| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 30,564 | 1,765,042 | +1,734,478 | 0.00 | 0.16 | +0.16 | buy |
| Avoro Capital Advisors LLC | 4,196,661 | 4,988,888 | +792,227 | 7.62 | 10.86 | +3.24 | buy |
| Camber Capital Management LP | 0 | 700,000 | +700,000 | 0.00 | 4.06 | +4.06 | buy |
| Point72 Asset Management, L.P. | 0 | 495,547 | +495,547 | 0.00 | 0.26 | +0.26 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,784,148 | 2,121,128 | +336,980 | 0.03 | 0.04 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 3,918,813 | 4,186,694 | +267,881 | 0.29 | 0.32 | +0.03 | buy |
| Duquesne Family Office LLC | 0 | 265,040 | +265,040 | 0.00 | 1.39 | +1.39 | buy |
| Polar Capital Holdings Plc | 0 | 225,000 | +225,000 | 0.00 | 0.16 | +0.16 | buy |
| FIL Ltd | 442,508 | 640,259 | +197,751 | 0.06 | 0.09 | +0.03 | buy |
| MARSHALL WACE, LLP | 30,289 | 221,075 | +190,786 | 0.01 | 0.04 | +0.04 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 4,962,824 | 5,133,766 | +170,942 | 3.33 | 3.46 | +0.14 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 1,711,015 | 1,866,986 | +155,971 | 0.07 | 0.08 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 99,946 | 253,124 | +153,178 | 0.01 | 0.03 | +0.02 | buy |
| MORGAN STANLEY | 166,969 | 312,488 | +145,519 | 0.00 | 0.00 | +0.00 | buy |
| Frazier Life Sciences Management, L.P. | 0 | 133,333 | +133,333 | 0.00 | 0.80 | +0.80 | buy |
| Schonfeld Strategic Advisors LLC | 98,141 | 228,525 | +130,384 | 0.10 | 0.28 | +0.17 | buy |
| CITADEL ADVISORS LLC | 537,762 | 663,924 | +126,162 | 0.07 | 0.10 | +0.03 | buy |
| Avidity Partners Management LP | 0 | 119,000 | +119,000 | 0.00 | 0.91 | +0.91 | buy |
| Artisan Partners Limited Partnership | 4,295,029 | 4,411,111 | +116,082 | 0.89 | 0.99 | +0.10 | buy |
| ADAR1 Capital Management, LLC | 51,263 | 161,402 | +110,139 | 1.41 | 4.04 | +2.63 | buy |
| PFM Health Sciences, LP | 0 | 90,766 | +90,766 | 0.00 | 0.78 | +0.78 | buy |
| Saturn V Capital Management LP | 113,224 | 200,285 | +87,061 | 5.83 | 10.69 | +4.85 | buy |
| Candriam S.C.A. | 195,347 | 282,331 | +86,984 | 0.16 | 0.24 | +0.08 | buy |
| BNP Paribas Asset Management Holding S.A. | 163,110 | 243,856 | +80,746 | 0.06 | 0.09 | +0.03 | buy |
| Zimmer Partners, LP | 0 | 78,000 | +78,000 | 0.00 | 0.22 | +0.22 | buy |
| GOLDMAN SACHS GROUP INC | 421,551 | 490,351 | +68,800 | 0.01 | 0.01 | +0.00 | buy |
| LOOMIS SAYLES & CO L P | 121,594 | 184,623 | +63,029 | 0.02 | 0.04 | +0.01 | buy |
| Resolute Capital Asset Partners LLC | 47,000 | 104,500 | +57,500 | 3.69 | 8.12 | +4.43 | buy |
| Invesco Ltd. | 1,106,449 | 1,162,245 | +55,796 | 0.03 | 0.03 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 60,000 | 115,000 | +55,000 | 0.05 | 0.09 | +0.04 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 346,218 | 397,013 | +50,795 | 0.18 | 0.22 | +0.04 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 128,074 | 178,705 | +50,631 | 0.02 | 0.03 | +0.01 | buy |
