| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| STATE STREET CORP | 4,150,615 | 7,626,869 | +3,476,254 | 0.00 | 0.00 | +0.00 | buy |
| Kynam Capital Management, LP | 5,854,766 | 8,500,000 | +2,645,234 | 3.90 | 6.35 | +2.46 | buy |
| Sofinnova Investments, Inc. | 0 | 2,400,771 | +2,400,771 | 0.00 | 0.95 | +0.95 | buy |
| JANUS HENDERSON GROUP PLC | 16,292 | 2,099,357 | +2,083,065 | 0.00 | 0.01 | +0.01 | buy |
| FMR LLC | 5,302,854 | 6,964,608 | +1,661,754 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 5,191,448 | 6,676,248 | +1,484,800 | 0.09 | 0.13 | +0.04 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 1,333,333 | +1,333,333 | 0.00 | 0.02 | +0.02 | buy |
| VANGUARD GROUP INC | 4,534,655 | 5,765,705 | +1,231,050 | 0.00 | 0.00 | +0.00 | buy |
| Fairmount Funds Management LLC | 3,558,975 | 4,725,641 | +1,166,666 | 2.21 | 3.46 | +1.25 | buy |
| Redmile Group, LLC | 2,914,022 | 3,962,602 | +1,048,580 | 0.61 | 0.98 | +0.36 | buy |
| Commodore Capital LP | 5,566,026 | 6,425,000 | +858,974 | 2.86 | 2.89 | +0.03 | buy |
| Saturn V Capital Management LP | 756,681 | 1,595,021 | +838,340 | 1.70 | 4.30 | +2.59 | buy |
| TCG Crossover Management, LLC | 5,631,042 | 6,214,375 | +583,333 | 3.67 | 3.30 | -0.37 | buy |
| Prosight Management, LP | 0 | 555,500 | +555,500 | 0.00 | 1.04 | +1.04 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 537,200 | +537,200 | 0.00 | 0.13 | +0.13 | buy |
| CITIGROUP INC | 121,851 | 599,989 | +478,138 | 0.00 | 0.00 | +0.00 | buy |
| Avidity Partners Management LP | 0 | 445,706 | +445,706 | 0.00 | 0.11 | +0.11 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,089,345 | 1,534,345 | +445,000 | 0.12 | 0.18 | +0.06 | buy |
| VR Adviser, LLC | 4,684,167 | 5,129,167 | +445,000 | 1.89 | 1.64 | -0.25 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 17,000 | 462,000 | +445,000 | 0.00 | 0.02 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 446,772 | 871,197 | +424,425 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 288,671 | 704,860 | +416,189 | 0.01 | 0.02 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 71,647 | 473,389 | +401,742 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 58,801 | 451,232 | +392,431 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 320,316 | 705,631 | +385,315 | 0.04 | 0.10 | +0.06 | buy |
| Deep Track Capital, LP | 0 | 316,000 | +316,000 | 0.00 | 0.06 | +0.06 | buy |
| Crestline Management, LP | 0 | 315,000 | +315,000 | 0.00 | 0.20 | +0.20 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 307,245 | +307,245 | 0.00 | 0.01 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 26,268 | 299,668 | +273,400 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 0 | 263,700 | +263,700 | 0.00 | 0.70 | +0.70 | buy |
| UBS Group AG | 227,407 | 431,005 | +203,598 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 37,435 | 238,926 | +201,491 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 176,290 | +176,290 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 127,444 | 296,311 | +168,867 | 0.00 | 0.00 | +0.00 | buy |
| Lighthouse Investment Partners, LLC | 0 | 167,878 | +167,878 | 0.00 | 0.05 | +0.05 | buy |
| Nantahala Capital Management, LLC | 640,936 | 790,936 | +150,000 | 0.38 | 0.52 | +0.14 | buy |
| Cinctive Capital Management LP | 0 | 145,514 | +145,514 | 0.00 | 0.05 | +0.05 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 140,710 | +140,710 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 966,748 | 1,036,667 | +69,919 | 1.75 | 1.95 | +0.20 | buy |
| Cubist Systematic Strategies, LLC | 33,974 | 100,005 | +66,031 | 0.00 | 0.01 | +0.01 | buy |
| NEW YORK LIFE INVESTMENT MANAGEMENT LLC | 0 | 61,111 | +61,111 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 47,569 | 108,486 | +60,917 | 0.01 | 0.03 | +0.02 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,728,782 | 1,777,104 | +48,322 | 0.00 | 0.00 | +0.00 | buy |
| Entropy Technologies, LP | 0 | 31,632 | +31,632 | 0.00 | 0.02 | +0.02 | buy |
