| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 10,281,496 | 10,281,496 | 0 | 26.76 | 29.90 | +3.14 | hold |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 5,479,259 | 5,451,401 | -27,858 | 4.16 | 3.95 | -0.21 | sell |
| Avoro Capital Advisors LLC | 5,218,000 | 4,980,000 | -238,000 | 12.69 | 15.05 | +2.36 | sell |
| FMR LLC | 4,672,943 | 4,531,724 | -141,219 | 0.05 | 0.04 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 4,486,949 | 4,427,792 | -59,157 | 0.38 | 0.37 | -0.01 | sell |
| Artisan Partners Limited Partnership | 4,256,627 | 3,990,424 | -266,203 | 1.08 | 1.03 | -0.05 | sell |
| T. Rowe Price Investment Management, Inc. | 3,053,824 | 3,583,546 | +529,722 | 0.31 | 0.39 | +0.08 | buy |
| Capital International Investors | 2,874,792 | 3,046,931 | +172,139 | 0.09 | 0.09 | +0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 1,999,999 | 2,000,000 | +1 | 0.01 | 0.01 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 0 | 2,000,000 | +2,000,000 | 0.00 | 0.01 | +0.01 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 1,877,917 | 1,901,843 | +23,926 | 0.10 | 0.10 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,256,102 | 1,875,491 | -380,611 | 0.04 | 0.04 | -0.01 | sell |
| FRANKLIN RESOURCES INC | 1,640,121 | 1,753,468 | +113,347 | 0.07 | 0.08 | +0.01 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 963,886 | +963,886 | 0.00 | 6.24 | +6.24 | buy |
| Invesco Ltd. | 1,198,478 | 947,226 | -251,252 | 0.04 | 0.03 | -0.01 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 587,763 | 918,095 | +330,332 | 0.02 | 0.03 | +0.01 | buy |
| Polar Capital Holdings Plc | 525,000 | 837,777 | +312,777 | 0.50 | 0.76 | +0.26 | buy |
| AMERIPRISE FINANCIAL INC | 679,943 | 588,069 | -91,874 | 0.03 | 0.03 | -0.00 | sell |
| CITADEL ADVISORS LLC | 1,125,183 | 587,342 | -537,841 | 0.17 | 0.09 | -0.08 | sell |
| GOLDMAN SACHS GROUP INC | 585,581 | 538,287 | -47,294 | 0.02 | 0.02 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 462,171 | 530,809 | +68,638 | 0.04 | 0.05 | +0.01 | buy |
| BlackRock, Inc. | 517,154 | 471,726 | -45,428 | 0.00 | 0.00 | -0.00 | sell |
| FIL Ltd | 462,366 | 464,096 | +1,730 | 0.07 | 0.07 | -0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 327,405 | 459,606 | +132,201 | 0.09 | 0.13 | +0.04 | buy |
| ALLIANCEBERNSTEIN L.P. | 432,098 | 377,701 | -54,397 | 0.02 | 0.02 | -0.00 | sell |
| Woodline Partners LP | 304,806 | 305,454 | +648 | 0.31 | 0.28 | -0.03 | buy |
| Bank of New York Mellon Corp | 300,000 | 300,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TD ASSET MANAGEMENT INC | 343,390 | 292,090 | -51,300 | 0.05 | 0.04 | -0.01 | sell |
| BNP Paribas Asset Management Holding S.A. | 330,153 | 276,984 | -53,169 | 0.14 | 0.12 | -0.02 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 346,018 | 263,267 | -82,751 | 0.20 | 0.17 | -0.03 | sell |
| Q Global Advisors, LLC | 248,887 | 255,000 | +6,113 | 31.55 | 37.03 | +5.48 | buy |
| MORGAN STANLEY | 1,903,531 | 254,785 | -1,648,746 | 0.02 | 0.00 | -0.02 | sell |