| Maven Securities LTD | 0 | 50,000 | +50,000 | 0.00 | 0.84 | +0.84 | buy |
| Atika Capital Management LLC | 0 | 43,000 | +43,000 | 0.00 | 0.69 | +0.69 | buy |
| Diversified Trust Co | 0 | 41,924 | +41,924 | 0.00 | 0.16 | +0.16 | buy |
| AMERICAN CENTURY COMPANIES INC | 305,974 | 346,746 | +40,772 | 0.03 | 0.03 | +0.00 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 0 | 40,000 | +40,000 | 0.00 | 0.17 | +0.17 | buy |
| STATE STREET CORP | 35,057 | 71,459 | +36,402 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 198,766 | 235,018 | +36,252 | 0.26 | 0.30 | +0.04 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 44,918 | 80,989 | +36,071 | 0.01 | 0.01 | +0.01 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 52,200 | 87,302 | +35,102 | 0.54 | 0.57 | +0.02 | buy |
| Rock Springs Capital Management LP | 290,000 | 325,000 | +35,000 | 1.19 | 1.58 | +0.39 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 81,396 | 114,314 | +32,918 | 0.11 | 0.15 | +0.04 | buy |
| MILLENNIUM MANAGEMENT LLC | 473,449 | 501,690 | +28,241 | 0.05 | 0.06 | +0.01 | buy |
| Exome Asset Management LLC | 20,000 | 43,849 | +23,849 | 2.43 | 4.43 | +2.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 47,712 | 71,307 | +23,595 | 0.01 | 0.01 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 21,000 | +21,000 | 0.00 | 2.54 | +2.54 | buy |
| Walleye Trading LLC | 0 | 20,900 | +20,900 | 0.00 | 0.07 | +0.07 | buy |
| JANE STREET GROUP, LLC | 16,261 | 35,454 | +19,193 | 0.00 | 0.01 | +0.01 | buy |
| First Light Asset Management, LLC | 36,157 | 51,723 | +15,566 | 0.43 | 0.64 | +0.21 | buy |
| XTX Topco Ltd | 0 | 11,333 | +11,333 | 0.00 | 0.12 | +0.12 | buy |
| Sivik Global Healthcare LLC | 0 | 10,000 | +10,000 | 0.00 | 0.64 | +0.64 | buy |
| Monashee Investment Management LLC | 0 | 10,000 | +10,000 | 0.00 | 0.16 | +0.16 | buy |
| ARS Investment Partners, LLC | 253,139 | 263,111 | +9,972 | 3.30 | 3.52 | +0.22 | buy |
| JACKSON SQUARE CAPITAL, LLC | 0 | 9,651 | +9,651 | 0.00 | 0.36 | +0.36 | buy |
| Neuberger Berman Group LLC | 30,296 | 39,762 | +9,466 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 264,571 | 273,747 | +9,176 | 0.05 | 0.05 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 660,662 | 669,717 | +9,055 | 0.02 | 0.03 | +0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 151,656 | 160,614 | +8,958 | 1.24 | 1.30 | +0.06 | buy |
| DAFNA Capital Management LLC | 80,972 | 89,572 | +8,600 | 2.64 | 3.16 | +0.52 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 4,730 | 13,072 | +8,342 | 0.05 | 0.15 | +0.10 | buy |
| Crossmark Global Holdings, Inc. | 0 | 8,120 | +8,120 | 0.00 | 0.02 | +0.02 | buy |
| Evolutionary Tree Capital Management, LLC | 24,862 | 32,753 | +7,891 | 3.49 | 4.90 | +1.41 | buy |
| Pictet Asset Management Holding SA | 146,327 | 154,044 | +7,717 | 0.02 | 0.02 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 0 | 7,376 | +7,376 | 0.00 | 0.00 | +0.00 | buy |
