| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Long Focus Capital Management, LLC | 10,684,233 | 12,346,417 | +1,662,184 | 1.95 | 1.25 | -0.70 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,391,775 | 1,786,341 | +394,566 | 0.00 | 0.00 | -0.00 | buy |
| TANG CAPITAL MANAGEMENT LLC | 1,443,619 | 1,743,619 | +300,000 | 0.24 | 0.17 | -0.06 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 242,144 | +242,144 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 915,030 | 1,037,238 | +122,208 | 0.00 | 0.00 | -0.00 | buy |
| PFM Health Sciences, LP | 10,423,135 | 10,520,231 | +97,096 | 0.82 | 0.56 | -0.26 | buy |
| LPL Financial LLC | 108,856 | 198,856 | +90,000 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 79,239 | +79,239 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 312,538 | 390,901 | +78,363 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 0 | 34,743 | +34,743 | 0.00 | 0.00 | +0.00 | buy |
| COLUMBIA ADVISORY PARTNERS LLC | 15,585 | 28,087 | +12,502 | 0.02 | 0.03 | +0.00 | buy |
| GROUP ONE TRADING LLC | 22,367 | 34,037 | +11,670 | 0.00 | 0.00 | -0.00 | buy |
| Baader Bank Aktiengesellschaft | 0 | 10,287 | +10,287 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 7,122 | 16,721 | +9,599 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 54,172 | 63,672 | +9,500 | 0.00 | 0.00 | -0.00 | buy |
| COMMONWEALTH EQUITY SERVICES, LLC | 16,346 | 20,195 | +3,849 | 0.00 | 0.00 | -0.00 | buy |
| STIFEL FINANCIAL CORP | 23,797 | 27,619 | +3,822 | 0.00 | 0.00 | -0.00 | buy |
| IFP Advisors, Inc | 0 | 3,023 | +3,023 | 0.00 | 0.00 | +0.00 | buy |
| Acuitas Investments, LLC | 538,321 | 541,201 | +2,880 | 0.43 | 0.28 | -0.15 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 32,239 | 35,102 | +2,863 | 0.00 | 0.00 | -0.00 | buy |
| Parallel Advisors, LLC | 0 | 250 | +250 | 0.00 | 0.00 | +0.00 | buy |
| CSS LLC/IL | 30,702 | 30,702 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 213 | 213 | 0 | 0.00 | 0.00 | -0.00 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 117,909 | 117,909 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MPM ASSET MANAGEMENT LLC | 5,555,461 | 5,555,461 | 0 | 3.58 | 2.97 | -0.61 | hold |
| Janney Montgomery Scott LLC | 30,000 | 30,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rathbones Group PLC | 432,818 | 432,818 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HUNTER ASSOCIATES INVESTMENT MANAGEMENT LLC | 23,000 | 23,000 | 0 | 0.01 | 0.00 | -0.00 | hold |
| DAFNA Capital Management LLC | 341,064 | 341,064 | 0 | 0.12 | 0.08 | -0.04 | hold |
| Marquette Asset Management, LLC | 98,589 | 98,589 | 0 | 0.03 | 0.02 | -0.01 | hold |
| Matrix Capital Management Company, LP | 38,974,185 | 38,974,185 | 0 | 0.57 | 0.29 | -0.28 | hold |
| Redmile Group, LLC | 715,607 | 715,607 | 0 | 0.04 | 0.04 | +0.00 | hold |
| NEA Management Company, LLC | 17,079,778 | 17,079,778 | 0 | 1.68 | 1.25 | -0.42 | hold |
| EcoR1 Capital, LLC | 27,404,070 | 27,404,070 | 0 | 1.10 | 0.82 | -0.28 | hold |
| Rock Springs Capital Management LP | 2,425,468 | 2,425,468 | 0 | 0.10 | 0.07 | -0.03 | hold |
| MPM BioImpact LLC | 5,095,912 | 5,095,912 | 0 | 1.29 | 0.77 | -0.52 | hold |
