| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| PFM Health Sciences, LP | 6,480,764 | 6,483,270 | +2,506 | 2.23 | 1.66 | -0.57 | buy |
| STATE STREET CORP | 5,119,666 | 6,347,321 | +1,227,655 | 0.00 | 0.00 | +0.00 | buy |
| Avidity Partners Management LP | 6,360,212 | 5,785,352 | -574,860 | 1.39 | 1.06 | -0.34 | sell |
| VANGUARD GROUP INC | 3,962,044 | 4,110,795 | +148,751 | 0.00 | 0.00 | -0.00 | buy |
| Point72 Asset Management, L.P. | 3,521,376 | 3,585,018 | +63,642 | 0.06 | 0.05 | -0.01 | buy |
| ALKEON CAPITAL MANAGEMENT LLC | 3,113,564 | 2,743,505 | -370,059 | 0.12 | 0.08 | -0.04 | sell |
| Elmwood Wealth Management, Inc. | 2,364,260 | 2,364,240 | -20 | 9.50 | 5.20 | -4.30 | sell |
| Paradigm Biocapital Advisors LP | 2,923,851 | 2,172,620 | -751,231 | 0.79 | 0.39 | -0.39 | sell |
| DIMENSIONAL FUND ADVISORS LP | 1,350,784 | 2,087,121 | +736,337 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 0 | 1,842,914 | +1,842,914 | 0.00 | 0.07 | +0.07 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,794,648 | 1,842,183 | +47,535 | 0.00 | 0.00 | -0.00 | buy |
| FMR LLC | 1,444,576 | 1,445,162 | +586 | 0.00 | 0.00 | -0.00 | buy |
| Candriam S.C.A. | 860,024 | 1,145,063 | +285,039 | 0.03 | 0.04 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 1,593,136 | 1,116,769 | -476,367 | 0.00 | 0.00 | -0.00 | sell |
| Kynam Capital Management, LP | 1,068,527 | 1,068,527 | 0 | 0.69 | 0.61 | -0.08 | hold |
| FIL Ltd | 860,666 | 860,666 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Rokos Capital Management LLP | 840,630 | 840,630 | 0 | 0.15 | 0.11 | -0.04 | hold |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 807,759 | 824,657 | +16,898 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 757,362 | 734,265 | -23,097 | 0.00 | 0.00 | -0.00 | sell |
| MAVERICK CAPITAL LTD | 652,542 | 652,542 | 0 | 0.08 | 0.06 | -0.01 | hold |
| GOLDMAN SACHS GROUP INC | 660,040 | 602,902 | -57,138 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 576,984 | 549,053 | -27,931 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 381,198 | 541,449 | +160,251 | 0.01 | 0.01 | +0.00 | buy |
| CITADEL ADVISORS LLC | 0 | 526,914 | +526,914 | 0.00 | 0.00 | +0.00 | buy |
| 72 Investment Holdings, LLC | 474,067 | 474,067 | 0 | 12.06 | 3.63 | -8.43 | hold |
| CITIGROUP INC | 161,719 | 469,520 | +307,801 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 314,080 | 441,806 | +127,726 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 1,104,813 | 414,497 | -690,316 | 0.00 | 0.00 | -0.00 | sell |
| UBS Group AG | 326,529 | 408,275 | +81,746 | 0.00 | 0.00 | -0.00 | buy |
| MARSHALL WACE, LLP | 57,730 | 368,257 | +310,527 | 0.00 | 0.00 | +0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 344,495 | +344,495 | 0.00 | 0.06 | +0.06 | buy |
| Bank of New York Mellon Corp | 295,234 | 270,175 | -25,059 | 0.00 | 0.00 | -0.00 | sell |
| ROYCE & ASSOCIATES LP | 253,102 | 258,928 | +5,826 | 0.01 | 0.01 | -0.00 | buy |
| WESTWOOD HOLDINGS GROUP INC | 277,205 | 251,467 | -25,738 | 0.01 | 0.01 | -0.00 | sell |
| Woodline Partners LP | 1,140,671 | 237,277 | -903,394 | 0.07 | 0.01 | -0.06 | sell |
| Mirae Asset Global Investments Co., Ltd. | 173,606 | 230,192 | +56,586 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 504,599 | 229,747 | -274,852 | 0.01 | 0.00 | -0.00 | sell |
| Bruce & Co., Inc. | 200,000 | 200,000 | 0 | 0.40 | 0.34 | -0.06 | hold |
| Resonant Capital Advisors, LLC | 184,198 | 184,198 | 0 | 0.10 | 0.08 | -0.02 | hold |
| Aberdeen Group plc | 181,487 | 181,487 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Squarepoint Ops LLC | 92,668 | 169,924 | +77,256 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 162,683 | +162,683 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 158,612 | +158,612 | 0.00 | 0.01 | +0.01 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 144,317 | 156,238 | +11,921 | 0.00 | 0.00 | -0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 203,933 | 153,933 | -50,000 | 0.00 | 0.00 | -0.00 | sell |
| DekaBank Deutsche Girozentrale | 130,000 | 130,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Alyeska Investment Group, L.P. | 125,000 | 125,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RHUMBLINE ADVISERS | 119,062 | 122,517 | +3,455 | 0.00 | 0.00 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 14,214 | 121,489 | +107,275 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA FUNDAMENTAL INVESTMENTS, LLC | 0 | 108,604 | +108,604 | 0.00 | 0.03 | +0.03 | buy |
