| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 2,725,546 | 3,053,824 | +328,278 | 0.23 | 0.31 | +0.08 | buy |
| CITADEL ADVISORS LLC | 895,984 | 1,125,183 | +229,199 | 0.17 | 0.24 | +0.08 | buy |
| Polar Capital Holdings Plc | 300,000 | 525,000 | +225,000 | 0.23 | 0.50 | +0.27 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 10,112,744 | 10,281,496 | +168,752 | 18.53 | 26.76 | +8.23 | buy |
| PFM Health Sciences, LP | 52,392 | 186,916 | +134,524 | 0.45 | 2.12 | +1.67 | buy |
| Avoro Capital Advisors LLC | 5,103,055 | 5,218,000 | +114,945 | 9.94 | 12.69 | +2.76 | buy |
| JANUS HENDERSON GROUP PLC | 4,380,382 | 4,486,949 | +106,567 | 0.31 | 0.38 | 0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 358,144 | 264,867 | +93,277 | 0.05 | 0.05 | 0.00 | sell |
| MOORE CAPITAL MANAGEMENT, LP | 20,000 | 90,000 | +70,000 | 0.03 | 0.29 | +0.26 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 88,496 | 151,829 | +63,333 | 0.10 | 0.23 | +0.13 | buy |
| AMERICAN CENTURY COMPANIES INC | 407,294 | 462,171 | +54,877 | 0.03 | 0.05 | +0.01 | buy |
| Resolute Capital Asset Partners LLC | 114,500 | 167,500 | +53,000 | 8.48 | 14.69 | +6.21 | buy |
| Allspring Global Investments Holdings, LLC | 152,738 | 189,613 | +36,875 | 0.03 | 0.05 | 0.00 | buy |
| First Turn Management, LLC | 87,804 | 113,278 | +25,474 | 2.17 | 3.56 | +1.39 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 51,491 | 75,751 | +24,260 | 1.59 | 2.47 | +0.88 | buy |
| BNP Paribas Asset Management Holding S.A. | 316,580 | 330,153 | +13,573 | 0.11 | 0.14 | +0.03 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 92,728 | 104,917 | +12,189 | 0.01 | 0.02 | +0.00 | buy |
| Capital International Investors | 2,863,249 | 2,874,792 | +11,543 | 0.07 | 0.09 | +0.01 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 1,867,551 | 1,877,917 | +10,366 | 0.08 | 0.10 | +0.02 | buy |
| Campbell & CO Investment Adviser LLC | 6,035 | 13,036 | +7,001 | 0.06 | 0.16 | +0.09 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 131,353 | 124,926 | +6,427 | 0.02 | 0.02 | +0.00 | sell |
| TD ASSET MANAGEMENT INC | 339,652 | 343,390 | +3,738 | 0.04 | 0.05 | +0.01 | buy |
| Quarry LP | 700 | 3,300 | +2,600 | 0.02 | 0.13 | 0.00 | buy |
| Gilbert & Cook, Inc. | 4,421 | 6,619 | +2,198 | 0.09 | 0.15 | +0.06 | buy |
| Capital International Sarl | 23,806 | 25,382 | +1,576 | 0.08 | 0.09 | +0.01 | buy |
| Diversified Trust Co | 45,038 | 46,548 | +1,510 | 0.15 | 0.18 | +0.03 | buy |
| DnB Asset Management AS | 3,586 | 4,987 | +1,401 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 84,873 | 85,960 | +1,087 | 0.51 | 0.61 | 0.00 | buy |
| CAPITAL INTERNATIONAL LTD /CA/ | 19,153 | 20,201 | +1,048 | 0.11 | 0.14 | +0.03 | buy |
| Advisors Asset Management, Inc. | 8,241 | 9,190 | +949 | 0.02 | 0.03 | 0.00 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 20,506 | 21,302 | +796 | 0.01 | 0.01 | +0.00 | buy |
| Capital International, Inc./CA/ | 8,375 | 8,950 | +575 | 0.01 | 0.02 | +0.00 | buy |
| ARISTEIA CAPITAL, L.L.C. | 10,800 | 11,300 | +500 | 0.05 | 0.04 | -0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 1,600 | 2,091 | +491 | 0.15 | 0.25 | +0.11 | buy |
| CI INVESTMENTS INC. | 1,105 | 655 | +450 | 0.00 | 0.00 | 0.00 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 22,976 | 23,340 | +364 | 3.18 | 4.22 | +1.04 | buy |
| Saturn V Capital Management LP | 198,977 | 199,264 | +287 | 10.73 | 15.67 | +4.95 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,266 | 1,544 | +278 | 0.00 | 0.01 | +0.00 | buy |
| Capital Group Investment Management Pte. Ltd. | 3,609 | 3,882 | +273 | 0.09 | 0.12 | +0.03 | buy |
| GUGGENHEIM CAPITAL LLC | 7,249 | 7,054 | +195 | 0.01 | 0.01 | 0.00 | sell |
