| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 10,281,496 | 10,281,496 | 0 | 29.90 | 25.19 | -4.71 | hold |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 5,451,401 | 5,259,909 | -191,492 | 3.95 | 4.39 | +0.44 | sell |
| Avoro Capital Advisors LLC | 4,980,000 | 5,110,000 | +130,000 | 15.05 | 13.14 | -1.91 | buy |
| FMR LLC | 4,531,724 | 4,471,733 | -59,991 | 0.04 | 0.05 | +0.00 | sell |
| JANUS HENDERSON GROUP PLC | 4,427,792 | 4,323,059 | -104,733 | 0.37 | 0.39 | +0.02 | sell |
| Artisan Partners Limited Partnership | 3,990,424 | 3,720,880 | -269,544 | 1.03 | 1.06 | +0.04 | sell |
| Capital International Investors | 3,046,931 | 3,060,616 | +13,685 | 0.09 | 0.10 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 2,000,000 | 3,000,000 | +1,000,000 | 0.01 | 0.01 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 3,583,546 | 2,666,618 | -916,928 | 0.39 | 0.32 | -0.07 | sell |
| BNP Paribas Asset Management Holding S.A. | 2,000,000 | 2,000,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 1,901,843 | 1,882,781 | -19,062 | 0.10 | 0.12 | +0.01 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 918,095 | 1,798,931 | +880,836 | 0.03 | 0.06 | +0.03 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,875,491 | 1,726,228 | -149,263 | 0.04 | 0.04 | +0.00 | sell |
| FRANKLIN RESOURCES INC | 1,753,468 | 1,589,956 | -163,512 | 0.08 | 0.08 | -0.00 | sell |
| PERCEPTIVE ADVISORS LLC | 963,886 | 1,088,501 | +124,615 | 6.24 | 6.25 | +0.01 | buy |
| Invesco Ltd. | 947,226 | 917,903 | -29,323 | 0.03 | 0.03 | +0.00 | sell |
| Polar Capital Holdings Plc | 837,777 | 857,911 | +20,134 | 0.76 | 0.82 | +0.06 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 28,116 | 793,677 | +765,561 | 0.00 | 0.08 | +0.08 | buy |
| GOLDMAN SACHS GROUP INC | 538,287 | 653,012 | +114,725 | 0.02 | 0.02 | +0.00 | buy |
| Vestal Point Capital, LP | 200,000 | 600,000 | +400,000 | 1.82 | 5.41 | +3.60 | buy |
| AMERIPRISE FINANCIAL INC | 588,069 | 562,936 | -25,133 | 0.03 | 0.03 | +0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 530,809 | 544,606 | +13,797 | 0.05 | 0.06 | +0.01 | buy |
| FIL Ltd | 464,096 | 459,340 | -4,756 | 0.07 | 0.07 | +0.00 | sell |
| BlackRock, Inc. | 471,726 | 451,497 | -20,229 | 0.00 | 0.00 | +0.00 | sell |
| MORGAN STANLEY | 254,785 | 406,761 | +151,976 | 0.00 | 0.00 | +0.00 | buy |
| Spyglass Capital Management LLC | 0 | 388,647 | +388,647 | 0.00 | 4.12 | +4.12 | buy |
| ALLIANCEBERNSTEIN L.P. | 377,701 | 375,899 | -1,802 | 0.02 | 0.02 | +0.00 | sell |
| MACQUARIE GROUP LTD | 116,735 | 309,539 | +192,804 | 0.02 | 0.07 | +0.05 | buy |
| Bank of New York Mellon Corp | 300,000 | 300,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TD ASSET MANAGEMENT INC | 292,090 | 296,346 | +4,256 | 0.04 | 0.05 | +0.00 | buy |
| JPMORGAN CHASE & CO | 208,141 | 292,396 | +84,255 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 201,044 | 290,172 | +89,128 | 0.05 | 0.08 | +0.03 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 165,667 | 238,531 | +72,864 | 0.02 | 0.04 | +0.01 | buy |