| Swiss National Bank | 92,600 | 124,000 | +31,400 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 0 | 23,716 | +23,716 | 0.00 | 0.02 | +0.02 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 0 | 22,442 | +22,442 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 15,411 | 33,308 | +17,897 | 0.01 | 0.01 | +0.01 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 0 | 17,822 | +17,822 | 0.00 | 0.03 | +0.03 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 16,744 | +16,744 | 0.00 | 0.02 | +0.02 | buy |
| OXFORD ASSET MANAGEMENT LLP | 0 | 15,808 | +15,808 | 0.00 | 0.13 | +0.13 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 20,561 | 33,921 | +13,360 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 606,029 | 619,036 | +13,007 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 11,470 | +11,470 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 10,848 | +10,848 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 34,671 | 44,722 | +10,051 | 0.00 | 0.00 | +0.00 | buy |
| SkyView Investment Advisors, LLC | 0 | 10,000 | +10,000 | 0.00 | 0.01 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 59,557 | 69,557 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 9,961 | 19,950 | +9,989 | 0.01 | 0.02 | +0.01 | buy |
| Caption Management, LLC | 0 | 9,400 | +9,400 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 55,547 | 64,351 | +8,804 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 355,570 | 364,112 | +8,542 | 0.08 | 0.10 | +0.01 | buy |
| SIMPLEX TRADING, LLC | 0 | 7,303 | +7,303 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 2,994 | 10,014 | +7,020 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 117,168 | 123,017 | +5,849 | 0.00 | 0.00 | -0.00 | buy |
| NEOS Investment Management LLC | 12,936 | 18,301 | +5,365 | 0.01 | 0.01 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 87,748 | 92,933 | +5,185 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 31,181 | 35,211 | +4,030 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 13,141 | 17,123 | +3,982 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 48,467 | 52,379 | +3,912 | 0.00 | 0.00 | +0.00 | buy |
| Pacer Advisors, Inc. | 0 | 3,279 | +3,279 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 115,951 | 119,133 | +3,182 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 23,723 | 26,853 | +3,130 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 19,253 | 22,206 | +2,953 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 11,213 | 13,867 | +2,654 | 0.00 | 0.00 | +0.00 | buy |
| 49 WEALTH MANAGEMENT, LLC | 10,901 | 13,137 | +2,236 | 0.02 | 0.02 | +0.00 | buy |
| Invesco Ltd. | 34,740 | 36,842 | +2,102 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 27,742 | 29,668 | +1,926 | 0.01 | 0.01 | +0.00 | buy |
| NORTHERN TRUST CORP | 713,587 | 715,094 | +1,507 | 0.00 | 0.00 | +0.00 | buy |
| COMERICA BANK | 0 | 1,272 | +1,272 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 50,977 | 52,029 | +1,052 | 0.00 | 0.00 | +0.00 | buy |
| QUADRANT CAPITAL GROUP LLC | 0 | 689 | +689 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 16,277 | 16,843 | +566 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 1,183 | 1,500 | +317 | 0.00 | 0.00 | +0.00 | buy |
| CORNERCAP INVESTMENT COUNSEL INC | 34,328 | 34,494 | +166 | 0.03 | 0.04 | +0.00 | buy |
| METROPOLITAN LIFE INSURANCE CO/NY | 3,300 | 3,461 | +161 | 0.00 | 0.00 | +0.00 | buy |
| Fortitude Family Office, LLC | 0 | 105 | +105 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 86 | +86 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 6 | 85 | +79 | 0.00 | 0.00 | +0.00 | buy |
| YHB Investment Advisors, Inc. | 0 | 50 | +50 | 0.00 | 0.00 | +0.00 | buy |
| SIGNATUREFD, LLC | 76 | 120 | +44 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 1,055 | 1,095 | +40 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 0 | 33 | +33 | 0.00 | 0.00 | +0.00 | buy |
| Avior Wealth Management, LLC | 0 | 16 | +16 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 8,129 | 8,129 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 72,200 | 72,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HighVista Strategies LLC | 281,093 | 281,093 | 0 | 0.60 | 0.67 | +0.07 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 18,934 | 18,934 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MACQUARIE GROUP LTD | 230,000 | 230,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Daiwa Securities Group Inc. | 281 | 281 | 0 | 0.00 | 0.00 | -0.00 | hold |