| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Candriam S.C.A. | 1,516,297 | 2,088,369 | +572,072 | 0.30 | 0.36 | +0.06 | buy |
| TimesSquare Capital Management, LLC | 85,000 | 447,745 | +362,745 | 55.51 | 100.00 | +44.49 | buy |
| Pier Capital, LLC | 101,304 | 188,951 | +87,647 | 0.64 | 0.97 | +0.33 | buy |
| TEMA ETFS LLC | 176,667 | 241,565 | +64,898 | 0.46 | 0.30 | -0.15 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 416,340 | 459,340 | +43,000 | 2.54 | 2.32 | -0.23 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 112,066 | 154,220 | +42,154 | 1.09 | 1.47 | +0.38 | buy |
| CASTLEARK MANAGEMENT LLC | 63,950 | 99,870 | +35,920 | 0.08 | 0.10 | +0.02 | buy |
| Alyeska Investment Group, L.P. | 250,000 | 274,849 | +24,849 | 0.03 | 0.03 | +0.00 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 201,959 | 226,350 | +24,391 | 0.29 | 0.28 | -0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 5,798 | 19,072 | +13,274 | 0.04 | 0.12 | +0.09 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 1,028,832 | 1,031,378 | +2,546 | 1.92 | 1.40 | -0.52 | buy |
| E Fund Management (Hong Kong) Co., Ltd. | 389 | 524 | +135 | 0.01 | 0.01 | -0.00 | buy |
| MEEDER ASSET MANAGEMENT INC | 140 | 71 | -69 | 0.00 | 0.00 | -0.00 | sell |
| J.Safra Asset Management Corp | 789 | 695 | -94 | 0.00 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 28,803 | 27,194 | -1,609 | 0.08 | 0.06 | -0.02 | sell |
| HighVista Strategies LLC | 197,051 | 188,780 | -8,271 | 2.09 | 1.67 | -0.43 | sell |
| Atika Capital Management LLC | 293,200 | 272,000 | -21,200 | 1.42 | 0.69 | -0.73 | sell |
| Fiera Capital Corp | 558,252 | 511,824 | -46,428 | 0.07 | 0.07 | -0.00 | sell |
| Informed Momentum Co LLC | 121,928 | 53,129 | -68,799 | 0.54 | 0.18 | -0.36 | sell |
| Cormorant Asset Management, LP | 200,000 | 100,000 | -100,000 | 0.39 | 0.20 | -0.19 | sell |
| Rock Springs Capital Management LP | 624,155 | 515,917 | -108,238 | 1.42 | 0.97 | -0.44 | sell |
| SummitTX Capital, L.P. | 293,780 | 179,734 | -114,046 | 0.35 | 0.18 | -0.17 | sell |
| J. Goldman & Co LP | 779,570 | 637,994 | -141,576 | 0.87 | 0.64 | -0.23 | sell |
| Redmile Group, LLC | 688,036 | 503,321 | -184,715 | 1.75 | 1.31 | -0.45 | sell |
| Hennion & Walsh Asset Management, Inc. | 326,472 | 131,775 | -194,697 | 0.42 | 0.15 | -0.28 | sell |
| VR Adviser, LLC | 2,000,000 | 1,642,166 | -357,834 | 2.87 | 1.93 | -0.95 | sell |
| Sofinnova Investments, Inc. | 2,113,551 | 1,035,148 | -1,078,403 | 3.09 | 2.07 | -1.02 | sell |
| RTW INVESTMENTS, LP | 5,458,675 | 2,309,021 | -3,149,654 | 2.09 | 0.76 | -1.33 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 9,043,903 | 5,006,104 | -4,037,799 | 4.11 | 2.02 | -2.09 | sell |