 | -47,967 | 3.11 | 1.82 | -1.29 | sell |
| Handelsbanken Fonder AB | 180,000 | 183,400 | +3,400 | 0.05 | 0.03 | -0.02 | buy |
| WASATCH ADVISORS LP | 227,720 | 180,918 | -46,802 | 0.07 | 0.04 | -0.03 | sell |
| STIFEL FINANCIAL CORP | 131,348 | 178,819 | +47,471 | 0.01 | 0.01 | -0.00 | buy |
| CITIGROUP INC | 129,345 | 178,647 | +49,302 | 0.01 | 0.01 | -0.00 | buy |
| AGF MANAGEMENT LTD | 109,449 | 164,263 | +54,814 | 0.04 | 0.03 | -0.00 | buy |
| OSTERWEIS CAPITAL MANAGEMENT INC | 125,520 | 155,445 | +29,925 | 0.40 | 0.29 | -0.11 | buy |
| Integral Health Asset Management, LLC | 0 | 150,000 | +150,000 | 0.00 | 0.53 | +0.53 | buy |
| Altium Capital Management LLC | 126,000 | 146,000 | +20,000 | 2.38 | 1.83 | -0.55 | buy |
| CALIFORNIA PUBLIC EMPLOYEES RETIREMENT SYSTEM | 184,168 | 136,592 | -47,576 | 0.01 | 0.00 | -0.00 | sell |
| Allianz Asset Management GmbH | 106,043 | 132,349 | +26,306 | 0.01 | 0.01 | -0.00 | buy |
| RHUMBLINE ADVISERS | 130,445 | 130,227 | -218 | 0.01 | 0.00 | -0.00 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 139,252 | 129,283 | -9,969 | 0.38 | 0.23 | -0.16 | sell |
| Portolan Capital Management, LLC | 125,762 | 128,420 | +2,658 | 0.58 | 0.35 | -0.23 | buy |
| BIT Capital GmbH | 116,113 | 124,443 | +8,330 | 0.71 | 0.44 | -0.27 | buy |
| DISCOVERY CAPITAL MANAGEMENT, LLC / CT | 131,400 | 124,400 | -7,000 | 1.02 | 0.34 | -0.67 | sell |
| OPPENHEIMER & CO INC | 102,324 | 121,062 | +18,738 | 0.10 | 0.07 | -0.03 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 122,398 | 118,898 | -3,500 | 0.01 | 0.01 | -0.00 | sell |
| Legal & General Group Plc | 108,115 | 107,370 | -745 | 0.00 | 0.00 | -0.00 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 133,066 | 103,270 | -29,796 | 1.38 | 0.77 | -0.61 | sell |
| MILLENNIUM MANAGEMENT LLC | 172,322 | 102,732 | -69,590 | 0.01 | 0.00 | -0.01 | sell |
| D. E. Shaw & Co., Inc. | 456,460 | 102,243 | -354,217 | 0.04 | 0.00 | -0.03 | sell |
| GOLDMAN SACHS GROUP INC | 156,719 | 101,702 | -55,017 | 0.00 | 0.00 | -0.00 | sell |
| DIMENSIONAL FUND ADVISORS LP | 111,156 | 100,762 | -10,394 | 0.00 | 0.00 | -0.00 | sell |
| LPL Financial LLC | 81,829 | 96,702 | +14,873 | 0.00 | 0.00 | -0.00 | buy |
| APIS CAPITAL ADVISORS, LLC | 77,000 | 96,000 | +19,000 | 3.39 | 2.57 | -0.82 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 94,364 | 93,794 | -570 | 0.01 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 0 | 93,372 | +93,372 | 0.00 | 0.08 | +0.08 | buy |
| Woodline Partners LP | 63,819 | 93,294 | +29,475 | 0.03 | 0.03 | -0.01 | buy |
| BARCLAYS PLC | 103,131 | 92,556 | -10,575 | 0.00 | 0.00 | -0.00 | sell |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 58,710 | 90,320 | +31,610 | 0.01 | 0.01 | -0.00 | buy |
| Artia Global Partners LP | 532,879 | 90,279 | -442,600 | 9.54 | 1.47 | -8.08 | sell |
| Rhenman & Partners Asset Management AB | 102,500 | 90,000 | -12,500 | 0.53 | 0.37 | -0.15 | sell |
| Cetera Investment Advisers | 80,547 | 86,181 | +5,634 | 0.01 | 0.01 | -0.00 | buy |
| Quantum Private Wealth, LLC | 84,084 | 85,916 | +1,832 | 1.80 | 1.11 | -0.70 | buy |
| Quinn Opportunity Partners LLC | 0 | 83,889 | +83,889 | 0.00 | 0.24 | +0.24 | buy |
| CANADA LIFE ASSURANCE Co | 84,275 | 83,579 | -696 | 0.01 | 0.01 | -0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 74,730 | 81,964 | +7,234 | 0.01 | 0.01 | -0.00 | buy |
| Institute for Wealth Management, LLC. | 36,237 | 80,602 | +44,365 | 0.29 | 0.41 | +0.12 | buy |
| ROYCE & ASSOCIATES LP | 13,334 | 75,261 | +61,927 | 0.01 | 0.03 | +0.02 | buy |
| Profit Investment Management, LLC | 68,001 | 73,714 | +5,713 | 3.39 | 2.38 | -1.01 | buy |
| EFG Asset Management (North America) Corp. | 31,099 | 71,773 | +40,674 | 0.33 | 0.39 | +0.06 | buy |
| FRED ALGER MANAGEMENT, LLC | 488,869 | 71,569 | -417,300 | 0.15 | 0.01 | -0.14 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 55,949 | 71,193 | +15,244 | 0.01 | 0.00 | -0.00 | buy |