| SIT INVESTMENT ASSOCIATES INC | 12,880 | 19,405 | +6,525 | 0.04 | 0.06 | +0.02 | buy |
| Main Management ETF Advisors, LLC | 0 | 6,208 | +6,208 | 0.00 | 0.04 | +0.04 | buy |
| WELLS FARGO & COMPANY/MN | 10,610 | 16,677 | +6,067 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 5,931 | +5,931 | 0.00 | 0.05 | +0.05 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 12,629 | 18,000 | +5,371 | 0.01 | 0.01 | +0.00 | buy |
| Scientech Research LLC | 0 | 5,196 | +5,196 | 0.00 | 0.15 | +0.15 | buy |
| Capital International Investors | 2,104,298 | 2,109,390 | +5,092 | 0.06 | 0.06 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 5,000 | +5,000 | 0.00 | 0.17 | +0.17 | buy |
| Ghisallo Capital Management LLC | 0 | 5,000 | +5,000 | 0.00 | 0.04 | +0.04 | buy |
| Valence8 US LP | 0 | 4,585 | +4,585 | 0.00 | 0.30 | +0.30 | buy |
| China Universal Asset Management Co., Ltd. | 6,804 | 11,142 | +4,338 | 0.13 | 0.18 | +0.05 | buy |
| Handelsbanken Fonder AB | 13,467 | 17,667 | +4,200 | 0.01 | 0.01 | +0.00 | buy |
| NEOS Investment Management LLC | 10,837 | 13,304 | +2,467 | 0.06 | 0.06 | -0.00 | buy |
| ASSETMARK, INC | 0 | 2,214 | +2,214 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 1,934 | +1,934 | 0.00 | 0.01 | +0.01 | buy |
| Erste Asset Management GmbH | 18,500 | 20,300 | +1,800 | 0.03 | 0.04 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 10,647 | 12,339 | +1,692 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 1,681 | +1,681 | 0.00 | 0.02 | +0.02 | buy |
| Vanguard Personalized Indexing Management, LLC | 0 | 1,464 | +1,464 | 0.00 | 0.00 | +0.00 | buy |
| PURSUE WEALTH PARTNERS LLC | 0 | 1,451 | +1,451 | 0.00 | 0.12 | +0.12 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 0 | 1,400 | +1,400 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 4,932 | 5,887 | +955 | 0.00 | 0.00 | +0.00 | buy |
| Advisors Asset Management, Inc. | 3,848 | 4,742 | +894 | 0.01 | 0.01 | +0.00 | buy |
| Finepoint Capital LP | 189,272 | 190,072 | +800 | 7.33 | 3.45 | -3.88 | buy |
| OPPENHEIMER ASSET MANAGEMENT INC. | 6,927 | 7,622 | +695 | 0.01 | 0.01 | +0.00 | buy |
| DnB Asset Management AS | 3,347 | 3,989 | +642 | 0.00 | 0.00 | +0.00 | buy |
| Walleye Capital LLC | 556 | 1,014 | +458 | 0.00 | 0.00 | +0.00 | buy |
| KBC Group NV | 0 | 411 | +411 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 379 | 773 | +394 | 0.00 | 0.00 | +0.00 | buy |
| Avior Wealth Management, LLC | 7,972 | 8,212 | +240 | 0.05 | 0.05 | +0.00 | buy |
| THRIVENT FINANCIAL FOR LUTHERANS | 78,245 | 78,473 | +228 | 0.02 | 0.02 | +0.00 | buy |
| GUGGENHEIM CAPITAL LLC | 1,814 | 2,031 | +217 | 0.00 | 0.00 | +0.00 | buy |
| Wilmington Savings Fund Society, FSB | 0 | 203 | +203 | 0.00 | 0.00 | +0.00 | buy |
| Allianz Asset Management GmbH | 3,767 | 3,967 | +200 | 0.00 | 0.00 | +0.00 | buy |
| TD Waterhouse Canada Inc. | 2,505 | 2,698 | +193 | 0.00 | 0.00 | +0.00 | buy |