| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 4,917,412 | 8,963,655 | +4,046,243 | 1.33 | 2.47 | +1.14 | buy |
| Vestal Point Capital, LP | 0 | 3,000,000 | +3,000,000 | 0.00 | 1.28 | +1.28 | buy |
| UBS Group AG | 213,934 | 3,104,130 | +2,890,196 | 0.00 | 0.00 | +0.00 | buy |
| Commodore Capital LP | 6,881,629 | 8,892,816 | +2,011,187 | 3.93 | 3.93 | -0.01 | buy |
| Sofinnova Investments, Inc. | 823,160 | 2,182,121 | +1,358,961 | 0.47 | 0.99 | +0.52 | buy |
| Woodline Partners LP | 613,165 | 1,687,540 | +1,074,375 | 0.03 | 0.07 | +0.03 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 1,071,258 | +1,071,258 | 0.00 | 0.00 | +0.00 | buy |
| Exome Asset Management LLC | 0 | 621,678 | +621,678 | 0.00 | 3.34 | +3.34 | buy |
| FMR LLC | 16,569,256 | 17,077,329 | +508,073 | 0.01 | 0.01 | -0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 56,512 | 514,498 | +457,986 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 97,663 | 489,688 | +392,025 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 0 | 335,024 | +335,024 | 0.00 | 0.49 | +0.49 | buy |
| MORGAN STANLEY | 958,629 | 1,275,695 | +317,066 | 0.00 | 0.00 | +0.00 | buy |
| DIADEMA PARTNERS LP | 90,000 | 392,213 | +302,213 | 0.79 | 1.88 | +1.09 | buy |
| Rosalind Advisors, Inc. | 0 | 248,285 | +248,285 | 0.00 | 0.72 | +0.72 | buy |
| Knott David M Jr | 0 | 213,302 | +213,302 | 0.00 | 0.60 | +0.60 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 205,030 | +205,030 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 3,918,130 | 4,116,796 | +198,666 | 0.00 | 0.00 | -0.00 | buy |
| ALGERT GLOBAL LLC | 344,235 | 528,262 | +184,027 | 0.06 | 0.08 | +0.02 | buy |
| PRELUDE CAPITAL MANAGEMENT, LLC | 0 | 169,449 | +169,449 | 0.00 | 0.10 | +0.10 | buy |
| AQR CAPITAL MANAGEMENT LLC | 27,593 | 160,767 | +133,174 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 864,893 | 988,962 | +124,069 | 0.00 | 0.00 | -0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,308,509 | 2,415,854 | +107,345 | 0.00 | 0.00 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 63,037 | 164,213 | +101,176 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 20,805 | 109,003 | +88,198 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 0 | 73,993 | +73,993 | 0.00 | 0.01 | +0.01 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 66,930 | +66,930 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 144,454 | 197,007 | +52,553 | 0.00 | 0.00 | -0.00 | buy |
| JANE STREET GROUP, LLC | 74,484 | 123,822 | +49,338 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 1,283,673 | 1,326,431 | +42,758 | 0.00 | 0.00 | -0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 10,108 | 46,626 | +36,518 | 0.01 | 0.04 | +0.03 | buy |
| Invesco Ltd. | 38,641 | 68,743 | +30,102 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 174 | 29,843 | +29,669 | 0.00 | 0.00 | +0.00 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 28,982 | +28,982 | 0.00 | 0.01 | +0.01 | buy |
| Hennion & Walsh Asset Management, Inc. | 275,292 | 302,481 | +27,189 | 0.10 | 0.08 | -0.02 | buy |
| TUDOR INVESTMENT CORP ET AL | 16,819 | 42,722 | +25,903 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 0 | 25,248 | +25,248 | 0.00 | 0.01 | +0.01 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 457,048 | 481,241 | +24,193 | 0.08 | 0.07 | -0.01 | buy |
| Persistent Asset Partners Ltd | 67,617 | 90,211 | +22,594 | 0.54 | 0.48 | -0.06 | buy |
| Swiss National Bank | 118,400 | 139,100 | +20,700 | 0.00 | 0.00 | -0.00 | buy |
| CIBC WORLD MARKETS CORP | 0 | 20,361 | +20,361 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 0 | 19,687 | +19,687 | 0.00 | 0.03 | +0.03 | buy |
| NEOS Investment Management LLC | 51,926 | 71,563 | +19,637 | 0.01 | 0.01 | -0.00 | buy |
| TEMA ETFS LLC | 51,926 | 71,563 | +19,637 | 0.17 | 0.13 | -0.04 | buy |
| LPL Financial LLC | 0 | 19,003 | +19,003 | 0.00 | 0.00 | +0.00 | buy |
| Ensign Peak Advisors, Inc | 0 | 18,825 | +18,825 | 0.00 | 0.00 | +0.00 | buy |
