| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,444,950 | 1,781,926 | +336,976 | 0.02 | 0.03 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 3,994,785 | 3,767,203 | +227,582 | 0.30 | 0.31 | 0.00 | sell |
| Avoro Capital Advisors LLC | 3,755,555 | 3,966,666 | +211,111 | 6.53 | 6.99 | +0.46 | buy |
| Woodline Partners LP | 16,149 | 196,030 | +179,881 | 0.02 | 0.27 | +0.25 | buy |
| Paradigm Biocapital Advisors LP | 351,700 | 507,952 | +156,252 | 2.08 | 2.70 | +0.63 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 1,519,219 | 1,617,830 | +98,611 | 0.06 | 0.07 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 265,157 | 340,118 | +74,961 | 0.05 | 0.07 | 0.00 | buy |
| Spyglass Capital Management LLC | 539,948 | 614,107 | +74,159 | 4.89 | 6.18 | +1.29 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 144,000 | 209,512 | +65,512 | 0.04 | 0.06 | +0.02 | buy |
| BIT Capital GmbH | 61,530 | 109,638 | +48,108 | 0.76 | 1.23 | +0.47 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 4,030,634 | 4,075,214 | +44,580 | 2.96 | 3.23 | +0.28 | buy |
| Penserra Capital Management LLC | 3,448 | 19,412 | +15,964 | 0.01 | 0.04 | +0.03 | buy |
| Allspring Global Investments Holdings, LLC | 203,172 | 189,208 | +13,964 | 0.04 | 0.05 | 0.00 | sell |
| Nicholas Investment Partners, LP | 4,267 | 17,984 | +13,717 | 0.06 | 0.28 | +0.22 | buy |
| Tri Locum Partners LP | 99,550 | 112,670 | +13,120 | 6.15 | 5.91 | -0.25 | buy |
| Finepoint Capital LP | 163,772 | 175,672 | +11,900 | 6.51 | 6.81 | +0.30 | buy |
| Resolute Capital Asset Partners LLC | 36,400 | 47,000 | +10,600 | 2.99 | 3.71 | +0.73 | buy |
| Capital International Investors | 2,181,268 | 2,191,312 | +10,044 | 0.06 | 0.07 | +0.01 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 12,085 | 22,006 | +9,921 | 0.29 | 0.43 | +0.14 | buy |
| NEOS Investment Management LLC | 3,782 | 11,160 | +7,378 | 0.05 | 0.10 | +0.06 | buy |
| FIL Ltd | 5,998 | 10,727 | +4,729 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 6,635 | 11,020 | +4,385 | 0.16 | 0.21 | +0.05 | buy |
| CIBC Private Wealth Group LLC | 5,668 | 8,378 | +2,710 | 0.00 | 0.00 | 0.00 | buy |
| ADAR1 Capital Management, LLC | 45,884 | 48,584 | +2,700 | 2.58 | 2.01 | -0.58 | buy |
| BAROMETER CAPITAL MANAGEMENT INC. | 1,000 | 3,104 | +2,104 | 0.04 | 0.11 | +0.08 | buy |
| HighVista Strategies LLC | 2,828 | 4,527 | +1,699 | 0.13 | 0.24 | +0.11 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 12,668 | 13,929 | +1,261 | 0.01 | 0.01 | +0.00 | buy |
| Matisse Capital | 34,635 | 35,540 | +905 | 2.32 | 2.58 | +0.26 | buy |
| Hennion & Walsh Asset Management, Inc. | 6,152 | 7,034 | +882 | 0.04 | 0.06 | +0.01 | buy |
| CI INVESTMENTS INC. | 790 | 1,468 | +678 | 0.00 | 0.00 | 0.00 | buy |
| TOBAM | 1,533 | 2,163 | +630 | 0.02 | 0.03 | +0.01 | buy |
| VIRTUS ADVISERS, LLC | 2,716 | 3,172 | +456 | 0.22 | 0.25 | +0.04 | buy |
| PROFUND ADVISORS LLC | 3,231 | 2,834 | +397 | 0.02 | 0.02 | 0.00 | sell |
| OPPENHEIMER ASSET MANAGEMENT INC. | 5,007 | 4,879 | +128 | 0.01 | 0.01 | 0.00 | sell |
| Gilbert & Cook, Inc. | 2,838 | 2,881 | +43 | 0.05 | 0.06 | +0.01 | buy |
| Henry James International Management Inc. | 24,495 | 24,521 | +26 | 1.16 | 1.14 | -0.01 | buy |
| Bell Investment Advisors, Inc | 43 | 47 | +4 | 0.00 | 0.00 | 0.00 | buy |
| Chicago Partners Investment Group LLC | 6,886 | 6,659 | -227 | 0.04 | 0.04 | -0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 4,441 | 4,011 | -430 | 0.24 | 0.24 | -0.00 | sell |
| BAILLIE GIFFORD & CO | 81,670 | 81,206 | -464 | 0.01 | 0.01 | +0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 307,737 | 306,141 | -1,596 | 0.03 | 0.03 | +0.00 | sell |
| Evolutionary Tree Capital Management, LLC | 16,726 | 13,639 | -3,087 | 2.33 | 2.08 | -0.25 | sell |
| Parkwood LLC | 16,096 | 12,247 | -3,849 | 0.24 | 0.17 | -0.08 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 168,883 | 162,412 | -6,471 | 1.23 | 1.40 | +0.17 | sell |
| FRED ALGER MANAGEMENT, LLC | 193,502 | 186,121 | -7,381 | 0.13 | 0.14 | +0.01 | sell |
| TD ASSET MANAGEMENT INC | 244,578 | 236,870 | -7,708 | 0.03 | 0.03 | +0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 204,548 | 196,079 | -8,469 | 0.04 | 0.04 | +0.00 | sell |
| ARS Investment Partners, LLC | 282,744 | 254,967 | -27,777 | 3.95 | 3.84 | -0.11 | sell |
| Saturn V Capital Management LP | 131,759 | 103,428 | -28,331 | 6.35 | 6.27 | -0.08 | sell |
| DAFNA Capital Management LLC | 123,472 | 92,472 | -31,000 | 3.73 | 3.18 | -0.54 | sell |
| Artisan Partners Limited Partnership | 5,749,227 | 5,671,934 | -77,293 | 1.11 | 1.24 | +0.13 | sell |
| Vestal Point Capital, LP | 625,000 | 525,000 | -100,000 | 8.34 | 6.56 | -1.78 | sell |
| TimesSquare Capital Management, LLC | 792,945 | 575,698 | -217,247 | 1.47 | 1.27 | -0.20 | sell |
| T. Rowe Price Investment Management, Inc. | 3,989,830 | 2,568,903 | -1,420,927 | 0.33 | 0.24 | -0.09 | sell |