| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| WESTFIELD CAPITAL MANAGEMENT CO LP | 4,075,214 | 4,962,824 | +887,610 | 3.23 | 3.33 | +0.09 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 209,512 | 820,512 | +611,000 | 0.06 | 0.21 | +0.15 | buy |
| FIL Ltd | 10,727 | 442,508 | +431,781 | 0.00 | 0.06 | +0.06 | buy |
| Avoro Capital Advisors LLC | 3,966,666 | 4,196,661 | +229,995 | 6.99 | 7.62 | +0.63 | buy |
| Vestal Point Capital, LP | 525,000 | 750,000 | +225,000 | 6.56 | 7.63 | +1.06 | buy |
| Paradigm Biocapital Advisors LP | 507,952 | 664,307 | +156,355 | 2.70 | 3.47 | +0.76 | buy |
| JANUS HENDERSON GROUP PLC | 3,767,203 | 3,918,813 | +151,610 | 0.31 | 0.29 | 0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 186,121 | 307,073 | +120,952 | 0.14 | 0.20 | +0.06 | buy |
| Tri Locum Partners LP | 112,670 | 227,762 | +115,092 | 5.91 | 7.85 | +1.95 | buy |
| MILLENNIUM MANAGEMENT LLC | 362,060 | 473,449 | +111,389 | 0.06 | 0.06 | 0.00 | buy |
| SOROS FUND MANAGEMENT LLC | 3,432 | 100,000 | +96,568 | 0.01 | 0.25 | +0.24 | buy |
| Candriam S.C.A. | 99,375 | 195,347 | +95,972 | 0.10 | 0.16 | +0.07 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 1,617,830 | 1,711,015 | +93,185 | 0.07 | 0.07 | -0.00 | buy |
| CITADEL ADVISORS LLC | 457,504 | 537,762 | +80,258 | 0.10 | 0.10 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 86,202 | 163,110 | +76,908 | 0.03 | 0.06 | +0.02 | buy |
| D. E. Shaw & Co., Inc. | 340,118 | 281,537 | +58,581 | 0.07 | 0.06 | 0.00 | sell |
| Spyglass Capital Management LLC | 614,107 | 662,888 | +48,781 | 6.18 | 6.62 | +0.43 | buy |
| TWO SIGMA INVESTMENTS, LP | 210,325 | 255,320 | +44,995 | 0.08 | 0.09 | 0.00 | buy |
| First Turn Management, LLC | 151,587 | 186,581 | +34,994 | 3.43 | 4.14 | +0.71 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 22,006 | 52,200 | +30,194 | 0.43 | 0.54 | +0.11 | buy |
| Altium Capital Management LLC | 25,000 | 50,000 | +25,000 | 1.69 | 2.82 | +1.13 | buy |
| Aberdeen Group plc | 138,791 | 160,602 | +21,811 | 0.04 | 0.04 | +0.00 | buy |
| TimesSquare Capital Management, LLC | 575,698 | 596,314 | +20,616 | 1.27 | 1.28 | +0.01 | buy |
| Finepoint Capital LP | 175,672 | 189,272 | +13,600 | 6.81 | 7.33 | +0.52 | buy |
| Evolutionary Tree Capital Management, LLC | 13,639 | 24,862 | +11,223 | 2.08 | 3.49 | +1.41 | buy |
| Allspring Global Investments Holdings, LLC | 189,208 | 179,252 | +9,956 | 0.05 | 0.04 | 0.00 | sell |
| Saturn V Capital Management LP | 103,428 | 113,224 | +9,796 | 6.27 | 5.83 | -0.43 | buy |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 225,111 | 233,673 | +8,562 | 1.17 | 1.22 | +0.05 | buy |
| Nicholas Investment Partners, LP | 17,984 | 23,216 | +5,232 | 0.28 | 0.33 | +0.05 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 196,079 | 199,401 | +3,322 | 0.04 | 0.04 | -0.00 | buy |
| Woodline Partners LP | 196,030 | 198,766 | +2,736 | 0.27 | 0.26 | -0.01 | buy |
| ADAR1 Capital Management, LLC | 48,584 | 51,263 | +2,679 | 2.01 | 1.41 | -0.60 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,781,926 | 1,784,148 | +2,222 | 0.03 | 0.03 | -0.00 | buy |
| OPPENHEIMER ASSET MANAGEMENT INC. | 4,879 | 6,927 | +2,048 | 0.01 | 0.01 | 0.00 | buy |
