| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 9,710,428 | 10,112,744 | +402,316 | 16.72 | 18.53 | +1.81 | buy |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 5,133,766 | 5,528,239 | +394,473 | 3.46 | 3.31 | -0.15 | buy |
| Avoro Capital Advisors LLC | 4,988,888 | 5,103,055 | +114,167 | 10.86 | 9.94 | -0.92 | buy |
| FMR LLC | 4,907,846 | 4,728,647 | -179,199 | 0.04 | 0.04 | -0.01 | sell |
| Artisan Partners Limited Partnership | 4,411,111 | 4,450,420 | +39,309 | 0.99 | 0.94 | -0.04 | buy |
| JANUS HENDERSON GROUP PLC | 4,186,694 | 4,380,382 | +193,688 | 0.32 | 0.31 | -0.01 | buy |
| Capital International Investors | 2,109,390 | 2,863,249 | +753,859 | 0.06 | 0.07 | +0.01 | buy |
| T. Rowe Price Investment Management, Inc. | 1,765,042 | 2,725,546 | +960,504 | 0.16 | 0.23 | +0.07 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,121,128 | 2,283,207 | +162,079 | 0.04 | 0.04 | -0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 2,000,000 | 2,000,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 1,866,986 | 1,867,551 | +565 | 0.08 | 0.08 | -0.00 | buy |
| FRANKLIN RESOURCES INC | 1,459,723 | 1,356,417 | -103,306 | 0.05 | 0.05 | -0.00 | sell |
| JANE STREET GROUP, LLC | 0 | 1,225,000 | +1,225,000 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 1,162,245 | 1,156,013 | -6,232 | 0.03 | 0.03 | -0.00 | sell |
| CITADEL ADVISORS LLC | 663,924 | 895,984 | +232,060 | 0.10 | 0.11 | +0.01 | buy |
| MORGAN STANLEY | 312,488 | 825,761 | +513,273 | 0.00 | 0.01 | +0.00 | buy |
| Camber Capital Management LP | 700,000 | 800,000 | +100,000 | 4.06 | 4.31 | +0.25 | buy |
| FIL Ltd | 640,259 | 729,275 | +89,016 | 0.09 | 0.09 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 1,261,480 | 704,175 | -557,305 | 0.03 | 0.02 | -0.02 | sell |
| AMERIPRISE FINANCIAL INC | 669,717 | 702,561 | +32,844 | 0.03 | 0.02 | -0.00 | buy |
| BlackRock, Inc. | 536,104 | 653,288 | +117,184 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 490,351 | 530,417 | +40,066 | 0.01 | 0.01 | +0.00 | buy |
| Vestal Point Capital, LP | 250,000 | 520,000 | +270,000 | 2.95 | 4.24 | +1.30 | buy |
| Point72 Asset Management, L.P. | 495,547 | 503,669 | +8,122 | 0.26 | 0.19 | -0.07 | buy |
| ALLIANCEBERNSTEIN L.P. | 454,788 | 445,028 | -9,760 | 0.02 | 0.02 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 346,746 | 407,294 | +60,548 | 0.03 | 0.03 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 501,690 | 358,144 | -143,546 | 0.06 | 0.04 | -0.02 | sell |
| TD ASSET MANAGEMENT INC | 253,124 | 339,652 | +86,528 | 0.03 | 0.04 | +0.01 | buy |
| Woodline Partners LP | 235,018 | 317,642 | +82,624 | 0.30 | 0.30 | -0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 243,856 | 316,580 | +72,724 | 0.09 | 0.11 | +0.02 | buy |
| Rock Springs Capital Management LP | 325,000 | 305,000 | -20,000 | 1.58 | 1.60 | +0.02 | sell |
| Polar Capital Holdings Plc | 225,000 | 300,000 | +75,000 | 0.16 | 0.23 | +0.07 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 397,013 | 298,996 | -98,017 | 0.22 | 0.15 | -0.07 | sell |
