| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MPM BioImpact LLC | 996,825 | 5,213,361 | +4,216,536 | 2.19 | 8.41 | +6.22 | buy |
| ADAR1 Capital Management, LLC | 0 | 1,012,866 | +1,012,866 | 0.00 | 1.27 | +1.27 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 964,391 | +964,391 | 0.00 | 0.40 | +0.40 | buy |
| Duquesne Family Office LLC | 0 | 383,363 | +383,363 | 0.00 | 0.27 | +0.27 | buy |
| Patient Square Capital LP | 359,050 | 693,534 | +334,484 | 1.47 | 2.57 | +1.10 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 231,417 | +231,417 | 0.00 | 0.00 | +0.00 | buy |
| Vivo Capital, LLC | 2,461,626 | 2,667,569 | +205,943 | 3.05 | 4.63 | +1.58 | buy |
| Russell Investments Group, Ltd. | 0 | 128,560 | +128,560 | 0.00 | 0.00 | +0.00 | buy |
| Dorsey Wright & Associates | 0 | 102,550 | +102,550 | 0.00 | 0.27 | +0.27 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 22,392 | 95,714 | +73,322 | 0.00 | 0.00 | +0.00 | buy |
| Atika Capital Management LLC | 206,881 | 271,300 | +64,419 | 0.55 | 0.89 | +0.34 | buy |
| DIVERSIFY WEALTH MANAGEMENT, LLC | 0 | 63,672 | +63,672 | 0.00 | 0.02 | +0.02 | buy |
| LPL Financial LLC | 0 | 55,871 | +55,871 | 0.00 | 0.00 | +0.00 | buy |
| AdvisorShares Investments LLC | 0 | 50,340 | +50,340 | 0.00 | 0.19 | +0.19 | buy |
| XTX Topco Ltd | 0 | 42,055 | +42,055 | 0.00 | 0.02 | +0.02 | buy |
| STIFEL FINANCIAL CORP | 0 | 30,736 | +30,736 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 24,085 | +24,085 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 13,736 | 37,427 | +23,691 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 122,495 | 146,116 | +23,621 | 0.00 | 0.00 | +0.00 | buy |
| Burns Matteson Capital Management, LLC | 0 | 22,631 | +22,631 | 0.00 | 0.18 | +0.18 | buy |
| Atria Investments, Inc | 0 | 21,135 | +21,135 | 0.00 | 0.00 | +0.00 | buy |
| PERSONAL CFO SOLUTIONS, LLC | 0 | 12,643 | +12,643 | 0.00 | 0.04 | +0.04 | buy |
| Cetera Investment Advisers | 13,115 | 25,358 | +12,243 | 0.00 | 0.00 | +0.00 | buy |
| Integrated Wealth Concepts LLC | 0 | 10,582 | +10,582 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 0 | 8,079 | +8,079 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 24,984 | 33,040 | +8,056 | 0.01 | 0.01 | +0.00 | buy |
| Persistent Asset Partners Ltd | 6,019 | 11,392 | +5,373 | 0.06 | 0.09 | +0.04 | buy |
| China Universal Asset Management Co., Ltd. | 0 | 5,000 | +5,000 | 0.00 | 0.01 | +0.01 | buy |
| ROYAL BANK OF CANADA | 0 | 4,680 | +4,680 | 0.00 | 0.00 | +0.00 | buy |
| ORG Wealth Partners, LLC | 0 | 259 | +259 | 0.00 | 0.00 | +0.00 | buy |
| HARBOUR INVESTMENTS, INC. | 0 | 259 | +259 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 2,680 | 2,899 | +219 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 164 | +164 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 67 | +67 | 0.00 | 0.00 | +0.00 | buy |
| Advisory Services Network, LLC | 0 | 30 | +30 | 0.00 | 0.00 | +0.00 | buy |
| Bell Investment Advisors, Inc | 0 | 21 | +21 | 0.00 | 0.00 | +0.00 | buy |