| Quarry LP | 700 | 2,500 | +1,800 | 0.04 | 0.15 | 0.00 | buy |
| Parkwood LLC | 12,247 | 13,696 | +1,449 | 0.17 | 0.23 | +0.07 | buy |
| ProShare Advisors LLC | 4,025 | 3,576 | +449 | 0.00 | 0.00 | 0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 134,564 | 134,409 | +155 | 0.02 | 0.02 | -0.00 | sell |
| CI INVESTMENTS INC. | 1,468 | 1,351 | +117 | 0.00 | 0.00 | 0.00 | sell |
| PROFUND ADVISORS LLC | 2,834 | 2,919 | +85 | 0.02 | 0.01 | 0.00 | buy |
| HOLLENCREST CAPITAL MANAGEMENT | 38 | 48 | +10 | 0.00 | 0.00 | 0.00 | buy |
| Bell Investment Advisors, Inc | 47 | 52 | +5 | 0.00 | 0.00 | 0.00 | buy |
| Henry James International Management Inc. | 24,521 | 24,497 | -24 | 1.14 | 1.18 | +0.04 | sell |
| Hennion & Walsh Asset Management, Inc. | 7,034 | 6,975 | -59 | 0.06 | 0.05 | -0.01 | sell |
| AMERICAN CENTURY COMPANIES INC | 306,141 | 305,974 | -167 | 0.03 | 0.03 | -0.00 | sell |
| Gilbert & Cook, Inc. | 2,881 | 2,619 | -262 | 0.06 | 0.05 | -0.01 | sell |
| NEOS Investment Management LLC | 11,160 | 10,837 | -323 | 0.10 | 0.06 | -0.04 | sell |
| Chicago Partners Investment Group LLC | 6,659 | 6,226 | -433 | 0.04 | 0.03 | -0.01 | sell |
| VIRTUS ADVISERS, LLC | 3,172 | 2,576 | -596 | 0.25 | 0.17 | -0.08 | sell |
| Matisse Capital | 35,540 | 34,729 | -811 | 2.58 | 2.34 | -0.24 | sell |
| NOMURA ASSET MANAGEMENT CO LTD | 13,929 | 12,629 | -1,300 | 0.01 | 0.01 | -0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 4,011 | 2,666 | -1,345 | 0.24 | 0.15 | -0.09 | sell |
| ARS Investment Partners, LLC | 254,967 | 253,139 | -1,828 | 3.84 | 3.30 | -0.54 | sell |
| BAROMETER CAPITAL MANAGEMENT INC. | 3,104 | 1,004 | -2,100 | 0.11 | 0.05 | -0.06 | sell |
| AIGEN INVESTMENT MANAGEMENT, LP | 5,910 | 3,157 | -2,753 | 0.19 | 0.08 | -0.11 | sell |
| China Universal Asset Management Co., Ltd. | 11,020 | 6,804 | -4,216 | 0.21 | 0.13 | -0.08 | sell |
| BIT Capital GmbH | 109,638 | 104,638 | -5,000 | 1.23 | 1.12 | -0.11 | sell |
| Artia Global Partners LP | 15,894 | 7,440 | -8,454 | 0.59 | 0.26 | -0.33 | sell |
| BAILLIE GIFFORD & CO | 81,206 | 71,071 | -10,135 | 0.01 | 0.01 | -0.00 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 162,412 | 151,656 | -10,756 | 1.40 | 1.24 | -0.16 | sell |
| DAFNA Capital Management LLC | 92,472 | 80,972 | -11,500 | 3.18 | 2.64 | -0.54 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 100,320 | 81,396 | -18,924 | 0.15 | 0.11 | -0.04 | sell |
| Sofinnova Investments, Inc. | 754,032 | 734,284 | -19,748 | 6.35 | 5.20 | -1.14 | sell |
| Cinctive Capital Management LP | 48,383 | 19,350 | -29,033 | 0.34 | 0.13 | -0.21 | sell |
| Polar Asset Management Partners Inc. | 44,089 | 6,589 | -37,500 | 0.11 | 0.02 | -0.10 | sell |
| Q Global Advisors, LLC | 285,000 | 219,459 | -65,541 | 16.34 | 21.23 | +4.89 | sell |
| Capital International Investors | 2,191,312 | 2,104,298 | -87,014 | 0.07 | 0.06 | -0.01 | sell |
| TD ASSET MANAGEMENT INC | 236,870 | 99,946 | -136,924 | 0.03 | 0.01 | -0.02 | sell |
| Artisan Partners Limited Partnership | 5,671,934 | 4,295,029 | -1,376,905 | 1.24 | 0.88 | -0.36 | sell |
| T. Rowe Price Investment Management, Inc. | 2,568,903 | 30,564 | -2,538,339 | 0.24 | 0.00 | -0.23 | sell |