| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Kynam Capital Management, LP | 5,854,766 | 8,500,000 | +2,645,234 | 3.90 | 6.35 | +2.46 | buy |
| Fairmount Funds Management LLC | 3,558,975 | 4,725,641 | +1,166,666 | 2.21 | 3.46 | +1.25 | buy |
| Redmile Group, LLC | 2,914,022 | 3,962,602 | +1,048,580 | 0.61 | 0.98 | +0.36 | buy |
| Commodore Capital LP | 5,566,026 | 6,425,000 | +858,974 | 2.86 | 2.89 | +0.03 | buy |
| Saturn V Capital Management LP | 756,681 | 1,595,021 | +838,340 | 1.70 | 4.30 | +2.59 | buy |
| TCG Crossover Management, LLC | 5,631,042 | 6,214,375 | +583,333 | 3.67 | 3.30 | -0.37 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,089,345 | 1,534,345 | +445,000 | 0.12 | 0.18 | +0.06 | buy |
| VR Adviser, LLC | 4,684,167 | 5,129,167 | +445,000 | 1.89 | 1.64 | -0.25 | buy |
| Rafferty Asset Management, LLC | 288,671 | 704,860 | +416,189 | 0.01 | 0.02 | +0.01 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 320,316 | 705,631 | +385,315 | 0.04 | 0.10 | +0.06 | buy |
| Nantahala Capital Management, LLC | 640,936 | 790,936 | +150,000 | 0.23 | 0.30 | +0.08 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 966,748 | 1,036,667 | +69,919 | 1.75 | 1.95 | +0.20 | buy |
| PROFUND ADVISORS LLC | 47,569 | 108,486 | +60,917 | 0.01 | 0.03 | 0.00 | buy |
| E Fund Management Co., Ltd. | 15,411 | 33,308 | +17,897 | 0.01 | 0.01 | +0.01 | buy |
| China Universal Asset Management Co., Ltd. | 9,961 | 19,950 | +9,989 | 0.01 | 0.02 | +0.01 | buy |
| ALGERT GLOBAL LLC | 355,570 | 364,112 | +8,542 | 0.08 | 0.10 | 0.00 | buy |
| NEOS Investment Management LLC | 12,936 | 18,301 | +5,365 | 0.01 | 0.01 | +0.00 | buy |
| 49 WEALTH MANAGEMENT, LLC | 10,901 | 13,137 | +2,236 | 0.02 | 0.02 | +0.00 | buy |
| CORNERCAP INVESTMENT COUNSEL INC | 34,328 | 34,494 | +166 | 0.03 | 0.04 | +0.00 | buy |
| Fisher Asset Management, LLC | 101,791 | 101,531 | -260 | 0.00 | 0.00 | +0.00 | sell |
| Forefront Analytics, LLC | 19,982 | 19,275 | -707 | 0.06 | 0.06 | +0.00 | sell |
| VIRTUS ADVISERS, LLC | 18,666 | 17,467 | -1,199 | 0.07 | 0.06 | -0.01 | sell |
| Atom Investors LP | 103,216 | 40,482 | -62,734 | 0.11 | 0.03 | -0.07 | sell |
| Woodline Partners LP | 790,484 | 698,378 | -92,106 | 0.05 | 0.04 | -0.01 | sell |
| PERCEPTIVE ADVISORS LLC | 1,122,958 | 883,333 | -239,625 | 0.15 | 0.10 | -0.04 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 475,634 | 186,254 | -289,380 | 0.11 | 0.05 | -0.06 | sell |
| Frazier Life Sciences Management, L.P. | 1,995,267 | 936,576 | -1,058,691 | 0.63 | 0.27 | -0.36 | sell |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 3,710,539 | 316,000 | -3,394,539 | 0.99 | 0.08 | -0.91 | sell |