| SIMON QUICK ADVISORS, LLC | 30,000 | 30,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| X-Square Capital, LLC | 11,192 | 11,192 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Investors Research Corp | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Global Retirement Partners, LLC | 6,000 | 6,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Main Street Financial Solutions, LLC | 31,190 | 31,190 | 0 | 0.01 | 0.00 | -0.00 | hold |
| HighMark Wealth Management LLC | 287 | 287 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JTC Employer Solutions Trustee Ltd | 26,156 | 26,156 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Prosperity Wealth Management, Inc. | 26,620 | 26,620 | 0 | 0.02 | 0.01 | -0.01 | hold |
| WETZEL INVESTMENT ADVISORS, INC. | 6,000 | 6,000 | 0 | 0.00 | 0.01 | +0.00 | hold |
| DLK Investment Management, LLC | 30,512 | 30,512 | 0 | 0.02 | 0.01 | -0.01 | hold |
| Federation des caisses Desjardins du Quebec | 785 | 785 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BARCLAYS PLC | 50,061 | 50,061 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| HSBC HOLDINGS PLC | 26,064 | 26,064 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NATIONAL BANK OF CANADA /FI/ | 10 | 10 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SIGNATUREFD, LLC | 2,037 | 0 | -2,037 | 0.00 | 0.00 | -0.00 | sell |
| QUADRANT CAPITAL GROUP LLC | 6,253 | 3,218 | -3,035 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 15,952 | 12,399 | -3,553 | 0.00 | 0.00 | -0.00 | sell |
| OPPENHEIMER & CO INC | 43,832 | 39,298 | -4,534 | 0.00 | 0.00 | -0.00 | sell |
| Key Client Fiduciary Advisors, LLC | 268,655 | 263,989 | -4,666 | 0.23 | 0.13 | -0.10 | sell |
| NORTHERN TRUST CORP | 57,500 | 51,861 | -5,639 | 0.00 | 0.00 | -0.00 | sell |
| Vontobel Holding Ltd. | 23,000 | 13,000 | -10,000 | 0.00 | 0.00 | -0.00 | sell |
| Atom Investors LP | 10,510 | 0 | -10,510 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 46,137 | 33,337 | -12,800 | 0.00 | 0.00 | -0.00 | sell |
| Procyon Advisors, LLC | 13,000 | 0 | -13,000 | 0.00 | 0.00 | -0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 4,667,787 | 4,653,325 | -14,462 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 14,474 | 0 | -14,474 | 0.00 | 0.00 | -0.00 | sell |
| Ballentine Partners, LLC | 14,489 | 0 | -14,489 | 0.00 | 0.00 | -0.00 | sell |
| CAPTRUST FINANCIAL ADVISORS | 111,952 | 83,041 | -28,911 | 0.00 | 0.00 | -0.00 | sell |
| FMR LLC | 1,732,565 | 1,690,481 | -42,084 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 825,179 | 779,615 | -45,564 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 67,665 | 0 | -67,665 | 0.00 | 0.00 | -0.00 | sell |
| CIBC Private Wealth Group LLC | 76,721 | 3,023 | -73,698 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 107,562 | 16,119 | -91,443 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 243,691 | 142,891 | -100,800 | 0.00 | 0.00 | -0.00 | sell |
| MARSHALL WACE, LLP | 254,013 | 144,880 | -109,133 | 0.00 | 0.00 | -0.00 | sell |
| HARBOR CAPITAL ADVISORS, INC. | 188,070 | 0 | -188,070 | 0.04 | 0.00 | -0.04 | sell |
| UBS Group AG | 196,696 | 0 | -196,696 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 370,179 | 0 | -370,179 | 0.05 | 0.00 | -0.05 | sell |
| Cubist Systematic Strategies, LLC | 675,882 | 0 | -675,882 | 0.01 | 0.00 | -0.01 | sell |
| BAILLIE GIFFORD & CO | 15,871,875 | 15,149,203 | -722,672 | 0.02 | 0.01 | -0.01 | sell |
| BAKER BROS. ADVISORS LP | 10,787,022 | 2,343,695 | -8,443,327 | 0.21 | 0.03 | -0.18 | sell |