| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 0 | 27,404,070 | +27,404,070 | 0.00 | 1.10 | +1.10 | buy |
| Cubist Systematic Strategies, LLC | 34,607 | 675,882 | +641,275 | 0.00 | 0.01 | +0.01 | buy |
| MILLENNIUM MANAGEMENT LLC | 441,032 | 825,179 | +384,147 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 254,013 | +254,013 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 0 | 196,696 | +196,696 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 0 | 108,856 | +108,856 | 0.00 | 0.00 | +0.00 | buy |
| CAPTRUST FINANCIAL ADVISORS | 17,254 | 111,952 | +94,698 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 15,979 | 107,562 | +91,583 | 0.00 | 0.00 | +0.00 | buy |
| CIBC Private Wealth Group LLC | 0 | 76,721 | +76,721 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 67,665 | +67,665 | 0.00 | 0.00 | +0.00 | buy |
| Acuitas Investments, LLC | 479,789 | 538,321 | +58,532 | 0.20 | 0.43 | +0.23 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 147,732 | 188,070 | +40,338 | 0.02 | 0.04 | +0.02 | buy |
| JTC Employer Solutions Trustee Ltd | 0 | 26,156 | +26,156 | 0.00 | 0.00 | +0.00 | buy |
| Vontobel Holding Ltd. | 0 | 23,000 | +23,000 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 51 | 22,367 | +22,316 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,370,239 | 1,391,775 | +21,536 | 0.00 | 0.00 | +0.00 | buy |
| COLUMBIA ADVISORY PARTNERS LLC | 0 | 15,585 | +15,585 | 0.00 | 0.02 | +0.02 | buy |
| Ballentine Partners, LLC | 0 | 14,489 | +14,489 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 14,474 | +14,474 | 0.00 | 0.00 | +0.00 | buy |
| Procyon Advisors, LLC | 0 | 13,000 | +13,000 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 0 | 10,510 | +10,510 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 305,336 | 312,538 | +7,202 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 0 | 6,253 | +6,253 | 0.00 | 0.00 | +0.00 | buy |
| WETZEL INVESTMENT ADVISORS, INC. | 3,000 | 6,000 | +3,000 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 0 | 2,037 | +2,037 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 5,912 | 7,122 | +1,210 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 57,423 | 57,500 | +77 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| CSS LLC/IL | 30,702 | 30,702 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 117,909 | 117,909 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MPM ASSET MANAGEMENT LLC | 5,555,461 | 5,555,461 | 0 | 2.16 | 3.58 | +1.42 | hold |
| Janney Montgomery Scott LLC | 30,000 | 30,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rathbones Group PLC | 432,818 | 432,818 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HUNTER ASSOCIATES INVESTMENT MANAGEMENT LLC | 23,000 | 23,000 | 0 | 0.00 | 0.01 | +0.00 | hold |
| Marquette Asset Management, LLC | 98,589 | 98,589 | 0 | 0.01 | 0.03 | +0.01 | hold |
| Matrix Capital Management Company, LP | 38,974,185 | 38,974,185 | 0 | 0.32 | 0.57 | +0.25 | hold |
| Redmile Group, LLC | 715,607 | 715,607 | 0 | 0.02 | 0.04 | +0.02 | hold |
| PFM Health Sciences, LP | 10,423,135 | 10,423,135 | 0 | 0.50 | 0.82 | +0.32 | hold |
| NEA Management Company, LLC | 17,079,778 | 17,079,778 | 0 | 0.90 | 1.68 | +0.77 | hold |
| Rock Springs Capital Management LP | 2,425,468 | 2,425,468 | 0 | 0.05 | 0.10 | +0.05 | hold |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 32,239 | 32,239 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MPM BioImpact LLC | 5,095,912 | 5,095,912 | 0 | 0.95 | 1.29 | +0.35 | hold |
