| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 23,086,967 | 23,122,748 | +35,781 | 0.04 | 0.05 | +0.01 | buy |
| BlackRock, Inc. | 12,974,591 | 16,045,014 | +3,070,423 | 0.01 | 0.01 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 9,043,903 | 9,043,903 | 0 | 4.12 | 4.11 | -0.01 | hold |
| JANUS HENDERSON GROUP PLC | 4,537,408 | 5,965,125 | +1,427,717 | 0.07 | 0.11 | +0.04 | buy |
| STATE STREET CORP | 4,940,300 | 5,663,543 | +723,243 | 0.01 | 0.01 | +0.00 | buy |
| Fairmount Funds Management LLC | 9,003,418 | 5,503,418 | -3,500,000 | 24.34 | 15.30 | -9.04 | sell |
| RTW INVESTMENTS, LP | 7,592,241 | 5,458,675 | -2,133,566 | 2.70 | 2.09 | -0.61 | sell |
| TCG Crossover Management, LLC | 5,868,162 | 4,946,894 | -921,268 | 6.90 | 5.45 | -1.45 | sell |
| SSI INVESTMENT MANAGEMENT LLC | 0 | 4,453,000 | +4,453,000 | 0.35 | 0.38 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 1,705,144 | 4,434,054 | +2,728,910 | 0.01 | 0.02 | +0.01 | buy |
| Kynam Capital Management, LP | 6,165,223 | 4,037,331 | -2,127,892 | 14.26 | 9.86 | -4.39 | sell |
| Polar Capital Holdings Plc | 5,500,000 | 3,700,000 | -1,800,000 | 0.03 | 0.02 | -0.01 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 3,514,562 | 3,699,519 | +184,957 | 0.01 | 0.01 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 3,655,000 | +3,655,000 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 2,712,336 | 3,578,622 | +866,286 | 0.02 | 0.03 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 2,564,062 | 3,212,815 | +648,753 | 0.01 | 0.01 | +0.00 | buy |
| LORD, ABBETT & CO. LLC | 1,870,537 | 3,181,270 | +1,310,733 | 0.20 | 0.40 | +0.20 | buy |
| Commodore Capital LP | 2,196,845 | 2,888,007 | +691,162 | 5.19 | 6.43 | +1.24 | buy |
| Invesco Ltd. | 585,765 | 2,429,629 | +1,843,864 | 0.00 | 0.01 | +0.01 | buy |
| Octagon Capital Advisors LP | 2,350,000 | 2,350,000 | 0 | 10.45 | 10.01 | -0.44 | hold |
| Holocene Advisors, LP | 1,178,208 | 2,250,196 | +1,071,988 | 0.09 | 0.21 | +0.12 | buy |
| Sofinnova Investments, Inc. | 1,973,625 | 2,113,551 | +139,926 | 3.02 | 4.08 | +1.05 | buy |
| VR Adviser, LLC | 2,000,000 | 2,000,000 | 0 | 3.51 | 2.87 | -0.64 | hold |
| D. E. Shaw & Co., Inc. | 2,247,804 | 1,868,389 | -379,415 | 0.06 | 0.06 | -0.00 | sell |
| Pictet Asset Management Holding SA | 112,476 | 1,798,768 | +1,686,292 | 0.00 | 0.07 | +0.07 | buy |
| CITADEL ADVISORS LLC | 1,438,994 | 1,714,927 | +275,933 | 0.03 | 0.05 | +0.01 | buy |
| Siren, L.L.C. | 1,629,279 | 1,709,279 | +80,000 | 1.73 | 1.82 | +0.10 | buy |
| MARSHALL WACE, LLP | 1,660,735 | 1,600,168 | -60,567 | 0.06 | 0.07 | +0.01 | sell |
| EMERALD ADVISERS, LLC | 1,583,346 | 1,588,132 | +4,786 | 1.73 | 1.93 | +0.20 | buy |
| Candriam S.C.A. | 1,296,475 | 1,516,297 | +219,822 | 0.23 | 0.30 | +0.07 | buy |
| Woodline Partners LP | 818,782 | 1,509,557 | +690,775 | 0.11 | 0.22 | +0.11 | buy |
| Point72 Asset Management, L.P. | 827,525 | 1,410,826 | +583,301 | 0.05 | 0.09 | +0.05 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,245,254 | 1,314,189 | +68,935 | 6.40 | 5.96 | -0.44 | buy |
