| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SSI INVESTMENT MANAGEMENT LLC | 0 | 10,834,000 | +10,834,000 | 1.04 | 1.10 | +0.05 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 10,281,496 | 10,281,496 | 0 | 22.46 | 24.92 | +2.46 | hold |
| T. Rowe Price Investment Management, Inc. | 0 | 6,162,042 | +6,162,042 | 0.00 | 0.97 | +0.97 | buy |
| Avoro Capital Advisors LLC | 5,111,111 | 5,062,500 | -48,611 | 10.71 | 11.41 | +0.69 | sell |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 5,185,696 | 4,813,440 | -372,256 | 4.61 | 4.62 | +0.01 | sell |
| FMR LLC | 4,153,311 | 3,876,601 | -276,710 | 0.05 | 0.05 | +0.00 | sell |
| Polar Capital Holdings Plc | 5,000,000 | 3,500,000 | -1,500,000 | 0.03 | 0.02 | -0.01 | sell |
| Artisan Partners Limited Partnership | 3,225,885 | 3,230,188 | +4,303 | 1.05 | 1.21 | +0.15 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 3,000,000 | +3,000,000 | 0.00 | 0.01 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 3,000,000 | 3,000,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| FRANKLIN RESOURCES INC | 1,910,079 | 2,051,948 | +141,869 | 0.10 | 0.11 | +0.01 | buy |
| BNP Paribas Asset Management Holding S.A. | 2,000,000 | 2,000,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Capital International Investors | 3,063,943 | 1,958,843 | -1,105,100 | 0.10 | 0.11 | +0.00 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 1,886,393 | 1,860,669 | -25,724 | 0.13 | 0.14 | +0.01 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 1,762,721 | 1,757,633 | -5,088 | 0.07 | 0.08 | +0.01 | sell |
| PERCEPTIVE ADVISORS LLC | 1,081,421 | 1,531,421 | +450,000 | 4.22 | 6.92 | +2.69 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 0 | 1,530,345 | +1,530,345 | 0.00 | 0.04 | +0.04 | buy |
| AMERICAN CENTURY COMPANIES INC | 1,443,141 | 1,397,119 | -46,022 | 0.15 | 0.16 | +0.01 | sell |
| Capital World Investors | 0 | 900,517 | +900,517 | 0.00 | 0.03 | +0.03 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 1,026,407 | 896,397 | -130,010 | 0.11 | 0.11 | -0.00 | sell |
| BlackRock, Inc. | 628,200 | 661,054 | +32,854 | 0.00 | 0.00 | +0.00 | buy |
| Polar Capital Holdings Plc | 370,473 | 651,712 | +281,239 | 0.36 | 0.65 | +0.29 | buy |
| MORGAN STANLEY | 617,968 | 606,348 | -11,620 | 0.01 | 0.01 | +0.00 | sell |
| GOLDMAN SACHS GROUP INC | 596,703 | 566,192 | -30,511 | 0.02 | 0.02 | -0.00 | sell |
| JPMORGAN CHASE & CO | 507,240 | 539,434 | +32,194 | 0.01 | 0.01 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 550,477 | 476,466 | -74,011 | 0.03 | 0.03 | -0.00 | sell |
| FIL Ltd | 478,641 | 447,421 | -31,220 | 0.08 | 0.08 | +0.00 | sell |
| Vestal Point Capital, LP | 175,000 | 375,000 | +200,000 | 1.37 | 2.40 | +1.03 | buy |
| Spyglass Capital Management LLC | 415,549 | 367,972 | -47,577 | 4.43 | 5.96 | +1.52 | sell |
| Invesco Ltd. | 586,094 | 362,109 | -223,985 | 0.02 | 0.01 | -0.00 | sell |
| SEI INVESTMENTS CO | 281,473 | 351,146 | +69,673 | 0.06 | 0.07 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 307,086 | 309,173 | +2,087 | 0.04 | 0.05 | +0.01 | buy |
