| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANE STREET GROUP, LLC | 0 | 1,225,000 | +1,225,000 | 0.00 | 0.00 | +0.00 | buy |
| T. Rowe Price Investment Management, Inc. | 1,765,042 | 2,725,546 | +960,504 | 0.16 | 0.23 | +0.07 | buy |
| Capital International Investors | 2,109,390 | 2,863,249 | +753,859 | 0.06 | 0.07 | +0.01 | buy |
| MORGAN STANLEY | 312,488 | 825,761 | +513,273 | 0.00 | 0.01 | +0.00 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 9,710,428 | 10,112,744 | +402,316 | 16.72 | 18.53 | +1.81 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 5,133,766 | 5,528,239 | +394,473 | 3.46 | 3.31 | -0.15 | buy |
| Vestal Point Capital, LP | 250,000 | 520,000 | +270,000 | 2.95 | 4.24 | +1.30 | buy |
| CITADEL ADVISORS LLC | 663,924 | 895,984 | +232,060 | 0.10 | 0.11 | +0.01 | buy |
| UBS Group AG | 12,425 | 225,687 | +213,262 | 0.00 | 0.01 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 4,186,694 | 4,380,382 | +193,688 | 0.32 | 0.31 | -0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,121,128 | 2,283,207 | +162,079 | 0.04 | 0.04 | -0.00 | buy |
| Soleus Capital Management, L.P. | 0 | 144,000 | +144,000 | 0.00 | 1.50 | +1.50 | buy |
| BlackRock, Inc. | 536,104 | 653,288 | +117,184 | 0.00 | 0.00 | +0.00 | buy |
| Avoro Capital Advisors LLC | 4,988,888 | 5,103,055 | +114,167 | 10.86 | 9.94 | -0.92 | buy |
| Camber Capital Management LP | 700,000 | 800,000 | +100,000 | 4.06 | 4.31 | +0.25 | buy |
| FIL Ltd | 640,259 | 729,275 | +89,016 | 0.09 | 0.09 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 253,124 | 339,652 | +86,528 | 0.03 | 0.04 | +0.01 | buy |
| Woodline Partners LP | 235,018 | 317,642 | +82,624 | 0.30 | 0.30 | -0.00 | buy |
| Polar Capital Holdings Plc | 225,000 | 300,000 | +75,000 | 0.16 | 0.23 | +0.07 | buy |
| BNP Paribas Asset Management Holding S.A. | 243,856 | 316,580 | +72,724 | 0.09 | 0.11 | +0.02 | buy |
| AMERICAN CENTURY COMPANIES INC | 346,746 | 407,294 | +60,548 | 0.03 | 0.03 | +0.00 | buy |
| JPMORGAN CHASE & CO | 25,121 | 77,427 | +52,306 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 5,000 | 51,491 | +46,491 | 0.17 | 1.59 | +1.42 | buy |
| Caption Management, LLC | 0 | 45,381 | +45,381 | 0.00 | 0.26 | +0.26 | buy |
| GOLDMAN SACHS GROUP INC | 490,351 | 530,417 | +40,066 | 0.01 | 0.01 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 115,000 | 155,000 | +40,000 | 0.09 | 0.08 | -0.01 | buy |
| Artisan Partners Limited Partnership | 4,411,111 | 4,450,420 | +39,309 | 0.99 | 0.94 | -0.04 | buy |
| AMERIPRISE FINANCIAL INC | 669,717 | 702,561 | +32,844 | 0.03 | 0.02 | -0.00 | buy |
| SG Americas Securities, LLC | 2,221 | 33,944 | +31,723 | 0.00 | 0.02 | +0.02 | buy |
| ROYAL BANK OF CANADA | 1,727 | 32,344 | +30,617 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 158,213 | 187,180 | +28,967 | 0.04 | 0.05 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 2,006 | 29,860 | +27,854 | 0.00 | 0.01 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 179,318 | 204,482 | +25,164 | 0.04 | 0.04 | +0.00 | buy |
| Capital International Sarl | 0 | 23,806 | +23,806 | 0.00 | 0.08 | +0.08 | buy |
| CAPITAL INTERNATIONAL LTD /CA/ | 0 | 19,153 | +19,153 | 0.00 | 0.11 | +0.11 | buy |
| Trexquant Investment LP | 8,057 | 27,067 | +19,010 | 0.02 | 0.04 | +0.03 | buy |
| Zimmer Partners, LP | 78,000 | 96,900 | +18,900 | 0.22 | 0.23 | +0.01 | buy |
| Legal & General Group Plc | 1,054 | 17,682 | +16,628 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 15,419 | +15,419 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 89,572 | 103,355 | +13,783 | 3.16 | 3.62 | +0.46 | buy |
| Proficio Capital Partners LLC | 0 | 12,528 | +12,528 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 12,105 | +12,105 | 0.00 | 0.04 | +0.04 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 80,989 | 92,728 | +11,739 | 0.01 | 0.01 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 71,307 | 82,955 | +11,648 | 0.01 | 0.01 | +0.00 | buy |
| ARISTEIA CAPITAL, L.L.C. | 0 | 10,800 | +10,800 | 0.00 | 0.05 | +0.05 | buy |
| BARCLAYS PLC | 18,736 | 28,976 | +10,240 | 0.00 | 0.00 | +0.00 | buy |
| Resolute Capital Asset Partners LLC | 104,500 | 114,500 | +10,000 | 8.12 | 8.48 | +0.36 | buy |
| Sterling Capital Management LLC | 47,785 | 56,850 | +9,065 | 0.09 | 0.11 | +0.02 | buy |