| AMERICAN CENTURY COMPANIES INC | 75,132 | 108,499 | +33,367 | 0.00 | 0.00 | +0.00 | buy |
| Artal Group S.A. | 105,347 | 105,347 | 0 | 0.02 | 0.01 | -0.01 | hold |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 117,606 | 99,954 | -17,652 | 0.00 | 0.00 | -0.00 | sell |
| BARCLAYS PLC | 263,471 | 97,233 | -166,238 | 0.00 | 0.00 | -0.00 | sell |
| Curi Capital, LLC | 76,350 | 93,259 | +16,909 | 0.01 | 0.01 | -0.00 | buy |
| Nelson Capital Management, LLC | 85,020 | 85,020 | 0 | 0.11 | 0.08 | -0.03 | hold |
| ALLIANCEBERNSTEIN L.P. | 85,760 | 84,630 | -1,130 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 62,237 | 83,787 | +21,550 | 0.02 | 0.02 | +0.00 | buy |
| Green Alpha Advisors, LLC | 79,564 | 83,521 | +3,957 | 0.33 | 0.31 | -0.02 | buy |
| Virtu Financial LLC | 16,558 | 82,100 | +65,542 | 0.01 | 0.03 | +0.02 | buy |
| PRUDENTIAL FINANCIAL INC | 14,924 | 81,618 | +66,694 | 0.00 | 0.00 | +0.00 | buy |
| Granahan Investment Management, LLC | 138,330 | 73,192 | -65,138 | 0.03 | 0.01 | -0.01 | sell |
| Invesco Ltd. | 77,029 | 70,262 | -6,767 | 0.00 | 0.00 | -0.00 | sell |
| STANSBERRY ASSET MANAGEMENT, LLC | 68,450 | 64,337 | -4,113 | 0.07 | 0.04 | -0.02 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 86,600 | 63,600 | -23,000 | 0.00 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 114,333 | 61,219 | -53,114 | 0.00 | 0.00 | -0.00 | sell |
| Cubist Systematic Strategies, LLC | 2,102 | 57,657 | +55,555 | 0.00 | 0.00 | +0.00 | buy |
| EXCHANGE TRADED CONCEPTS, LLC | 23,924 | 53,160 | +29,236 | 0.00 | 0.01 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 51,291 | 50,962 | -329 | 0.00 | 0.00 | -0.00 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 50,135 | 49,530 | -605 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 68,800 | 46,400 | -22,400 | 0.00 | 0.00 | -0.00 | sell |
| Allspring Global Investments Holdings, LLC | 39,059 | 42,653 | +3,594 | 0.00 | 0.00 | -0.00 | buy |
| Mitsubishi UFJ Asset Management Co., Ltd. | 44,202 | 42,266 | -1,936 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 40,690 | 40,690 | 0 | 0.00 | 0.00 | -0.00 | hold |
| AMERICAN INTERNATIONAL GROUP, INC. | 40,693 | 40,347 | -346 | 0.00 | 0.00 | -0.00 | sell |
| ROYAL BANK OF CANADA | 281,937 | 38,757 | -243,180 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 36,551 | 36,555 | +4 | 0.00 | 0.00 | -0.00 | buy |
| CORNERCAP INVESTMENT COUNSEL INC | 0 | 35,754 | +35,754 | 0.00 | 0.03 | +0.03 | buy |
| DEUTSCHE BANK AG\ | 34,887 | 35,672 | +785 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 26,927 | 35,301 | +8,374 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 34,249 | 34,232 | -17 | 0.00 | 0.00 | -0.00 | sell |
| Thrive Wealth Management, LLC | 32,000 | 32,000 | 0 | 0.04 | 0.03 | -0.01 | hold |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 32,103 | 31,245 | -858 | 0.00 | 0.00 | +0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 30,703 | 30,703 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Walleye Trading LLC | 0 | 30,071 | +30,071 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 29,583 | +29,583 | 0.00 | 0.00 | +0.00 | buy |
| Bayesian Capital Management, LP | 0 | 29,284 | +29,284 | 0.00 | 0.01 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 32,684 | 27,052 | -5,632 | 0.00 | 0.00 | -0.00 | sell |
| SG Americas Securities, LLC | 39,577 | 26,635 | -12,942 | 0.00 | 0.00 | -0.00 | sell |
| Assenagon Asset Management S.A. | 2,258,539 | 26,592 | -2,231,947 | 0.04 | 0.00 | -0.04 | sell |
| E Fund Management Co., Ltd. | 20,351 | 25,586 | +5,235 | 0.01 | 0.01 | +0.00 | buy |
| LPL Financial LLC | 0 | 23,897 | +23,897 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 20,835 | 23,380 | +2,545 | 0.00 | 0.00 | -0.00 | buy |
| Entropy Technologies, LP | 0 | 22,062 | +22,062 | 0.00 | 0.01 | +0.01 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 23,745 | 22,019 | -1,726 | 0.00 | 0.00 | -0.00 | sell |
| Pale Fire Capital SE | 28,200 | 21,700 | -6,500 | 0.03 | 0.02 | -0.01 | sell |
| ProShare Advisors LLC | 19,203 | 20,907 | +1,704 | 0.00 | 0.00 | -0.00 | buy |
| Ancora Advisors LLC | 0 | 20,000 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 16,134 | 19,610 | +3,476 | 0.01 | 0.01 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 17,313 | 19,212 | +1,899 | 0.00 | 0.00 | -0.00 | buy |