| NORTHERN TRUST CORP | 1,199,300 | 1,245,751 | +46,451 | 0.01 | 0.01 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,280,779 | 1,242,322 | -38,457 | 0.01 | 0.01 | +0.00 | sell |
| FRED ALGER MANAGEMENT, LLC | 1,102,181 | 1,239,700 | +137,519 | 0.15 | 0.21 | +0.06 | buy |
| Vestal Point Capital, LP | 0 | 1,230,888 | +1,230,888 | 0.00 | 1.32 | +1.32 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,208,228 | 1,192,406 | -15,822 | 0.03 | 0.03 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 1,191,930 | 1,043,805 | -148,125 | 0.00 | 0.00 | -0.00 | sell |
| EMERALD MUTUAL FUND ADVISERS TRUST | 1,038,494 | 1,028,832 | -9,662 | 1.80 | 1.92 | +0.12 | sell |
| Deep Track Capital, LP | 453,102 | 1,000,000 | +546,898 | 0.37 | 0.79 | +0.43 | buy |
| First Turn Management, LLC | 824,283 | 947,339 | +123,056 | 3.35 | 4.07 | +0.73 | buy |
| AMERICAN CENTURY COMPANIES INC | 892,920 | 890,568 | -2,352 | 0.02 | 0.02 | +0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 1,440,318 | 856,598 | -583,720 | 0.10 | 0.06 | -0.03 | sell |
| Nuveen, LLC | 932,621 | 831,602 | -101,019 | 0.01 | 0.01 | -0.00 | sell |
| J. Goldman & Co LP | 439,269 | 779,570 | +340,301 | 0.61 | 1.39 | +0.78 | buy |
| Affinity Asset Advisors, LLC | 350,000 | 750,000 | +400,000 | 0.89 | 1.69 | +0.80 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 689,068 | 706,268 | +17,200 | 0.04 | 0.04 | +0.00 | buy |
| Redmile Group, LLC | 1,437,918 | 688,036 | -749,882 | 3.76 | 1.75 | -2.01 | sell |
| Burkehill Global Management, LP | 325,000 | 675,000 | +350,000 | 0.76 | 1.29 | +0.53 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 133,214 | 664,146 | +530,932 | 0.00 | 0.03 | +0.02 | buy |
| MORGAN STANLEY | 726,777 | 642,679 | -84,098 | 0.00 | 0.00 | -0.00 | sell |
| Saturn V Capital Management LP | 1,217,064 | 626,635 | -590,429 | 7.93 | 4.37 | -3.57 | sell |
| Rock Springs Capital Management LP | 849,030 | 624,155 | -224,875 | 1.55 | 1.42 | -0.13 | sell |
| Patient Square Capital LP | 317,372 | 596,000 | +278,628 | 2.41 | 4.07 | +1.66 | buy |
| Ensign Peak Advisors, Inc | 421,540 | 572,872 | +151,332 | 0.03 | 0.04 | +0.01 | buy |
| Fiera Capital Corp | 0 | 558,252 | +558,252 | 0.00 | 0.07 | +0.07 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 0 | 449,482 | +449,482 | 0.00 | 0.01 | +0.01 | buy |
| Vivo Capital, LLC | 2,398,993 | 422,300 | -1,976,693 | 5.51 | 1.35 | -4.16 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 378,500 | 416,340 | +37,840 | 2.81 | 2.76 | -0.05 | buy |
| Qube Research & Technologies Ltd | 276,728 | 394,000 | +117,272 | 0.01 | 0.02 | +0.01 | buy |
| Russell Investments Group, Ltd. | 385,457 | 374,868 | -10,589 | 0.01 | 0.02 | +0.00 | sell |
| Bank of New York Mellon Corp | 376,296 | 372,796 | -3,500 | 0.00 | 0.00 | +0.00 | sell |
| ExodusPoint Capital Management, LP | 0 | 372,175 | +372,175 | 0.00 | 0.14 | +0.14 | buy |
| RAYMOND JAMES FINANCIAL INC | 375,919 | 369,715 | -6,204 | 0.00 | 0.00 | +0.00 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 352,387 | 360,490 | +8,103 | 0.27 | 0.29 | +0.03 | buy |