| Siren, L.L.C. | 347,921 | 297,321 | -50,600 | 2.60 | 1.81 | -0.79 | sell |
| Candriam S.C.A. | 282,331 | 280,154 | -2,177 | 0.24 | 0.22 | -0.02 | sell |
| ARS Investment Partners, LLC | 263,111 | 265,480 | +2,369 | 3.52 | 3.29 | -0.23 | buy |
| Duquesne Family Office LLC | 265,040 | 265,040 | 0 | 1.39 | 1.03 | -0.36 | hold |
| SEI INVESTMENTS CO | 273,747 | 263,582 | -10,165 | 0.05 | 0.05 | -0.01 | sell |
| UBS Group AG | 12,425 | 225,687 | +213,262 | 0.00 | 0.01 | +0.01 | buy |
| Q Global Advisors, LLC | 219,459 | 219,459 | 0 | 28.82 | 31.14 | +2.32 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 179,318 | 204,482 | +25,164 | 0.04 | 0.04 | +0.00 | buy |
| Saturn V Capital Management LP | 200,285 | 198,977 | -1,308 | 10.69 | 10.73 | +0.04 | sell |
| Aberdeen Group plc | 158,213 | 187,180 | +28,967 | 0.04 | 0.05 | +0.01 | buy |
| Finepoint Capital LP | 190,072 | 184,872 | -5,200 | 3.45 | 2.94 | -0.52 | sell |
| LOOMIS SAYLES & CO L P | 184,623 | 178,899 | -5,724 | 0.04 | 0.03 | -0.01 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 160,614 | 163,888 | +3,274 | 1.30 | 1.24 | -0.06 | buy |
| Alyeska Investment Group, L.P. | 115,000 | 155,000 | +40,000 | 0.09 | 0.08 | -0.01 | buy |
| Allspring Global Investments Holdings, LLC | 161,410 | 152,738 | -8,672 | 0.04 | 0.03 | -0.00 | sell |
| Pictet Asset Management Holding SA | 154,044 | 144,199 | -9,845 | 0.02 | 0.02 | -0.00 | sell |
| Soleus Capital Management, L.P. | 0 | 144,000 | +144,000 | 0.00 | 1.50 | +1.50 | buy |
| Schonfeld Strategic Advisors LLC | 228,525 | 138,593 | -89,932 | 0.28 | 0.12 | -0.16 | sell |
| Frazier Life Sciences Management, L.P. | 133,333 | 133,333 | 0 | 0.80 | 0.76 | -0.04 | hold |
| VICTORY CAPITAL MANAGEMENT INC | 133,858 | 131,353 | -2,505 | 0.02 | 0.02 | -0.00 | sell |
| Resolute Capital Asset Partners LLC | 104,500 | 114,500 | +10,000 | 8.12 | 8.48 | +0.36 | buy |
| MARSHALL WACE, LLP | 221,075 | 114,245 | -106,830 | 0.04 | 0.02 | -0.02 | sell |
| FRED ALGER MANAGEMENT, LLC | 258,210 | 111,854 | -146,356 | 0.19 | 0.07 | -0.11 | sell |
| DAFNA Capital Management LLC | 89,572 | 103,355 | +13,783 | 3.16 | 3.62 | +0.46 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 178,705 | 100,023 | -78,682 | 0.03 | 0.01 | -0.02 | sell |
| Bank of New York Mellon Corp | 105,218 | 98,392 | -6,826 | 0.00 | 0.00 | -0.00 | sell |
| Zimmer Partners, LP | 78,000 | 96,900 | +18,900 | 0.22 | 0.23 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 80,989 | 92,728 | +11,739 | 0.01 | 0.01 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 114,314 | 88,496 | -25,818 | 0.15 | 0.10 | -0.05 | sell |
| First Turn Management, LLC | 150,593 | 87,804 | -62,789 | 3.56 | 2.17 | -1.39 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 87,302 | 84,873 | -2,429 | 0.57 | 0.51 | -0.06 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 71,307 | 82,955 | +11,648 | 0.01 | 0.01 | +0.00 | buy |
