| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MILLENNIUM MANAGEMENT LLC | 268,014 | 337,863 | +69,849 | 0.00 | 0.00 | +0.00 | buy |
| Artisan Partners Limited Partnership | 0 | 51,920 | +51,920 | 0.00 | 0.00 | +0.00 | buy |
| DLD Asset Management, LP | 0 | 25,000 | +25,000 | 0.00 | 0.03 | +0.03 | buy |
| BARCLAYS PLC | 6,611 | 30,005 | +23,394 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 16,682 | +16,682 | 0.00 | 0.00 | +0.00 | buy |
| GREAT POINT PARTNERS LLC | 374,679 | 378,594 | +3,915 | 2.23 | 1.58 | -0.65 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 0 | 3,420 | +3,420 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 346 | 1,936 | +1,590 | 0.00 | 0.00 | +0.00 | buy |
| Truvestments Capital LLC | 1,822 | 2,272 | +450 | 0.00 | 0.00 | +0.00 | buy |
| TORONTO DOMINION BANK | 0 | 320 | +320 | 0.00 | 0.00 | +0.00 | buy |
| Advisory Services Network, LLC | 0 | 130 | +130 | 0.00 | 0.00 | +0.00 | buy |
| TRUST CO OF TOLEDO NA /OH/ | 10 | 10 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 111 | 111 | 0 | 0.00 | 0.00 | -0.00 | hold |
| PRINCIPAL SECURITIES, INC. | 8 | 8 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BAKER BROS. ADVISORS LP | 1,461,425 | 1,461,425 | 0 | 0.13 | 0.11 | -0.02 | hold |
| Yiheng Capital Management, L.P. | 656,309 | 656,309 | 0 | 2.18 | 2.17 | -0.01 | hold |
| MARK SHEPTOFF FINANCIAL PLANNING, LLC | 300 | 300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Vivo Capital, LLC | 1,054,506 | 1,054,506 | 0 | 0.99 | 0.85 | -0.14 | hold |
| MPM BioImpact LLC | 1,054,504 | 1,054,504 | 0 | 1.67 | 1.73 | +0.05 | hold |
| NAN FUNG TRINITY (HK) Ltd | 37,095 | 37,095 | 0 | 0.04 | 0.04 | -0.00 | hold |
| Octagon Capital Advisors LP | 1,018,021 | 1,018,021 | 0 | 2.04 | 1.59 | -0.46 | hold |
| Optiver Holding B.V. | 8,347 | 8,347 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CURIO WEALTH, LLC | 27 | 27 | 0 | 0.00 | 0.00 | +0.00 | hold |
| RHUMBLINE ADVISERS | 3,692 | 3,611 | -81 | 0.00 | 0.00 | +0.00 | sell |
| Federation des caisses Desjardins du Quebec | 425 | 150 | -275 | 0.00 | 0.00 | -0.00 | sell |
| EverSource Wealth Advisors, LLC | 524 | 23 | -501 | 0.00 | 0.00 | -0.00 | sell |
| Steward Partners Investment Advisory, LLC | 1,518 | 0 | -1,518 | 0.00 | 0.00 | -0.00 | sell |
| Point72 Asset Management, L.P. | 17,000 | 0 | -17,000 | 0.00 | 0.00 | -0.00 | sell |
| MYDA Advisors LLC | 30,220 | 0 | -30,220 | 0.08 | 0.00 | -0.08 | sell |
| UBS Group AG | 164,200 | 0 | -164,200 | 0.00 | 0.00 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,054,506 | 345,934 | -708,572 | 0.02 | 0.01 | -0.01 | sell |