| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| UBS Group AG | 79,537 | 1,313,439 | +1,233,902 | 0.00 | 0.00 | +0.00 | buy |
| Logos Global Management LP | 0 | 915,000 | +915,000 | 0.00 | 0.65 | +0.65 | buy |
| MORGAN STANLEY | 146,116 | 954,908 | +808,792 | 0.00 | 0.00 | +0.00 | buy |
| PERCEPTIVE ADVISORS LLC | 964,391 | 1,653,350 | +688,959 | 0.40 | 0.42 | +0.02 | buy |
| JANE STREET GROUP, LLC | 0 | 223,915 | +223,915 | 0.00 | 0.00 | +0.00 | buy |
| Patient Square Capital LP | 693,534 | 909,474 | +215,940 | 2.57 | 2.31 | -0.26 | buy |
| GREAT POINT PARTNERS LLC | 0 | 156,906 | +156,906 | 0.00 | 0.61 | +0.61 | buy |
| AMERIPRISE FINANCIAL INC | 231,417 | 378,497 | +147,080 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 24,085 | 151,197 | +127,112 | 0.00 | 0.00 | +0.00 | buy |
| Diversify Advisory Services, LLC | 0 | 89,692 | +89,692 | 0.00 | 0.02 | +0.02 | buy |
| DEUTSCHE BANK AG\ | 0 | 59,240 | +59,240 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 42,055 | 91,202 | +49,147 | 0.02 | 0.02 | +0.00 | buy |
| DIVERSIFY WEALTH MANAGEMENT, LLC | 63,672 | 89,692 | +26,020 | 0.02 | 0.02 | -0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 22,782 | +22,782 | 0.00 | 0.00 | +0.00 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 95,714 | 113,823 | +18,109 | 0.00 | 0.00 | -0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 12,148 | +12,148 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 11,630 | +11,630 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 0 | 11,574 | +11,574 | 0.00 | 0.00 | +0.00 | buy |
| Cetera Investment Advisers | 25,358 | 35,257 | +9,899 | 0.00 | 0.00 | -0.00 | buy |
| Persistent Asset Partners Ltd | 11,392 | 15,630 | +4,238 | 0.09 | 0.08 | -0.01 | buy |
| China Universal Asset Management Co., Ltd. | 5,000 | 8,000 | +3,000 | 0.01 | 0.01 | -0.00 | buy |
| State of Wyoming | 0 | 1,445 | +1,445 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 0 | 1,246 | +1,246 | 0.00 | 0.00 | +0.00 | buy |
| Continuum Advisory, LLC | 0 | 400 | +400 | 0.00 | 0.00 | +0.00 | buy |
| PERSONAL CFO SOLUTIONS, LLC | 12,643 | 12,940 | +297 | 0.04 | 0.03 | -0.01 | buy |
| Wilmington Savings Fund Society, FSB | 0 | 276 | +276 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 0 | 200 | +200 | 0.00 | 0.00 | +0.00 | buy |
| HARBOUR INVESTMENTS, INC. | 259 | 362 | +103 | 0.00 | 0.00 | -0.00 | buy |
| Larson Financial Group LLC | 0 | 66 | +66 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 23 | +23 | 0.00 | 0.00 | +0.00 | buy |
| Stone House Investment Management, LLC | 0 | 9 | +9 | 0.00 | 0.00 | +0.00 | buy |
| TRUST CO OF TOLEDO NA /OH/ | 10 | 10 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BAKER BROS. ADVISORS LP | 1,461,425 | 1,461,425 | 0 | 0.18 | 0.12 | -0.06 | hold |
| Yiheng Capital Management, L.P. | 170,142 | 170,142 | 0 | 1.54 | 1.19 | -0.35 | hold |
| Duquesne Family Office LLC | 383,363 | 383,363 | 0 | 0.27 | 0.14 | -0.13 | hold |
| BOOTHBAY FUND MANAGEMENT, LLC | 163,401 | 163,401 | 0 | 0.08 | 0.05 | -0.03 | hold |
| Allworth Financial LP | 1,683 | 1,683 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Pinnacle Wealth Planning Services, Inc. | 40 | 40 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Truvestments Capital LLC | 3,892 | 3,892 | 0 | 0.01 | 0.01 | -0.01 | hold |
| Ikarian Capital, LLC | 525,000 | 525,000 | 0 | 0.31 | 0.28 | -0.04 | hold |
