| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MORGAN STANLEY | 825,761 | 1,903,531 | +1,077,770 | 0.01 | 0.02 | +0.01 | buy |
| T. Rowe Price Investment Management, Inc. | 2,725,546 | 3,053,824 | +328,278 | 0.23 | 0.31 | +0.08 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 327,405 | +327,405 | 0.00 | 0.09 | +0.09 | buy |
| Bank of New York Mellon Corp | 0 | 300,000 | +300,000 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 1,356,417 | 1,640,121 | +283,704 | 0.05 | 0.07 | +0.02 | buy |
| CITADEL ADVISORS LLC | 895,984 | 1,125,183 | +229,199 | 0.11 | 0.17 | +0.06 | buy |
| Polar Capital Holdings Plc | 300,000 | 525,000 | +225,000 | 0.23 | 0.50 | +0.27 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 10,112,744 | 10,281,496 | +168,752 | 18.53 | 26.76 | +8.23 | buy |
| PFM Health Sciences, LP | 52,392 | 186,916 | +134,524 | 0.55 | 2.23 | +1.69 | buy |
| Avoro Capital Advisors LLC | 5,103,055 | 5,218,000 | +114,945 | 9.94 | 12.69 | +2.76 | buy |
| BANK OF AMERICA CORP /DE/ | 26,383 | 137,892 | +111,509 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 77,427 | 185,122 | +107,695 | 0.00 | 0.00 | +0.00 | buy |
| BRAIDWELL LP | 0 | 106,713 | +106,713 | 0.00 | 0.58 | +0.58 | buy |
| JANUS HENDERSON GROUP PLC | 4,380,382 | 4,486,949 | +106,567 | 0.31 | 0.38 | +0.07 | buy |
| Integral Health Asset Management, LLC | 0 | 100,000 | +100,000 | 0.00 | 1.73 | +1.73 | buy |
| Qube Research & Technologies Ltd | 12,745 | 109,632 | +96,887 | 0.00 | 0.03 | +0.02 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 20,000 | 90,000 | +70,000 | 0.05 | 0.47 | +0.42 | buy |
| Point72 Asset Management, L.P. | 503,669 | 569,146 | +65,477 | 0.19 | 0.25 | +0.06 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 88,496 | 151,829 | +63,333 | 0.10 | 0.23 | +0.13 | buy |
| Ensign Peak Advisors, Inc | 2,223 | 61,724 | +59,501 | 0.00 | 0.02 | +0.02 | buy |
| Eagle Health Investments LP | 0 | 56,500 | +56,500 | 0.00 | 2.29 | +2.29 | buy |
| GOLDMAN SACHS GROUP INC | 530,417 | 585,581 | +55,164 | 0.01 | 0.02 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 407,294 | 462,171 | +54,877 | 0.03 | 0.04 | +0.01 | buy |
| Resolute Capital Asset Partners LLC | 114,500 | 167,500 | +53,000 | 8.48 | 14.69 | +6.21 | buy |
| GREAT POINT PARTNERS LLC | 0 | 50,000 | +50,000 | 0.00 | 4.24 | +4.24 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 298,996 | 346,018 | +47,022 | 0.15 | 0.20 | +0.05 | buy |
| LAZARD ASSET MANAGEMENT LLC | 0 | 43,123 | +43,123 | 0.00 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 100,023 | 142,624 | +42,601 | 0.01 | 0.02 | +0.01 | buy |
| Invesco Ltd. | 1,156,013 | 1,198,478 | +42,465 | 0.03 | 0.04 | +0.01 | buy |
| Allspring Global Investments Holdings, LLC | 152,738 | 189,613 | +36,875 | 0.03 | 0.05 | +0.02 | buy |
| Atika Capital Management LLC | 0 | 35,200 | +35,200 | 0.00 | 0.84 | +0.84 | buy |
