| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Point72 Asset Management, L.P. | 6,676,248 | 10,470,398 | +3,794,150 | 0.13 | 0.29 | +0.16 | buy |
| Commodore Capital LP | 6,425,000 | 9,738,000 | +3,313,000 | 2.89 | 5.60 | +2.72 | buy |
| Kynam Capital Management, LP | 8,500,000 | 9,260,385 | +760,385 | 6.35 | 8.17 | +1.82 | buy |
| FMR LLC | 6,964,608 | 7,693,668 | +729,060 | 0.00 | 0.00 | +0.00 | buy |
| TCG Crossover Management, LLC | 6,214,375 | 6,964,375 | +750,000 | 3.30 | 6.12 | +2.82 | buy |
| Fairmount Funds Management LLC | 4,725,641 | 6,225,641 | +1,500,000 | 3.46 | 5.93 | +2.47 | buy |
| VR Adviser, LLC | 5,129,167 | 5,684,167 | +555,000 | 1.64 | 3.05 | +1.41 | buy |
| VANGUARD GROUP INC | 5,765,705 | 5,259,879 | -505,826 | 0.00 | 0.00 | +0.00 | sell |
| Redmile Group, LLC | 3,962,602 | 4,799,973 | +837,371 | 0.98 | 2.45 | +1.47 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,333,333 | 4,248,888 | +2,915,555 | 0.02 | 0.07 | +0.05 | buy |
| STATE STREET CORP | 7,626,869 | 3,836,962 | -3,789,907 | 0.00 | 0.00 | -0.00 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,534,345 | 3,744,263 | +2,209,918 | 0.18 | 0.53 | +0.35 | buy |
| Paradigm Biocapital Advisors LP | 0 | 3,624,342 | +3,624,342 | 0.00 | 1.17 | +1.17 | buy |
| Sofinnova Investments, Inc. | 2,400,771 | 2,773,286 | +372,515 | 0.95 | 1.47 | +0.52 | buy |
| Vivo Capital, LLC | 2,244,941 | 2,244,941 | 0 | 1.19 | 1.75 | +0.56 | hold |
| GEODE CAPITAL MANAGEMENT, LLC | 1,777,104 | 1,980,731 | +203,627 | 0.00 | 0.00 | +0.00 | buy |
| Saturn V Capital Management LP | 1,595,021 | 1,673,919 | +78,898 | 4.30 | 5.33 | +1.03 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 0 | 1,398,992 | +1,398,992 | 0.00 | 0.20 | +0.20 | buy |
| MILLENNIUM MANAGEMENT LLC | 2,355,926 | 1,231,857 | -1,124,069 | 0.01 | 0.01 | -0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,036,667 | 1,206,214 | +169,547 | 1.95 | 2.51 | +0.56 | buy |
| Avidity Partners Management LP | 445,706 | 1,000,706 | +555,000 | 0.11 | 0.36 | +0.25 | buy |
| FRANKLIN RESOURCES INC | 0 | 1,000,116 | +1,000,116 | 0.00 | 0.00 | +0.00 | buy |
| MORGAN STANLEY | 1,850,716 | 981,644 | -869,072 | 0.00 | 0.00 | -0.00 | sell |
| Frazier Life Sciences Management, L.P. | 936,576 | 936,576 | 0 | 0.27 | 0.37 | +0.10 | hold |
| DIMENSIONAL FUND ADVISORS LP | 1,394,198 | 930,297 | -463,901 | 0.00 | 0.00 | -0.00 | sell |
| Nantahala Capital Management, LLC | 790,936 | 790,936 | 0 | 0.52 | 0.67 | +0.15 | hold |
| 5AM Venture Management, LLC | 790,440 | 790,440 | 0 | 1.19 | 1.49 | +0.30 | hold |
| READYSTATE ASSET MANAGEMENT LP | 537,200 | 734,197 | +196,997 | 0.13 | 0.29 | +0.17 | buy |
| NORTHERN TRUST CORP | 715,094 | 719,452 | +4,358 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 619,036 | 686,697 | +67,661 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 600,764 | 600,764 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Woodline Partners LP | 698,378 | 600,098 | -98,280 | 0.04 | 0.05 | +0.01 | sell |
| GOLDMAN SACHS GROUP INC | 871,197 | 513,747 | -357,450 | 0.00 | 0.00 | -0.00 | sell |
| Prosight Management, LP | 555,500 | 500,000 | -55,500 | 1.04 | 1.26 | +0.22 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 705,631 | 459,938 | -245,693 | 0.10 | 0.08 | -0.01 | sell |
| FARALLON CAPITAL MANAGEMENT LLC | 462,000 | 425,161 | -36,839 | 0.02 | 0.02 | +0.00 | sell |
| BANK OF AMERICA CORP /DE/ | 473,389 | 406,317 | -67,072 | 0.00 | 0.00 | +0.00 | sell |
| Bank of New York Mellon Corp | 280,814 | 326,584 | +45,770 | 0.00 | 0.00 | +0.00 | buy |
| Crestline Management, LP | 315,000 | 326,070 | +11,070 | 0.20 | 0.22 | +0.02 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 296,311 | 316,853 | +20,542 | 0.00 | 0.00 | +0.00 | buy |
| Deep Track Capital, LP | 316,000 | 308,235 | -7,765 | 0.06 | 0.08 | +0.02 | sell |
| D. E. Shaw & Co., Inc. | 451,232 | 298,711 | -152,521 | 0.00 | 0.00 | -0.00 | sell |
| HighVista Strategies LLC | 281,093 | 281,093 | 0 | 0.67 | 0.87 | +0.19 | hold |
| New Leaf Venture Partners, L.L.C. | 250,765 | 250,765 | 0 | 1.47 | 2.57 | +1.10 | hold |
| JANE STREET GROUP, LLC | 44,722 | 248,544 | +203,822 | 0.00 | 0.00 | +0.00 | buy |
| PANAGORA ASSET MANAGEMENT INC | 307,245 | 246,333 | -60,912 | 0.01 | 0.01 | -0.00 | sell |
| DEUTSCHE BANK AG\ | 238,926 | 238,440 | -486 | 0.00 | 0.00 | +0.00 | sell |
| MACQUARIE GROUP LTD | 230,000 | 230,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Rafferty Asset Management, LLC | 704,860 | 183,963 | -520,897 | 0.02 | 0.01 | -0.01 | sell |
