| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| MORGAN STANLEY | 0 | 1,699,025 | +1,699,025 | 0.00 | 0.00 | +0.00 | buy |
| BAILLIE GIFFORD & CO | 15,149,203 | 16,775,860 | +1,626,657 | 0.01 | 0.01 | +0.00 | buy |
| Long Focus Capital Management, LLC | 12,346,417 | 13,299,890 | +953,473 | 1.25 | 1.12 | -0.13 | buy |
| MARSHALL WACE, LLP | 144,880 | 522,608 | +377,728 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 99,662 | +99,662 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 16,119 | 84,410 | +68,291 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 57,201 | +57,201 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 1,690,481 | 1,740,900 | +50,419 | 0.00 | 0.00 | -0.00 | buy |
| Palisades Investment Partners, LLC | 0 | 43,455 | +43,455 | 0.00 | 0.02 | +0.02 | buy |
| FULLCIRCLE WEALTH LLC | 0 | 35,000 | +35,000 | 0.00 | 0.01 | +0.01 | buy |
| Vontobel Holding Ltd. | 13,000 | 43,000 | +30,000 | 0.00 | 0.00 | +0.00 | buy |
| Newman Dignan & Sheerar, Inc. | 0 | 27,957 | +27,957 | 0.00 | 0.00 | +0.00 | buy |
| IFG Advisory, LLC | 0 | 27,500 | +27,500 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 117,909 | 139,801 | +21,892 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 79,239 | 101,008 | +21,769 | 0.01 | 0.01 | -0.00 | buy |
| Ballentine Partners, LLC | 0 | 16,758 | +16,758 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 34,037 | 48,370 | +14,333 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 12,592 | +12,592 | 0.00 | 0.00 | +0.00 | buy |
| GREENLEAF TRUST | 0 | 11,856 | +11,856 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 3,218 | 12,280 | +9,062 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 1,037,238 | 1,045,533 | +8,295 | 0.00 | 0.00 | -0.00 | buy |
| Parallel Advisors, LLC | 250 | 7,183 | +6,933 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 0 | 6,620 | +6,620 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 390,901 | 396,792 | +5,891 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 0 | 4,665 | +4,665 | 0.00 | 0.00 | +0.00 | buy |
| COLUMBIA ADVISORY PARTNERS LLC | 28,087 | 31,420 | +3,333 | 0.03 | 0.03 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 63,672 | 66,821 | +3,149 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 16,721 | 19,160 | +2,439 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 1,052 | +1,052 | 0.00 | 0.00 | 0.00 | buy |
| Plante Moran Financial Advisors, LLC | 0 | 925 | +925 | 0.00 | 0.00 | +0.00 | buy |
| Wilmington Savings Fund Society, FSB | 0 | 604 | +604 | 0.00 | 0.00 | +0.00 | buy |
| SIMON QUICK ADVISORS, LLC | 30,000 | 30,452 | +452 | 0.00 | 0.00 | -0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 0 | 69 | +69 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 34,743 | 34,809 | +66 | 0.00 | 0.00 | -0.00 | buy |
| TD Waterhouse Canada Inc. | 0 | 14 | +14 | 0.00 | 0.00 | +0.00 | buy |
| CSS LLC/IL | 30,702 | 30,702 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BNP PARIBAS FINANCIAL MARKETS | 213 | 213 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MPM ASSET MANAGEMENT LLC | 5,555,461 | 5,555,461 | 0 | 2.97 | 3.63 | +0.66 | hold |
| CIBC Private Wealth Group LLC | 3,023 | 3,023 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Janney Montgomery Scott LLC | 30,000 | 30,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rathbones Group PLC | 432,818 | 432,818 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HUNTER ASSOCIATES INVESTMENT MANAGEMENT LLC | 23,000 | 23,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DAFNA Capital Management LLC | 341,064 | 341,064 | 0 | 0.08 | 0.08 | -0.00 | hold |