| Main Management ETF Advisors, LLC | 5,696 | 5,768 | +72 | 0.04 | 0.04 | +0.01 | buy |
| J.Safra Asset Management Corp | 141 | 166 | +25 | 0.00 | 0.00 | +0.00 | buy |
| Washington Trust Advisors, Inc. | 38 | 52 | +14 | 0.00 | 0.00 | +0.00 | buy |
| BELLEVUE ASSET MANAGEMENT, LLC | 15 | 19 | +4 | 0.00 | 0.00 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 2,000,000 | 1,999,999 | -1 | 0.01 | 0.01 | +0.00 | sell |
| ARS Investment Partners, LLC | 265,480 | 265,164 | -316 | 3.29 | 3.30 | +0.01 | sell |
| Bellevue Group AG | 2,500 | 1,900 | -600 | 0.01 | 0.01 | +0.00 | sell |
| China Universal Asset Management Co., Ltd. | 12,789 | 12,113 | -676 | 0.16 | 0.18 | +0.01 | sell |
| Matisse Capital | 30,496 | 29,674 | -822 | 2.13 | 2.44 | +0.30 | sell |
| AIGEN INVESTMENT MANAGEMENT, LP | 2,332 | 1,463 | -869 | 0.06 | 0.04 | -0.02 | sell |
| Chicago Partners Investment Group LLC | 5,225 | 3,571 | -1,654 | 0.02 | 0.02 | -0.00 | sell |
| New Age Alpha Advisors, LLC | 3,680 | 1,721 | -1,959 | 0.02 | 0.01 | -0.01 | sell |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 4,635 | 2,524 | -2,111 | 0.00 | 0.00 | -0.00 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 163,888 | 160,796 | -3,092 | 1.24 | 1.47 | +0.23 | sell |
| LOOMIS SAYLES & CO L P | 178,899 | 174,913 | -3,986 | 0.03 | 0.04 | +0.01 | sell |
| Finepoint Capital LP | 184,872 | 179,872 | -5,000 | 1.55 | 2.14 | +0.58 | sell |
| Persistent Asset Partners Ltd | 8,940 | 1,906 | -7,034 | 1.00 | 0.26 | -0.74 | sell |
| Evolutionary Tree Capital Management, LLC | 30,115 | 20,656 | -9,459 | 4.22 | 3.74 | -0.48 | sell |
| Siren, L.L.C. | 297,321 | 287,366 | -9,955 | 1.81 | 2.53 | +0.72 | sell |
| Woodline Partners LP | 317,642 | 304,806 | -12,836 | 0.30 | 0.31 | +0.01 | sell |
| NEOS Investment Management LLC | 19,040 | 6,106 | -12,934 | 0.06 | 0.02 | -0.04 | sell |
| TEMA ETFS LLC | 19,040 | 6,106 | -12,934 | 1.09 | 0.28 | -0.80 | sell |
| Aberdeen Group plc | 187,180 | 171,731 | -15,449 | 0.05 | 0.05 | +0.00 | sell |
| DIADEMA PARTNERS LP | 25,276 | 8,321 | -16,955 | 3.92 | 1.04 | -2.88 | sell |
| Catalio Capital Management, LP | 215,587 | 195,523 | -20,064 | 6.49 | 7.56 | +1.06 | sell |
| AMERIPRISE FINANCIAL INC | 702,561 | 679,943 | -22,618 | 0.03 | 0.03 | +0.00 | sell |
| DAFNA Capital Management LLC | 103,355 | 80,398 | -22,957 | 3.62 | 3.55 | -0.06 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,283,207 | 2,256,102 | -27,105 | 0.04 | 0.04 | +0.01 | sell |
| Candriam S.C.A. | 280,154 | 242,761 | -37,393 | 0.22 | 0.24 | +0.01 | sell |
| FRED ALGER MANAGEMENT, LLC | 111,854 | 64,806 | -47,048 | 0.07 | 0.06 | -0.02 | sell |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 5,528,239 | 5,479,259 | -48,980 | 3.31 | 4.16 | +0.84 | sell |
| Zimmer Partners, LP | 96,900 | 36,100 | -60,800 | 0.23 | 0.11 | -0.12 | sell |
| ADAR1 Capital Management, LLC | 71,402 | 1,402 | -70,000 | 2.03 | 0.04 | -1.98 | sell |
| Soleus Capital Management, L.P. | 144,000 | 56,300 | -87,700 | 1.50 | 0.69 | -0.81 | sell |
| Rock Springs Capital Management LP | 305,000 | 216,000 | -89,000 | 1.60 | 1.93 | +0.33 | sell |
| Duquesne Family Office LLC | 265,040 | 158,720 | -106,320 | 0.98 | 0.81 | -0.17 | sell |
| Alyeska Investment Group, L.P. | 155,000 | 42,416 | -112,584 | 0.08 | 0.03 | -0.05 | sell |
| Artisan Partners Limited Partnership | 4,450,420 | 4,256,627 | -193,793 | 0.92 | 1.07 | +0.15 | sell |
| FIL Ltd | 729,275 | 462,366 | -266,909 | 0.09 | 0.07 | -0.03 | sell |
| Vestal Point Capital, LP | 520,000 | 150,142 | -369,858 | 4.24 | 1.67 | -2.57 | sell |
| Camber Capital Management LP | 800,000 | 350,000 | -450,000 | 2.55 | 1.94 | -0.61 | sell |