| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RA CAPITAL MANAGEMENT, L.P. | 10,281,496 | 10,281,496 | 0 | 25.19 | 22.46 | -2.73 | hold |
| WESTFIELD CAPITAL MANAGEMENT CO LP | 5,259,909 | 5,185,696 | -74,213 | 4.39 | 4.61 | +0.22 | sell |
| Avoro Capital Advisors LLC | 5,110,000 | 5,111,111 | +1,111 | 13.14 | 10.71 | -2.43 | buy |
| Polar Capital Holdings Plc | 0 | 5,000,000 | +5,000,000 | 0.03 | 0.03 | -0.00 | buy |
| FMR LLC | 4,471,733 | 4,153,311 | -318,422 | 0.05 | 0.05 | -0.00 | sell |
| JANUS HENDERSON GROUP PLC | 4,323,059 | 4,061,641 | -261,418 | 0.39 | 0.39 | -0.00 | sell |
| Artisan Partners Limited Partnership | 3,720,880 | 3,225,885 | -494,995 | 1.06 | 1.05 | -0.01 | sell |
| Capital International Investors | 3,060,616 | 3,063,943 | +3,327 | 0.10 | 0.10 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 3,000,000 | 3,000,000 | 0 | 0.01 | 0.01 | +0.00 | hold |
| BNP Paribas Asset Management Holding S.A. | 2,000,000 | 2,000,000 | 0 | 0.01 | 0.00 | -0.00 | hold |
| FRANKLIN RESOURCES INC | 1,589,956 | 1,910,079 | +320,123 | 0.08 | 0.10 | +0.02 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 1,882,781 | 1,886,393 | +3,612 | 0.12 | 0.13 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 1,798,931 | 1,762,721 | -36,210 | 0.06 | 0.07 | +0.00 | sell |
| T. Rowe Price Investment Management, Inc. | 2,666,618 | 1,667,625 | -998,993 | 0.32 | 0.22 | -0.10 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 1,726,228 | 1,570,260 | -155,968 | 0.04 | 0.04 | -0.00 | sell |
| AMERICAN CENTURY COMPANIES INC | 544,606 | 1,443,141 | +898,535 | 0.06 | 0.15 | +0.10 | buy |
| PERCEPTIVE ADVISORS LLC | 1,088,501 | 1,081,421 | -7,080 | 6.25 | 4.22 | -2.03 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 793,677 | 1,026,407 | +232,730 | 0.08 | 0.11 | +0.03 | buy |
| BlackRock, Inc. | 451,497 | 628,200 | +176,703 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 406,761 | 617,968 | +211,207 | 0.00 | 0.01 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 653,012 | 596,703 | -56,309 | 0.02 | 0.02 | -0.00 | sell |
| Invesco Ltd. | 917,903 | 586,094 | -331,809 | 0.03 | 0.02 | -0.01 | sell |
| AMERIPRISE FINANCIAL INC | 562,936 | 550,477 | -12,459 | 0.03 | 0.03 | +0.00 | sell |
| CITADEL ADVISORS LLC | 27,640 | 519,516 | +491,876 | 0.00 | 0.08 | +0.07 | buy |
| JPMORGAN CHASE & CO | 292,396 | 507,240 | +214,844 | 0.00 | 0.01 | +0.00 | buy |
| FIL Ltd | 459,340 | 478,641 | +19,301 | 0.07 | 0.08 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 470,951 | +470,951 | 0.00 | 0.14 | +0.14 | buy |
| Spyglass Capital Management LLC | 388,647 | 415,549 | +26,902 | 4.12 | 4.43 | +0.31 | buy |
| Polar Capital Holdings Plc | 857,911 | 370,473 | -487,438 | 0.82 | 0.36 | -0.46 | sell |
| FRED ALGER MANAGEMENT, LLC | 170,701 | 352,109 | +181,408 | 0.13 | 0.29 | +0.16 | buy |
| UBS Group AG | 195,204 | 308,190 | +112,986 | 0.01 | 0.01 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 238,531 | 307,086 | +68,555 | 0.04 | 0.04 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 69,559 | 296,818 | +227,259 | 0.00 | 0.02 | +0.02 | buy |
