| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 4,917,412 | 8,963,655 | +4,046,243 | 1.33 | 2.47 | +1.14 | buy |
| Commodore Capital LP | 6,881,629 | 8,892,816 | +2,011,187 | 3.93 | 3.93 | -0.01 | buy |
| Sofinnova Investments, Inc. | 823,160 | 2,182,121 | +1,358,961 | 0.47 | 0.85 | +0.39 | buy |
| Woodline Partners LP | 613,165 | 1,687,540 | +1,074,375 | 0.03 | 0.07 | +0.03 | buy |
| DIADEMA PARTNERS LP | 90,000 | 392,213 | +302,213 | 0.79 | 1.88 | +1.09 | buy |
| ALGERT GLOBAL LLC | 344,235 | 528,262 | +184,027 | 0.06 | 0.08 | 0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 10,108 | 46,626 | +36,518 | 0.01 | 0.04 | +0.03 | buy |
| Y-Intercept (Hong Kong) Ltd | 75,037 | 43,499 | +31,538 | 0.04 | 0.02 | 0.00 | sell |
| Hennion & Walsh Asset Management, Inc. | 275,292 | 302,481 | +27,189 | 0.10 | 0.08 | -0.02 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 457,048 | 481,241 | +24,193 | 0.08 | 0.07 | -0.01 | buy |
| Persistent Asset Partners Ltd | 67,617 | 90,211 | +22,594 | 0.54 | 0.48 | -0.06 | buy |
| NEOS Investment Management LLC | 51,926 | 71,563 | +19,637 | 0.01 | 0.01 | -0.00 | buy |
| TEMA ETFS LLC | 51,926 | 71,563 | +19,637 | 0.17 | 0.13 | -0.04 | buy |
| Rafferty Asset Management, LLC | 160,873 | 167,675 | +6,802 | 0.00 | 0.00 | -0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 73,800 | 79,020 | +5,220 | 0.38 | 0.37 | -0.02 | buy |
| E Fund Management Co., Ltd. | 11,380 | 15,670 | +4,290 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 31,589 | 34,895 | +3,306 | 0.01 | 0.01 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,631,000 | 2,633,862 | +2,862 | 0.39 | 0.31 | -0.08 | buy |
| GF FUND MANAGEMENT CO. LTD. | 2,319 | 2,828 | +509 | 0.00 | 0.00 | +0.00 | buy |
| 49 WEALTH MANAGEMENT, LLC | 12,582 | 13,032 | +450 | 0.01 | 0.01 | -0.00 | buy |
| Forefront Analytics, LLC | 13,760 | 14,015 | +255 | 0.05 | 0.10 | +0.05 | buy |
| PDT Partners, LLC | 23,724 | 23,668 | -56 | 0.02 | 0.01 | -0.01 | sell |
| China Universal Asset Management Co., Ltd. | 23,422 | 22,836 | -586 | 0.02 | 0.01 | -0.00 | sell |
| SkyView Investment Advisors, LLC | 12,500 | 10,000 | -2,500 | 0.02 | 0.01 | -0.01 | sell |
| Nantahala Capital Management, LLC | 852,855 | 843,489 | -9,366 | 0.29 | 0.20 | -0.08 | sell |
| Corton Capital Inc. | 28,761 | 16,392 | -12,369 | 0.13 | 0.32 | +0.20 | sell |
| Freestone Grove Partners LP | 32,193 | 16,511 | -15,682 | 0.00 | 0.00 | -0.00 | sell |
| Saturn V Capital Management LP | 1,498,425 | 1,480,020 | -18,405 | 4.58 | 4.47 | -0.10 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 157,851 | 133,910 | -23,941 | 0.07 | 0.05 | -0.03 | sell |
| EntryPoint Capital, LLC | 52,346 | 28,005 | -24,341 | 0.17 | 0.08 | -0.09 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 910,865 | 774,721 | -136,144 | 6.24 | 5.54 | -0.70 | sell |
| READYSTATE ASSET MANAGEMENT LP | 520,000 | 350,180 | -169,820 | 0.17 | 0.11 | -0.07 | sell |
| Redmile Group, LLC | 3,554,836 | 3,216,026 | -338,810 | 1.93 | 1.82 | -0.11 | sell |
| Springhill Fund Asset Management (HK) Co Ltd | 548,554 | 29,491 | -519,063 | 6.95 | 0.85 | -6.10 | sell |