| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Long Focus Capital Management, LLC | 10,963,158 | 12,086,915 | +1,123,757 | 1.23 | 1.24 | +0.01 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 508,808 | +508,808 | 0.00 | 0.03 | +0.03 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 1,027,860 | 1,370,239 | +342,379 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 300,061 | 441,032 | +140,971 | 0.00 | 0.00 | +0.00 | buy |
| HRT FINANCIAL LP | 0 | 59,906 | +59,906 | 0.00 | 0.00 | +0.00 | buy |
| TWIN FOCUS CAPITAL PARTNERS, LLC | 0 | 55,526 | +55,526 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 36,977 | +36,977 | 0.00 | 0.01 | +0.01 | buy |
| Cubist Systematic Strategies, LLC | 0 | 34,607 | +34,607 | 0.00 | 0.00 | +0.00 | buy |
| SIMON QUICK ADVISORS, LLC | 0 | 30,000 | +30,000 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 28,406 | +28,406 | 0.00 | 0.00 | +0.00 | buy |
| Newman Dignan & Sheerar, Inc. | 0 | 23,031 | +23,031 | 0.00 | 0.01 | +0.01 | buy |
| Key Client Fiduciary Advisors, LLC | 316,325 | 336,620 | +20,295 | 0.15 | 0.16 | +0.00 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 134,415 | 147,732 | +13,317 | 0.02 | 0.02 | +0.00 | buy |
| STATE STREET CORP | 299,101 | 305,336 | +6,235 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 8,037 | 10,664 | +2,627 | 0.00 | 0.00 | -0.00 | buy |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 30,239 | 32,239 | +2,000 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 54,745 | 56,177 | +1,432 | 0.00 | 0.00 | -0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 4,697,125 | 4,697,954 | +829 | 0.00 | 0.00 | -0.00 | buy |
| X-Square Capital, LLC | 26,771 | 27,425 | +654 | 0.02 | 0.01 | -0.00 | buy |
| HSBC HOLDINGS PLC | 26,064 | 26,504 | +440 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 5,582 | 5,912 | +330 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 0 | 300 | +300 | 0.00 | 0.00 | 0.00 | buy |
| Advisory Services Network, LLC | 0 | 125 | +125 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 51 | +51 | 0.00 | 0.00 | +0.00 | buy |
| Acuitas Investments, LLC | 479,764 | 479,789 | +25 | 0.22 | 0.20 | -0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 117,909 | 117,909 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BAKER BROS. ADVISORS LP | 10,969,282 | 10,969,282 | 0 | 0.05 | 0.10 | +0.05 | hold |
| Janney Montgomery Scott LLC | 30,000 | 30,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Rathbones Group PLC | 432,818 | 432,818 | 0 | 0.00 | 0.00 | -0.00 | hold |
| DAFNA Capital Management LLC | 351,064 | 351,064 | 0 | 0.09 | 0.07 | -0.02 | hold |
| Matrix Capital Management Company, LP | 38,974,185 | 38,974,185 | 0 | 0.36 | 0.32 | -0.05 | hold |
| Redmile Group, LLC | 715,607 | 715,607 | 0 | 0.03 | 0.02 | -0.01 | hold |
| PFM Health Sciences, LP | 10,423,135 | 10,423,135 | 0 | 0.39 | 0.50 | +0.11 | hold |
| NEA Management Company, LLC | 17,079,778 | 17,079,778 | 0 | 1.03 | 0.90 | -0.13 | hold |
| Douglas Lane & Associates, LLC | 11,000 | 11,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MPM BioImpact LLC | 5,095,912 | 5,095,912 | 0 | 1.06 | 0.95 | -0.12 | hold |
| Syncona Portfolio Ltd | 1,377,294 | 1,377,294 | 0 | 1.60 | 0.69 | -0.91 | hold |