| Tri Locum Partners LP | 0 | 32,325 | +32,325 | 0.00 | 2.58 | +2.58 | buy |
| Q Global Advisors, LLC | 219,459 | 248,887 | +29,428 | 31.14 | 31.55 | +0.41 | buy |
| Aquatic Capital Management LLC | 1,674 | 30,510 | +28,836 | 0.01 | 0.12 | +0.11 | buy |
| First Turn Management, LLC | 87,804 | 113,278 | +25,474 | 2.17 | 3.56 | +1.39 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 51,491 | 75,751 | +24,260 | 1.59 | 2.47 | +0.88 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 21,299 | +21,299 | 0.00 | 0.03 | +0.03 | buy |
| Russell Investments Group, Ltd. | 3,208 | 23,740 | +20,532 | 0.00 | 0.01 | +0.00 | buy |
| SECTOR GAMMA AS | 0 | 17,000 | +17,000 | 0.00 | 0.85 | +0.85 | buy |
| Trexquant Investment LP | 27,067 | 43,760 | +16,693 | 0.04 | 0.08 | +0.04 | buy |
| Walleye Capital LLC | 0 | 15,837 | +15,837 | 0.00 | 0.03 | +0.03 | buy |
| STEMPOINT CAPITAL LP | 0 | 14,732 | +14,732 | 0.00 | 0.73 | +0.73 | buy |
| HighTower Advisors, LLC | 3,514 | 18,032 | +14,518 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 316,580 | 330,153 | +13,573 | 0.11 | 0.14 | +0.03 | buy |
| JANE STREET GROUP, LLC | 35,330 | 48,299 | +12,969 | 0.01 | 0.01 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 92,728 | 104,917 | +12,189 | 0.01 | 0.02 | +0.00 | buy |
| Point72 Europe (London) LLP | 0 | 12,053 | +12,053 | 0.00 | 0.13 | +0.13 | buy |
| Capital International Investors | 2,863,249 | 2,874,792 | +11,543 | 0.07 | 0.09 | +0.01 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 1,867,551 | 1,877,917 | +10,366 | 0.08 | 0.10 | +0.02 | buy |
| Neuberger Berman Group LLC | 38,129 | 46,330 | +8,201 | 0.00 | 0.01 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 10,915 | 18,761 | +7,846 | 0.00 | 0.01 | +0.00 | buy |
| Cinctive Capital Management LP | 0 | 7,640 | +7,640 | 0.00 | 0.09 | +0.09 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 0 | 7,376 | +7,376 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 6,035 | 13,036 | +7,001 | 0.06 | 0.16 | +0.09 | buy |
| Quantessence Capital LLC | 0 | 6,788 | +6,788 | 0.00 | 0.26 | +0.26 | buy |
| DIVERSIFY WEALTH MANAGEMENT, LLC | 0 | 5,994 | +5,994 | 0.00 | 0.07 | +0.07 | buy |
| WELLS FARGO & COMPANY/MN | 18,648 | 24,081 | +5,433 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 0 | 5,344 | +5,344 | 0.00 | 0.00 | +0.00 | buy |
| TOTH FINANCIAL ADVISORY CORP | 0 | 5,335 | +5,335 | 0.00 | 0.10 | +0.10 | buy |
| Engineers Gate Manager LP | 6,733 | 11,785 | +5,052 | 0.02 | 0.03 | +0.01 | buy |
| WEXFORD CAPITAL LP | 0 | 5,000 | +5,000 | 0.00 | 0.20 | +0.20 | buy |
| HSBC HOLDINGS PLC | 0 | 4,378 | +4,378 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Trading LLC | 0 | 3,935 | +3,935 | 0.00 | 0.02 | +0.02 | buy |
| SIH Partners, LLLP | 0 | 3,807 | +3,807 | 0.00 | 0.05 | +0.05 | buy |
| XTX Topco Ltd | 0 | 3,746 | +3,746 | 0.00 | 0.03 | +0.03 | buy |
