| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| WESTFIELD CAPITAL MANAGEMENT CO LP | 4,075,214 | 4,962,824 | +887,610 | 3.23 | 3.33 | +0.09 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 209,512 | 820,512 | +611,000 | 0.06 | 0.21 | +0.15 | buy |
| AMERIPRISE FINANCIAL INC | 55,166 | 660,662 | +605,496 | 0.00 | 0.02 | +0.02 | buy |
| FIL Ltd | 10,727 | 442,508 | +431,781 | 0.00 | 0.06 | +0.06 | buy |
| Avoro Capital Advisors LLC | 3,966,666 | 4,196,661 | +229,995 | 6.99 | 7.62 | +0.63 | buy |
| Vestal Point Capital, LP | 525,000 | 750,000 | +225,000 | 6.56 | 7.63 | +1.06 | buy |
| Paradigm Biocapital Advisors LP | 507,952 | 664,307 | +156,355 | 2.70 | 3.47 | +0.76 | buy |
| JANUS HENDERSON GROUP PLC | 3,767,203 | 3,918,813 | +151,610 | 0.31 | 0.29 | -0.02 | buy |
| Invesco Ltd. | 964,663 | 1,106,449 | +141,786 | 0.03 | 0.03 | +0.00 | buy |
| LOOMIS SAYLES & CO L P | 0 | 121,594 | +121,594 | 0.00 | 0.02 | +0.02 | buy |
| FRED ALGER MANAGEMENT, LLC | 186,121 | 307,073 | +120,952 | 0.14 | 0.20 | +0.06 | buy |
| Tri Locum Partners LP | 112,670 | 227,762 | +115,092 | 5.91 | 7.85 | +1.95 | buy |
| MILLENNIUM MANAGEMENT LLC | 362,060 | 473,449 | +111,389 | 0.05 | 0.05 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 1,981,869 | 2,084,851 | +102,982 | 0.09 | 0.09 | -0.01 | buy |
| Artal Group S.A. | 0 | 101,100 | +101,100 | 0.00 | 0.35 | +0.35 | buy |
| SOROS FUND MANAGEMENT LLC | 3,432 | 100,000 | +96,568 | 0.01 | 0.31 | +0.29 | buy |
| Candriam S.C.A. | 99,375 | 195,347 | +95,972 | 0.10 | 0.16 | +0.07 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 1,617,830 | 1,711,015 | +93,185 | 0.07 | 0.07 | -0.00 | buy |
| CITADEL ADVISORS LLC | 457,504 | 537,762 | +80,258 | 0.07 | 0.07 | +0.01 | buy |
| BNP Paribas Asset Management Holding S.A. | 86,202 | 163,110 | +76,908 | 0.03 | 0.06 | +0.02 | buy |
| Alyeska Investment Group, L.P. | 0 | 60,000 | +60,000 | 0.00 | 0.05 | +0.05 | buy |
| Qube Research & Technologies Ltd | 0 | 54,748 | +54,748 | 0.00 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 75,540 | 128,074 | +52,534 | 0.01 | 0.02 | +0.00 | buy |
| Spyglass Capital Management LLC | 614,107 | 662,888 | +48,781 | 6.18 | 6.62 | +0.43 | buy |
| TWO SIGMA INVESTMENTS, LP | 210,325 | 255,320 | +44,995 | 0.08 | 0.08 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 44,918 | +44,918 | 0.00 | 0.01 | +0.01 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 307,499 | 346,218 | +38,719 | 0.17 | 0.18 | +0.01 | buy |
| TWO SIGMA ADVISERS, LP | 163,400 | 202,000 | +38,600 | 0.06 | 0.06 | +0.00 | buy |
| First Light Asset Management, LLC | 0 | 36,157 | +36,157 | 0.00 | 0.43 | +0.43 | buy |
| First Turn Management, LLC | 151,587 | 186,581 | +34,994 | 3.43 | 4.14 | +0.71 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 33,375 | +33,375 | 0.00 | 0.05 | +0.05 | buy |
| Neuberger Berman Group LLC | 0 | 30,296 | +30,296 | 0.00 | 0.00 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 22,006 | 52,200 | +30,194 | 0.43 | 0.54 | +0.11 | buy |
| Altium Capital Management LLC | 25,000 | 50,000 | +25,000 | 1.69 | 2.82 | +1.13 | buy |
| JPMORGAN CHASE & CO | 14,231 | 37,220 | +22,989 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 138,791 | 160,602 | +21,811 | 0.04 | 0.04 | +0.00 | buy |
| TimesSquare Capital Management, LLC | 575,698 | 596,314 | +20,616 | 1.27 | 1.28 | +0.01 | buy |
| Lighthouse Investment Partners, LLC | 0 | 20,250 | +20,250 | 0.00 | 0.15 | +0.15 | buy |
| Exome Asset Management LLC | 0 | 20,000 | +20,000 | 0.00 | 2.43 | +2.43 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 17,260 | +17,260 | 0.00 | 0.20 | +0.20 | buy |
| MORGAN STANLEY | 152,052 | 166,969 | +14,917 | 0.00 | 0.00 | -0.00 | buy |
| LOOMIS SAYLES & CO L P | 0 | 14,909 | +14,909 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 14,231 | 28,042 | +13,811 | 0.00 | 0.00 | +0.00 | buy |
| Finepoint Capital LP | 175,672 | 189,272 | +13,600 | 6.81 | 7.33 | +0.52 | buy |
| SIT INVESTMENT ASSOCIATES INC | 0 | 12,880 | +12,880 | 0.00 | 0.04 | +0.04 | buy |
| Evolutionary Tree Capital Management, LLC | 13,639 | 24,862 | +11,223 | 2.08 | 3.49 | +1.41 | buy |
| CenterBook Partners LP | 0 | 10,905 | +10,905 | 0.00 | 0.09 | +0.09 | buy |
| LMR Partners LLP | 0 | 10,000 | +10,000 | 0.00 | 0.03 | +0.03 | buy |