| Siren, L.L.C. | 245,943 | 235,862 | -10,081 | 2.20 | 1.83 | -0.36 | sell |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 263,267 | 234,397 | -28,870 | 0.17 | 0.16 | -0.01 | sell |
| Rock Springs Capital Management LP | 217,000 | 214,500 | -2,500 | 2.33 | 2.49 | +0.16 | sell |
| Lombard Odier Asset Management (Europe) Ltd | 0 | 211,600 | +211,600 | 0.00 | 2.38 | +2.38 | buy |
| Bank of New York Mellon Corp | 117,616 | 209,298 | +91,682 | 0.00 | 0.01 | +0.00 | buy |
| SEI INVESTMENTS CO | 236,570 | 205,319 | -31,251 | 0.05 | 0.04 | -0.00 | sell |
| VICTORY CAPITAL MANAGEMENT INC | 219,118 | 203,128 | -15,990 | 0.02 | 0.02 | -0.00 | sell |
| UBS Group AG | 82,760 | 195,204 | +112,444 | 0.00 | 0.01 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 34,400 | 191,905 | +157,505 | 0.15 | 0.91 | +0.77 | buy |
| Allspring Global Investments Holdings, LLC | 200,257 | 191,672 | -8,585 | 0.06 | 0.06 | +0.01 | sell |
| BNP Paribas Asset Management Holding S.A. | 276,984 | 189,654 | -87,330 | 0.12 | 0.10 | -0.02 | sell |
| TWO SIGMA INVESTMENTS, LP | 3,115 | 183,886 | +180,771 | 0.00 | 0.06 | +0.06 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 195,108 | 179,168 | -15,940 | 0.27 | 0.26 | -0.01 | sell |
| Candriam S.C.A. | 195,115 | 178,956 | -16,159 | 0.19 | 0.19 | -0.01 | sell |
| ARS Investment Partners, LLC | 209,930 | 175,667 | -34,263 | 2.64 | 2.31 | -0.34 | sell |
| Tri Locum Partners LP | 147,642 | 174,829 | +27,187 | 7.73 | 7.99 | +0.26 | buy |
| MILLENNIUM MANAGEMENT LLC | 72,888 | 174,603 | +101,715 | 0.01 | 0.03 | +0.02 | buy |
| FRED ALGER MANAGEMENT, LLC | 3,795 | 170,701 | +166,906 | 0.00 | 0.13 | +0.13 | buy |
| Q Global Advisors, LLC | 255,000 | 170,000 | -85,000 | 37.03 | 53.09 | +16.06 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 182,558 | 169,894 | -12,664 | 0.04 | 0.04 | +0.00 | sell |
| Resolute Capital Asset Partners LLC | 160,672 | 165,672 | +5,000 | 14.49 | 17.23 | +2.74 | buy |
| LOOMIS SAYLES & CO L P | 148,497 | 153,405 | +4,908 | 0.03 | 0.04 | +0.00 | buy |
| LORD, ABBETT & CO. LLC | 154,176 | 151,427 | -2,749 | 0.09 | 0.09 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 97,818 | 148,012 | +50,194 | 0.00 | 0.00 | +0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 160,110 | 147,090 | -13,020 | 1.49 | 1.59 | +0.11 | sell |
| First Turn Management, LLC | 134,687 | 146,291 | +11,604 | 4.34 | 4.37 | +0.03 | buy |
| PFM Health Sciences, LP | 221,754 | 145,311 | -76,443 | 3.32 | 2.46 | -0.85 | sell |
| Catalio Capital Management, LP | 179,926 | 144,954 | -34,972 | 6.51 | 5.33 | -1.18 | sell |
| Frazier Life Sciences Management, L.P. | 133,333 | 133,333 | 0 | 0.92 | 0.79 | -0.13 | hold |
| ODDO BHF ASSET MANAGEMENT SAS | 63,547 | 119,983 | +56,436 | 0.42 | 0.91 | +0.49 | buy |
| 1832 Asset Management L.P. | 0 | 110,000 | +110,000 | 0.00 | 0.04 | +0.04 | buy |
| Woodline Partners LP | 305,454 | 102,461 | -202,993 | 0.28 | 0.10 | -0.18 | sell |
| SUMMIT PARTNERS PUBLIC ASSET MANAGEMENT, LLC | 130,000 | 100,000 | -30,000 | 0.87 | 0.65 | -0.23 | sell |