| Octagon Capital Advisors LP | 574,200 | 574,200 | 0 | 1.33 | 0.86 | -0.46 | hold |
| Bell Investment Advisors, Inc | 21 | 21 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Polymer Capital Management (HK) LTD | 64,500 | 64,500 | 0 | 0.19 | 0.11 | -0.08 | hold |
| Farther Finance Advisors, LLC | 164 | 164 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Siren, L.L.C. | 1,857,362 | 1,857,362 | 0 | 1.08 | 0.62 | -0.46 | hold |
| Federation des caisses Desjardins du Quebec | 145 | 145 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ORG Wealth Partners, LLC | 259 | 259 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EverSource Wealth Advisors, LLC | 14 | 0 | -14 | 0.00 | 0.00 | -0.00 | sell |
| CURIO WEALTH, LLC | 27 | 0 | -27 | 0.00 | 0.00 | -0.00 | sell |
| Advisory Services Network, LLC | 30 | 0 | -30 | 0.00 | 0.00 | -0.00 | sell |
| Caitong International Asset Management Co., Ltd | 67 | 13 | -54 | 0.00 | 0.00 | -0.00 | sell |
| GAMMA Investing LLC | 2,899 | 2,832 | -67 | 0.00 | 0.00 | -0.00 | sell |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 111 | 0 | -111 | 0.00 | 0.00 | -0.00 | sell |
| Integrated Wealth Concepts LLC | 10,582 | 10,369 | -213 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 6,099 | 5,611 | -488 | 0.00 | 0.00 | -0.00 | sell |
| Engineers Gate Manager LP | 33,040 | 32,439 | -601 | 0.01 | 0.01 | -0.00 | sell |
| Burns Matteson Capital Management, LLC | 22,631 | 21,818 | -813 | 0.18 | 0.11 | -0.07 | sell |
| BARCLAYS PLC | 8,079 | 7,198 | -881 | 0.00 | 0.00 | -0.00 | sell |
| LPL Financial LLC | 55,871 | 53,751 | -2,120 | 0.00 | 0.00 | -0.00 | sell |
| Atria Investments, Inc | 21,135 | 18,902 | -2,233 | 0.00 | 0.00 | -0.00 | sell |
| STIFEL FINANCIAL CORP | 30,736 | 27,608 | -3,128 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 4,680 | 0 | -4,680 | 0.00 | 0.00 | -0.00 | sell |
| SEI INVESTMENTS CO | 16,764 | 10,809 | -5,955 | 0.00 | 0.00 | -0.00 | sell |
| AdvisorShares Investments LLC | 50,340 | 43,663 | -6,677 | 0.19 | 0.09 | -0.11 | sell |
| Qube Research & Technologies Ltd | 37,427 | 28,805 | -8,622 | 0.00 | 0.00 | -0.00 | sell |
| ExodusPoint Capital Management, LP | 11,538 | 0 | -11,538 | 0.00 | 0.00 | -0.00 | sell |
| Optiver Holding B.V. | 19,047 | 6,455 | -12,592 | 0.02 | 0.00 | -0.01 | sell |
| Dorsey Wright & Associates | 102,550 | 73,115 | -29,435 | 0.27 | 0.20 | -0.06 | sell |
| NAN FUNG TRINITY (HK) Ltd | 37,095 | 0 | -37,095 | 0.09 | 0.00 | -0.09 | sell |
| Russell Investments Group, Ltd. | 128,560 | 84,196 | -44,364 | 0.00 | 0.00 | -0.00 | sell |
| NEW YORK STATE COMMON RETIREMENT FUND | 168,180 | 119,335 | -48,845 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 318,959 | 267,783 | -51,176 | 0.00 | 0.00 | -0.00 | sell |
| Redmile Group, LLC | 491,340 | 410,440 | -80,900 | 0.68 | 0.45 | -0.23 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 233,429 | 0 | -233,429 | 0.01 | 0.00 | -0.01 | sell |
| Atika Capital Management LLC | 271,300 | 0 | -271,300 | 0.89 | 0.00 | -0.89 | sell |
| ADAR1 Capital Management, LLC | 1,012,866 | 528,295 | -484,571 | 1.27 | 0.41 | -0.86 | sell |
| Vivo Capital, LLC | 2,667,569 | 1,844,758 | -822,811 | 4.63 | 2.76 | -1.87 | sell |
| Artisan Partners Limited Partnership | 2,219,386 | 1,372,851 | -846,535 | 0.08 | 0.04 | -0.04 | sell |
| MPM BioImpact LLC | 5,213,361 | 3,666,284 | -1,547,077 | 8.41 | 3.67 | -4.74 | sell |