| ALLIANCEBERNSTEIN L.P. | 375,899 | 288,592 | -87,307 | 0.02 | 0.02 | -0.00 | sell |
| SEI INVESTMENTS CO | 205,319 | 281,473 | +76,154 | 0.04 | 0.06 | +0.02 | buy |
| Tri Locum Partners LP | 174,829 | 265,015 | +90,186 | 7.99 | 7.34 | -0.65 | buy |
| MILLENNIUM MANAGEMENT LLC | 174,603 | 262,329 | +87,726 | 0.03 | 0.04 | +0.01 | buy |
| TWO SIGMA INVESTMENTS, LP | 183,886 | 247,892 | +64,006 | 0.06 | 0.08 | +0.02 | buy |
| Siren, L.L.C. | 235,862 | 235,862 | 0 | 1.83 | 1.50 | -0.33 | hold |
| TD ASSET MANAGEMENT INC | 296,346 | 234,012 | -62,334 | 0.05 | 0.04 | -0.01 | sell |
| Aberdeen Group plc | 49,426 | 221,677 | +172,251 | 0.02 | 0.07 | +0.06 | buy |
| Jain Global LLC | 35,962 | 216,526 | +180,564 | 0.09 | 0.45 | +0.36 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 234,397 | 216,173 | -18,224 | 0.16 | 0.16 | +0.01 | sell |
| Rock Springs Capital Management LP | 214,500 | 203,500 | -11,000 | 2.49 | 2.23 | -0.27 | sell |
| Bank of New York Mellon Corp | 300,000 | 200,000 | -100,000 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 209,298 | 194,605 | -14,693 | 0.01 | 0.01 | -0.00 | sell |
| Qube Research & Technologies Ltd | 290,172 | 193,464 | -96,708 | 0.08 | 0.06 | -0.02 | sell |
| Q Global Advisors, LLC | 170,000 | 190,000 | +20,000 | 53.09 | 39.86 | -13.23 | buy |
| Allspring Global Investments Holdings, LLC | 191,672 | 187,642 | -4,030 | 0.06 | 0.06 | +0.00 | sell |
| Candriam S.C.A. | 178,956 | 186,940 | +7,984 | 0.19 | 0.20 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 169,894 | 182,234 | +12,340 | 0.04 | 0.05 | +0.01 | buy |
| PFM Health Sciences, LP | 145,311 | 177,685 | +32,374 | 2.46 | 3.84 | +1.37 | buy |
| Vestal Point Capital, LP | 600,000 | 175,000 | -425,000 | 5.41 | 1.37 | -4.04 | sell |
| ARS Investment Partners, LLC | 175,667 | 174,611 | -1,056 | 2.31 | 2.18 | -0.13 | sell |
| ORBIMED ADVISORS LLC | 191,905 | 171,977 | -19,928 | 0.91 | 0.75 | -0.16 | sell |
| BANK OF AMERICA CORP /DE/ | 148,012 | 162,503 | +14,491 | 0.00 | 0.00 | +0.00 | buy |
| DRIEHAUS CAPITAL MANAGEMENT LLC | 179,168 | 156,272 | -22,896 | 0.26 | 0.23 | -0.03 | sell |
| RICE HALL JAMES & ASSOCIATES, LLC | 147,090 | 145,046 | -2,044 | 1.59 | 1.70 | +0.11 | sell |
| Frazier Life Sciences Management, L.P. | 133,333 | 133,333 | 0 | 0.79 | 0.76 | -0.03 | hold |
| First Turn Management, LLC | 146,291 | 131,808 | -14,483 | 4.37 | 3.21 | -1.16 | sell |
| ODDO BHF ASSET MANAGEMENT SAS | 119,983 | 129,941 | +9,958 | 0.91 | 1.04 | +0.13 | buy |
| D. E. Shaw & Co., Inc. | 3,586 | 125,768 | +122,182 | 0.00 | 0.02 | +0.02 | buy |
| MOORE CAPITAL MANAGEMENT, LP | 90,000 | 125,000 | +35,000 | 0.36 | 0.54 | +0.19 | buy |
| LORD, ABBETT & CO. LLC | 151,427 | 120,197 | -31,230 | 0.09 | 0.08 | -0.01 | sell |
| Catalio Capital Management, LP | 144,954 | 119,265 | -25,689 | 5.33 | 4.49 | -0.83 | sell |
| BRAUN STACEY ASSOCIATES INC | 93,947 | 119,095 | +25,148 | 0.61 | 0.82 | +0.21 | buy |
| IMC-Chicago, LLC | 0 | 113,682 | +113,682 | 0.00 | 0.43 | +0.43 | buy |
