| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Two Seas Capital LP | 14,835,146 | 20,529,685 | +5,694,539 | 0.94 | 0.63 | -0.32 | buy |
| Long Focus Capital Management, LLC | 20,494,393 | 23,756,687 | +3,262,294 | 0.85 | 0.32 | -0.53 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 510,216 | 2,218,215 | +1,707,999 | 0.00 | 0.00 | +0.00 | buy |
| Clear Harbor Asset Management, LLC | 18,525 | 240,725 | +222,200 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 70,735 | 206,732 | +135,997 | 0.00 | 0.00 | +0.00 | buy |
| State of Tennessee, Department of Treasury | 0 | 73,376 | +73,376 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 29,559 | 94,283 | +64,724 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 76,347 | 135,947 | +59,600 | 0.00 | 0.00 | -0.00 | buy |
| SEI INVESTMENTS CO | 0 | 54,824 | +54,824 | 0.00 | 0.00 | +0.00 | buy |
| State of New Jersey Common Pension Fund D | 0 | 54,718 | +54,718 | 0.00 | 0.00 | +0.00 | buy |
| Federation des caisses Desjardins du Quebec | 755 | 53,186 | +52,431 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 37,195 | 87,274 | +50,079 | 0.00 | 0.00 | -0.00 | buy |
| STATE STREET CORP | 400,079 | 421,292 | +21,213 | 0.00 | 0.00 | -0.00 | buy |
| COLUMBIA ADVISORY PARTNERS LLC | 16,420 | 36,530 | +20,110 | 0.01 | 0.01 | -0.00 | buy |
| Invesco Ltd. | 63,335 | 78,031 | +14,696 | 0.00 | 0.00 | -0.00 | buy |
| Ausdal Financial Partners, Inc. | 0 | 12,476 | +12,476 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 10,113 | +10,113 | 0.00 | 0.00 | +0.00 | buy |
| IFG Advisory, LLC | 0 | 10,000 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 19,530 | 21,966 | +2,436 | 0.00 | 0.00 | -0.00 | buy |
| Banque Transatlantique SA | 0 | 1,824 | +1,824 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 20 | +20 | 0.00 | 0.00 | +0.00 | buy |
| SBI Securities Co., Ltd. | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 50,061 | 50,068 | +7 | 0.00 | 0.00 | -0.00 | buy |
| CSS LLC/IL | 30,702 | 30,702 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 213 | 213 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CIBC Private Wealth Group LLC | 3,023 | 3,023 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rathbones Group PLC | 432,818 | 432,818 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Plante Moran Financial Advisors, LLC | 925 | 925 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEA Management Company, LLC | 17,079,778 | 17,079,778 | 0 | 0.52 | 0.26 | -0.26 | hold |
| Newman Dignan & Sheerar, Inc. | 27,957 | 27,957 | 0 | 0.00 | 0.00 | -0.00 | hold |
| EcoR1 Capital, LLC | 27,404,070 | 27,404,070 | 0 | 0.59 | 0.32 | -0.27 | hold |
| Rock Springs Capital Management LP | 2,483,468 | 2,483,468 | 0 | 0.05 | 0.03 | -0.02 | hold |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 26,816 | 26,816 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Parallel Advisors, LLC | 250 | 250 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SIMON QUICK ADVISORS, LLC | 30,000 | 30,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| X-Square Capital, LLC | 11,173 | 11,173 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Investors Research Corp | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HighMark Wealth Management LLC | 287 | 287 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TD