| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Artisan Partners Limited Partnership | 51,920 | 3,309,055 | +3,257,135 | 0.00 | 0.10 | +0.10 | buy |
| Siren, L.L.C. | 0 | 1,857,362 | +1,857,362 | 0.00 | 1.06 | +1.06 | buy |
| Vivo Capital, LLC | 1,054,506 | 2,461,626 | +1,407,120 | 0.85 | 3.05 | +2.20 | buy |
| Redmile Group, LLC | 0 | 549,840 | +549,840 | 0.00 | 0.78 | +0.78 | buy |
| Ikarian Capital, LLC | 0 | 525,000 | +525,000 | 0.00 | 0.27 | +0.27 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 454,343 | +454,343 | 0.00 | 0.04 | +0.04 | buy |
| Patient Square Capital LP | 0 | 359,050 | +359,050 | 0.00 | 1.47 | +1.47 | buy |
| MILLENNIUM MANAGEMENT LLC | 337,863 | 640,885 | +303,022 | 0.00 | 0.01 | +0.01 | buy |
| Vestal Point Capital, LP | 0 | 300,000 | +300,000 | 0.00 | 0.21 | +0.21 | buy |
| UBS Group AG | 0 | 244,862 | +244,862 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 235,023 | +235,023 | 0.00 | 0.01 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 3,420 | 223,186 | +219,766 | 0.00 | 0.01 | +0.01 | buy |
| Atika Capital Management LLC | 0 | 206,881 | +206,881 | 0.00 | 0.55 | +0.55 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 163,401 | +163,401 | 0.00 | 0.08 | +0.08 | buy |
| CITADEL ADVISORS LLC | 0 | 145,129 | +145,129 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 0 | 122,495 | +122,495 | 0.00 | 0.00 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 66,341 | +66,341 | 0.00 | 0.00 | +0.00 | buy |
| Polymer Capital Management (HK) LTD | 0 | 64,500 | +64,500 | 0.00 | 0.19 | +0.19 | buy |
| Optiver Holding B.V. | 8,347 | 47,728 | +39,381 | 0.00 | 0.02 | +0.02 | buy |
| JPMORGAN CHASE & CO | 0 | 28,379 | +28,379 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 27,211 | +27,211 | 0.00 | 0.01 | +0.01 | buy |
| Logos Global Management LP | 0 | 25,000 | +25,000 | 0.00 | 0.03 | +0.03 | buy |
| Engineers Gate Manager LP | 0 | 24,984 | +24,984 | 0.00 | 0.01 | +0.01 | buy |
| ENVESTNET ASSET MANAGEMENT INC | 0 | 22,392 | +22,392 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 20,961 | +20,961 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 16,682 | 33,947 | +17,265 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 0 | 15,877 | +15,877 | 0.00 | 0.08 | +0.08 | buy |
| Qube Research & Technologies Ltd | 0 | 13,736 | +13,736 | 0.00 | 0.00 | +0.00 | buy |
| Cetera Investment Advisers | 0 | 13,115 | +13,115 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 0 | 6,019 | +6,019 | 0.00 | 0.06 | +0.06 | buy |
| RHUMBLINE ADVISERS | 3,611 | 6,433 | +2,822 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 0 | 1,683 | +1,683 | 0.00 | 0.00 | +0.00 | buy |
| Truvestments Capital LLC | 2,272 | 3,892 | +1,620 | 0.00 | 0.01 | +0.01 | buy |
| GAMMA Investing LLC | 1,936 | 2,680 | +744 | 0.00 | 0.00 | +0.00 | buy |
| EverSource Wealth Advisors, LLC | 23 | 479 | +456 | 0.00 | 0.00 | +0.00 | buy |
| Pinnacle Wealth Planning Services, Inc. | 0 | 40 | +40 | 0.00 | 0.00 | +0.00 | buy |
| TRUST CO OF TOLEDO NA /OH/ | 10 | 10 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 111 | 111 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BAKER BROS. ADVISORS LP | 1,461,425 | 1,461,425 | 0 | 0.11 | 0.16 | +0.06 | hold |
| MARK SHEPTOFF FINANCIAL PLANNING, LLC | 300 | 300 | 0 | 0.00 | 0.00 | +0.00 | hold |
| NAN FUNG TRINITY (HK) Ltd | 37,095 | 37,095 | 0 | 0.04 | 0.06 | +0.02 | hold |
| CURIO WEALTH, LLC | 27 | 27 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Federation des caisses Desjardins du Quebec | 150 | 145 | -5 | 0.00 | 0.00 | +0.00 | sell |
| PRINCIPAL SECURITIES, INC. | 8 | 0 | -8 | 0.00 | 0.00 | -0.00 | sell |
| Advisory Services Network, LLC | 130 | 0 | -130 | 0.00 | 0.00 | -0.00 | sell |
| TORONTO DOMINION BANK | 320 | 0 | -320 | 0.00 | 0.00 | -0.00 | sell |
| Yiheng Capital Management, L.P. | 656,309 | 639,769 | -16,540 | 2.17 | 5.35 | +3.18 | sell |
| DLD Asset Management, LP | 25,000 | 0 | -25,000 | 0.03 | 0.00 | -0.03 | sell |
| BARCLAYS PLC | 30,005 | 0 | -30,005 | 0.00 | 0.00 | -0.00 | sell |
| MPM BioImpact LLC | 1,054,504 | 996,825 | -57,679 | 1.73 | 2.19 | +0.46 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 345,934 | 0 | -345,934 | 0.01 | 0.00 | -0.01 | sell |
| GREAT POINT PARTNERS LLC | 378,594 | 0 | -378,594 | 1.58 | 0.00 | -1.58 | sell |
| Octagon Capital Advisors LP | 1,018,021 | 574,200 | -443,821 | 1.59 | 1.38 | -0.21 | sell |