| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BlackRock, Inc. | 3,873,786 | 3,547,195 | -326,591 | 0.01 | 0.00 | -0.00 | sell |
| VANGUARD GROUP INC | 3,203,591 | 3,000,087 | -203,504 | 0.01 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 8,675 | 1,748,409 | +1,739,734 | 0.00 | 0.10 | +0.10 | buy |
| WILLIAM BLAIR INVESTMENT MANAGEMENT, LLC | 769,169 | 1,297,573 | +528,404 | 0.26 | 0.25 | -0.02 | buy |
| BAILLIE GIFFORD & CO | 1,113,888 | 1,084,350 | -29,538 | 0.11 | 0.06 | -0.05 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 140,000 | 1,047,694 | +907,694 | 0.33 | 1.19 | +0.86 | buy |
| STATE STREET CORP | 1,030,902 | 979,309 | -51,593 | 0.01 | 0.00 | -0.00 | sell |
| BRAIDWELL LP | 522,410 | 883,747 | +361,337 | 2.32 | 1.95 | -0.37 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 608,308 | 833,599 | +225,291 | 0.02 | 0.01 | -0.00 | buy |
| FMR LLC | 2,285,742 | 749,312 | -1,536,430 | 0.02 | 0.00 | -0.01 | sell |
| Soleus Capital Management, L.P. | 109,000 | 728,188 | +619,188 | 0.98 | 2.89 | +1.91 | buy |
| JANUS HENDERSON GROUP PLC | 640,923 | 667,078 | +26,155 | 0.04 | 0.02 | -0.02 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 614,359 | +614,359 | 0.00 | 0.09 | +0.09 | buy |
| Artisan Partners Limited Partnership | 362,326 | 526,242 | +163,916 | 0.07 | 0.06 | -0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 59,768 | 522,180 | +462,412 | 0.01 | 0.03 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 512,836 | 504,987 | -7,849 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 430,694 | 467,736 | +37,042 | 0.01 | 0.01 | -0.00 | buy |
| MORGAN STANLEY | 302,872 | 450,641 | +147,769 | 0.00 | 0.00 | -0.00 | buy |
| Champlain Investment Partners, LLC | 412,106 | 407,059 | -5,047 | 0.37 | 0.23 | -0.15 | sell |
| Aberdeen Group plc | 243,102 | 396,340 | +153,238 | 0.05 | 0.05 | -0.01 | buy |
| D. E. Shaw & Co., Inc. | 14,222 | 358,857 | +344,635 | 0.00 | 0.02 | +0.02 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 356,808 | +356,808 | 0.00 | 0.02 | +0.02 | buy |
| DIMENSIONAL FUND ADVISORS LP | 344,867 | 343,718 | -1,149 | 0.01 | 0.01 | -0.00 | sell |
| FRANKLIN RESOURCES INC | 228,564 | 297,245 | +68,681 | 0.01 | 0.01 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 254,474 | 288,828 | +34,354 | 0.00 | 0.00 | -0.00 | buy |
| BROWN CAPITAL MANAGEMENT LLC | 367,441 | 278,040 | -89,401 | 1.39 | 0.85 | -0.54 | sell |
| GOLDMAN SACHS GROUP INC | 94,066 | 263,224 | +169,158 | 0.00 | 0.00 | +0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 156,658 | 256,658 | +100,000 | 0.36 | 0.31 | -0.04 | buy |
| Amundi | 183,956 | 255,124 | +71,168 | 0.01 | 0.01 | -0.00 | buy |
| KEYBANK NATIONAL ASSOCIATION/OH | 200,631 | 200,005 | -626 | 0.10 | 0.05 | -0.04 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 283,600 | 193,134 | -90,466 | 0.01 | 0.00 | -0.00 | sell |
| BAMCO INC /NY/ | 491,752 | 190,023 | -301,729 | 0.17 | 0.04 | -0.14 | sell |
