| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| T. Rowe Price Investment Management, Inc. | 1,765,042 | 2,725,546 | +960,504 | 0.16 | 0.23 | +0.07 | buy |
| Capital International Investors | 2,109,390 | 2,863,249 | +753,859 | 0.06 | 0.07 | +0.01 | buy |
| RA CAPITAL MANAGEMENT, L.P. | 9,710,428 | 10,112,744 | +402,316 | 16.72 | 18.53 | +1.81 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 5,133,766 | 5,528,239 | +394,473 | 3.46 | 3.31 | -0.15 | buy |
| Vestal Point Capital, LP | 250,000 | 520,000 | +270,000 | 2.95 | 4.24 | +1.30 | buy |
| CITADEL ADVISORS LLC | 663,924 | 895,984 | +232,060 | 0.15 | 0.17 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 4,186,694 | 4,380,382 | +193,688 | 0.32 | 0.31 | 0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,121,128 | 2,283,207 | +162,079 | 0.04 | 0.04 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 501,690 | 358,144 | +143,546 | 0.08 | 0.05 | 0.00 | sell |
| Avoro Capital Advisors LLC | 4,988,888 | 5,103,055 | +114,167 | 10.86 | 9.94 | -0.92 | buy |
| Camber Capital Management LP | 700,000 | 800,000 | +100,000 | 3.32 | 2.55 | -0.77 | buy |
| FIL Ltd | 640,259 | 729,275 | +89,016 | 0.09 | 0.09 | +0.01 | buy |
| TD ASSET MANAGEMENT INC | 253,124 | 339,652 | +86,528 | 0.03 | 0.04 | +0.01 | buy |
| Candriam S.C.A. | 195,347 | 280,154 | +84,807 | 0.16 | 0.22 | +0.06 | buy |
| Woodline Partners LP | 235,018 | 317,642 | +82,624 | 0.30 | 0.30 | -0.00 | buy |
| Polar Capital Holdings Plc | 225,000 | 300,000 | +75,000 | 0.16 | 0.23 | +0.07 | buy |
| BNP Paribas Asset Management Holding S.A. | 243,856 | 316,580 | +72,724 | 0.09 | 0.11 | +0.02 | buy |
| AMERICAN CENTURY COMPANIES INC | 346,746 | 407,294 | +60,548 | 0.03 | 0.03 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 5,000 | 51,491 | +46,491 | 0.17 | 1.59 | +1.42 | buy |
| Alyeska Investment Group, L.P. | 115,000 | 155,000 | +40,000 | 0.09 | 0.08 | -0.01 | buy |
| Artisan Partners Limited Partnership | 4,411,111 | 4,450,420 | +39,309 | 0.98 | 0.92 | -0.06 | buy |
| AMERIPRISE FINANCIAL INC | 669,717 | 702,561 | +32,844 | 0.03 | 0.03 | -0.00 | buy |
| Aberdeen Group plc | 158,213 | 187,180 | +28,967 | 0.04 | 0.05 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 179,318 | 204,482 | +25,164 | 0.04 | 0.04 | +0.00 | buy |
| Zimmer Partners, LP | 78,000 | 96,900 | +18,900 | 0.21 | 0.23 | +0.02 | buy |
| DAFNA Capital Management LLC | 89,572 | 103,355 | +13,783 | 3.16 | 3.62 | +0.46 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 80,989 | 92,728 | +11,739 | 0.01 | 0.01 | +0.00 | buy |
| Resolute Capital Asset Partners LLC | 104,500 | 114,500 | +10,000 | 8.12 | 8.48 | +0.36 | buy |
| Allspring Global Investments Holdings, LLC | 161,410 | 152,738 | +8,672 | 0.04 | 0.03 | 0.00 | sell |
| NEOS Investment Management LLC | 13,304 | 19,040 | +5,736 | 0.06 | 0.06 | +0.00 | buy |
| BIT Capital GmbH | 68,421 | 73,990 | +5,569 | 0.95 | 0.81 | -0.14 | buy |
| Advisors Asset Management, Inc. | 4,742 | 8,241 | +3,499 | 0.01 | 0.02 | 0.00 | buy |
| RICE HALL JAMES & ASSOCIATES, LLC | 160,614 | 163,888 | +3,274 | 1.30 | 1.24 | -0.06 | buy |