| TRUST CO OF TOLEDO NA /OH/ | 10 | 10 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 111 | 111 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BAKER BROS. ADVISORS LP | 1,461,425 | 1,461,425 | 0 | 0.16 | 0.18 | +0.01 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 163,401 | 163,401 | 0 | 0.08 | 0.08 | -0.00 | hold |
| Allworth Financial LP | 1,683 | 1,683 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Pinnacle Wealth Planning Services, Inc. | 40 | 40 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Truvestments Capital LLC | 3,892 | 3,892 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Ikarian Capital, LLC | 525,000 | 525,000 | 0 | 0.27 | 0.31 | +0.04 | hold |
| NAN FUNG TRINITY (HK) Ltd | 37,095 | 37,095 | 0 | 0.06 | 0.09 | +0.03 | hold |
| Octagon Capital Advisors LP | 574,200 | 574,200 | 0 | 1.38 | 1.33 | -0.05 | hold |
| Polymer Capital Management (HK) LTD | 64,500 | 64,500 | 0 | 0.19 | 0.19 | -0.00 | hold |
| Siren, L.L.C. | 1,857,362 | 1,857,362 | 0 | 1.06 | 1.08 | +0.01 | hold |
| Federation des caisses Desjardins du Quebec | 145 | 145 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CURIO WEALTH, LLC | 27 | 27 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MARK SHEPTOFF FINANCIAL PLANNING, LLC | 300 | 0 | -300 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 6,433 | 6,099 | -334 | 0.00 | 0.00 | +0.00 | sell |
| EverSource Wealth Advisors, LLC | 479 | 14 | -465 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 235,023 | 233,429 | -1,594 | 0.01 | 0.01 | +0.00 | sell |
| ExodusPoint Capital Management, LP | 27,211 | 11,538 | -15,673 | 0.01 | 0.00 | -0.00 | sell |
| HighVista Strategies LLC | 15,877 | 0 | -15,877 | 0.08 | 0.00 | -0.08 | sell |
| MARSHALL WACE, LLP | 20,961 | 0 | -20,961 | 0.00 | 0.00 | -0.00 | sell |
| Logos Global Management LP | 25,000 | 0 | -25,000 | 0.03 | 0.00 | -0.03 | sell |
| JPMORGAN CHASE & CO | 28,379 | 0 | -28,379 | 0.00 | 0.00 | -0.00 | sell |
| Optiver Holding B.V. | 47,728 | 19,047 | -28,681 | 0.02 | 0.02 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 33,947 | 0 | -33,947 | 0.00 | 0.00 | -0.00 | sell |
| SEI INVESTMENTS CO | 66,341 | 16,764 | -49,577 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 223,186 | 168,180 | -55,006 | 0.01 | 0.00 | -0.00 | sell |
| Redmile Group, LLC | 549,840 | 491,340 | -58,500 | 0.78 | 0.68 | -0.10 | sell |
| CITADEL ADVISORS LLC | 145,129 | 0 | -145,129 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 244,862 | 79,537 | -165,325 | 0.00 | 0.00 | -0.00 | sell |
| Vestal Point Capital, LP | 300,000 | 0 | -300,000 | 0.21 | 0.00 | -0.21 | sell |
| MILLENNIUM MANAGEMENT LLC | 640,885 | 318,959 | -321,926 | 0.01 | 0.00 | -0.00 | sell |
| Schonfeld Strategic Advisors LLC | 454,343 | 0 | -454,343 | 0.04 | 0.00 | -0.04 | sell |
| Yiheng Capital Management, L.P. | 639,769 | 170,142 | -469,627 | 5.35 | 1.54 | -3.81 | sell |
| Artisan Partners Limited Partnership | 3,309,055 | 2,219,386 | -1,089,669 | 0.10 | 0.08 | -0.02 | sell |