| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| BNP Paribas Asset Management Holding S.A. | 0 | 2,000,000 | +2,000,000 | 0.00 | 0.01 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 1,064,805 | 1,981,869 | +917,064 | 0.06 | 0.09 | +0.03 | buy |
| MILLENNIUM MANAGEMENT LLC | 22,391 | 362,060 | +339,669 | 0.00 | 0.05 | +0.04 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,444,950 | 1,781,926 | +336,976 | 0.02 | 0.03 | +0.01 | buy |
| CITADEL ADVISORS LLC | 171,571 | 457,504 | +285,933 | 0.02 | 0.07 | +0.04 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 16,046 | 250,492 | +234,446 | 0.01 | 0.13 | +0.12 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 73,335 | 307,499 | +234,164 | 0.04 | 0.17 | +0.13 | buy |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 0 | 225,111 | +225,111 | 0.00 | 1.63 | +1.63 | buy |
| Avoro Capital Advisors LLC | 3,755,555 | 3,966,666 | +211,111 | 6.53 | 6.99 | +0.46 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 210,325 | +210,325 | 0.00 | 0.08 | +0.08 | buy |
| Woodline Partners LP | 16,149 | 196,030 | +179,881 | 0.02 | 0.27 | +0.25 | buy |
| BROWN ADVISORY INC | 505,947 | 684,072 | +178,125 | 0.09 | 0.14 | +0.05 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 163,400 | +163,400 | 0.00 | 0.06 | +0.06 | buy |
| Paradigm Biocapital Advisors LP | 351,700 | 507,952 | +156,252 | 2.08 | 2.70 | +0.63 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 134,564 | +134,564 | 0.00 | 0.02 | +0.02 | buy |
| BANK OF AMERICA CORP /DE/ | 151,838 | 264,445 | +112,607 | 0.00 | 0.00 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 109,000 | +109,000 | 0.00 | 0.10 | +0.10 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 100,320 | +100,320 | 0.00 | 0.15 | +0.15 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 1,519,219 | 1,617,830 | +98,611 | 0.06 | 0.07 | +0.01 | buy |
| BNP Paribas Asset Management Holding S.A. | 0 | 86,202 | +86,202 | 0.00 | 0.03 | +0.03 | buy |
| D. E. Shaw & Co., Inc. | 265,157 | 340,118 | +74,961 | 0.05 | 0.07 | +0.02 | buy |
| Spyglass Capital Management LLC | 539,948 | 614,107 | +74,159 | 4.89 | 6.18 | +1.29 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 1,744 | 75,540 | +73,796 | 0.00 | 0.01 | +0.01 | buy |
| Pictet Asset Management Holding SA | 203,654 | 270,770 | +67,116 | 0.03 | 0.04 | +0.02 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 144,000 | 209,512 | +65,512 | 0.04 | 0.06 | +0.02 | buy |
| Invesco Ltd. | 907,911 | 964,663 | +56,752 | 0.03 | 0.03 | +0.00 | buy |
| Atika Capital Management LLC | 0 | 48,500 | +48,500 | 0.00 | 0.82 | +0.82 | buy |
| Cinctive Capital Management LP | 0 | 48,383 | +48,383 | 0.00 | 0.38 | +0.38 | buy |
| BIT Capital GmbH | 61,530 | 109,638 | +48,108 | 0.84 | 1.46 | +0.62 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 4,030,634 | 4,075,214 | +44,580 | 2.96 | 3.23 | +0.28 | buy |
| Polar Asset Management Partners Inc. | 0 | 44,089 | +44,089 | 0.00 | 0.18 | +0.18 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 22,788 | 54,526 | +31,738 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 121,876 | 152,052 | +30,176 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 25,084 | +25,084 | 0.00 | 0.01 | +0.01 | buy |
| Penserra Capital Management LLC | 3,448 | 19,412 | +15,964 | 0.01 | 0.04 | +0.03 | buy |
| Artia Global Partners LP | 0 | 15,894 | +15,894 | 0.00 | 0.59 | +0.59 | buy |
| Cubist Systematic Strategies, LLC | 18,891 | 33,661 | +14,770 | 0.03 | 0.06 | +0.03 | buy |
| GOLDMAN SACHS GROUP INC | 422,854 | 437,092 | +14,238 | 0.01 | 0.01 | +0.00 | buy |
| Nicholas Investment Partners, LP | 4,267 | 17,984 | +13,717 | 0.06 | 0.28 | +0.22 | buy |
| Nan Fung Group Holdings Ltd | 0 | 13,600 | +13,600 | 0.00 | 1.90 | +1.90 | buy |
| Tri Locum Partners LP | 99,550 | 112,670 | +13,120 | 6.15 | 5.91 | -0.25 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 12,754 | +12,754 | 0.00 | 1.27 | +1.27 | buy |
| Finepoint Capital LP | 163,772 | 175,672 | +11,900 | 7.13 | 6.81 | -0.32 | buy |
| OSAIC HOLDINGS, INC. | 869 | 12,325 | +11,456 | 0.00 | 0.00 | +0.00 | buy |
| Resolute Capital Asset Partners LLC | 36,400 | 47,000 | +10,600 | 2.99 | 3.71 | +0.73 | buy |
| Trexquant Investment LP | 9,868 | 20,289 | +10,421 | 0.03 | 0.06 | +0.03 | buy |