| IEQ CAPITAL, LLC | 0 | 16,792 | +16,792 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 61,460 | 75,144 | +13,684 | 0.00 | 0.00 | -0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 135,604 | 148,280 | +12,676 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 242,929 | 254,768 | +11,839 | 0.00 | 0.00 | -0.00 | buy |
| AlphaQuest LLC | 8,012 | 18,750 | +10,738 | 0.01 | 0.01 | +0.00 | buy |
| Creative Planning | 0 | 10,494 | +10,494 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 73 | 8,738 | +8,665 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 160,873 | 167,675 | +6,802 | 0.00 | 0.00 | -0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 73,800 | 79,020 | +5,220 | 0.38 | 0.37 | -0.02 | buy |
| RHUMBLINE ADVISERS | 125,581 | 130,458 | +4,877 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 49,643 | 54,386 | +4,743 | 0.00 | 0.00 | -0.00 | buy |
| E Fund Management Co., Ltd. | 11,380 | 15,670 | +4,290 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 58,582 | 62,275 | +3,693 | 0.00 | 0.00 | -0.00 | buy |
| PROFUND ADVISORS LLC | 31,589 | 34,895 | +3,306 | 0.01 | 0.01 | +0.00 | buy |
| Arizona State Retirement System | 17,425 | 20,567 | +3,142 | 0.00 | 0.00 | -0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,631,000 | 2,633,862 | +2,862 | 0.39 | 0.31 | -0.08 | buy |
| CROWLEY WEALTH MANAGEMENT, INC. | 0 | 1,700 | +1,700 | 0.00 | 0.01 | +0.01 | buy |
| Aster Capital Management (DIFC) Ltd | 595 | 2,061 | +1,466 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 17,983 | 19,217 | +1,234 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 43,645 | 44,628 | +983 | 0.00 | 0.00 | -0.00 | buy |
| GROUP ONE TRADING LLC | 0 | 660 | +660 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 56,657 | 57,205 | +548 | 0.00 | 0.00 | -0.00 | buy |
| SVB WEALTH LLC | 0 | 539 | +539 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 2,319 | 2,828 | +509 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 11,000 | 11,501 | +501 | 0.00 | 0.00 | -0.00 | buy |
| 49 WEALTH MANAGEMENT, LLC | 12,582 | 13,032 | +450 | 0.01 | 0.01 | -0.00 | buy |
| AMALGAMATED BANK | 2,824 | 3,178 | +354 | 0.00 | 0.00 | -0.00 | buy |
| Brooklyn Investment Group | 0 | 316 | +316 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 42 | 326 | +284 | 0.00 | 0.00 | +0.00 | buy |
| True Wealth Design, LLC | 0 | 277 | +277 | 0.00 | 0.00 | +0.00 | buy |
| J.Safra Asset Management Corp | 0 | 266 | +266 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 95 | 352 | +257 | 0.00 | 0.00 | +0.00 | buy |
| Forefront Analytics, LLC | 13,760 | 14,015 | +255 | 0.05 | 0.10 | +0.05 | buy |
| US BANCORP \DE\ | 0 | 226 | +226 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 363 | 510 | +147 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 3,681 | 3,810 | +129 | 0.00 | 0.00 | -0.00 | buy |
| SIGNATUREFD, LLC | 120 | 211 | +91 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 70 | 155 | +85 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 10,000 | 10,080 | +80 | 0.00 | 0.00 | -0.00 | buy |
| Parkside Financial Bank & Trust | 0 | 65 | +65 | 0.00 | 0.00 | +0.00 | buy |
| CoreCap Advisors, LLC | 0 | 62 | +62 | 0.00 | 0.00 | +0.00 | buy |
| Stephens Consulting, LLC | 0 | 60 | +60 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 0 | 16 | +16 | 0.00 | 0.00 | +0.00 | buy |
| Amundi | 112 | 123 | +11 | 0.00 | 0.00 | -0.00 | buy |
| Garde Capital, Inc. | 0 | 10 | +10 | 0.00 | 0.00 | +0.00 | buy |
| IFP Advisors, Inc | 0 | 8 | +8 | 0.00 | 0.00 | -0.00 | buy |
| EverSource Wealth Advisors, LLC | 17 | 19 | +2 | 0.00 | 0.00 | -0.00 | buy |
| Ameritas Investment Partners, Inc. | 9,296 | 9,296 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 58,649 | 58,649 | 0 | 0.00 | 0.00 | -0.00 | hold |
| JANUS HENDERSON GROUP PLC | 29,073 | 29,073 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HighVista Strategies LLC | 279,673 | 279,673 | 0 | 0.81 | 0.65 | -0.17 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 7,024 | 7,024 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MACQUARIE GROUP LTD | 230,000 | 230,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Mesirow Financial Investment Management, Inc. | 21,736 | 21,736 | 0 | 0.00 | 0.00 | -0.00 | hold |