| Integral Health Asset Management, LLC | 0 | 350,000 | +350,000 | 0.00 | 0.71 | +0.71 | buy |
| Weiss Asset Management LP | 0 | 346,104 | +346,104 | 0.00 | 0.24 | +0.24 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 198,969 | 343,082 | +144,113 | 0.00 | 0.01 | +0.00 | buy |
| Longaeva Partners L.P. | 0 | 335,000 | +335,000 | 0.00 | 0.62 | +0.62 | buy |
| Hennion & Walsh Asset Management, Inc. | 338,065 | 326,472 | -11,593 | 0.41 | 0.42 | +0.01 | sell |
| DIADEMA PARTNERS LP | 131,852 | 322,764 | +190,912 | 2.79 | 5.13 | +2.34 | buy |
| ORBIMED ADVISORS LLC | 371,000 | 322,100 | -48,900 | 0.27 | 0.27 | +0.00 | sell |
| Assenagon Asset Management S.A. | 375,626 | 295,650 | -79,976 | 0.02 | 0.02 | -0.00 | sell |
| SummitTX Capital, L.P. | 257,171 | 293,780 | +36,609 | 0.28 | 0.36 | +0.08 | buy |
| Atika Capital Management LLC | 506,000 | 293,200 | -212,800 | 2.50 | 1.78 | -0.72 | sell |
| UBS Group AG | 264,047 | 291,486 | +27,439 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 426,782 | 285,661 | -141,121 | 0.03 | 0.02 | -0.01 | sell |
| Exome Asset Management LLC | 305,568 | 278,533 | -27,035 | 5.36 | 6.31 | +0.95 | sell |
| Aberdeen Group plc | 0 | 272,707 | +272,707 | 0.00 | 0.02 | +0.02 | buy |
| JPMORGAN CHASE & CO | 400,931 | 262,704 | -138,227 | 0.00 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 188,349 | 252,114 | +63,765 | 0.00 | 0.00 | +0.00 | buy |
| Alyeska Investment Group, L.P. | 493,934 | 250,000 | -243,934 | 0.05 | 0.03 | -0.02 | sell |
| Nantahala Capital Management, LLC | 250,000 | 250,000 | 0 | 0.53 | 0.60 | +0.07 | hold |
| Evergreen Quality Fund GP, Ltd. | 250,000 | 250,000 | 0 | 0.18 | 0.22 | +0.04 | hold |
| NWI MANAGEMENT LP | 241,671 | 241,671 | 0 | 0.52 | 0.57 | +0.04 | hold |
| Tidal Investments LLC | 0 | 231,569 | +231,569 | 0.00 | 0.03 | +0.03 | buy |
| Susquehanna Portfolio Strategies, LLC | 229,755 | 229,755 | 0 | 0.13 | 0.13 | +0.01 | hold |
| Squarepoint Ops LLC | 155,984 | 226,259 | +70,275 | 0.01 | 0.02 | +0.01 | buy |
| F/m Investments LLC | 235,804 | 226,142 | -9,662 | 0.32 | 0.58 | +0.26 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 366,238 | 225,158 | -141,080 | 6.96 | 6.19 | -0.77 | sell |
| Boxer Capital Management, LLC | 225,000 | 225,000 | 0 | 1.75 | 1.14 | -0.61 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 44,402 | 223,216 | +178,814 | 0.00 | 0.01 | +0.01 | buy |
| Hudson Bay Capital Management LP | 0 | 207,574 | +207,574 | 0.00 | 0.05 | +0.05 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 0 | 201,959 | +201,959 | 0.00 | 0.29 | +0.29 | buy |
| Cormorant Asset Management, LP | 225,000 | 200,000 | -25,000 | 0.45 | 0.39 | -0.06 | sell |
| SEI INVESTMENTS CO | 179,414 | 197,510 | +18,096 | 0.01 | 0.01 | +0.00 | buy |
| HighVista Strategies LLC | 336,667 | 197,051 | -139,616 | 3.08 | 2.09 | -0.99 | sell |
| Man Group plc | 292,082 | 194,801 | -97,281 | 0.02 | 0.02 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 121,800 | 189,796 | +67,996 | 0.00 | 0.00 | +0.00 | buy |