| NORTHERN TRUST CORP | 202,511 | 189,764 | -12,747 | 0.00 | 0.00 | -0.00 | sell |
| Atika Capital Management LLC | 161,900 | 187,600 | +25,700 | 2.19 | 1.19 | -1.01 | buy |
| Bank of New York Mellon Corp | 327,753 | 166,876 | -160,877 | 0.01 | 0.00 | -0.01 | sell |
| FRONTIER CAPITAL MANAGEMENT CO LLC | 693,203 | 162,295 | -530,908 | 0.83 | 0.11 | -0.72 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 126,800 | 155,000 | +28,200 | 0.02 | 0.02 | -0.01 | buy |
| M&G Plc | 52,924 | 144,960 | +92,036 | 0.04 | 0.06 | +0.02 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 212,743 | 139,317 | -73,426 | 0.10 | 0.03 | -0.06 | sell |
| CAPSTONE INVESTMENT ADVISORS, LLC | 4,375 | 136,807 | +132,432 | 0.00 | 0.09 | +0.08 | buy |
| WASATCH ADVISORS LP | 1,634,395 | 135,914 | -1,498,481 | 1.11 | 0.05 | -1.06 | sell |
| Vestal Point Capital, LP | 0 | 135,000 | +135,000 | 0.00 | 0.45 | +0.45 | buy |
| MARSHALL WACE, LLP | 15,905 | 134,269 | +118,364 | 0.00 | 0.01 | +0.01 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 145,702 | 128,984 | -16,718 | 0.01 | 0.00 | -0.01 | sell |
| Walleye Capital LLC | 18 | 128,613 | +128,595 | 0.00 | 0.08 | +0.08 | buy |
| Integral Health Asset Management, LLC | 70,000 | 120,000 | +50,000 | 0.85 | 0.65 | -0.20 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 0 | 114,901 | +114,901 | 0.00 | 0.11 | +0.11 | buy |
| Rock Springs Capital Management LP | 107,500 | 110,500 | +3,000 | 0.87 | 0.48 | -0.39 | buy |
| WCM INVESTMENT MANAGEMENT, LLC | 110,733 | 107,032 | -3,701 | 0.03 | 0.02 | -0.02 | sell |
| PUBLIC SECTOR PENSION INVESTMENT BOARD | 100,505 | 104,984 | +4,479 | 0.06 | 0.03 | -0.03 | buy |
| FEDERATED HERMES, INC. | 228,332 | 103,804 | -124,528 | 0.06 | 0.01 | -0.04 | sell |
| RIVERBRIDGE PARTNERS LLC | 113,886 | 103,571 | -10,315 | 0.24 | 0.13 | -0.11 | sell |
| Regal Partners Ltd | 0 | 101,714 | +101,714 | 0.00 | 0.54 | +0.54 | buy |
| Y-Intercept (Hong Kong) Ltd | 15,166 | 99,049 | +83,883 | 0.05 | 0.18 | +0.13 | buy |
| Cubist Systematic Strategies, LLC | 0 | 97,387 | +97,387 | 0.00 | 0.10 | +0.10 | buy |
| Invesco Ltd. | 333,232 | 92,787 | -240,445 | 0.01 | 0.00 | -0.01 | sell |
| Point72 Asset Management, L.P. | 75,405 | 91,896 | +16,491 | 0.02 | 0.01 | -0.01 | buy |
| WINTON GROUP Ltd | 8,089 | 91,458 | +83,369 | 0.05 | 0.25 | +0.20 | buy |
| LAZARD ASSET MANAGEMENT LLC | 72,105 | 89,605 | +17,500 | 0.01 | 0.01 | -0.00 | buy |
| AMERIPRISE FINANCIAL INC | 112,450 | 89,071 | -23,379 | 0.00 | 0.00 | -0.00 | sell |
| Bridgewater Associates, LP | 141,647 | 88,952 | -52,695 | 0.07 | 0.03 | -0.05 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 88,301 | +88,301 | 0.00 | 0.02 | +0.02 | buy |
| Legal & General Group Plc | 95,688 | 84,280 | -11,408 | 0.00 | 0.00 | -0.00 | sell |
| Man Group plc | 380,298 | 83,845 | -296,453 | 0.11 | 0.01 | -0.09 | sell |
| Qube Research & Technologies Ltd | 0 | 82,810 | +82,810 | 0.00 | 0.01 | +0.01 | buy |
| JPMORGAN CHASE & CO | 384,041 | 80,374 | -303,667 | 0.00 | 0.00 | -0.00 | sell |