| Camber Capital Management LP | 350,000 | 250,000 | -100,000 | 3.40 | 6.01 | +2.61 | sell |
| Siren, L.L.C. | 287,366 | 245,943 | -41,423 | 2.53 | 2.20 | -0.33 | sell |
| SEI INVESTMENTS CO | 258,013 | 236,570 | -21,443 | 0.05 | 0.05 | -0.00 | sell |
| PFM Health Sciences, LP | 186,916 | 221,754 | +34,838 | 2.23 | 3.32 | +1.08 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 124,926 | 219,118 | +94,192 | 0.02 | 0.02 | +0.00 | buy |
| Rock Springs Capital Management LP | 216,000 | 217,000 | +1,000 | 1.93 | 2.33 | +0.41 | buy |
| ARS Investment Partners, LLC | 265,164 | 209,930 | -55,234 | 3.30 | 2.64 | -0.66 | sell |
| JPMORGAN CHASE & CO | 185,122 | 208,141 | +23,019 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 109,632 | 201,044 | +91,412 | 0.03 | 0.05 | +0.02 | buy |
| Allspring Global Investments Holdings, LLC | 189,613 | 200,257 | +10,644 | 0.05 | 0.06 | +0.01 | buy |
| Vestal Point Capital, LP | 150,142 | 200,000 | +49,858 | 1.67 | 1.82 | +0.15 | buy |
| Candriam S.C.A. | 242,761 | 195,115 | -47,646 | 0.24 | 0.19 | -0.04 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 151,829 | 195,108 | +43,279 | 0.23 | 0.27 | +0.04 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 204,482 | 182,558 | -21,924 | 0.05 | 0.04 | -0.00 | sell |
| Catalio Capital Management, LP | 195,523 | 179,926 | -15,597 | 7.56 | 6.51 | -1.04 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 142,624 | 165,667 | +23,043 | 0.02 | 0.02 | +0.01 | buy |
| Resolute Capital Asset Partners LLC | 167,500 | 160,672 | -6,828 | 14.69 | 14.49 | -0.20 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 160,796 | 160,110 | -686 | 1.47 | 1.49 | +0.02 | sell |
| LORD, ABBETT & CO. LLC | 0 | 154,176 | +154,176 | 0.00 | 0.09 | +0.09 | buy |
| LOOMIS SAYLES & CO L P | 174,913 | 148,497 | -26,416 | 0.04 | 0.03 | -0.01 | sell |
| Tri Locum Partners LP | 32,325 | 147,642 | +115,317 | 2.58 | 7.73 | +5.15 | buy |
| Aberdeen Group plc | 171,731 | 139,606 | -32,125 | 0.05 | 0.04 | -0.01 | sell |
| First Turn Management, LLC | 113,278 | 134,687 | +21,409 | 3.56 | 4.34 | +0.78 | buy |
| Frazier Life Sciences Management, L.P. | 133,333 | 133,333 | 0 | 0.95 | 0.92 | -0.03 | hold |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 0 | 130,000 | +130,000 | 0.00 | 0.87 | +0.87 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 90,000 | 120,000 | +30,000 | 0.47 | 0.41 | -0.06 | buy |
| Bank of New York Mellon Corp | 89,209 | 117,616 | +28,407 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 22,294 | 117,162 | +94,868 | 0.00 | 0.02 | +0.02 | buy |
| MACQUARIE GROUP LTD | 0 | 116,735 | +116,735 | 0.00 | 0.02 | +0.02 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 100,917 | +100,917 | 0.00 | 0.72 | +0.72 | buy |
| BANK OF AMERICA CORP /DE/ | 137,892 | 97,818 | -40,074 | 0.00 | 0.00 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 75,751 | 86,552 | +10,801 | 2.47 | 3.06 | +0.59 | buy |
| Pictet Asset Management Holding SA | 106,758 | 85,538 | -21,220 | 0.02 | 0.01 | -0.00 | sell |
