| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Kynam Capital Management, LP | 5,854,766 | 8,500,000 | +2,645,234 | 3.90 | 6.35 | +2.46 | buy |
| STATE STREET CORP | 4,150,615 | 7,626,869 | +3,476,254 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 5,302,854 | 6,964,608 | +1,661,754 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 5,191,448 | 6,676,248 | +1,484,800 | 0.09 | 0.13 | +0.04 | buy |
| Commodore Capital LP | 5,566,026 | 6,425,000 | +858,974 | 2.86 | 2.89 | +0.03 | buy |
| TCG Crossover Management, LLC | 5,631,042 | 6,214,375 | +583,333 | 3.67 | 3.30 | -0.37 | buy |
| VANGUARD GROUP INC | 4,534,655 | 5,765,705 | +1,231,050 | 0.00 | 0.00 | +0.00 | buy |
| VR Adviser, LLC | 4,684,167 | 5,129,167 | +445,000 | 1.89 | 1.64 | -0.25 | buy |
| Fairmount Funds Management LLC | 3,558,975 | 4,725,641 | +1,166,666 | 2.21 | 3.46 | +1.25 | buy |
| Redmile Group, LLC | 2,914,022 | 3,962,602 | +1,048,580 | 0.61 | 0.98 | +0.36 | buy |
| Sofinnova Investments, Inc. | 0 | 2,400,771 | +2,400,771 | 0.00 | 0.95 | +0.95 | buy |
| MILLENNIUM MANAGEMENT LLC | 2,797,244 | 2,355,926 | -441,318 | 0.02 | 0.01 | -0.00 | sell |
| Vivo Capital, LLC | 2,244,941 | 2,244,941 | 0 | 1.08 | 1.19 | +0.10 | hold |
| JANUS HENDERSON GROUP PLC | 16,292 | 2,099,357 | +2,083,065 | 0.00 | 0.01 | +0.01 | buy |
| MORGAN STANLEY | 2,259,201 | 1,850,716 | -408,485 | 0.00 | 0.00 | -0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,728,782 | 1,777,104 | +48,322 | 0.00 | 0.00 | +0.00 | buy |
| Saturn V Capital Management LP | 756,681 | 1,595,021 | +838,340 | 1.70 | 4.30 | +2.59 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,089,345 | 1,534,345 | +445,000 | 0.12 | 0.18 | +0.06 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,636,834 | 1,394,198 | -242,636 | 0.00 | 0.00 | -0.00 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 1,333,333 | +1,333,333 | 0.00 | 0.02 | +0.02 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 966,748 | 1,036,667 | +69,919 | 1.75 | 1.95 | +0.20 | buy |
| Frazier Life Sciences Management, L.P. | 1,995,267 | 936,576 | -1,058,691 | 0.63 | 0.27 | -0.36 | sell |
| PERCEPTIVE ADVISORS LLC | 1,122,958 | 883,333 | -239,625 | 0.15 | 0.10 | -0.04 | sell |
| GOLDMAN SACHS GROUP INC | 446,772 | 871,197 | +424,425 | 0.00 | 0.00 | +0.00 | buy |
| Nantahala Capital Management, LLC | 640,936 | 790,936 | +150,000 | 0.38 | 0.52 | +0.14 | buy |
| 5AM Venture Management, LLC | 790,440 | 790,440 | 0 | 1.23 | 1.19 | -0.04 | hold |
| NORTHERN TRUST CORP | 713,587 | 715,094 | +1,507 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 320,316 | 705,631 | +385,315 | 0.04 | 0.10 | +0.06 | buy |
| Rafferty Asset Management, LLC | 288,671 | 704,860 | +416,189 | 0.01 | 0.02 | +0.01 | buy |
| Woodline Partners LP | 790,484 | 698,378 | -92,106 | 0.05 | 0.04 | -0.01 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 606,029 | 619,036 | +13,007 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 600,764 | 600,764 | 0 | 0.01 | 0.01 | -0.00 | hold |
| CITIGROUP INC | 121,851 | 599,989 | +478,138 | 0.00 | 0.00 | +0.00 | buy |
| Prosight Management, LP | 0 | 555,500 | +555,500 | 0.00 | 1.04 | +1.04 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 537,200 | +537,200 | 0.00 | 0.13 | +0.13 | buy |
| BANK OF AMERICA CORP /DE/ | 71,647 | 473,389 | +401,742 | 0.00 | 0.00 | +0.00 | buy |
| FARALLON CAPITAL MANAGEMENT LLC | 17,000 | 462,000 | +445,000 | 0.00 | 0.02 | +0.02 | buy |
| D. E. Shaw & Co., Inc. | 58,801 | 451,232 | +392,431 | 0.00 | 0.00 | +0.00 | buy |
| Avidity Partners Management LP | 0 | 445,706 | +445,706 | 0.00 | 0.11 | +0.11 | buy |
| UBS Group AG | 227,407 | 431,005 | +203,598 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 355,570 | 364,112 | +8,542 | 0.08 | 0.10 | +0.01 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 3,710,539 | 316,000 | -3,394,539 | 1.00 | 0.09 | -0.91 | sell |
| Deep Track Capital, LP | 0 | 316,000 | +316,000 | 0.00 | 0.06 | +0.06 | buy |
| Crestline Management, LP | 0 | 315,000 | +315,000 | 0.00 | 0.20 | +0.20 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 307,245 | +307,245 | 0.00 | 0.01 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 26,268 | 299,668 | +273,400 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 127,444 | 296,311 | +168,867 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 281,093 | 281,093 | 0 | 0.60 | 0.67 | +0.07 | hold |
