| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 10,107,400 | 10,108,400 | +1,000 | 19.88 | 19.44 | -0.44 | buy |
| Artisan Partners Limited Partnership | 5,749,227 | 5,671,934 | -77,293 | 1.14 | 1.25 | +0.11 | sell |
| FMR LLC | 5,114,369 | 4,938,461 | -175,908 | 0.05 | 0.05 | +0.00 | sell |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 4,030,634 | 4,075,214 | +44,580 | 2.96 | 3.23 | +0.28 | buy |
| Avoro Capital Advisors LLC | 3,755,555 | 3,966,666 | +211,111 | 6.53 | 6.99 | +0.46 | buy |
| JANUS HENDERSON GROUP PLC | 3,994,785 | 3,767,203 | -227,582 | 0.30 | 0.31 | +0.01 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 3,248,293 | 2,745,872 | -502,421 | 0.08 | 0.07 | -0.00 | sell |
| T. Rowe Price Investment Management, Inc. | 3,989,830 | 2,568,903 | -1,420,927 | 0.33 | 0.24 | -0.09 | sell |
| Capital International Investors | 2,181,268 | 2,191,312 | +10,044 | 0.06 | 0.07 | +0.01 | buy |
| BNP Paribas Asset Management Holding S.A. | 0 | 2,000,000 | +2,000,000 | 0.00 | 0.01 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 1,064,805 | 1,981,869 | +917,064 | 0.06 | 0.09 | +0.03 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,444,950 | 1,781,926 | +336,976 | 0.02 | 0.03 | +0.01 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 1,519,219 | 1,617,830 | +98,611 | 0.06 | 0.07 | +0.01 | buy |
| Invesco Ltd. | 907,911 | 964,663 | +56,752 | 0.03 | 0.03 | +0.00 | buy |
| Sofinnova Investments, Inc. | 754,032 | 754,032 | 0 | 5.32 | 6.73 | +1.41 | hold |
| BROWN ADVISORY INC | 505,947 | 684,072 | +178,125 | 0.09 | 0.14 | +0.05 | buy |
| Spyglass Capital Management LLC | 539,948 | 614,107 | +74,159 | 4.89 | 6.18 | +1.29 | buy |
| TimesSquare Capital Management, LLC | 792,945 | 575,698 | -217,247 | 1.47 | 1.27 | -0.20 | sell |
| Vestal Point Capital, LP | 625,000 | 525,000 | -100,000 | 8.34 | 6.56 | -1.78 | sell |
| Paradigm Biocapital Advisors LP | 351,700 | 507,952 | +156,252 | 2.08 | 2.70 | +0.63 | buy |
| ALLIANCEBERNSTEIN L.P. | 588,936 | 473,753 | -115,183 | 0.03 | 0.03 | -0.00 | sell |
| CITADEL ADVISORS LLC | 171,571 | 457,504 | +285,933 | 0.02 | 0.07 | +0.04 | buy |
| GOLDMAN SACHS GROUP INC | 422,854 | 437,092 | +14,238 | 0.01 | 0.01 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 22,391 | 362,060 | +339,669 | 0.00 | 0.05 | +0.04 | buy |
| JANE STREET GROUP, LLC | 10,051,000 | 350,000 | -9,701,000 | 0.01 | 0.00 | -0.01 | sell |
| SEI INVESTMENTS CO | 361,830 | 346,186 | -15,644 | 0.07 | 0.08 | +0.00 | sell |
| D. E. Shaw & Co., Inc. | 265,157 | 340,118 | +74,961 | 0.05 | 0.07 | +0.02 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 73,335 | 307,499 | +234,164 | 0.04 | 0.17 | +0.13 | buy |
| AMERICAN CENTURY COMPANIES INC | 307,737 | 306,141 | -1,596 | 0.03 | 0.03 | +0.00 | sell |
| Rock Springs Capital Management LP | 290,000 | 290,000 | 0 | 0.90 | 1.11 | +0.21 | hold |
| Q Global Advisors, LLC | 285,000 | 285,000 | 0 | 27.20 | 16.34 | -10.86 | hold |
| Pictet Asset Management Holding SA | 203,654 | 270,770 | +67,116 | 0.03 | 0.04 | +0.02 | buy |