| FRED ALGER MANAGEMENT, LLC | 352,109 | 304,896 | -47,213 | 0.29 | 0.31 | +0.01 | sell |
| ALLIANCEBERNSTEIN L.P. | 288,592 | 278,203 | -10,389 | 0.02 | 0.02 | -0.00 | sell |
| Tri Locum Partners LP | 265,015 | 255,332 | -9,683 | 7.34 | 8.20 | +0.86 | sell |
| Pictet Asset Management Holding SA | 73,418 | 251,833 | +178,415 | 0.02 | 0.06 | +0.05 | buy |
| Candriam S.C.A. | 186,940 | 230,278 | +43,338 | 0.20 | 0.27 | +0.07 | buy |
| Bank of New York Mellon Corp | 194,605 | 228,675 | +34,070 | 0.01 | 0.01 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 247,892 | 220,341 | -27,551 | 0.08 | 0.04 | -0.04 | sell |
| TD ASSET MANAGEMENT INC | 234,012 | 217,992 | -16,020 | 0.04 | 0.04 | +0.00 | sell |
| Aberdeen Group plc | 221,677 | 210,154 | -11,523 | 0.07 | 0.08 | +0.00 | sell |
| ARS Investment Partners, LLC | 174,611 | 209,456 | +34,845 | 2.18 | 2.49 | +0.31 | buy |
| UBS Group AG | 308,190 | 207,339 | -100,851 | 0.01 | 0.01 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 162,503 | 198,505 | +36,002 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 203,500 | 194,000 | -9,500 | 2.23 | 2.62 | +0.39 | sell |
| MILLENNIUM MANAGEMENT LLC | 262,329 | 189,027 | -73,302 | 0.04 | 0.03 | -0.01 | sell |
| Allspring Global Investments Holdings, LLC | 187,642 | 184,224 | -3,418 | 0.06 | 0.07 | +0.01 | sell |
| ORBIMED ADVISORS LLC | 171,977 | 181,977 | +10,000 | 0.75 | 0.91 | +0.16 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 182,234 | 171,112 | -11,122 | 0.05 | 0.05 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 33,780 | 154,199 | +120,419 | 0.00 | 0.01 | +0.01 | buy |
| PFM Health Sciences, LP | 177,685 | 152,034 | -25,651 | 3.84 | 3.66 | -0.18 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 145,046 | 148,386 | +3,340 | 1.70 | 1.89 | +0.19 | buy |
| LORD, ABBETT & CO. LLC | 120,197 | 145,317 | +25,120 | 0.08 | 0.11 | +0.03 | buy |
| DEUTSCHE BANK AG\ | 296,818 | 135,187 | -161,631 | 0.02 | 0.01 | -0.01 | sell |
| Frazier Life Sciences Management, L.P. | 133,333 | 133,333 | 0 | 0.76 | 0.78 | +0.02 | hold |
| BRAUN STACEY ASSOCIATES INC | 119,095 | 130,992 | +11,897 | 0.82 | 1.00 | +0.17 | buy |
| Catalio Capital Management, LP | 119,265 | 129,111 | +9,846 | 4.49 | 6.17 | +1.67 | buy |
| ODDO BHF ASSET MANAGEMENT SAS | 129,941 | 128,657 | -1,284 | 1.04 | 1.16 | +0.12 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 0 | 127,562 | +127,562 | 0.00 | 0.21 | +0.21 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 49,228 | 124,658 | +75,430 | 1.52 | 3.36 | +1.84 | buy |
| Chevy Chase Trust Holdings, LLC | 56,695 | 123,467 | +66,772 | 0.03 | 0.08 | +0.05 | buy |
| SG Americas Securities, LLC | 11,213 | 120,790 | +109,577 | 0.00 | 0.03 | +0.03 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 117,332 | +117,332 | 0.00 | 0.04 | +0.04 | buy |
| Integral Health Asset Management, LLC | 90,000 | 115,000 | +25,000 | 0.97 | 1.39 | +0.42 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 216,173 | 114,275 | -101,898 | 0.16 | 0.10 | -0.06 | sell |