| SIMON QUICK ADVISORS, LLC | 30,000 | 30,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Investors Research Corp | 100 | 100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Global Retirement Partners, LLC | 6,000 | 6,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Main Street Financial Solutions, LLC | 31,190 | 31,190 | 0 | 0.00 | 0.01 | +0.00 | hold |
| HighMark Wealth Management LLC | 287 | 287 | 0 | 0.00 | 0.00 | +0.00 | hold |
| DLK Investment Management, LLC | 30,512 | 30,512 | 0 | 0.01 | 0.02 | +0.01 | hold |
| Federation des caisses Desjardins du Quebec | 785 | 785 | 0 | 0.00 | 0.00 | +0.00 | hold |
| BARCLAYS PLC | 50,061 | 50,061 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Advisory Services Network, LLC | 125 | 0 | -125 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 300 | 0 | -300 | 0.00 | 0.00 | 0.00 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 16,758 | 16,346 | -412 | 0.00 | 0.00 | +0.00 | sell |
| HSBC HOLDINGS PLC | 26,504 | 26,064 | -440 | 0.00 | 0.00 | +0.00 | sell |
| FMR LLC | 1,733,141 | 1,732,565 | -576 | 0.00 | 0.00 | +0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 2,162 | 213 | -1,949 | 0.00 | 0.00 | -0.00 | sell |
| Prosperity Wealth Management, Inc. | 28,620 | 26,620 | -2,000 | 0.01 | 0.02 | +0.01 | sell |
| WELLS FARGO & COMPANY/MN | 56,177 | 54,172 | -2,005 | 0.00 | 0.00 | +0.00 | sell |
| Qube Research & Technologies Ltd | 2,087 | 0 | -2,087 | 0.00 | 0.00 | -0.00 | sell |
| STIFEL FINANCIAL CORP | 27,259 | 23,797 | -3,462 | 0.00 | 0.00 | +0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 4,160 | 0 | -4,160 | 0.00 | 0.00 | -0.00 | sell |
| OPPENHEIMER & CO INC | 50,103 | 43,832 | -6,271 | 0.00 | 0.00 | +0.00 | sell |
| DAFNA Capital Management LLC | 351,064 | 341,064 | -10,000 | 0.07 | 0.12 | +0.06 | sell |
| Scientech Research LLC | 10,205 | 0 | -10,205 | 0.01 | 0.00 | -0.01 | sell |
| Tower Research Capital LLC (TRC) | 10,664 | 0 | -10,664 | 0.00 | 0.00 | -0.00 | sell |
| Douglas Lane & Associates, LLC | 11,000 | 0 | -11,000 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 928,224 | 915,030 | -13,194 | 0.00 | 0.00 | +0.00 | sell |
| TWO SIGMA ADVISERS, LP | 59,837 | 46,137 | -13,700 | 0.00 | 0.00 | +0.00 | sell |
| X-Square Capital, LLC | 27,425 | 11,192 | -16,233 | 0.01 | 0.01 | -0.01 | sell |
| XTX Topco Ltd | 36,977 | 15,952 | -21,025 | 0.01 | 0.00 | -0.00 | sell |
| Newman Dignan & Sheerar, Inc. | 23,031 | 0 | -23,031 | 0.01 | 0.00 | -0.01 | sell |
| Virtu Financial LLC | 28,406 | 0 | -28,406 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 4,697,954 | 4,667,787 | -30,167 | 0.00 | 0.00 | +0.00 | sell |
| BAILLIE GIFFORD & CO | 15,912,140 | 15,871,875 | -40,265 | 0.01 | 0.02 | +0.01 | sell |
| TWIN FOCUS CAPITAL PARTNERS, LLC | 55,526 | 0 | -55,526 | 0.00 | 0.00 | -0.00 | sell |
| HRT FINANCIAL LP | 59,906 | 0 | -59,906 | 0.00 | 0.00 | -0.00 | sell |
| Key Client Fiduciary Advisors, LLC | 336,620 | 268,655 | -67,965 | 0.16 | 0.23 | +0.07 | sell |
| GSA CAPITAL PARTNERS LLP | 508,808 | 370,179 | -138,629 | 0.03 | 0.05 | +0.01 | sell |
| BAKER BROS. ADVISORS LP | 10,969,282 | 10,787,022 | -182,260 | 0.10 | 0.21 | +0.11 | sell |
| Syncona Portfolio Ltd | 1,377,294 | 0 | -1,377,294 | 0.69 | 0.00 | -0.69 | sell |
| Long Focus Capital Management, LLC | 12,086,915 | 10,684,233 | -1,402,682 | 1.24 | 1.95 | +0.71 | sell |
| MORGAN STANLEY | 1,956,658 | 0 | -1,956,658 | 0.00 | 0.00 | -0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 4,387,238 | 1,443,619 | -2,943,619 | 0.32 | 0.24 | -0.08 | sell |
| CITADEL ADVISORS LLC | 3,399,514 | 243,691 | -3,155,823 | 0.00 | 0.00 | -0.00 | sell |