| BRAUN STACEY ASSOCIATES INC | 0 | 93,947 | +93,947 | 0.00 | 0.61 | +0.61 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 120,000 | 90,000 | -30,000 | 0.41 | 0.36 | -0.06 | sell |
| Hudson Bay Capital Management LP | 0 | 78,934 | +78,934 | 0.00 | 0.10 | +0.10 | buy |
| Pictet Asset Management Holding SA | 85,538 | 77,058 | -8,480 | 0.01 | 0.01 | -0.00 | sell |
| GREAT POINT PARTNERS LLC | 0 | 75,000 | +75,000 | 0.00 | 6.23 | +6.23 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 33,325 | 73,205 | +39,880 | 0.01 | 0.01 | +0.01 | buy |
| Ensign Peak Advisors, Inc | 61,724 | 70,724 | +9,000 | 0.02 | 0.02 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 29,731 | 69,559 | +39,828 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 60,804 | 68,048 | +7,244 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 58,251 | 66,215 | +7,964 | 0.01 | 0.01 | +0.00 | buy |
| STATE STREET CORP | 58,203 | 61,538 | +3,335 | 0.00 | 0.00 | +0.00 | buy |
| ARROWSTREET CAPITAL, LIMITED PARTNERSHIP | 0 | 60,658 | +60,658 | 0.00 | 0.01 | +0.01 | buy |
| Integral Health Asset Management, LLC | 0 | 60,000 | +60,000 | 0.00 | 0.87 | +0.87 | buy |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 0 | 53,730 | +53,730 | 0.00 | 0.01 | +0.01 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 86,552 | 53,554 | -32,998 | 3.06 | 1.54 | -1.52 | sell |
| Ally Bridge Group (NY) LLC | 0 | 51,080 | +51,080 | 0.00 | 8.50 | +8.50 | buy |
| Aberdeen Group plc | 139,606 | 49,426 | -90,180 | 0.04 | 0.02 | -0.03 | sell |
| Diversified Trust Co | 45,418 | 45,681 | +263 | 0.17 | 0.18 | +0.01 | buy |
| CASTLEARK MANAGEMENT LLC | 0 | 42,656 | +42,656 | 0.00 | 0.24 | +0.24 | buy |
| LAZARD ASSET MANAGEMENT LLC | 52,628 | 41,731 | -10,897 | 0.01 | 0.01 | -0.00 | sell |
| Russell Investments Group, Ltd. | 29,289 | 41,390 | +12,101 | 0.01 | 0.01 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 42,108 | 40,343 | -1,765 | 0.84 | 0.88 | +0.04 | sell |
| Schonfeld Strategic Advisors LLC | 1,871 | 38,250 | +36,379 | 0.00 | 0.05 | +0.05 | buy |
| ADAR1 Capital Management, LLC | 1,402 | 36,345 | +34,943 | 0.04 | 0.72 | +0.68 | buy |
| Empowered Funds, LLC | 33,196 | 36,077 | +2,881 | 0.06 | 0.07 | +0.01 | buy |
| Jain Global LLC | 0 | 35,962 | +35,962 | 0.00 | 0.09 | +0.09 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 56,989 | 33,391 | -23,598 | 0.01 | 0.01 | -0.00 | sell |
| DAFNA Capital Management LLC | 72,677 | 33,177 | -39,500 | 3.46 | 1.63 | -1.83 | sell |
| TWO SIGMA ADVISERS, LP | 0 | 32,900 | +32,900 | 0.00 | 0.01 | +0.01 | buy |
| Voleon Capital Management LP | 0 | 31,926 | +31,926 | 0.00 | 0.16 | +0.16 | buy |
| WELLS FARGO & COMPANY/MN | 31,491 | 31,670 | +179 | 0.00 | 0.00 | +0.00 | buy |
| Capital International Sarl | 28,161 | 30,862 | +2,701 | 0.09 | 0.11 | +0.01 | buy |
| DekaBank Deutsche Girozentrale | 30,000 | 30,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Troluce Capital Advisors LLC | 30,000 | 30,000 | 0 | 2.64 | 2.11 | -0.52 | hold |