| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 0 | 10,281,496 | +10,281,496 | 0.00 | 23.83 | +23.83 | buy |
| Avoro Capital Advisors LLC | 0 | 5,111,111 | +5,111,111 | 0.00 | 12.24 | +12.24 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 0 | 4,798,267 | +4,798,267 | 0.00 | 4.18 | +4.18 | buy |
| Artisan Partners Limited Partnership | 0 | 2,634,024 | +2,634,024 | 0.00 | 1.15 | +1.15 | buy |
| Capital International Investors | 0 | 1,988,614 | +1,988,614 | 0.00 | 0.11 | +0.11 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 1,163,721 | +1,163,721 | 0.00 | 4.82 | +4.82 | buy |
| Capital World Investors | 0 | 906,081 | +906,081 | 0.00 | 0.03 | +0.03 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 0 | 873,502 | +873,502 | 0.00 | 0.11 | +0.11 | buy |
| Polar Capital Holdings Plc | 0 | 616,908 | +616,908 | 0.00 | 0.47 | +0.47 | buy |
| T. Rowe Price Investment Management, Inc. | 6,162,042 | 6,754,846 | +592,804 | 0.97 | 1.18 | +0.21 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 0 | 403,151 | +403,151 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 0 | 401,881 | +401,881 | 0.00 | 0.02 | +0.02 | buy |
| ALLIANCEBERNSTEIN L.P. | 0 | 399,292 | +399,292 | 0.00 | 0.04 | +0.04 | buy |
| Bank of New York Mellon Corp | 0 | 319,412 | +319,412 | 0.00 | 0.01 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 305,803 | +305,803 | 0.00 | 0.06 | +0.06 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 266,708 | +266,708 | 0.00 | 0.05 | +0.05 | buy |
| Tri Locum Partners LP | 0 | 258,740 | +258,740 | 0.00 | 8.49 | +8.49 | buy |
| ORBIMED ADVISORS LLC | 0 | 244,456 | +244,456 | 0.00 | 1.24 | +1.24 | buy |
| PFM Health Sciences, LP | 0 | 233,171 | +233,171 | 0.00 | 5.40 | +5.40 | buy |
| Spyglass Capital Management LLC | 0 | 215,398 | +215,398 | 0.00 | 3.11 | +3.11 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 206,234 | +206,234 | 0.00 | 6.12 | +6.12 | buy |
| Empowered Funds, LLC | 0 | 187,271 | +187,271 | 0.00 | 0.26 | +0.26 | buy |
| JANE STREET GROUP, LLC | 0 | 187,141 | +187,141 | 0.00 | 0.03 | +0.03 | buy |
| Allspring Global Investments Holdings, LLC | 0 | 178,738 | +178,738 | 0.00 | 0.07 | +0.07 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 173,449 | +173,449 | 0.00 | 0.02 | +0.02 | buy |
| Rock Springs Capital Management LP | 0 | 168,750 | +168,750 | 0.00 | 2.20 | +2.20 | buy |
| SG Americas Securities, LLC | 0 | 161,026 | +161,026 | 0.00 | 0.02 | +0.02 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 0 | 148,644 | +148,644 | 0.00 | 1.93 | +1.93 | buy |
| Neuberger Berman Group LLC | 0 | 142,705 | +142,705 | 0.00 | 0.03 | +0.03 | buy |
| USS Investment Management Ltd | 0 | 141,010 | +141,010 | 0.00 | 0.14 | +0.14 | buy |
| CITADEL ADVISORS LLC | 0 | 137,889 | +137,889 | 0.00 | 0.02 | +0.02 | buy |