| Diversified Trust Co | 41,924 | 45,038 | +3,114 | 0.16 | 0.15 | -0.01 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 18,000 | 20,506 | +2,506 | 0.01 | 0.01 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 133,858 | 131,353 | +2,505 | 0.02 | 0.02 | -0.00 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 87,302 | 84,873 | +2,429 | 0.57 | 0.51 | 0.00 | sell |
| ARS Investment Partners, LLC | 263,111 | 265,480 | +2,369 | 3.52 | 3.29 | -0.23 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 21,000 | 22,976 | +1,976 | 2.54 | 3.18 | +0.64 | buy |
| Gilbert & Cook, Inc. | 2,563 | 4,421 | +1,858 | 0.05 | 0.09 | +0.03 | buy |
| China Universal Asset Management Co., Ltd. | 11,142 | 12,789 | +1,647 | 0.18 | 0.16 | -0.02 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 1,666 | 2,332 | +666 | 0.05 | 0.06 | +0.01 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 1,866,986 | 1,867,551 | +565 | 0.08 | 0.08 | -0.00 | buy |
| CI INVESTMENTS INC. | 1,255 | 1,105 | +150 | 0.00 | 0.00 | 0.00 | sell |
| VIRTUS ADVISERS, LLC | 2,576 | 2,676 | +100 | 0.18 | 0.15 | -0.03 | buy |
| Elequin Capital, LP | 6 | 53 | +47 | 0.00 | 0.00 | +0.00 | buy |
| J.Safra Asset Management Corp | 103 | 141 | +38 | 0.00 | 0.00 | +0.00 | buy |
| Bell Investment Advisors, Inc | 57 | 44 | +13 | 0.00 | 0.00 | 0.00 | sell |
| DnB Asset Management AS | 3,989 | 3,586 | -403 | 0.00 | 0.00 | -0.00 | sell |
| Main Management ETF Advisors, LLC | 6,208 | 5,696 | -512 | 0.04 | 0.04 | -0.01 | sell |
| SECTORAL ASSET MANAGEMENT INC | 2,141 | 1,600 | -541 | 0.19 | 0.15 | -0.04 | sell |
| TOBAM | 2,163 | 1,622 | -541 | 0.06 | 0.07 | +0.01 | sell |
| Chicago Partners Investment Group LLC | 6,075 | 5,225 | -850 | 0.03 | 0.02 | -0.00 | sell |
| Saturn V Capital Management LP | 200,285 | 198,977 | -1,308 | 10.69 | 10.73 | +0.04 | sell |
| Candriam S.C.A. | 282,331 | 280,154 | -2,177 | 0.24 | 0.22 | -0.02 | sell |
| Evolutionary Tree Capital Management, LLC | 32,753 | 30,115 | -2,638 | 4.90 | 4.22 | -0.68 | sell |
| Matisse Capital | 33,684 | 30,496 | -3,188 | 2.45 | 2.13 | -0.31 | sell |
| Henry James International Management Inc. | 21,351 | 17,851 | -3,500 | 1.11 | 0.88 | -0.23 | sell |
| Finepoint Capital LP | 190,072 | 184,872 | -5,200 | 2.06 | 1.55 | -0.51 | sell |
| LOOMIS SAYLES & CO L P | 184,623 | 178,899 | -5,724 | 0.04 | 0.03 | -0.01 | sell |
| Rock Springs Capital Management LP | 325,000 | 305,000 | -20,000 | 1.58 | 1.60 | +0.02 | sell |
| MOORE CAPITAL MANAGEMENT, LP | 40,000 | 20,000 | -20,000 | 0.11 | 0.03 | -0.08 | sell |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 114,314 | 88,496 | -25,818 | 0.15 | 0.10 | -0.05 | sell |
| PFM Health Sciences, LP | 90,766 | 52,392 | -38,374 | 0.77 | 0.45 | -0.32 | sell |
| Maven Securities LTD | 50,000 | 10,000 | -40,000 | 0.14 | 0.03 | -0.11 | sell |
| Siren, L.L.C. | 347,921 | 297,321 | -50,600 | 2.60 | 1.81 | -0.79 | sell |
| Avidity Partners Management LP | 119,000 | 62,000 | -57,000 | 0.91 | 0.85 | -0.06 | sell |
| First Turn Management, LLC | 150,593 | 87,804 | -62,789 | 3.56 | 2.17 | -1.39 | sell |
| ADAR1 Capital Management, LLC | 161,402 | 71,402 | -90,000 | 4.04 | 2.03 | -2.01 | sell |
| FRED ALGER MANAGEMENT, LLC | 258,210 | 111,854 | -146,356 | 0.19 | 0.07 | -0.11 | sell |