| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Point72 Asset Management, L.P. | 6,676,248 | 10,470,398 | +3,794,150 | 0.13 | 0.29 | +0.16 | buy |
| Paradigm Biocapital Advisors LP | 0 | 3,624,342 | +3,624,342 | 0.00 | 1.17 | +1.17 | buy |
| Commodore Capital LP | 6,425,000 | 9,738,000 | +3,313,000 | 2.89 | 5.60 | +2.72 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,333,333 | 4,248,888 | +2,915,555 | 0.02 | 0.07 | +0.05 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,534,345 | 3,744,263 | +2,209,918 | 0.18 | 0.53 | +0.35 | buy |
| Fairmount Funds Management LLC | 4,725,641 | 6,225,641 | +1,500,000 | 3.46 | 5.93 | +2.47 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 1,398,992 | +1,398,992 | 0.00 | 0.20 | +0.20 | buy |
| FRANKLIN RESOURCES INC | 0 | 1,000,116 | +1,000,116 | 0.00 | 0.00 | +0.00 | buy |
| Redmile Group, LLC | 3,962,602 | 4,799,973 | +837,371 | 0.98 | 2.45 | +1.47 | buy |
| Kynam Capital Management, LP | 8,500,000 | 9,260,385 | +760,385 | 6.35 | 8.17 | +1.82 | buy |
| TCG Crossover Management, LLC | 6,214,375 | 6,964,375 | +750,000 | 3.30 | 6.12 | +2.82 | buy |
| FMR LLC | 6,964,608 | 7,693,668 | +729,060 | 0.00 | 0.00 | +0.00 | buy |
| VR Adviser, LLC | 5,129,167 | 5,684,167 | +555,000 | 1.64 | 3.05 | +1.41 | buy |
| Avidity Partners Management LP | 445,706 | 1,000,706 | +555,000 | 0.11 | 0.36 | +0.25 | buy |
| Sofinnova Investments, Inc. | 2,400,771 | 2,773,286 | +372,515 | 0.95 | 1.47 | +0.52 | buy |
| JANE STREET GROUP, LLC | 44,722 | 248,544 | +203,822 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,777,104 | 1,980,731 | +203,627 | 0.00 | 0.00 | +0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 537,200 | 734,197 | +196,997 | 0.13 | 0.29 | +0.17 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,036,667 | 1,206,214 | +169,547 | 1.95 | 2.51 | +0.56 | buy |
| Trexquant Investment LP | 18,853 | 148,854 | +130,001 | 0.00 | 0.02 | +0.02 | buy |
| Hennion & Walsh Asset Management, Inc. | 0 | 127,712 | +127,712 | 0.00 | 0.06 | +0.06 | buy |
| Invesco Ltd. | 36,842 | 163,966 | +127,124 | 0.00 | 0.00 | +0.00 | buy |
| Saturn V Capital Management LP | 1,595,021 | 1,673,919 | +78,898 | 4.30 | 5.33 | +1.03 | buy |
| ALPS ADVISORS INC | 0 | 74,598 | +74,598 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 619,036 | 686,697 | +67,661 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 69,557 | 126,217 | +56,660 | 0.00 | 0.00 | +0.00 | buy |
| Fisher Asset Management, LLC | 101,531 | 149,045 | +47,514 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 280,814 | 326,584 | +45,770 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 44,859 | +44,859 | 0.00 | 0.02 | +0.02 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 44,441 | +44,441 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 42,532 | +42,532 | 0.00 | 0.00 | +0.00 | buy |
| Cubist Systematic Strategies, LLC | 100,005 | 134,660 | +34,655 | 0.01 | 0.02 | +0.01 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 25,427 | 59,395 | +33,968 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 23,716 | 53,716 | +30,000 | 0.02 | 0.04 | +0.03 | buy |
| Jump Financial, LLC | 10,525 | 37,695 | +27,170 | 0.00 | 0.01 | +0.00 | buy |
| Cinctive Capital Management LP | 145,514 | 172,450 | +26,936 | 0.05 | 0.08 | +0.03 | buy |
| NEOS Investment Management LLC | 18,301 | 43,856 | +25,555 | 0.01 | 0.02 | +0.01 | buy |
| Brevan Howard Capital Management LP | 0 | 22,559 | +22,559 | 0.00 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 296,311 | 316,853 | +20,542 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,644 | 22,364 | +19,720 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 10,848 | 29,052 | +18,204 | 0.00 | 0.00 | +0.00 | buy |
| Catalyst Funds Management Pty Ltd | 0 | 17,600 | +17,600 | 0.00 | 0.04 | +0.04 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 16,598 | +16,598 | 0.00 | 0.00 | +0.00 | buy |
| Laurion Capital Management LP | 0 | 13,612 | +13,612 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 54,118 | 67,300 | +13,182 | 0.00 | 0.00 | +0.00 | buy |
| Corton Capital Inc. | 0 | 12,162 | +12,162 | 0.00 | 0.05 | +0.05 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 12,005 | +12,005 | 0.00 | 0.00 | +0.00 | buy |