| Redmile Group, LLC | 715,607 | 715,607 | 0 | 0.04 | 0.04 | -0.00 | hold |
| CAPTRUST FINANCIAL ADVISORS | 83,041 | 83,041 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEA Management Company, LLC | 17,079,778 | 17,079,778 | 0 | 1.25 | 0.88 | -0.37 | hold |
| EcoR1 Capital, LLC | 27,404,070 | 27,404,070 | 0 | 0.82 | 0.89 | +0.07 | hold |
| Rock Springs Capital Management LP | 2,425,468 | 2,425,468 | 0 | 0.07 | 0.07 | +0.00 | hold |
| IFP Advisors, Inc | 3,023 | 3,023 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MPM BioImpact LLC | 5,095,912 | 5,095,912 | 0 | 0.77 | 0.73 | -0.05 | hold |
| Investors Research Corp | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Global Retirement Partners, LLC | 6,000 | 6,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HighMark Wealth Management LLC | 287 | 287 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DLK Investment Management, LLC | 30,512 | 30,512 | 0 | 0.01 | 0.01 | -0.00 | hold |
| BARCLAYS PLC | 50,061 | 50,061 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BANK OF AMERICA CORP /DE/ | 4,653,325 | 4,653,325 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STIFEL FINANCIAL CORP | 27,619 | 27,619 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| HSBC HOLDINGS PLC | 26,064 | 26,064 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NATIONAL BANK OF CANADA /FI/ | 10 | 0 | -10 | 0.00 | 0.00 | -0.00 | sell |
| X-Square Capital, LLC | 11,192 | 11,180 | -12 | 0.00 | 0.00 | -0.00 | sell |
| Federation des caisses Desjardins du Quebec | 785 | 755 | -30 | 0.00 | 0.00 | -0.00 | sell |
| NORTHERN TRUST CORP | 51,861 | 51,333 | -528 | 0.00 | 0.00 | -0.00 | sell |
| Prosperity Wealth Management, Inc. | 26,620 | 24,620 | -2,000 | 0.01 | 0.01 | -0.00 | sell |
| OPPENHEIMER & CO INC | 39,298 | 36,275 | -3,023 | 0.00 | 0.00 | -0.00 | sell |
| WETZEL INVESTMENT ADVISORS, INC. | 6,000 | 0 | -6,000 | 0.01 | 0.00 | -0.01 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 20,195 | 13,433 | -6,762 | 0.00 | 0.00 | -0.00 | sell |
| Key Client Fiduciary Advisors, LLC | 263,989 | 255,359 | -8,630 | 0.13 | 0.11 | -0.02 | sell |
| Baader Bank Aktiengesellschaft | 10,287 | 0 | -10,287 | 0.00 | 0.00 | -0.00 | sell |
| XTX Topco Ltd | 12,399 | 0 | -12,399 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 33,337 | 11,948 | -21,389 | 0.00 | 0.00 | -0.00 | sell |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 35,102 | 10,816 | -24,286 | 0.00 | 0.00 | -0.00 | sell |
| JTC Employer Solutions Trustee Ltd | 26,156 | 0 | -26,156 | 0.00 | 0.00 | -0.00 | sell |
| Main Street Financial Solutions, LLC | 31,190 | 0 | -31,190 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 242,144 | 189,472 | -52,672 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 779,615 | 715,350 | -64,265 | 0.00 | 0.00 | -0.00 | sell |
| Marquette Asset Management, LLC | 98,589 | 0 | -98,589 | 0.02 | 0.00 | -0.02 | sell |
| LPL Financial LLC | 198,856 | 88,856 | -110,000 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 1,786,341 | 1,656,575 | -129,766 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 142,891 | 0 | -142,891 | 0.00 | 0.00 | -0.00 | sell |
| PFM Health Sciences, LP | 10,520,231 | 10,000,787 | -519,444 | 0.56 | 0.55 | -0.01 | sell |
| Acuitas Investments, LLC | 541,201 | 0 | -541,201 | 0.28 | 0.00 | -0.28 | sell |
| Matrix Capital Management Company, LP | 38,974,185 | 37,681,515 | -1,292,670 | 0.29 | 1.71 | +1.42 | sell |
| TANG CAPITAL MANAGEMENT LLC | 1,743,619 | 0 | -1,743,619 | 0.17 | 0.00 | -0.17 | sell |
| BAKER BROS. ADVISORS LP | 2,343,695 | 0 | -2,343,695 | 0.03 | 0.00 | -0.03 | sell |