| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 27,404,070 | 27,404,070 | 0 | 0.89 | 0.59 | -0.30 | hold |
| Long Focus Capital Management, LLC | 13,299,890 | 20,494,393 | +7,194,503 | 1.12 | 0.85 | -0.27 | buy |
| NEA Management Company, LLC | 17,079,778 | 17,079,778 | 0 | 0.88 | 0.52 | -0.36 | hold |
| Two Seas Capital LP | 0 | 14,835,146 | +14,835,146 | 0.00 | 0.94 | +0.94 | buy |
| BAILLIE GIFFORD & CO | 16,775,860 | 11,819,095 | -4,956,765 | 0.01 | 0.00 | -0.01 | sell |
| MPM ASSET MANAGEMENT LLC | 5,555,461 | 5,555,461 | 0 | 3.63 | 2.41 | -1.23 | hold |
| MPM BioImpact LLC | 5,095,912 | 5,095,912 | 0 | 0.73 | 0.39 | -0.34 | hold |
| PFM Health Sciences, LP | 10,000,787 | 4,871,969 | -5,128,818 | 0.55 | 0.20 | -0.35 | sell |
| BANK OF AMERICA CORP /DE/ | 4,653,325 | 2,862,330 | -1,790,995 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 1,656,575 | 2,526,524 | +869,949 | 0.00 | 0.00 | -0.00 | buy |
| Rock Springs Capital Management LP | 2,425,468 | 2,483,468 | +58,000 | 0.07 | 0.05 | -0.02 | buy |
| FMR LLC | 1,740,900 | 1,764,506 | +23,606 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 1,045,533 | 916,941 | -128,592 | 0.00 | 0.00 | -0.00 | sell |
| Redmile Group, LLC | 715,607 | 715,607 | 0 | 0.04 | 0.03 | -0.01 | hold |
| MARSHALL WACE, LLP | 522,608 | 529,123 | +6,515 | 0.00 | 0.00 | -0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 510,216 | +510,216 | 0.00 | 0.00 | +0.00 | buy |
| Rathbones Group PLC | 432,818 | 432,818 | 0 | 0.00 | 0.00 | -0.00 | hold |
| STATE STREET CORP | 396,792 | 400,079 | +3,287 | 0.00 | 0.00 | -0.00 | buy |
| Key Client Fiduciary Advisors, LLC | 255,359 | 255,359 | 0 | 0.11 | 0.06 | -0.05 | hold |
| BlackRock, Inc. | 283,626 | 183,686 | -99,940 | 0.00 | 0.00 | -0.00 | sell |
| LPL Financial LLC | 88,856 | 183,479 | +94,623 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 139,801 | 139,801 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Virtu Financial LLC | 101,008 | 122,696 | +21,688 | 0.01 | 0.00 | -0.00 | buy |
| HRT FINANCIAL LP | 0 | 83,199 | +83,199 | 0.00 | 0.00 | +0.00 | buy |
| CAPTRUST FINANCIAL ADVISORS | 83,041 | 81,629 | -1,412 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 57,201 | 76,347 | +19,146 | 0.00 | 0.00 | -0.00 | buy |
| TWO SIGMA ADVISERS, LP | 11,948 | 70,735 | +58,787 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 34,809 | 63,335 | +28,526 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 51,333 | 51,333 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BARCLAYS PLC | 50,061 | 50,061 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Palisades Investment Partners, LLC | 43,455 | 47,114 | +3,659 | 0.02 | 0.01 | -0.01 | buy |
| Vontobel Holding Ltd. | 43,000 | 43,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Graham Capital Management, L.P. | 12,592 | 37,195 | +24,603 | 0.00 | 0.00 | +0.00 | buy |
| OPPENHEIMER & CO INC | 36,275 | 32,043 | -4,232 | 0.00 | 0.00 | -0.00 | sell |
| CSS LLC/IL | 30,702 | 30,702 | 0 | 0.00 | 0.00 | -0.00 | hold |
| SIMON QUICK ADVISORS, LLC | 30,452 | 30,000 | -452 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 715,350 | 29,559 | -685,791 | 0.00 | 0.00 | -0.00 | sell |
| Newman Dignan & Sheerar, Inc. | 27,957 | 27,957 | 0 | 0.00 | 0.00 | -0.00 | hold |
| WEALTH ENHANCEMENT ADVISORY SERVICES, LLC | 10,816 | 26,816 | +16,000 | 0.00 | 0.00 | +0.00 | buy |
| STIFEL FINANCIAL CORP | 27,619 | 26,469 | -1,150 | 0.00 | 0.00 | -0.00 | sell |