| TD ASSET MANAGEMENT INC | 339,652 | 343,390 | +3,738 | 0.04 | 0.05 | +0.01 | buy |
| Virtus Investment Advisers, LLC | 0 | 2,747 | +2,747 | 0.00 | 0.12 | +0.12 | buy |
| Penserra Capital Management LLC | 0 | 2,695 | +2,695 | 0.00 | 0.01 | +0.01 | buy |
| Quarry LP | 700 | 3,300 | +2,600 | 0.02 | 0.13 | +0.11 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 0 | 2,550 | +2,550 | 0.00 | 0.01 | +0.01 | buy |
| ALGERT GLOBAL LLC | 0 | 2,549 | +2,549 | 0.00 | 0.01 | +0.01 | buy |
| Gilbert & Cook, Inc. | 4,421 | 6,619 | +2,198 | 0.09 | 0.15 | +0.06 | buy |
| Springhill Fund Asset Management (HK) Co Ltd | 0 | 2,173 | +2,173 | 0.00 | 1.62 | +1.62 | buy |
| ALTFEST L J & CO INC | 0 | 2,111 | +2,111 | 0.00 | 0.04 | +0.04 | buy |
| Diversify Advisory Services, LLC | 0 | 1,991 | +1,991 | 0.00 | 0.02 | +0.02 | buy |
| CERTUITY, LLC | 0 | 1,907 | +1,907 | 0.00 | 0.03 | +0.03 | buy |
| Vident Advisory, LLC | 0 | 1,750 | +1,750 | 0.00 | 0.00 | +0.00 | buy |
| Bridgefront Capital, LLC | 0 | 1,714 | +1,714 | 0.00 | 0.08 | +0.08 | buy |
| NORTHERN TRUST CORP | 0 | 1,592 | +1,592 | 0.00 | 0.00 | +0.00 | buy |
| Capital International Sarl | 23,806 | 25,382 | +1,576 | 0.08 | 0.09 | +0.01 | buy |
| Sigma Planning Corp | 0 | 1,515 | +1,515 | 0.00 | 0.01 | +0.01 | buy |
| Diversified Trust Co | 45,038 | 46,548 | +1,510 | 0.15 | 0.18 | +0.03 | buy |
| PURSUE WEALTH PARTNERS LLC | 0 | 1,451 | +1,451 | 0.00 | 0.14 | +0.14 | buy |
| NEW WAVE WEALTH ADVISORS LLC | 0 | 1,426 | +1,426 | 0.00 | 0.10 | +0.10 | buy |
| DnB Asset Management AS | 3,586 | 4,987 | +1,401 | 0.00 | 0.00 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 1,400 | +1,400 | 0.00 | 0.00 | +0.00 | buy |
| DEARBORN PARTNERS LLC | 0 | 1,300 | +1,300 | 0.00 | 0.01 | +0.01 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 10,577 | 11,851 | +1,274 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 84,873 | 85,960 | +1,087 | 0.51 | 0.61 | +0.10 | buy |
| CAPITAL INTERNATIONAL LTD /CA/ | 19,153 | 20,201 | +1,048 | 0.11 | 0.14 | +0.03 | buy |
| BAROMETER CAPITAL MANAGEMENT INC. | 0 | 1,004 | +1,004 | 0.00 | 0.06 | +0.06 | buy |
| Advisors Asset Management, Inc. | 8,241 | 9,190 | +949 | 0.02 | 0.03 | +0.01 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 20,506 | 21,302 | +796 | 0.01 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 57,077 | 57,851 | +774 | 0.00 | 0.00 | +0.00 | buy |
| Capital International, Inc./CA/ | 8,375 | 8,950 | +575 | 0.01 | 0.02 | +0.00 | buy |
| ARISTEIA CAPITAL, L.L.C. | 10,800 | 11,300 | +500 | 0.05 | 0.05 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 1,600 | 2,091 | +491 | 0.15 | 0.25 | +0.11 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 22,976 | 23,340 | +364 | 3.18 | 4.22 | +1.04 | buy |
| Saturn V Capital Management LP | 198,977 | 199,264 | +287 | 10.73 | 15.67 | +4.95 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,266 | 1,544 | +278 | 0.00 | 0.01 | +0.00 | buy |