| Woodline Partners LP | 102,461 | 102,469 | +8 | 0.08 | 0.09 | +0.00 | buy |
| Perpetual Ltd | 0 | 100,638 | +100,638 | 0.00 | 0.35 | +0.35 | buy |
| Q Global Advisors, LLC | 0 | 100,000 | +100,000 | 0.00 | 21.99 | +21.99 | buy |
| Troluce Capital Advisors LLC | 0 | 99,600 | +99,600 | 0.00 | 2.41 | +2.41 | buy |
| Resolute Capital Asset Partners LLC | 88,627 | 98,627 | +10,000 | 9.13 | 11.87 | +2.74 | buy |
| Cormorant Asset Management, LP | 100,000 | 95,000 | -5,000 | 1.21 | 1.10 | -0.11 | sell |
| Affinity Asset Advisors, LLC | 30,000 | 95,000 | +65,000 | 0.46 | 1.27 | +0.81 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 91,470 | +91,470 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 67,949 | 87,334 | +19,385 | 0.00 | 0.00 | +0.00 | buy |
| Eagle Health Investments LP | 0 | 86,650 | +86,650 | 0.00 | 4.16 | +4.16 | buy |
| LOOMIS SAYLES & CO L P | 112,240 | 80,405 | -31,835 | 0.03 | 0.02 | -0.00 | sell |
| NATIONAL BANK OF CANADA /FI/ | 0 | 80,017 | +80,017 | 0.00 | 0.02 | +0.02 | buy |
| First Turn Management, LLC | 131,808 | 76,300 | -55,508 | 3.21 | 1.95 | -1.26 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 68,855 | 72,941 | +4,086 | 0.00 | 0.00 | +0.00 | buy |
| Synergy Asset Management, LLC | 0 | 70,456 | +70,456 | 0.00 | 1.71 | +1.71 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 73,310 | 67,902 | -5,408 | 0.01 | 0.01 | +0.00 | sell |
| Voleon Capital Management LP | 69,389 | 67,839 | -1,550 | 0.32 | 0.33 | +0.02 | sell |
| CASTLEARK MANAGEMENT LLC | 66,336 | 67,616 | +1,280 | 0.42 | 0.51 | +0.10 | buy |
| Trexquant Investment LP | 59,025 | 65,517 | +6,492 | 0.11 | 0.11 | -0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 60,895 | 58,859 | -2,036 | 0.01 | 0.01 | +0.00 | sell |
| Qube Research & Technologies Ltd | 193,464 | 52,753 | -140,711 | 0.06 | 0.02 | -0.04 | sell |
| Empowered Funds, LLC | 36,697 | 51,135 | +14,438 | 0.06 | 0.07 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 57,075 | 45,590 | -11,485 | 0.01 | 0.01 | -0.00 | sell |
| NORTHERN TRUST CORP | 32,854 | 44,971 | +12,117 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 43,701 | 43,484 | -217 | 0.02 | 0.03 | +0.00 | sell |
| Russell Investments Group, Ltd. | 69 | 40,178 | +40,109 | 0.00 | 0.01 | +0.01 | buy |
| Diversified Trust Co | 42,251 | 37,161 | -5,090 | 0.17 | 0.16 | -0.01 | sell |
| BARCLAYS PLC | 11,244 | 35,453 | +24,209 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 12,230 | 31,135 | +18,905 | 0.00 | 0.01 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 43,190 | 30,770 | -12,420 | 0.01 | 0.00 | -0.00 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 71,516 | 30,663 | -40,853 | 0.01 | 0.00 | -0.01 | sell |
| CITIGROUP INC | 30,843 | 29,701 | -1,142 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 470,951 | 28,062 | -442,889 | 0.14 | 0.01 | -0.13 | sell |
| Nicholas Investment Partners, LP | 6,265 | 26,867 | +20,602 | 0.10 | 0.44 | +0.35 | buy |
| Brevan Howard Capital Management LP | 48,260 | 26,200 | -22,060 | 0.19 | 0.06 | -0.13 | sell |