| BANK OF AMERICA CORP /DE/ | 151,838 | 264,445 | +112,607 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 372,414 | 261,029 | -111,385 | 0.02 | 0.02 | -0.01 | sell |
| ARS Investment Partners, LLC | 282,744 | 254,967 | -27,777 | 3.95 | 3.84 | -0.11 | sell |
| ACADIAN ASSET MANAGEMENT LLC | 16,046 | 250,492 | +234,446 | 0.01 | 0.13 | +0.12 | buy |
| TD ASSET MANAGEMENT INC | 244,578 | 236,870 | -7,708 | 0.03 | 0.03 | +0.00 | sell |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 0 | 225,111 | +225,111 | 0.00 | 1.63 | +1.63 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 210,325 | +210,325 | 0.00 | 0.08 | +0.08 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 144,000 | 209,512 | +65,512 | 0.04 | 0.06 | +0.02 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 204,548 | 196,079 | -8,469 | 0.04 | 0.04 | +0.00 | sell |
| Woodline Partners LP | 16,149 | 196,030 | +179,881 | 0.02 | 0.27 | +0.25 | buy |
| Allspring Global Investments Holdings, LLC | 203,172 | 189,208 | -13,964 | 0.04 | 0.04 | +0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 193,502 | 186,121 | -7,381 | 0.13 | 0.14 | +0.01 | sell |
| Finepoint Capital LP | 163,772 | 175,672 | +11,900 | 7.13 | 6.81 | -0.32 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 163,400 | +163,400 | 0.00 | 0.06 | +0.06 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 168,883 | 162,412 | -6,471 | 1.23 | 1.40 | +0.17 | sell |
| MORGAN STANLEY | 121,876 | 152,052 | +30,176 | 0.00 | 0.00 | +0.00 | buy |
| First Turn Management, LLC | 151,587 | 151,587 | 0 | 2.74 | 3.43 | +0.69 | hold |
| Bank of New York Mellon Corp | 213,169 | 150,944 | -62,225 | 0.01 | 0.00 | -0.00 | sell |
| Aberdeen Group plc | 138,791 | 138,791 | 0 | 0.04 | 0.04 | +0.00 | hold |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 134,564 | +134,564 | 0.00 | 0.02 | +0.02 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 113,264 | 114,401 | +1,137 | 0.03 | 0.03 | +0.00 | buy |
| Tri Locum Partners LP | 99,550 | 112,670 | +13,120 | 6.15 | 5.91 | -0.25 | buy |
| BIT Capital GmbH | 61,530 | 109,638 | +48,108 | 0.84 | 1.46 | +0.62 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 109,000 | +109,000 | 0.00 | 0.10 | +0.10 | buy |
| Saturn V Capital Management LP | 131,759 | 103,428 | -28,331 | 6.35 | 6.27 | -0.08 | sell |
| Schonfeld Strategic Advisors LLC | 124,901 | 102,000 | -22,901 | 0.13 | 0.12 | -0.01 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 100,320 | +100,320 | 0.00 | 0.15 | +0.15 | buy |
| Candriam S.C.A. | 99,375 | 99,375 | 0 | 0.09 | 0.10 | +0.01 | hold |
| DAFNA Capital Management LLC | 123,472 | 92,472 | -31,000 | 3.73 | 3.18 | -0.54 | sell |
| BNP Paribas Asset Management Holding S.A. | 0 | 86,202 | +86,202 | 0.00 | 0.03 | +0.03 | buy |
| BAILLIE GIFFORD & CO | 81,670 | 81,206 | -464 | 0.01 | 0.01 | +0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 1,744 | 75,540 | +73,796 | 0.00 | 0.01 | +0.01 | buy |