| JPMORGAN CHASE & CO | 25,121 | 77,427 | +52,306 | 0.00 | 0.00 | +0.00 | buy |
| BIT Capital GmbH | 68,421 | 73,990 | +5,569 | 0.98 | 0.89 | -0.09 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 120,894 | 72,059 | -48,835 | 0.06 | 0.03 | -0.03 | sell |
| STATE STREET CORP | 71,459 | 71,756 | +297 | 0.00 | 0.00 | -0.00 | buy |
| ADAR1 Capital Management, LLC | 161,402 | 71,402 | -90,000 | 4.04 | 2.03 | -2.01 | sell |
| Avidity Partners Management LP | 119,000 | 62,000 | -57,000 | 0.91 | 0.85 | -0.06 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 56,448 | 57,077 | +629 | 0.00 | 0.00 | -0.00 | buy |
| Sterling Capital Management LLC | 47,785 | 56,850 | +9,065 | 0.09 | 0.11 | +0.02 | buy |
| PFM Health Sciences, LP | 90,766 | 52,392 | -38,374 | 0.78 | 0.55 | -0.23 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 5,000 | 51,491 | +46,491 | 0.17 | 1.59 | +1.42 | buy |
| Caption Management, LLC | 0 | 45,381 | +45,381 | 0.00 | 0.26 | +0.26 | buy |
| Diversified Trust Co | 41,924 | 45,038 | +3,114 | 0.16 | 0.15 | -0.01 | buy |
| Neuberger Berman Group LLC | 39,762 | 38,129 | -1,633 | 0.00 | 0.00 | -0.00 | sell |
| D. E. Shaw & Co., Inc. | 90,380 | 37,980 | -52,400 | 0.02 | 0.01 | -0.01 | sell |
| BROWN ADVISORY INC | 467,652 | 36,286 | -431,366 | 0.09 | 0.01 | -0.08 | sell |
| THRIVENT FINANCIAL FOR LUTHERANS | 78,473 | 35,941 | -42,532 | 0.02 | 0.01 | -0.01 | sell |
| JANE STREET GROUP, LLC | 35,454 | 35,330 | -124 | 0.01 | 0.01 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 45,506 | 34,385 | -11,121 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 2,221 | 33,944 | +31,723 | 0.00 | 0.02 | +0.02 | buy |
| ROYAL BANK OF CANADA | 1,727 | 32,344 | +30,617 | 0.00 | 0.00 | +0.00 | buy |
| Matisse Capital | 33,684 | 30,496 | -3,188 | 2.45 | 2.13 | -0.31 | sell |
| Evolutionary Tree Capital Management, LLC | 32,753 | 30,115 | -2,638 | 4.90 | 4.22 | -0.68 | sell |
| DekaBank Deutsche Girozentrale | 30,000 | 30,000 | 0 | 0.01 | 0.01 | -0.00 | hold |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 2,006 | 29,860 | +27,854 | 0.00 | 0.01 | +0.01 | buy |
| BARCLAYS PLC | 18,736 | 28,976 | +10,240 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 8,057 | 27,067 | +19,010 | 0.02 | 0.04 | +0.03 | buy |
| BANK OF AMERICA CORP /DE/ | 112,572 | 26,383 | -86,189 | 0.00 | 0.00 | -0.00 | sell |
| Capital International Sarl | 0 | 23,806 | +23,806 | 0.00 | 0.08 | +0.08 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 21,000 | 22,976 | +1,976 | 2.54 | 3.18 | +0.64 | buy |
| CITIGROUP INC | 21,268 | 21,048 | -220 | 0.00 | 0.00 | -0.00 | sell |
| NOMURA ASSET MANAGEMENT CO LTD | 18,000 | 20,506 | +2,506 | 0.01 | 0.01 | +0.00 | buy |
| Erste Asset Management GmbH | 20,300 | 20,300 | 0 | 0.04 | 0.03 | -0.00 | hold |
| MOORE CAPITAL MANAGEMENT, LP | 40,000 | 20,000 | -20,000 | 0.17 | 0.05 | -0.12 | sell |
| SIT INVESTMENT ASSOCIATES INC | 19,405 | 19,405 | 0 | 0.06 | 0.06 | -0.00 | hold |
| CAPITAL INTERNATIONAL LTD /CA/ | 0 | 19,153 | +19,153 | 0.00 | 0.11 | +0.11 | buy |