| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| ALKEON CAPITAL MANAGEMENT LLC | 1,644,863 | 3,113,564 | +1,468,701 | 0.01 | 0.04 | +0.03 | buy |
| Woodline Partners LP | 461,538 | 1,140,671 | +679,133 | 0.03 | 0.07 | +0.05 | buy |
| Avidity Partners Management LP | 6,050,212 | 6,360,212 | +310,000 | 1.16 | 1.39 | +0.23 | buy |
| ROYCE & ASSOCIATES LP | 24,315 | 253,102 | +228,787 | 0.00 | 0.01 | +0.01 | buy |
| WESTWOOD HOLDINGS GROUP INC | 152,436 | 277,205 | +124,769 | 0.01 | 0.01 | +0.01 | buy |
| Atom Investors LP | 123,427 | 160,661 | +37,234 | 0.13 | 0.16 | +0.03 | buy |
| Laurion Capital Management LP | 165,192 | 192,351 | +27,159 | 0.00 | 0.01 | +0.00 | buy |
| PROFUND ADVISORS LLC | 84,899 | 62,237 | +22,662 | 0.02 | 0.02 | 0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 892,786 | 900,818 | +8,032 | 1.59 | 1.59 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 2,258 | 10,226 | +7,968 | 0.00 | 0.01 | +0.01 | buy |
| Granahan Investment Management, LLC | 136,378 | 138,330 | +1,952 | 0.02 | 0.03 | +0.00 | buy |
| Elmwood Wealth Management, Inc. | 2,364,415 | 2,364,260 | -155 | 5.45 | 9.50 | +4.05 | sell |
| E Fund Management Co., Ltd. | 26,065 | 20,351 | -5,714 | 0.01 | 0.01 | -0.00 | sell |
| VIRTUS ADVISERS, LLC | 21,358 | 15,005 | -6,353 | 0.06 | 0.05 | -0.01 | sell |
| STANSBERRY ASSET MANAGEMENT, LLC | 77,232 | 68,450 | -8,782 | 0.06 | 0.07 | +0.00 | sell |
| Prime Capital Investment Advisors, LLC | 36,463 | 17,676 | -18,787 | 0.00 | 0.00 | -0.00 | sell |
| Paradigm Biocapital Advisors LP | 2,944,513 | 2,923,851 | -20,662 | 0.96 | 0.79 | -0.17 | sell |
| Green Alpha Advisors, LLC | 110,524 | 79,564 | -30,960 | 0.41 | 0.33 | -0.08 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 253,933 | 203,933 | -50,000 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 507,400 | 381,198 | -126,202 | 0.01 | 0.01 | -0.01 | sell |
| PFM Health Sciences, LP | 6,724,715 | 6,480,764 | -243,951 | 1.51 | 2.23 | +0.71 | sell |
| Rokos Capital Management LLP | 2,748,139 | 840,630 | -1,907,509 | 0.10 | 0.04 | -0.05 | sell |