| Capital International, Inc./CA/ | 0 | 8,375 | +8,375 | 0.00 | 0.01 | +0.01 | buy |
| Point72 Asset Management, L.P. | 495,547 | 503,669 | +8,122 | 0.26 | 0.19 | -0.07 | buy |
| Qube Research & Technologies Ltd | 5,551 | 12,745 | +7,194 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 0 | 6,072 | +6,072 | 0.00 | 0.31 | +0.31 | buy |
| NEOS Investment Management LLC | 13,304 | 19,040 | +5,736 | 0.06 | 0.06 | +0.00 | buy |
| BIT Capital GmbH | 68,421 | 73,990 | +5,569 | 0.98 | 0.89 | -0.09 | buy |
| GUGGENHEIM CAPITAL LLC | 2,031 | 7,249 | +5,218 | 0.00 | 0.01 | +0.01 | buy |
| Cambridge Investment Research Advisors, Inc. | 0 | 5,007 | +5,007 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 12,563 | 17,097 | +4,534 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 1,934 | 6,288 | +4,354 | 0.01 | 0.02 | +0.01 | buy |
| Verition Fund Management LLC | 0 | 4,300 | +4,300 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 4,101 | +4,101 | 0.00 | 0.02 | +0.02 | buy |
| New Age Alpha Advisors, LLC | 0 | 3,680 | +3,680 | 0.00 | 0.02 | +0.02 | buy |
| Capital Group Investment Management Pte. Ltd. | 0 | 3,609 | +3,609 | 0.00 | 0.09 | +0.09 | buy |
| HighTower Advisors, LLC | 0 | 3,514 | +3,514 | 0.00 | 0.00 | +0.00 | buy |
| Advisors Asset Management, Inc. | 4,742 | 8,241 | +3,499 | 0.01 | 0.02 | +0.01 | buy |
| Creative Planning | 0 | 3,471 | +3,471 | 0.00 | 0.00 | +0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 160,614 | 163,888 | +3,274 | 1.30 | 1.24 | -0.06 | buy |
| Corient Private Wealth LLC | 0 | 3,271 | +3,271 | 0.00 | 0.00 | +0.00 | buy |
| Diversified Trust Co | 41,924 | 45,038 | +3,114 | 0.16 | 0.15 | -0.01 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 18,000 | 20,506 | +2,506 | 0.01 | 0.01 | +0.00 | buy |
| Bellevue Group AG | 0 | 2,500 | +2,500 | 0.00 | 0.01 | +0.01 | buy |
| Engineers Gate Manager LP | 4,261 | 6,733 | +2,472 | 0.01 | 0.02 | +0.00 | buy |
| ARS Investment Partners, LLC | 263,111 | 265,480 | +2,369 | 3.52 | 3.29 | -0.23 | buy |
| Crossmark Global Holdings, Inc. | 8,120 | 10,435 | +2,315 | 0.02 | 0.03 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 21,000 | 22,976 | +1,976 | 2.54 | 3.18 | +0.64 | buy |
| WELLS FARGO & COMPANY/MN | 16,677 | 18,648 | +1,971 | 0.00 | 0.00 | +0.00 | buy |
| Gilbert & Cook, Inc. | 2,563 | 4,421 | +1,858 | 0.05 | 0.09 | +0.03 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 1,717 | +1,717 | 0.00 | 0.02 | +0.02 | buy |
| Aquatic Capital Management LLC | 0 | 1,674 | +1,674 | 0.00 | 0.01 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 11,142 | 12,789 | +1,647 | 0.18 | 0.16 | -0.02 | buy |
| MML INVESTORS SERVICES, LLC | 0 | 1,644 | +1,644 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 2,622 | 4,199 | +1,577 | 0.00 | 0.00 | +0.00 | buy |
| OSAIC HOLDINGS, INC. | 773 | 1,904 | +1,131 | 0.00 | 0.00 | +0.00 | buy |
| ASSETMARK, INC | 2,214 | 2,942 | +728 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 700 | +700 | 0.00 | 0.02 | +0.02 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 1,666 | 2,332 | +666 | 0.05 | 0.06 | +0.01 | buy |
| Tower Research Capital LLC (TRC) | 340 | 1,004 | +664 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 56,448 | 57,077 | +629 | 0.00 | 0.00 | -0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 1,866,986 | 1,867,551 | +565 | 0.08 | 0.08 | -0.00 | buy |
| Mariner, LLC | 1,649 | 2,160 | +511 | 0.00 | 0.00 | +0.00 | buy |
| Atria Investments, Inc | 2,043 | 2,436 | +393 | 0.00 | 0.00 | +0.00 | buy |
| Blue Trust, Inc. | 79 | 407 | +328 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 71,459 | 71,756 | +297 | 0.00 | 0.00 | -0.00 | buy |
| GAMMA Investing LLC | 369 | 583 | +214 | 0.01 | 0.01 | +0.00 | buy |
| Point72 Asia (Singapore) Pte. Ltd. | 0 | 202 | +202 | 0.00 | 0.01 | +0.01 | buy |
| JONES FINANCIAL COMPANIES LLLP | 50 | 247 | +197 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 2,576 | 2,676 | +100 | 0.18 | 0.15 | -0.03 | buy |
| Brooklyn Investment Group | 0 | 82 | +82 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 288 | 361 | +73 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 335 | 393 | +58 | 0.00 | 0.00 | +0.00 | buy |
| TD Waterhouse Canada Inc. | 2,698 | 2,748 | +50 | 0.00 | 0.00 | -0.00 | buy |