| LOOMIS SAYLES & CO L P | 153,405 | 112,240 | -41,165 | 0.04 | 0.03 | -0.01 | sell |
| 1832 Asset Management L.P. | 110,000 | 110,000 | 0 | 0.04 | 0.03 | -0.01 | hold |
| Woodline Partners LP | 102,461 | 102,461 | 0 | 0.10 | 0.08 | -0.01 | hold |
| Cormorant Asset Management, LP | 0 | 100,000 | +100,000 | 0.00 | 1.21 | +1.21 | buy |
| BAROMETER CAPITAL MANAGEMENT INC. | 3,904 | 91,392 | +87,488 | 0.18 | 2.61 | +2.43 | buy |
| Integral Health Asset Management, LLC | 60,000 | 90,000 | +30,000 | 0.87 | 0.97 | +0.10 | buy |
| Resolute Capital Asset Partners LLC | 165,672 | 88,627 | -77,045 | 17.23 | 9.13 | -8.10 | sell |
| ExodusPoint Capital Management, LP | 24,723 | 82,888 | +58,165 | 0.07 | 0.20 | +0.13 | buy |
| Beck Bode, LLC | 0 | 81,087 | +81,087 | 0.00 | 2.88 | +2.88 | buy |
| Pictet Asset Management Holding SA | 77,058 | 73,418 | -3,640 | 0.01 | 0.02 | +0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 33,391 | 73,310 | +39,919 | 0.01 | 0.01 | +0.01 | buy |
| BNP Paribas Asset Management Holding S.A. | 189,654 | 72,106 | -117,548 | 0.10 | 0.02 | -0.08 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 26,531 | 71,516 | +44,985 | 0.00 | 0.01 | +0.01 | buy |
| Ensign Peak Advisors, Inc | 70,724 | 69,560 | -1,164 | 0.02 | 0.03 | +0.00 | sell |
| Voleon Capital Management LP | 31,926 | 69,389 | +37,463 | 0.16 | 0.32 | +0.16 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 68,048 | 68,855 | +807 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 61,538 | 67,949 | +6,411 | 0.00 | 0.00 | +0.00 | buy |
| CASTLEARK MANAGEMENT LLC | 42,656 | 66,336 | +23,680 | 0.24 | 0.42 | +0.18 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 66,215 | 60,895 | -5,320 | 0.01 | 0.01 | -0.00 | sell |
| Trexquant Investment LP | 27,585 | 59,025 | +31,440 | 0.06 | 0.11 | +0.06 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 73,205 | 57,075 | -16,130 | 0.01 | 0.01 | -0.00 | sell |
| Chevy Chase Trust Holdings, LLC | 0 | 56,695 | +56,695 | 0.00 | 0.03 | +0.03 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 53,554 | 49,228 | -4,326 | 1.54 | 1.52 | -0.02 | sell |
| Brevan Howard Capital Management LP | 0 | 48,260 | +48,260 | 0.00 | 0.19 | +0.19 | buy |
| Eversept Partners, LP | 0 | 48,241 | +48,241 | 0.00 | 0.58 | +0.58 | buy |
| DZ BANK AG Deutsche Zentral Genossenschafts Bank, Frankfurt am Main | 53,730 | 48,097 | -5,633 | 0.01 | 0.01 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 32,900 | 47,400 | +14,500 | 0.01 | 0.02 | +0.01 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 27,751 | 43,701 | +15,950 | 0.01 | 0.02 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 203,128 | 43,190 | -159,938 | 0.02 | 0.01 | -0.02 | sell |
| Diversified Trust Co | 45,681 | 42,251 | -3,430 | 0.18 | 0.17 | -0.02 | sell |
| LAZARD ASSET MANAGEMENT LLC | 41,731 | 39,135 | -2,596 | 0.01 | 0.01 | +0.00 | sell |
| Skandinaviska Enskilda Banken AB (publ) | 28,767 | 38,990 | +10,223 | 0.02 | 0.03 | +0.01 | buy |
| Empowered Funds, LLC | 36,077 | 36,697 | +620 | 0.07 | 0.06 | -0.01 | buy |