| Investors Research Corp | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Global Retirement Partners, LLC | 6,000 | 6,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Main Street Financial Solutions, LLC | 31,190 | 31,190 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HighMark Wealth Management LLC | 287 | 287 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Federation des caisses Desjardins du Quebec | 785 | 785 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BARCLAYS PLC | 50,061 | 50,061 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FMR LLC | 1,733,141 | 1,733,141 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NORTHERN TRUST CORP | 57,423 | 57,423 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Beaird Harris Wealth Management, LLC | 92 | 0 | -92 | 0.00 | 0.00 | -0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 4,353 | 4,160 | -193 | 0.00 | 0.00 | -0.00 | sell |
| Daiwa Securities Group Inc. | 469 | 0 | -469 | 0.00 | 0.00 | 0.00 | sell |
| Marquette Asset Management, LLC | 99,349 | 98,589 | -760 | 0.02 | 0.01 | -0.00 | sell |
| HUNTER ASSOCIATES INVESTMENT MANAGEMENT LLC | 24,000 | 23,000 | -1,000 | 0.00 | 0.00 | -0.00 | sell |
| US BANCORP \DE\ | 1,058 | 0 | -1,058 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 4,053 | 2,162 | -1,891 | 0.00 | 0.00 | -0.00 | sell |
| Prosperity Wealth Management, Inc. | 30,620 | 28,620 | -2,000 | 0.02 | 0.01 | -0.00 | sell |
| STIFEL FINANCIAL CORP | 29,833 | 27,259 | -2,574 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA ADVISERS, LP | 64,437 | 59,837 | -4,600 | 0.00 | 0.00 | -0.00 | sell |
| CAPTRUST FINANCIAL ADVISORS | 21,924 | 17,254 | -4,670 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 5,285 | 0 | -5,285 | 0.00 | 0.00 | -0.00 | sell |
| Bayesian Capital Management, LP | 10,486 | 0 | -10,486 | 0.00 | 0.00 | -0.00 | sell |
| COURIER CAPITAL LLC | 12,000 | 0 | -12,000 | 0.00 | 0.00 | -0.00 | sell |
| ProShare Advisors LLC | 13,466 | 0 | -13,466 | 0.00 | 0.00 | -0.00 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 31,875 | 16,758 | -15,117 | 0.00 | 0.00 | -0.00 | sell |
| OPPENHEIMER & CO INC | 68,171 | 50,103 | -18,068 | 0.00 | 0.00 | -0.00 | sell |
| Qube Research & Technologies Ltd | 21,561 | 2,087 | -19,474 | 0.00 | 0.00 | -0.00 | sell |
| GOLDMAN SACHS GROUP INC | 57,611 | 15,979 | -41,632 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 45,906 | 0 | -45,906 | 0.00 | 0.00 | -0.00 | sell |
| CSS LLC/IL | 90,702 | 30,702 | -60,000 | 0.01 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 60,074 | 0 | -60,074 | 0.00 | 0.00 | -0.00 | sell |
| Black Maple Capital Management LP | 69,839 | 0 | -69,839 | 0.05 | 0.00 | -0.05 | sell |
| MORGAN STANLEY | 2,051,346 | 1,956,658 | -94,688 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 1,031,417 | 928,224 | -103,193 | 0.00 | 0.00 | -0.00 | sell |
| Simplify Asset Management Inc. | 150,000 | 0 | -150,000 | 0.02 | 0.00 | -0.02 | sell |
| CITADEL ADVISORS LLC | 3,549,559 | 3,399,514 | -150,045 | 0.00 | 0.00 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 166,888 | 0 | -166,888 | 0.00 | 0.00 | -0.00 | sell |
| Rock Springs Capital Management LP | 2,787,845 | 2,425,468 | -362,377 | 0.06 | 0.05 | -0.01 | sell |
| CITIGROUP INC | 582,275 | 0 | -582,275 | 0.00 | 0.00 | -0.00 | sell |
| MPM ASSET MANAGEMENT LLC | 6,287,101 | 5,555,461 | -731,640 | 2.63 | 2.16 | -0.46 | sell |
| TANG CAPITAL MANAGEMENT LLC | 5,166,954 | 4,387,238 | -779,716 | 0.57 | 0.32 | -0.25 | sell |
| Artal Group S.A. | 1,133,775 | 0 | -1,133,775 | 0.04 | 0.00 | -0.04 | sell |
| BAILLIE GIFFORD & CO | 17,147,409 | 15,912,140 | -1,235,269 | 0.01 | 0.01 | -0.00 | sell |