| Saturn V Capital Management LP | 103,428 | 113,224 | +9,796 | 6.27 | 5.83 | -0.43 | buy |
| Simplify Asset Management Inc. | 0 | 8,877 | +8,877 | 0.00 | 0.11 | +0.11 | buy |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 225,111 | 233,673 | +8,562 | 1.63 | 1.47 | -0.16 | buy |
| Bayesian Capital Management, LP | 0 | 8,013 | +8,013 | 0.00 | 0.13 | +0.13 | buy |
| Headlands Technologies LLC | 0 | 6,338 | +6,338 | 0.00 | 0.09 | +0.09 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 4,314 | 10,647 | +6,333 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 6,313 | +6,313 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 513 | 6,488 | +5,975 | 0.00 | 0.01 | +0.01 | buy |
| CITIGROUP INC | 19,976 | 25,281 | +5,305 | 0.00 | 0.00 | +0.00 | buy |
| Nicholas Investment Partners, LP | 17,984 | 23,216 | +5,232 | 0.28 | 0.33 | +0.05 | buy |
| MARSHALL WACE, LLP | 25,084 | 30,289 | +5,205 | 0.01 | 0.01 | -0.00 | buy |
| FIRST TRUST ADVISORS LP | 0 | 4,932 | +4,932 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 4,730 | +4,730 | 0.00 | 0.05 | +0.05 | buy |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 0 | 4,635 | +4,635 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 4,221 | +4,221 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 1,903 | 6,108 | +4,205 | 0.00 | 0.01 | +0.00 | buy |
| Advisors Asset Management, Inc. | 0 | 3,848 | +3,848 | 0.00 | 0.01 | +0.01 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 3,613 | +3,613 | 0.00 | 0.09 | +0.09 | buy |
| Trexquant Investment LP | 20,289 | 23,697 | +3,408 | 0.06 | 0.05 | -0.01 | buy |
| DnB Asset Management AS | 0 | 3,347 | +3,347 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 196,079 | 199,401 | +3,322 | 0.04 | 0.04 | -0.00 | buy |
| HighTower Advisors, LLC | 0 | 2,833 | +2,833 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 196,030 | 198,766 | +2,736 | 0.27 | 0.26 | -0.01 | buy |
| ADAR1 Capital Management, LLC | 48,584 | 51,263 | +2,679 | 2.01 | 1.41 | -0.60 | buy |
| Graham Capital Management, L.P. | 0 | 2,502 | +2,502 | 0.00 | 0.01 | +0.01 | buy |
| Taikang Asset Management (Hong Kong) Co Ltd | 0 | 2,500 | +2,500 | 0.00 | 0.05 | +0.05 | buy |
| TD Waterhouse Canada Inc. | 164 | 2,505 | +2,341 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,781,926 | 1,784,148 | +2,222 | 0.03 | 0.03 | -0.00 | buy |
| OPPENHEIMER ASSET MANAGEMENT INC. | 4,879 | 6,927 | +2,048 | 0.01 | 0.01 | +0.00 | buy |
| Atria Investments, Inc | 0 | 2,037 | +2,037 | 0.00 | 0.00 | +0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 0 | 1,814 | +1,814 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 700 | 2,500 | +1,800 | 0.04 | 0.14 | +0.10 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 56,102 | 57,786 | +1,684 | 0.00 | 0.00 | -0.00 | buy |
| SEARLE & CO. | 0 | 1,500 | +1,500 | 0.00 | 0.05 | +0.05 | buy |
| Parkwood LLC | 12,247 | 13,696 | +1,449 | 0.19 | 0.23 | +0.04 | buy |
| ALLIANCEBERNSTEIN L.P. | 473,753 | 475,001 | +1,248 | 0.03 | 0.02 | -0.00 | buy |
| Handelsbanken Fonder AB | 12,267 | 13,467 | +1,200 | 0.01 | 0.01 | +0.00 | buy |
| ALGERT GLOBAL LLC | 1,410 | 2,180 | +770 | 0.01 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 34,352 | 35,057 | +705 | 0.00 | 0.00 | -0.00 | buy |
| Engineers Gate Manager LP | 6,476 | 7,103 | +627 | 0.03 | 0.02 | -0.00 | buy |
| Walleye Capital LLC | 29 | 556 | +527 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 7,147 | 7,445 | +298 | 0.00 | 0.00 | -0.00 | buy |
| LPL Financial LLC | 2,578 | 2,874 | +296 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 865 | 1,054 | +189 | 0.00 | 0.00 | +0.00 | buy |
| Avior Wealth Management, LLC | 7,822 | 7,972 | +150 | 0.05 | 0.05 | -0.01 | buy |
| RHUMBLINE ADVISERS | 1,390 | 1,533 | +143 | 0.00 | 0.00 | -0.00 | buy |
| Clearstead Advisors, LLC | 1,055 | 1,164 | +109 | 0.01 | 0.00 | -0.00 | buy |
| PROFUND ADVISORS LLC | 2,834 | 2,919 | +85 | 0.02 | 0.01 | -0.00 | buy |
| Blue Trust, Inc. | 0 | 66 | +66 | 0.00 | 0.00 | +0.00 | buy |
| JONES FINANCIAL COMPANIES LLLP | 0 | 50 | +50 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 175 | 214 | +39 | 0.00 | 0.00 | -0.00 | buy |
| J.Safra Asset Management Corp | 0 | 11 | +11 | 0.00 | 0.00 | +0.00 | buy |