| Voleon Capital Management LP | 0 | 78,518 | +78,518 | 0.00 | 0.14 | +0.14 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 75,555 | +75,555 | 0.00 | 0.09 | +0.09 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 68,480 | 73,104 | +4,624 | 0.02 | 0.01 | -0.01 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 68,663 | 72,997 | +4,334 | 0.10 | 0.05 | -0.04 | buy |
| Verition Fund Management LLC | 16,434 | 71,695 | +55,261 | 0.01 | 0.03 | +0.02 | buy |
| JANE STREET GROUP, LLC | 0 | 71,451 | +71,451 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 18,029 | 69,328 | +51,299 | 0.00 | 0.01 | +0.00 | buy |
| RHUMBLINE ADVISERS | 70,755 | 67,200 | -3,555 | 0.01 | 0.00 | -0.00 | sell |
| MAIRS & POWER INC | 67,804 | 65,446 | -2,358 | 0.09 | 0.05 | -0.04 | sell |
| Weiss Asset Management LP | 0 | 63,029 | +63,029 | 0.00 | 0.07 | +0.07 | buy |
| Rhenman & Partners Asset Management AB | 30,500 | 61,000 | +30,500 | 0.50 | 0.50 | +0.00 | buy |
| Bellevue Group AG | 75,660 | 58,648 | -17,012 | 0.22 | 0.09 | -0.13 | sell |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 0 | 58,497 | +58,497 | 0.00 | 0.01 | +0.01 | buy |
| Mitsubishi UFJ Trust & Banking Corp | 57,611 | 55,805 | -1,806 | 0.02 | 0.01 | -0.01 | sell |
| Swiss National Bank | 56,800 | 54,400 | -2,400 | 0.00 | 0.00 | -0.00 | sell |
| Rheos Capital Works Inc. | 52,400 | 52,400 | 0 | 0.39 | 0.22 | -0.17 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 191,268 | 50,247 | -141,021 | 0.03 | 0.00 | -0.03 | sell |
| Affinity Asset Advisors, LLC | 0 | 50,000 | +50,000 | 0.00 | 0.35 | +0.35 | buy |
| AQR CAPITAL MANAGEMENT LLC | 121,410 | 49,417 | -71,993 | 0.01 | 0.00 | -0.01 | sell |
| Nuveen, LLC | 48,017 | 47,852 | -165 | 0.00 | 0.00 | -0.00 | sell |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 42,724 | 46,366 | +3,642 | 0.04 | 0.03 | -0.02 | buy |
| HRT FINANCIAL LP | 0 | 45,681 | +45,681 | 0.00 | 0.01 | +0.01 | buy |
| HSBC HOLDINGS PLC | 7,962 | 43,538 | +35,576 | 0.00 | 0.00 | +0.00 | buy |
| MACQUARIE GROUP LTD | 495,556 | 43,324 | -452,232 | 0.08 | 0.00 | -0.08 | sell |
| CITIGROUP INC | 51,528 | 42,328 | -9,200 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF MONTREAL /CAN/ | 5,507 | 41,916 | +36,409 | 0.00 | 0.00 | +0.00 | buy |
| Quantbot Technologies LP | 0 | 41,063 | +41,063 | 0.00 | 0.08 | +0.08 | buy |
| Kopp Family Office, LLC | 40,614 | 40,614 | 0 | 3.41 | 1.96 | -1.45 | hold |
| CANADA PENSION PLAN INVESTMENT BOARD | 10,400 | 39,600 | +29,200 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Hong Kong Ltd | 17,450 | 39,122 | +21,672 | 0.16 | 0.13 | -0.02 | buy |
| TWO SIGMA INVESTMENTS, LP | 19,350 | 37,152 | +17,802 | 0.00 | 0.00 | -0.00 | buy |
| Aquatic Capital Management LLC | 0 | 37,058 | +37,058 | 0.00 | 0.05 | +0.05 | buy |
| Bullseye Asset Management LLC | 36,128 | 36,128 | 0 | 2.34 | 1.40 | -0.93 | hold |
| VOYA INVESTMENT MANAGEMENT LLC | 178,319 | 35,826 | -142,493 | 0.02 | 0.00 | -0.02 | sell |