Waterhouse Canada Inc. | 14 | 14 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BlackRock, Inc. | 183,686 | 183,686 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Transce3nd, LLC | 175 | 175 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Raiffeisen Bank International AG | 907 | 907 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STIFEL FINANCIAL CORP | 26,469 | 26,469 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NORTHERN TRUST CORP | 51,333 | 51,333 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| HSBC HOLDINGS PLC | 26,064 | 26,064 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Wilmington Savings Fund Society, FSB | 604 | 604 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GOLDMAN SACHS GROUP INC | 16,160 | 16,149 | -11 | 0.00 | 0.00 | -0.00 | sell |
| CAPTRUST FINANCIAL ADVISORS | 81,629 | 80,609 | -1,020 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 19,748 | 18,313 | -1,435 | 0.00 | 0.00 | -0.00 | sell |
| Prosperity Wealth Management, Inc. | 21,870 | 19,798 | -2,072 | 0.00 | 0.00 | -0.00 | sell |
| IFP Advisors, Inc | 3,023 | 0 | -3,023 | 0.00 | 0.00 | -0.00 | sell |
| RAYMOND JAMES FINANCIAL INC | 31,081 | 25,261 | -5,820 | 0.00 | 0.00 | -0.00 | sell |
| R Squared Ltd | 8,770 | 0 | -8,770 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 1,764,506 | 1,754,889 | -9,617 | 0.00 | 0.00 | -0.00 | sell |
| Squarepoint Ops LLC | 16,563 | 0 | -16,563 | 0.00 | 0.00 | -0.00 | sell |
| PKS Advisory Services, LLC | 17,000 | 0 | -17,000 | 0.00 | 0.00 | -0.00 | sell |
| Baader Bank Aktiengesellschaft | 18,095 | 0 | -18,095 | 0.00 | 0.00 | -0.00 | sell |
| KINGSWOOD WEALTH ADVISORS, LLC | 18,690 | 0 | -18,690 | 0.00 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 20,515 | 147 | -20,368 | 0.00 | 0.00 | -0.00 | sell |
| HUNTER ASSOCIATES INVESTMENT MANAGEMENT LLC | 22,000 | 0 | -22,000 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 139,801 | 109,066 | -30,735 | 0.00 | 0.00 | -0.00 | sell |
| OPPENHEIMER & CO INC | 32,043 | 0 | -32,043 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 916,941 | 882,331 | -34,610 | 0.00 | 0.00 | -0.00 | sell |
| Vontobel Holding Ltd. | 43,000 | 0 | -43,000 | 0.00 | 0.00 | -0.00 | sell |
| Palisades Investment Partners, LLC | 47,114 | 0 | -47,114 | 0.01 | 0.00 | -0.01 | sell |
| HRT FINANCIAL LP | 83,199 | 0 | -83,199 | 0.00 | 0.00 | -0.00 | sell |
| Key Client Fiduciary Advisors, LLC | 255,359 | 150,150 | -105,209 | 0.06 | 0.01 | -0.05 | sell |
| Virtu Financial LLC | 122,696 | 0 | -122,696 | 0.00 | 0.00 | -0.00 | sell |
| LPL Financial LLC | 183,479 | 0 | -183,479 | 0.00 | 0.00 | -0.00 | sell |
| MPM BioImpact LLC | 5,095,912 | 4,894,344 | -201,568 | 0.39 | 0.17 | -0.22 | sell |
| MPM ASSET MANAGEMENT LLC | 5,555,461 | 5,335,715 | -219,746 | 2.41 | 1.51 | -0.89 | sell |
| MARSHALL WACE, LLP | 529,123 | 0 | -529,123 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 2,526,524 | 1,813,860 | -712,664 | 0.00 | 0.00 | -0.00 | sell |
| Redmile Group, LLC | 715,607 | 0 | -715,607 | 0.03 | 0.00 | -0.03 | sell |
| BANK OF AMERICA CORP /DE/ | 2,862,330 | 0 | -2,862,330 | 0.00 | 0.00 | -0.00 | sell |
| PFM Health Sciences, LP | 4,871,969 | 0 | -4,871,969 | 0.20 | 0.00 | -0.20 | sell |
| BAILLIE GIFFORD & CO | 11,819,095 | 0 | -11,819,095 | 0.00 | 0.00 | -0.00 | sell |