| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Commodore Capital LP | 6,425,000 | 9,738,000 | +3,313,000 | 2.89 | 5.60 | +2.72 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,333,333 | 4,248,888 | +2,915,555 | 0.02 | 0.07 | +0.05 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,534,345 | 3,744,263 | +2,209,918 | 0.18 | 0.53 | +0.35 | buy |
| Fairmount Funds Management LLC | 4,725,641 | 6,225,641 | +1,500,000 | 3.46 | 5.93 | +2.47 | buy |
| Redmile Group, LLC | 3,962,602 | 4,799,973 | +837,371 | 0.98 | 2.45 | +1.47 | buy |
| Kynam Capital Management, LP | 8,500,000 | 9,260,385 | +760,385 | 6.35 | 8.17 | +1.82 | buy |
| TCG Crossover Management, LLC | 6,214,375 | 6,964,375 | +750,000 | 3.30 | 6.12 | +2.82 | buy |
| Avidity Partners Management LP | 445,706 | 1,000,706 | +555,000 | 0.11 | 0.36 | +0.25 | buy |
| VR Adviser, LLC | 5,129,167 | 5,684,167 | +555,000 | 1.64 | 3.05 | +1.41 | buy |
| Sofinnova Investments, Inc. | 2,400,771 | 2,773,286 | +372,515 | 0.90 | 1.22 | +0.32 | buy |
| ALGERT GLOBAL LLC | 364,112 | 157,034 | +207,078 | 0.10 | 0.05 | 0.00 | sell |
| READYSTATE ASSET MANAGEMENT LP | 537,200 | 734,197 | +196,997 | 0.13 | 0.29 | +0.17 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,036,667 | 1,206,214 | +169,547 | 1.95 | 2.51 | +0.56 | buy |
| Saturn V Capital Management LP | 1,595,021 | 1,673,919 | +78,898 | 4.30 | 5.33 | +1.03 | buy |
| PROFUND ADVISORS LLC | 108,486 | 34,494 | +73,992 | 0.03 | 0.01 | 0.00 | sell |
| Fisher Asset Management, LLC | 101,531 | 149,045 | +47,514 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 23,716 | 53,716 | +30,000 | 0.02 | 0.04 | +0.03 | buy |
| Cinctive Capital Management LP | 145,514 | 172,450 | +26,936 | 0.05 | 0.08 | +0.03 | buy |
| NEOS Investment Management LLC | 18,301 | 43,856 | +25,555 | 0.01 | 0.02 | +0.01 | buy |
| Crestline Management, LP | 315,000 | 326,070 | +11,070 | 0.19 | 0.21 | +0.03 | buy |
| SkyView Investment Advisors, LLC | 10,000 | 12,500 | +2,500 | 0.01 | 0.02 | +0.01 | buy |
| CORNERCAP INVESTMENT COUNSEL INC | 34,494 | 34,138 | -356 | 0.04 | 0.05 | +0.01 | sell |
| 49 WEALTH MANAGEMENT, LLC | 13,137 | 12,582 | -555 | 0.02 | 0.02 | +0.00 | sell |
| Forefront Analytics, LLC | 19,275 | 15,627 | -3,648 | 0.06 | 0.06 | +0.00 | sell |
| VIRTUS ADVISERS, LLC | 17,467 | 10,081 | -7,386 | 0.06 | 0.04 | -0.02 | sell |
| Deep Track Capital, LP | 316,000 | 308,235 | -7,765 | 0.06 | 0.08 | +0.02 | sell |
| China Universal Asset Management Co., Ltd. | 19,950 | 11,232 | -8,718 | 0.02 | 0.01 | -0.00 | sell |
| Atom Investors LP | 40,482 | 23,174 | -17,308 | 0.03 | 0.02 | -0.01 | sell |
| Entropy Technologies, LP | 31,632 | 10,638 | -20,994 | 0.02 | 0.01 | -0.01 | sell |
| E Fund Management Co., Ltd. | 33,308 | 11,173 | -22,135 | 0.01 | 0.01 | -0.01 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 186,254 | 157,851 | -28,403 | 0.05 | 0.05 | +0.00 | sell |
| Prosight Management, LP | 555,500 | 500,000 | -55,500 | 1.04 | 1.26 | +0.22 | sell |
| Woodline Partners LP | 698,378 | 600,098 | -98,280 | 0.04 | 0.05 | +0.01 | sell |
| SECTORAL ASSET MANAGEMENT INC | 263,700 | 85,600 | -178,100 | 0.70 | 0.29 | -0.40 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 705,631 | 459,938 | -245,693 | 0.10 | 0.08 | -0.01 | sell |
| Rafferty Asset Management, LLC | 704,860 | 183,963 | -520,897 | 0.02 | 0.01 | -0.01 | sell |