| Ensign Peak Advisors, Inc | 67,544 | 67,544 | 0 | 0.02 | 0.02 | +0.00 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 55,090 | 56,102 | +1,012 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 62,310 | 55,166 | -7,144 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 22,788 | 54,526 | +31,738 | 0.00 | 0.01 | +0.01 | buy |
| Gray Foundation | 51,700 | 51,700 | 0 | 2.30 | 2.44 | +0.14 | hold |
| ADAR1 Capital Management, LLC | 45,884 | 48,584 | +2,700 | 2.58 | 2.01 | -0.58 | buy |
| Atika Capital Management LLC | 0 | 48,500 | +48,500 | 0.00 | 0.82 | +0.82 | buy |
| Cinctive Capital Management LP | 0 | 48,383 | +48,383 | 0.00 | 0.38 | +0.38 | buy |
| Resolute Capital Asset Partners LLC | 36,400 | 47,000 | +10,600 | 2.99 | 3.71 | +0.73 | buy |
| Polar Asset Management Partners Inc. | 0 | 44,089 | +44,089 | 0.00 | 0.18 | +0.18 | buy |
| Matisse Capital | 34,635 | 35,540 | +905 | 2.32 | 2.58 | +0.26 | buy |
| STATE STREET CORP | 31,252 | 34,352 | +3,100 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 18,891 | 33,661 | +14,770 | 0.03 | 0.06 | +0.03 | buy |
| DekaBank Deutsche Girozentrale | 30,000 | 30,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| UBS Group AG | 27,927 | 27,755 | -172 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 0 | 25,084 | +25,084 | 0.00 | 0.01 | +0.01 | buy |
| Altium Capital Management LLC | 25,000 | 25,000 | 0 | 2.17 | 1.69 | -0.48 | hold |
| Henry James International Management Inc. | 24,495 | 24,521 | +26 | 1.16 | 1.14 | -0.01 | buy |
| Jefferies Financial Group Inc. | 28,000 | 24,151 | -3,849 | 0.06 | 0.07 | +0.02 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 12,085 | 22,006 | +9,921 | 0.29 | 0.43 | +0.14 | buy |
| BARCLAYS PLC | 17,325 | 21,072 | +3,747 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 31,468 | 20,394 | -11,074 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 9,868 | 20,289 | +10,421 | 0.03 | 0.06 | +0.03 | buy |
| CITIGROUP INC | 19,024 | 19,976 | +952 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 19,580 | 19,580 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Penserra Capital Management LLC | 3,448 | 19,412 | +15,964 | 0.01 | 0.04 | +0.03 | buy |
| Erste Asset Management GmbH | 18,500 | 18,500 | 0 | 0.03 | 0.04 | +0.00 | hold |
| Nicholas Investment Partners, LP | 4,267 | 17,984 | +13,717 | 0.06 | 0.28 | +0.22 | buy |
| Artia Global Partners LP | 0 | 15,894 | +15,894 | 0.00 | 0.59 | +0.59 | buy |
| JPMORGAN CHASE & CO | 61,864 | 14,231 | -47,633 | 0.00 | 0.00 | -0.00 | sell |
| NOMURA ASSET MANAGEMENT CO LTD | 12,668 | 13,929 | +1,261 | 0.01 | 0.01 | +0.00 | buy |
| JPMORGAN CHASE & CO | 61,864 | 13,775 | -48,089 | 0.00 | 0.00 | -0.00 | sell |
| Evolutionary Tree Capital Management, LLC | 16,726 | 13,639 | -3,087 | 2.33 | 2.08 | -0.25 | sell |
| Nan Fung Group Holdings Ltd | 0 | 13,600 | +13,600 | 0.00 | 1.90 | +1.90 | buy |
| Mirae Asset Global Investments Co., Ltd. | 13,989 | 13,276 | -713 | 0.00 | 0.00 | +0.00 | sell |
| STIFEL FINANCIAL CORP | 12,581 | 13,160 | +579 | 0.00 | 0.00 | +0.00 | buy |