| Bank of New York Mellon Corp | 300,899 | 280,814 | -20,085 | 0.00 | 0.00 | +0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 0 | 263,700 | +263,700 | 0.00 | 0.70 | +0.70 | buy |
| New Leaf Venture Partners, L.L.C. | 250,765 | 250,765 | 0 | 1.19 | 1.47 | +0.29 | hold |
| DEUTSCHE BANK AG\ | 37,435 | 238,926 | +201,491 | 0.00 | 0.00 | +0.00 | buy |
| MACQUARIE GROUP LTD | 230,000 | 230,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PLATINUM INVESTMENT MANAGEMENT LTD | 475,634 | 186,254 | -289,380 | 0.11 | 0.05 | -0.06 | sell |
| TWO SIGMA ADVISERS, LP | 0 | 176,290 | +176,290 | 0.00 | 0.00 | +0.00 | buy |
| Lighthouse Investment Partners, LLC | 0 | 167,878 | +167,878 | 0.00 | 0.05 | +0.05 | buy |
| Cinctive Capital Management LP | 0 | 145,514 | +145,514 | 0.00 | 0.05 | +0.05 | buy |
| TWO SIGMA INVESTMENTS, LP | 0 | 140,710 | +140,710 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 640,771 | 131,891 | -508,880 | 0.00 | 0.00 | -0.00 | sell |
| Swiss National Bank | 92,600 | 124,000 | +31,400 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 117,168 | 123,017 | +5,849 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 115,951 | 119,133 | +3,182 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 47,569 | 108,486 | +60,917 | 0.01 | 0.03 | +0.02 | buy |
| BARCLAYS PLC | 229,205 | 107,653 | -121,552 | 0.00 | 0.00 | -0.00 | sell |
| Fisher Asset Management, LLC | 101,791 | 101,531 | -260 | 0.00 | 0.00 | +0.00 | sell |
| Cubist Systematic Strategies, LLC | 33,974 | 100,005 | +66,031 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 87,748 | 92,933 | +5,185 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 123,194 | 86,604 | -36,590 | 0.00 | 0.00 | -0.00 | sell |
| ALLIANCEBERNSTEIN L.P. | 72,200 | 72,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 59,557 | 69,557 | +10,000 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 55,547 | 64,351 | +8,804 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK LIFE INVESTMENT MANAGEMENT LLC | 0 | 61,111 | +61,111 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 54,818 | 54,118 | -700 | 0.00 | 0.00 | +0.00 | sell |
| Mirae Asset Global Investments Co., Ltd. | 48,467 | 52,379 | +3,912 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 50,977 | 52,029 | +1,052 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 34,671 | 44,722 | +10,051 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 42,855 | 42,642 | -213 | 0.00 | 0.00 | +0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 41,288 | 40,935 | -353 | 0.00 | 0.00 | -0.00 | sell |
| Atom Investors LP | 103,216 | 40,482 | -62,734 | 0.11 | 0.03 | -0.07 | sell |
| Invesco Ltd. | 34,740 | 36,842 | +2,102 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 31,181 | 35,211 | +4,030 | 0.00 | 0.00 | +0.00 | buy |
| CORNERCAP INVESTMENT COUNSEL INC | 34,328 | 34,494 | +166 | 0.03 | 0.04 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 20,561 | 33,921 | +13,360 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 15,411 | 33,308 | +17,897 | 0.01 | 0.01 | +0.01 | buy |
| XTX Topco Ltd | 83,424 | 32,851 | -50,573 | 0.11 | 0.03 | -0.08 | sell |
| Entropy Technologies, LP | 0 | 31,632 | +31,632 | 0.00 | 0.02 | +0.02 | buy |
| EntryPoint Capital, LLC | 33,043 | 31,292 | -1,751 | 0.19 | 0.19 | +0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 39,545 | 31,224 | -8,321 | 0.00 | 0.00 | +0.00 | sell |
| Graham Capital Management, L.P. | 27,742 | 29,668 | +1,926 | 0.01 | 0.01 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 32,796 | 27,320 | -5,476 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 23,723 | 26,853 | +3,130 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 27,869 | 25,427 | -2,442 | 0.00 | 0.00 | -0.00 | sell |
| PDT Partners, LLC | 0 | 23,716 | +23,716 | 0.00 | 0.02 | +0.02 | buy |
| OCONNOR, A Distinct Business Unit of UBS ASSET MANAGEMENT AMERICAS (LLC) | 0 | 22,442 | +22,442 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 19,253 | 22,206 | +2,953 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 9,961 | 19,950 | +9,989 | 0.01 | 0.02 | +0.01 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 20,143 | 19,915 | -228 | 0.00 | 0.00 | +0.00 | sell |
| Forefront Analytics, LLC | 19,982 | 19,275 | -707 | 0.06 | 0.06 | +0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 18,934 | 18,934 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Trexquant Investment LP | 77,402 | 18,853 | -58,549 | 0.01 | 0.00 | -0.01 | sell |