| Focus Partners Wealth | 0 | 11,628 | +11,628 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 119,133 | 130,516 | +11,383 | 0.00 | 0.00 | +0.00 | buy |
| Crestline Management, LP | 315,000 | 326,070 | +11,070 | 0.20 | 0.22 | +0.02 | buy |
| Creative Planning | 0 | 11,052 | +11,052 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 42,642 | 53,368 | +10,726 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 0 | 10,561 | +10,561 | 0.00 | 0.01 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 92,933 | 103,200 | +10,267 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA INVESTMENTS, LP | 140,710 | 149,401 | +8,691 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 14,982 | 23,142 | +8,160 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 35,211 | 40,617 | +5,406 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 31,224 | 35,752 | +4,528 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 715,094 | 719,452 | +4,358 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 86 | 3,896 | +3,810 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 27,320 | 30,823 | +3,503 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 26,853 | 30,144 | +3,291 | 0.00 | 0.00 | +0.00 | buy |
| SkyView Investment Advisors, LLC | 10,000 | 12,500 | +2,500 | 0.01 | 0.02 | +0.01 | buy |
| COMERICA BANK | 1,272 | 1,724 | +452 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 17,123 | 17,399 | +276 | 0.00 | 0.00 | +0.00 | buy |
| Smartleaf Asset Management LLC | 0 | 273 | +273 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 137 | +137 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 1,095 | 1,210 | +115 | 0.00 | 0.00 | +0.00 | buy |
| INNEALTA CAPITAL, LLC | 0 | 86 | +86 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 70 | +70 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 28 | +28 | 0.00 | 0.00 | +0.00 | buy |
| Allworth Financial LP | 33 | 60 | +27 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 15 | +15 | 0.00 | 0.00 | 0.00 | buy |
| Farther Finance Advisors, LLC | 85 | 95 | +10 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 8,129 | 8,129 | 0 | 0.00 | 0.00 | +0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 72,200 | 72,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HighVista Strategies LLC | 281,093 | 281,093 | 0 | 0.67 | 0.87 | +0.19 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 18,934 | 18,934 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MACQUARIE GROUP LTD | 230,000 | 230,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SIGNATUREFD, LLC | 120 | 120 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Nantahala Capital Management, LLC | 790,936 | 790,936 | 0 | 0.52 | 0.67 | +0.15 | hold |
| Daiwa Securities Group Inc. | 281 | 281 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Assenagon Asset Management S.A. | 600,764 | 600,764 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Swiss National Bank | 124,000 | 124,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| New Leaf Venture Partners, L.L.C. | 250,765 | 250,765 | 0 | 1.47 | 2.57 | +1.10 | hold |
| LGL PARTNERS, LLC | 14,500 | 14,500 | 0 | 0.02 | 0.02 | +0.00 | hold |
| Vivo Capital, LLC | 2,244,941 | 2,244,941 | 0 | 1.19 | 1.75 | +0.56 | hold |
| 5AM Venture Management, LLC | 790,440 | 790,440 | 0 | 1.19 | 1.49 | +0.30 | hold |
| Frazier Life Sciences Management, L.P. | 936,576 | 936,576 | 0 | 0.27 | 0.37 | +0.10 | hold |
| Covestor Ltd | 11 | 11 | 0 | 0.00 | 0.00 | 0.00 | hold |
| Fortitude Family Office, LLC | 105 | 105 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Clear Point Advisors Inc. | 1 | 1 | 0 | 0.00 | 0.00 | +0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |
| AMALGAMATED BANK | 2,824 | 2,824 | 0 | 0.00 | 0.00 | +0.00 | hold |
| GAMMA Investing LLC | 134 | 122 | -12 | 0.00 | 0.00 | -0.00 | sell |
| Avior Wealth Management, LLC | 16 | 0 | -16 | 0.00 | 0.00 | -0.00 | sell |
| YHB Investment Advisors, Inc. | 50 | 0 | -50 | 0.00 | 0.00 | -0.00 | sell |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 13,867 | 13,650 | -217 | 0.00 | 0.00 | +0.00 | sell |
| CORNERCAP INVESTMENT COUNSEL INC | 34,494 | 34,138 | -356 | 0.04 | 0.05 | +0.01 | sell |