| Walleye Capital LLC | 0 | 126,005 | +126,005 | 0.00 | 0.16 | +0.16 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 125,772 | +125,772 | 0.00 | 0.01 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 119,699 | +119,699 | 0.00 | 0.04 | +0.04 | buy |
| TD ASSET MANAGEMENT INC | 0 | 119,085 | +119,085 | 0.00 | 0.03 | +0.03 | buy |
| Resolute Capital Asset Partners LLC | 0 | 118,627 | +118,627 | 0.00 | 13.52 | +13.52 | buy |
| Eagle Health Investments LP | 0 | 106,158 | +106,158 | 0.00 | 4.69 | +4.69 | buy |
| Fiera Capital Corp | 0 | 103,313 | +103,313 | 0.00 | 0.10 | +0.10 | buy |
| Woodline Partners LP | 0 | 102,469 | +102,469 | 0.00 | 0.08 | +0.08 | buy |
| Frazier Life Sciences Management, L.P. | 133,333 | 225,155 | +91,822 | 0.78 | 1.31 | +0.52 | buy |
| Synergy Asset Management, LLC | 0 | 91,228 | +91,228 | 0.00 | 2.29 | +2.29 | buy |
| Nuveen, LLC | 0 | 90,318 | +90,318 | 0.00 | 0.01 | +0.01 | buy |
| CANADA PENSION PLAN INVESTMENT BOARD | 0 | 85,478 | +85,478 | 0.00 | 0.01 | +0.01 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 66,500 | +66,500 | 0.00 | 0.02 | +0.02 | buy |
| CASTLEARK MANAGEMENT LLC | 0 | 61,696 | +61,696 | 0.00 | 0.44 | +0.44 | buy |
| Atika Capital Management LLC | 0 | 61,000 | +61,000 | 0.00 | 1.61 | +1.61 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 54,332 | +54,332 | 0.00 | 0.01 | +0.01 | buy |
| Cormorant Asset Management, LP | 0 | 50,000 | +50,000 | 0.00 | 0.68 | +0.68 | buy |
| RHUMBLINE ADVISERS | 0 | 48,612 | +48,612 | 0.00 | 0.01 | +0.01 | buy |
| DAFNA Capital Management LLC | 0 | 48,469 | +48,469 | 0.00 | 2.47 | +2.47 | buy |
| Russell Investments Group, Ltd. | 0 | 48,261 | +48,261 | 0.00 | 0.01 | +0.01 | buy |
| Trexquant Investment LP | 0 | 47,269 | +47,269 | 0.00 | 0.08 | +0.08 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 0 | 45,776 | +45,776 | 0.00 | 0.00 | +0.00 | buy |
| Integral Health Asset Management, LLC | 0 | 45,000 | +45,000 | 0.00 | 0.49 | +0.49 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 43,678 | +43,678 | 0.00 | 0.02 | +0.02 | buy |
| XTX Topco Ltd | 0 | 43,289 | +43,289 | 0.00 | 0.15 | +0.15 | buy |
| Eversept Partners, LP | 0 | 41,621 | +41,621 | 0.00 | 0.61 | +0.61 | buy |
| Quadrature Capital Ltd | 0 | 40,845 | +40,845 | 0.00 | 0.09 | +0.09 | buy |
| Nicholas Investment Partners, LP | 0 | 38,160 | +38,160 | 0.00 | 0.57 | +0.57 | buy |
| Aberdeen Group plc | 0 | 36,512 | +36,512 | 0.00 | 0.01 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 31,023 | +31,023 | 0.00 | 0.02 | +0.02 | buy |
| D. E. Shaw & Co., Inc. | 0 | 30,883 | +30,883 | 0.00 | 0.01 | +0.01 | buy |
| Affinity Asset Advisors, LLC | 0 | 30,000 | +30,000 | 0.00 | 0.39 | +0.39 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 29,303 | +29,303 | 0.00 | 0.03 | +0.03 | buy |
| ADAR1 Capital Management, LLC | 0 | 28,604 | +28,604 | 0.00 | 0.36 | +0.36 | buy |
