| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 0 | 10,281,496 | +10,281,496 | 0.00 | 23.83 | +23.83 | buy |
| Avoro Capital Advisors LLC | 0 | 5,111,111 | +5,111,111 | 0.00 | 12.24 | +12.24 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 0 | 4,798,267 | +4,798,267 | 0.00 | 4.18 | +4.18 | buy |
| FMR LLC | 0 | 3,545,575 | +3,545,575 | 0.00 | 0.04 | +0.04 | buy |
| Artisan Partners Limited Partnership | 0 | 2,634,024 | +2,634,024 | 0.00 | 1.15 | +1.15 | buy |
| BlackRock, Inc. | 0 | 2,211,833 | +2,211,833 | 0.00 | 0.01 | +0.01 | buy |
| Capital International Investors | 0 | 1,988,614 | +1,988,614 | 0.00 | 0.11 | +0.11 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 0 | 1,875,301 | +1,875,301 | 0.00 | 0.16 | +0.16 | buy |
| FRANKLIN RESOURCES INC | 0 | 1,862,503 | +1,862,503 | 0.00 | 0.11 | +0.11 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 1,548,636 | +1,548,636 | 0.00 | 0.07 | +0.07 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 1,400,575 | +1,400,575 | 0.00 | 0.17 | +0.17 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 1,163,721 | +1,163,721 | 0.00 | 4.82 | +4.82 | buy |
| Capital World Investors | 0 | 906,081 | +906,081 | 0.00 | 0.03 | +0.03 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 0 | 873,502 | +873,502 | 0.00 | 0.11 | +0.11 | buy |
| Polar Capital Holdings Plc | 0 | 616,908 | +616,908 | 0.00 | 0.47 | +0.47 | buy |
| T. Rowe Price Investment Management, Inc. | 6,162,042 | 6,754,846 | +592,804 | 0.97 | 1.18 | +0.21 | buy |
| GOLDMAN SACHS GROUP INC | 0 | 559,534 | +559,534 | 0.00 | 0.02 | +0.02 | buy |
| MORGAN STANLEY | 0 | 544,393 | +544,393 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 87,334 | 513,969 | +426,635 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 414,196 | +414,196 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 0 | 403,151 | +403,151 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 0 | 401,881 | +401,881 | 0.00 | 0.02 | +0.02 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 399,292 | +399,292 | 0.00 | 0.04 | +0.04 | buy |
| Vestal Point Capital, LP | 0 | 375,000 | +375,000 | 0.00 | 2.34 | +2.34 | buy |
| JPMORGAN CHASE & CO | 0 | 367,781 | +367,781 | 0.00 | 0.01 | +0.01 | buy |
| FIL Ltd | 0 | 345,567 | +345,567 | 0.00 | 0.07 | +0.07 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 320,514 | +320,514 | 0.00 | 0.02 | +0.02 | buy |
| Bank of New York Mellon Corp | 0 | 319,412 | +319,412 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 305,803 | +305,803 | 0.00 | 0.06 | +0.06 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 266,708 | +266,708 | 0.00 | 0.05 | +0.05 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 260,638 | +260,638 | 0.00 | 0.00 | +0.00 | buy |
| Tri Locum Partners LP | 0 | 258,740 | +258,740 | 0.00 | 8.49 | +8.49 | buy |
| ORBIMED ADVISORS LLC | 0 | 244,456 | +244,456 | 0.00 | 1.24 | +1.24 | buy |
| SEI INVESTMENTS CO | 0 | 237,869 | +237,869 | 0.00 | 0.06 | +0.06 | buy |
| Pictet Asset Management Holding SA | 0 | 234,039 | +234,039 | 0.00 | 0.06 | +0.06 | buy |
| PFM Health Sciences, LP | 0 | 233,171 | +233,171 | 0.00 | 5.40 | +5.40 | buy |
| Spyglass Capital Management LLC | 0 | 215,398 | +215,398 | 0.00 | 3.11 | +3.11 | buy |
| ARS Investment Partners, LLC | 0 | 210,462 | +210,462 | 0.00 | 2.45 | +2.45 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 206,234 | +206,234 | 0.00 | 6.12 | +6.12 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 191,791 | +191,791 | 0.00 | 0.06 | +0.06 | buy |
| Empowered Funds, LLC | 0 | 187,271 | +187,271 | 0.00 | 0.26 | +0.26 | buy |
| JANE STREET GROUP, LLC | 0 | 187,141 | +187,141 | 0.00 | 0.03 | +0.03 | buy |
| Allspring Global Investments Holdings, LLC | 0 | 178,738 | +178,738 | 0.00 | 0.07 | +0.07 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 173,449 | +173,449 | 0.00 | 0.02 | +0.02 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 171,447 | +171,447 | 0.00 | 0.15 | +0.15 | buy |
| Rock Springs Capital Management LP | 0 | 168,750 | +168,750 | 0.00 | 2.20 | +2.20 | buy |
| SG Americas Securities, LLC | 0 | 161,026 | +161,026 | 0.00 | 0.02 | +0.02 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 0 | 148,644 | +148,644 | 0.00 | 1.93 | +1.93 | buy |