| TWO SIGMA ADVISERS, LP | 176,290 | 173,790 | -2,500 | 0.00 | 0.00 | +0.00 | sell |
| Cinctive Capital Management LP | 145,514 | 172,450 | +26,936 | 0.05 | 0.08 | +0.03 | buy |
| Invesco Ltd. | 36,842 | 163,966 | +127,124 | 0.00 | 0.00 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 186,254 | 157,851 | -28,403 | 0.05 | 0.05 | +0.00 | sell |
| ALGERT GLOBAL LLC | 364,112 | 157,034 | -207,078 | 0.10 | 0.04 | -0.05 | sell |
| TWO SIGMA INVESTMENTS, LP | 140,710 | 149,401 | +8,691 | 0.00 | 0.00 | +0.00 | buy |
| Fisher Asset Management, LLC | 101,531 | 149,045 | +47,514 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 18,853 | 148,854 | +130,001 | 0.00 | 0.02 | +0.02 | buy |
| Cubist Systematic Strategies, LLC | 100,005 | 134,660 | +34,655 | 0.01 | 0.02 | +0.01 | buy |
| RHUMBLINE ADVISERS | 119,133 | 130,516 | +11,383 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 0 | 127,712 | +127,712 | 0.00 | 0.06 | +0.06 | buy |
| UBS Group AG | 431,005 | 126,539 | -304,466 | 0.00 | 0.00 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 69,557 | 126,217 | +56,660 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 124,000 | 124,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 92,933 | 103,200 | +10,267 | 0.00 | 0.00 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 263,700 | 85,600 | -178,100 | 0.70 | 0.29 | -0.40 | sell |
| BARCLAYS PLC | 107,653 | 78,143 | -29,510 | 0.00 | 0.00 | -0.00 | sell |
| ALPS ADVISORS INC | 0 | 74,598 | +74,598 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 72,200 | 72,200 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 54,118 | 67,300 | +13,182 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 64,351 | 62,945 | -1,406 | 0.00 | 0.00 | +0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 25,427 | 59,395 | +33,968 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 86,604 | 59,108 | -27,496 | 0.00 | 0.00 | -0.00 | sell |
| PDT Partners, LLC | 23,716 | 53,716 | +30,000 | 0.02 | 0.04 | +0.03 | buy |
| MetLife Investment Management, LLC | 42,642 | 53,368 | +10,726 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 52,029 | 44,997 | -7,032 | 0.00 | 0.00 | +0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 0 | 44,859 | +44,859 | 0.00 | 0.02 | +0.02 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 44,441 | +44,441 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 18,301 | 43,856 | +25,555 | 0.01 | 0.02 | +0.01 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 42,532 | +42,532 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 35,211 | 40,617 | +5,406 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 599,989 | 39,330 | -560,659 | 0.00 | 0.00 | -0.00 | sell |
| Jump Financial, LLC | 10,525 | 37,695 | +27,170 | 0.00 | 0.01 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 31,224 | 35,752 | +4,528 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 108,486 | 34,494 | -73,992 | 0.03 | 0.01 | -0.02 | sell |
| CORNERCAP INVESTMENT COUNSEL INC | 34,494 | 34,138 | -356 | 0.04 | 0.05 | +0.01 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 27,320 | 30,823 | +3,503 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 26,853 | 30,144 | +3,291 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 33,921 | 29,902 | -4,019 | 0.00 | 0.00 | +0.00 | sell |
| Verition Fund Management LLC | 10,848 | 29,052 | +18,204 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 31,292 | 25,137 | -6,155 | 0.19 | 0.10 | -0.09 | sell |
| Atom Investors LP | 40,482 | 23,174 | -17,308 | 0.03 | 0.02 | -0.01 | sell |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 14,982 | 23,142 | +8,160 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 29,668 | 23,101 | -6,567 | 0.01 | 0.01 | +0.00 | sell |
| Brevan Howard Capital Management LP | 0 | 22,559 | +22,559 | 0.00 | 0.01 | +0.01 | buy |
| Tower Research Capital LLC (TRC) | 2,644 | 22,364 | +19,720 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 18,934 | 18,934 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Catalyst Funds Management Pty Ltd | 0 | 17,600 | +17,600 | 0.00 | 0.04 | +0.04 | buy |
| Arizona State Retirement System | 17,123 | 17,399 | +276 | 0.00 | 0.00 | +0.00 | buy |
| ProShare Advisors LLC | 22,206 | 17,028 | -5,178 | 0.00 | 0.00 | -0.00 | sell |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 16,598 | +16,598 | 0.00 | 0.00 | +0.00 | buy |