| HSBC HOLDINGS PLC | 26,064 | 26,064 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HUNTER ASSOCIATES INVESTMENT MANAGEMENT LLC | 23,000 | 22,000 | -1,000 | 0.00 | 0.00 | -0.00 | sell |
| Prosperity Wealth Management, Inc. | 24,620 | 21,870 | -2,750 | 0.01 | 0.00 | -0.00 | sell |
| GROUP ONE TRADING LLC | 48,370 | 20,515 | -27,855 | 0.00 | 0.00 | -0.00 | sell |
| RHUMBLINE ADVISERS | 19,160 | 19,748 | +588 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 4,665 | 19,530 | +14,865 | 0.00 | 0.00 | +0.00 | buy |
| KINGSWOOD WEALTH ADVISORS, LLC | 0 | 18,690 | +18,690 | 0.00 | 0.00 | +0.00 | buy |
| Clear Harbor Asset Management, LLC | 0 | 18,525 | +18,525 | 0.00 | 0.00 | +0.00 | buy |
| Baader Bank Aktiengesellschaft | 0 | 18,095 | +18,095 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 16,563 | +16,563 | 0.00 | 0.00 | +0.00 | buy |
| COLUMBIA ADVISORY PARTNERS LLC | 31,420 | 16,420 | -15,000 | 0.03 | 0.01 | -0.02 | sell |
| GOLDMAN SACHS GROUP INC | 84,410 | 16,160 | -68,250 | 0.00 | 0.00 | -0.00 | sell |
| X-Square Capital, LLC | 11,180 | 11,173 | -7 | 0.00 | 0.00 | -0.00 | sell |
| Global Retirement Partners, LLC | 6,000 | 6,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CIBC Private Wealth Group LLC | 3,023 | 3,023 | 0 | 0.00 | 0.00 | -0.00 | hold |
| IFP Advisors, Inc | 3,023 | 3,023 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Plante Moran Financial Advisors, LLC | 925 | 925 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Federation des caisses Desjardins du Quebec | 755 | 755 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Wilmington Savings Fund Society, FSB | 604 | 604 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HighMark Wealth Management LLC | 287 | 287 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Parallel Advisors, LLC | 7,183 | 250 | -6,933 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 213 | 213 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Investors Research Corp | 100 | 100 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TD Waterhouse Canada Inc. | 14 | 14 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 69 | 0 | -69 | 0.00 | 0.00 | -0.00 | sell |
| GREENLEAF TRUST | 11,856 | 0 | -11,856 | 0.00 | 0.00 | -0.00 | sell |
| Janney Montgomery Scott LLC | 30,000 | 0 | -30,000 | 0.00 | 0.00 | -0.00 | sell |
| GSA CAPITAL PARTNERS LLP | 99,662 | 0 | -99,662 | 0.01 | 0.00 | -0.01 | sell |
| Ballentine Partners, LLC | 16,758 | 0 | -16,758 | 0.00 | 0.00 | -0.00 | sell |
| DAFNA Capital Management LLC | 341,064 | 0 | -341,064 | 0.08 | 0.00 | -0.08 | sell |
| Matrix Capital Management Company, LP | 37,681,515 | 0 | -37,681,515 | 1.71 | 0.00 | -1.71 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 189,472 | 0 | -189,472 | 0.00 | 0.00 | -0.00 | sell |
| SIGNATUREFD, LLC | 6,620 | 0 | -6,620 | 0.00 | 0.00 | -0.00 | sell |
| SIMPLEX TRADING, LLC | 1,052 | 0 | -1,052 | 0.00 | 0.00 | 0.00 | sell |
| QUADRANT CAPITAL GROUP LLC | 12,280 | 0 | -12,280 | 0.00 | 0.00 | -0.00 | sell |
| IFG Advisory, LLC | 27,500 | 0 | -27,500 | 0.00 | 0.00 | -0.00 | sell |
| DLK Investment Management, LLC | 30,512 | 0 | -30,512 | 0.01 | 0.00 | -0.01 | sell |
| FULLCIRCLE WEALTH LLC | 35,000 | 0 | -35,000 | 0.01 | 0.00 | -0.01 | sell |
| COMMONWEALTH EQUITY SERVICES, LLC | 13,433 | 0 | -13,433 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 66,821 | 0 | -66,821 | 0.00 | 0.00 | -0.00 | sell |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| MORGAN STANLEY | 1,699,025 | 0 | -1,699,025 | 0.00 | 0.00 | -0.00 | sell |