| Matisse Capital | 0 | 28,107 | +28,107 | 0.00 | 3.00 | +3.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 27,540 | +27,540 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 27,283 | +27,283 | 0.00 | 0.00 | +0.00 | buy |
| Handelsbanken Fonder AB | 0 | 27,050 | +27,050 | 0.00 | 0.02 | +0.02 | buy |
| Capital International Sarl | 0 | 26,222 | +26,222 | 0.00 | 0.10 | +0.10 | buy |
| Diversified Trust Co | 0 | 25,991 | +25,991 | 0.00 | 0.11 | +0.11 | buy |
| Caption Management, LLC | 0 | 25,500 | +25,500 | 0.00 | 0.24 | +0.24 | buy |
| MARSHALL WACE, LLP | 0 | 22,503 | +22,503 | 0.00 | 0.01 | +0.01 | buy |
| SECTOR GAMMA AS | 0 | 21,305 | +21,305 | 0.00 | 1.23 | +1.23 | buy |
| Treasurer of the State of North Carolina | 0 | 21,210 | +21,210 | 0.00 | 0.01 | +0.01 | buy |
| Tredje AP-fonden | 0 | 20,448 | +20,448 | 0.00 | 0.02 | +0.02 | buy |
| Artia Global Partners LP | 0 | 17,740 | +17,740 | 0.00 | 0.90 | +0.90 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 17,014 | +17,014 | 0.00 | 0.00 | +0.00 | buy |
| Henry James International Management Inc. | 0 | 16,987 | +16,987 | 0.00 | 1.36 | +1.36 | buy |
| CAPITAL INTERNATIONAL LTD /CA/ | 0 | 16,394 | +16,394 | 0.00 | 0.14 | +0.14 | buy |
| FIRST TRUST ADVISORS LP | 0 | 16,226 | +16,226 | 0.00 | 0.00 | +0.00 | buy |
| Rhenman & Partners Asset Management AB | 0 | 15,000 | +15,000 | 0.00 | 0.38 | +0.38 | buy |
| LPL Financial LLC | 0 | 14,345 | +14,345 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 5,784 | 19,977 | +14,193 | 0.00 | 0.02 | +0.01 | buy |
| Sterling Capital Management LLC | 0 | 13,727 | +13,727 | 0.00 | 0.06 | +0.06 | buy |
| Nan Fung Group Holdings Ltd | 0 | 13,600 | +13,600 | 0.00 | 2.76 | +2.76 | buy |
| ASSETMARK, INC | 0 | 13,495 | +13,495 | 0.00 | 0.01 | +0.01 | buy |
| Lighthouse Investment Partners, LLC | 0 | 12,000 | +12,000 | 0.00 | 0.10 | +0.10 | buy |
| Amundi | 0 | 11,812 | +11,812 | 0.00 | 0.00 | +0.00 | buy |
| Baird Financial Group, Inc. | 0 | 10,735 | +10,735 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 9,798 | +9,798 | 0.00 | 0.16 | +0.16 | buy |
| Squarepoint Ops LLC | 0 | 9,686 | +9,686 | 0.00 | 0.01 | +0.01 | buy |
| Engineers Gate Manager LP | 0 | 9,648 | +9,648 | 0.00 | 0.03 | +0.03 | buy |
| Morse Asset Management, Inc | 0 | 9,589 | +9,589 | 0.00 | 0.42 | +0.42 | buy |
| Advisors Asset Management, Inc. | 0 | 9,146 | +9,146 | 0.00 | 0.04 | +0.04 | buy |
| Gilbert & Cook, Inc. | 0 | 8,543 | +8,543 | 0.00 | 0.26 | +0.26 | buy |
| Dorsey Wright & Associates | 0 | 8,427 | +8,427 | 0.00 | 0.38 | +0.38 | buy |
| Creative Planning | 0 | 8,356 | +8,356 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 8,275 | +8,275 | 0.00 | 0.06 | +0.06 | buy |
| Brevan Howard Capital Management LP | 0 | 7,930 | +7,930 | 0.00 | 0.03 | +0.03 | buy |