| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 1,054,506 | +1,054,506 | 0.00 | 0.02 | +0.02 | buy |
| Vivo Capital, LLC | 0 | 1,054,506 | +1,054,506 | 0.00 | 0.99 | +0.99 | buy |
| MPM BioImpact LLC | 0 | 1,054,504 | +1,054,504 | 0.00 | 1.67 | +1.67 | buy |
| Octagon Capital Advisors LP | 0 | 1,018,021 | +1,018,021 | 0.00 | 2.04 | +2.04 | buy |
| GREAT POINT PARTNERS LLC | 0 | 374,679 | +374,679 | 0.00 | 2.23 | +2.23 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 268,014 | +268,014 | 0.00 | 0.00 | +0.00 | buy |
| NAN FUNG TRINITY (HK) Ltd | 0 | 37,095 | +37,095 | 0.00 | 0.04 | +0.04 | buy |
| MYDA Advisors LLC | 0 | 30,220 | +30,220 | 0.00 | 0.08 | +0.08 | buy |
| Point72 Asset Management, L.P. | 0 | 17,000 | +17,000 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 298 | 6,611 | +6,313 | 0.00 | 0.00 | +0.00 | buy |
| Truvestments Capital LLC | 0 | 1,822 | +1,822 | 0.00 | 0.00 | +0.00 | buy |
| Steward Partners Investment Advisory, LLC | 0 | 1,518 | +1,518 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 163,487 | 164,200 | +713 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 0 | 524 | +524 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 0 | 346 | +346 | 0.00 | 0.00 | +0.00 | buy |
| CURIO WEALTH, LLC | 1 | 27 | +26 | 0.00 | 0.00 | +0.00 | buy |
| TRUST CO OF TOLEDO NA /OH/ | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL SECURITIES, INC. | 0 | 8 | +8 | 0.00 | 0.00 | +0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 111 | 111 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BAKER BROS. ADVISORS LP | 1,461,425 | 1,461,425 | 0 | 0.11 | 0.13 | +0.02 | hold |
| Yiheng Capital Management, L.P. | 656,309 | 656,309 | 0 | 1.57 | 2.18 | +0.60 | hold |
| MARK SHEPTOFF FINANCIAL PLANNING, LLC | 300 | 300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Optiver Holding B.V. | 8,347 | 8,347 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Federation des caisses Desjardins du Quebec | 425 | 425 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Banque Transatlantique SA | 92 | 0 | -92 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 3,890 | 3,692 | -198 | 0.00 | 0.00 | +0.00 | sell |
| TORONTO DOMINION BANK | 320 | 0 | -320 | 0.00 | 0.00 | -0.00 | sell |
| Nan Fung Group Holdings Ltd | 37,095 | 0 | -37,095 | 0.21 | 0.00 | -0.21 | sell |
| CANTOR FITZGERALD, L. P. | 95,460 | 0 | -95,460 | 0.02 | 0.00 | -0.02 | sell |