| Soleus Capital Management, L.P. | 56,300 | 85,000 | +28,700 | 0.69 | 1.01 | +0.33 | buy |
| UBS Group AG | 173,841 | 82,760 | -91,081 | 0.01 | 0.00 | -0.00 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 85,960 | 78,560 | -7,400 | 0.61 | 0.57 | -0.04 | sell |
| MILLENNIUM MANAGEMENT LLC | 264,867 | 72,888 | -191,979 | 0.04 | 0.01 | -0.03 | sell |
| DAFNA Capital Management LLC | 80,398 | 72,677 | -7,721 | 3.55 | 3.46 | -0.09 | sell |
| Trexquant Investment LP | 43,760 | 64,135 | +20,375 | 0.08 | 0.12 | +0.05 | buy |
| ODDO BHF ASSET MANAGEMENT SAS | 0 | 63,547 | +63,547 | 0.00 | 0.42 | +0.42 | buy |
| Ensign Peak Advisors, Inc | 61,724 | 61,724 | 0 | 0.02 | 0.02 | -0.00 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 57,851 | 60,804 | +2,953 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 79,132 | 58,251 | -20,881 | 0.01 | 0.01 | -0.00 | sell |
| STATE STREET CORP | 66,779 | 58,203 | -8,576 | 0.00 | 0.00 | -0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 104,917 | 56,989 | -47,928 | 0.02 | 0.01 | -0.01 | sell |
| Sterling Capital Management LLC | 51,077 | 54,509 | +3,432 | 0.12 | 0.13 | +0.01 | buy |
| LAZARD ASSET MANAGEMENT LLC | 43,123 | 52,628 | +9,505 | 0.01 | 0.01 | +0.00 | buy |
| Diversified Trust Co | 46,548 | 45,418 | -1,130 | 0.18 | 0.17 | -0.01 | sell |
| Parkman Healthcare Partners LLC | 0 | 42,108 | +42,108 | 0.00 | 0.84 | +0.84 | buy |
| Walleye Capital LLC | 15,837 | 40,403 | +24,566 | 0.03 | 0.06 | +0.04 | buy |
| Zimmer Partners, LP | 36,100 | 40,300 | +4,200 | 0.11 | 0.16 | +0.05 | buy |
| Saturn V Capital Management LP | 199,264 | 38,191 | -161,073 | 15.67 | 2.67 | -13.00 | sell |
| ORBIMED ADVISORS LLC | 0 | 34,400 | +34,400 | 0.00 | 0.15 | +0.15 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 17,655 | 33,325 | +15,670 | 0.00 | 0.01 | +0.00 | buy |
| Empowered Funds, LLC | 0 | 33,196 | +33,196 | 0.00 | 0.06 | +0.06 | buy |
| WELLS FARGO & COMPANY/MN | 24,081 | 31,491 | +7,410 | 0.00 | 0.00 | +0.00 | buy |
| DekaBank Deutsche Girozentrale | 30,000 | 30,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Troluce Capital Advisors LLC | 0 | 30,000 | +30,000 | 0.00 | 2.64 | +2.64 | buy |
| DEUTSCHE BANK AG\ | 28,651 | 29,731 | +1,080 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 23,740 | 29,289 | +5,549 | 0.01 | 0.01 | +0.00 | buy |
| Bellevue Group AG | 1,900 | 28,655 | +26,755 | 0.01 | 0.11 | +0.10 | buy |
| Capital International Sarl | 25,382 | 28,161 | +2,779 | 0.09 | 0.09 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 0 | 28,116 | +28,116 | 0.00 | 0.00 | +0.00 | buy |
| Matisse Capital | 29,674 | 27,942 | -1,732 | 2.44 | 2.28 | -0.16 | sell |
| CITIGROUP INC | 21,164 | 26,099 | +4,935 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 21,302 | 25,645 | +4,343 | 0.01 | 0.01 | +0.00 | buy |
| BROWN ADVISORY INC | 25,860 | 25,505 | -355 | 0.01 | 0.01 | +0.00 | sell |
| Neuberger Berman Group LLC | 46,330 | 23,234 | -23,096 | 0.01 | 0.00 | -0.00 | sell |