| Capital International Investors | 2,181,268 | 2,191,312 | +10,044 | 0.06 | 0.07 | +0.01 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 12,085 | 22,006 | +9,921 | 0.29 | 0.43 | +0.14 | buy |
| Caption Management, LLC | 0 | 9,426 | +9,426 | 0.00 | 0.16 | +0.16 | buy |
| NEOS Investment Management LLC | 3,782 | 11,160 | +7,378 | 0.05 | 0.10 | +0.06 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 6,564 | +6,564 | 0.00 | 0.08 | +0.08 | buy |
| Engineers Gate Manager LP | 0 | 6,476 | +6,476 | 0.00 | 0.03 | +0.03 | buy |
| Boussard & Gavaudan Investment Management LLP | 0 | 6,000 | +6,000 | 0.00 | 1.00 | +1.00 | buy |
| AXS Investments LLC | 0 | 6,000 | +6,000 | 0.00 | 0.22 | +0.22 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 0 | 5,910 | +5,910 | 0.00 | 0.19 | +0.19 | buy |
| FIL Ltd | 5,998 | 10,727 | +4,729 | 0.00 | 0.00 | +0.00 | buy |
| FORA Capital, LLC | 0 | 4,649 | +4,649 | 0.00 | 0.06 | +0.06 | buy |
| TORNO CAPITAL, LLC | 0 | 4,500 | +4,500 | 0.00 | 0.15 | +0.15 | buy |
| China Universal Asset Management Co., Ltd. | 6,635 | 11,020 | +4,385 | 0.16 | 0.21 | +0.05 | buy |
| Aquatic Capital Management LLC | 0 | 4,300 | +4,300 | 0.00 | 0.02 | +0.02 | buy |
| BARCLAYS PLC | 17,325 | 21,072 | +3,747 | 0.00 | 0.00 | +0.00 | buy |
| SOROS FUND MANAGEMENT LLC | 0 | 3,432 | +3,432 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 31,252 | 34,352 | +3,100 | 0.00 | 0.00 | +0.00 | buy |
| CIBC Private Wealth Group LLC | 5,668 | 8,378 | +2,710 | 0.00 | 0.00 | +0.00 | buy |
| ADAR1 Capital Management, LLC | 45,884 | 48,584 | +2,700 | 2.58 | 2.01 | -0.58 | buy |
| BAROMETER CAPITAL MANAGEMENT INC. | 1,000 | 3,104 | +2,104 | 0.04 | 0.11 | +0.08 | buy |
| SG Americas Securities, LLC | 0 | 1,903 | +1,903 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 2,828 | 4,527 | +1,699 | 0.13 | 0.24 | +0.11 | buy |
| Mariner, LLC | 0 | 1,686 | +1,686 | 0.00 | 0.00 | +0.00 | buy |
| CM WEALTH ADVISORS LLC | 0 | 1,674 | +1,674 | 0.00 | 0.07 | +0.07 | buy |
| MOODY ALDRICH PARTNERS LLC | 0 | 1,523 | +1,523 | 0.00 | 0.04 | +0.04 | buy |
| HC Advisors, LLC | 0 | 1,479 | +1,479 | 0.00 | 0.11 | +0.11 | buy |
| PURSUE WEALTH PARTNERS LLC | 0 | 1,451 | +1,451 | 0.00 | 0.13 | +0.13 | buy |
| ALGERT GLOBAL LLC | 0 | 1,410 | +1,410 | 0.00 | 0.01 | +0.01 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 12,668 | 13,929 | +1,261 | 0.01 | 0.01 | +0.00 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 113,264 | 114,401 | +1,137 | 0.03 | 0.03 | +0.00 | buy |
| MACKENZIE FINANCIAL CORP | 4,455 | 5,527 | +1,072 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 55,090 | 56,102 | +1,012 | 0.00 | 0.00 | +0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 10,107,400 | 10,108,400 | +1,000 | 19.88 | 19.44 | -0.44 | buy |
| CITIGROUP INC | 19,024 | 19,976 | +952 | 0.00 | 0.00 | +0.00 | buy |
| Matisse Capital | 34,635 | 35,540 | +905 | 2.32 | 2.58 | +0.26 | buy |
| Handelsbanken Fonder AB | 11,367 | 12,267 | +900 | 0.01 | 0.01 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 6,152 | 7,034 | +882 | 0.04 | 0.06 | +0.01 | buy |
| Quarry LP | 0 | 700 | +700 | 0.00 | 0.04 | +0.04 | buy |
| CI INVESTMENTS INC. | 790 | 1,468 | +678 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 198 | 865 | +667 | 0.00 | 0.00 | +0.00 | buy |
| TOBAM | 1,533 | 2,163 | +630 | 0.02 | 0.03 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 10,465 | 11,061 | +596 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 12,581 | 13,160 | +579 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 3,787 | 4,314 | +527 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 2,716 | 3,172 | +456 | 0.22 | 0.25 | +0.04 | buy |
| ProShare Advisors LLC | 3,664 | 4,025 | +361 | 0.00 | 0.00 | +0.00 | buy |
| BESSEMER GROUP INC | 544 | 876 | +332 | 0.00 | 0.00 | +0.00 | buy |
| TD Waterhouse Canada Inc. | 0 | 164 | +164 | 0.00 | 0.00 | +0.00 | buy |
| Allianz Asset Management GmbH | 3,600 | 3,763 | +163 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 155 | +155 | 0.00 | 0.00 | +0.00 | buy |
| Clearstead Advisors, LLC | 915 | 1,055 | +140 | 0.01 | 0.01 | +0.00 | buy |
| GAMMA Investing LLC | 196 | 298 | +102 | 0.01 | 0.01 | +0.00 | buy |
| RHUMBLINE ADVISERS | 1,290 | 1,390 | +100 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 563 | 652 | +89 | 0.00 | 0.00 | +0.00 | buy |