| LORD, ABBETT & CO. LLC | 0 | 144,468 | +144,468 | 0.00 | 0.11 | +0.11 | buy |
| Neuberger Berman Group LLC | 0 | 142,705 | +142,705 | 0.00 | 0.03 | +0.03 | buy |
| USS Investment Management Ltd | 0 | 141,010 | +141,010 | 0.00 | 0.14 | +0.14 | buy |
| CITADEL ADVISORS LLC | 0 | 137,889 | +137,889 | 0.00 | 0.02 | +0.02 | buy |
| BRAUN STACEY ASSOCIATES INC | 0 | 132,682 | +132,682 | 0.00 | 1.00 | +1.00 | buy |
| Walleye Capital LLC | 0 | 126,005 | +126,005 | 0.00 | 0.16 | +0.16 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 125,772 | +125,772 | 0.00 | 0.01 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 119,699 | +119,699 | 0.00 | 0.04 | +0.04 | buy |
| TD ASSET MANAGEMENT INC | 0 | 119,085 | +119,085 | 0.00 | 0.03 | +0.03 | buy |
| Resolute Capital Asset Partners LLC | 0 | 118,627 | +118,627 | 0.00 | 13.52 | +13.52 | buy |
| Eagle Health Investments LP | 0 | 106,158 | +106,158 | 0.00 | 4.69 | +4.69 | buy |
| First Turn Management, LLC | 0 | 104,877 | +104,877 | 0.00 | 2.99 | +2.99 | buy |
| NORTHERN TRUST CORP | 0 | 103,933 | +103,933 | 0.00 | 0.00 | +0.00 | buy |
| Fiera Capital Corp | 0 | 103,313 | +103,313 | 0.00 | 0.10 | +0.10 | buy |
| Woodline Partners LP | 0 | 102,469 | +102,469 | 0.00 | 0.08 | +0.08 | buy |
| SAPIENT CAPITAL LLC | 0 | 92,162 | +92,162 | 0.00 | 0.32 | +0.32 | buy |
| Frazier Life Sciences Management, L.P. | 133,333 | 225,155 | +91,822 | 0.78 | 1.31 | +0.52 | buy |
| Synergy Asset Management, LLC | 0 | 91,228 | +91,228 | 0.00 | 2.29 | +2.29 | buy |
| Nuveen, LLC | 0 | 90,318 | +90,318 | 0.00 | 0.01 | +0.01 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 85,478 | +85,478 | 0.00 | 0.01 | +0.01 | buy |
| LOOMIS SAYLES & CO L P | 0 | 78,941 | +78,941 | 0.00 | 0.03 | +0.03 | buy |
| BARCLAYS PLC | 0 | 76,540 | +76,540 | 0.00 | 0.01 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 66,500 | +66,500 | 0.00 | 0.02 | +0.02 | buy |
| CASTLEARK MANAGEMENT LLC | 0 | 61,696 | +61,696 | 0.00 | 0.44 | +0.44 | buy |
| Atika Capital Management LLC | 0 | 61,000 | +61,000 | 0.00 | 1.61 | +1.61 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 54,332 | +54,332 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 0 | 50,353 | +50,353 | 0.00 | 0.00 | +0.00 | buy |
| Cormorant Asset Management, LP | 0 | 50,000 | +50,000 | 0.00 | 0.68 | +0.68 | buy |
| RHUMBLINE ADVISERS | 0 | 48,612 | +48,612 | 0.00 | 0.01 | +0.01 | buy |
| DAFNA Capital Management LLC | 0 | 48,469 | +48,469 | 0.00 | 2.47 | +2.47 | buy |
| Russell Investments Group, Ltd. | 0 | 48,261 | +48,261 | 0.00 | 0.01 | +0.01 | buy |
| Trexquant Investment LP | 0 | 47,269 | +47,269 | 0.00 | 0.08 | +0.08 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 0 | 45,776 | +45,776 | 0.00 | 0.00 | +0.00 | buy |
| Integral Health Asset Management, LLC | 0 | 45,000 | +45,000 | 0.00 | 0.49 | +0.49 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 43,678 | +43,678 | 0.00 | 0.02 | +0.02 | buy |
| XTX Topco Ltd | 0 | 43,289 | +43,289 | 0.00 | 0.15 | +0.15 | buy |
| Eversept Partners, LP | 0 | 41,621 | +41,621 | 0.00 | 0.61 | +0.61 | buy |
| Quadrature Capital Ltd | 0 | 40,845 | +40,845 | 0.00 | 0.09 | +0.09 | buy |
| Nicholas Investment Partners, LP | 0 | 38,160 | +38,160 | 0.00 | 0.57 | +0.57 | buy |
| Aberdeen Group plc | 0 | 36,512 | +36,512 | 0.00 | 0.01 | +0.01 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 33,383 | +33,383 | 0.00 | 0.01 | +0.01 | buy |
| Longaeva Partners L.P. | 0 | 32,036 | +32,036 | 0.00 | 0.25 | +0.25 | buy |
| Catalio Capital Management, LP | 0 | 31,759 | +31,759 | 0.00 | 1.59 | +1.59 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 31,023 | +31,023 | 0.00 | 0.02 | +0.02 | buy |
| D. E. Shaw & Co., Inc. | 0 | 30,883 | +30,883 | 0.00 | 0.01 | +0.01 | buy |
| Affinity Asset Advisors, LLC | 0 | 30,000 | +30,000 | 0.00 | 0.39 | +0.39 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 29,303 | +29,303 | 0.00 | 0.03 | +0.03 | buy |
| CITIGROUP INC | 0 | 28,693 | +28,693 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 0 | 28,604 | +28,604 | 0.00 | 0.36 | +0.36 | buy |
| Matisse Capital | 0 | 28,107 | +28,107 | 0.00 | 3.00 | +3.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 27,540 | +27,540 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 27,283 | +27,283 | 0.00 | 0.00 | +0.00 | buy |