| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 8,963,655 | 10,352,449 | +1,388,794 | 2.47 | 3.17 | +0.70 | buy |
| Saturn V Capital Management LP | 1,480,020 | 2,297,524 | +817,504 | 4.47 | 6.69 | +2.21 | buy |
| Nantahala Capital Management, LLC | 843,489 | 1,655,689 | +812,200 | 0.20 | 0.47 | +0.27 | buy |
| Frazier Life Sciences Management, L.P. | 936,576 | 1,734,601 | +798,025 | 0.26 | 0.50 | +0.24 | buy |
| ALGERT GLOBAL LLC | 528,262 | 864,066 | +335,804 | 0.08 | 0.13 | 0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 774,721 | 962,951 | +188,230 | 5.54 | 8.61 | +3.08 | buy |
| Sofinnova Investments, Inc. | 2,182,121 | 2,355,505 | +173,384 | 0.85 | 1.03 | +0.18 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 133,910 | 219,504 | +85,594 | 0.05 | 0.10 | +0.06 | buy |
| Vestal Point Capital, LP | 3,000,000 | 3,080,000 | +80,000 | 1.28 | 1.16 | -0.12 | buy |
| NEOS Investment Management LLC | 71,563 | 117,639 | +46,076 | 0.01 | 0.01 | +0.00 | buy |
| TEMA ETFS LLC | 71,563 | 117,639 | +46,076 | 0.13 | 0.22 | +0.10 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 481,241 | 520,127 | +38,886 | 0.07 | 0.09 | +0.02 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,633,862 | 2,640,215 | +6,353 | 0.31 | 0.34 | +0.03 | buy |
| HighVista Strategies LLC | 279,673 | 283,186 | +3,513 | 0.65 | 0.75 | +0.10 | buy |
| Hennion & Walsh Asset Management, Inc. | 302,481 | 305,615 | +3,134 | 0.08 | 0.09 | +0.01 | buy |
| SummitTX Capital, L.P. | 297,128 | 299,939 | +2,811 | 0.08 | 0.09 | +0.02 | buy |
| 49 WEALTH MANAGEMENT, LLC | 13,032 | 15,508 | +2,476 | 0.01 | 0.01 | +0.00 | buy |
| Corton Capital Inc. | 16,392 | 17,438 | +1,046 | 0.32 | 0.15 | -0.18 | buy |
| China Universal Asset Management Co., Ltd. | 22,836 | 22,868 | +32 | 0.01 | 0.02 | +0.00 | buy |
| E Fund Management Co., Ltd. | 15,670 | 10,205 | -5,465 | 0.00 | 0.00 | -0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 169,449 | 163,181 | -6,268 | 0.08 | 0.11 | +0.04 | sell |
| Virtus Investment Advisers, LLC | 19,687 | 13,024 | -6,663 | 0.03 | 0.03 | -0.00 | sell |
| PROFUND ADVISORS LLC | 34,895 | 20,157 | -14,738 | 0.01 | 0.01 | -0.00 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 46,626 | 26,385 | -20,241 | 0.04 | 0.03 | -0.01 | sell |
| Rafferty Asset Management, LLC | 167,675 | 91,662 | -76,013 | 0.00 | 0.00 | -0.00 | sell |
| Exome Asset Management LLC | 621,678 | 533,647 | -88,031 | 3.34 | 3.16 | -0.18 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 335,024 | 143,693 | -191,331 | 0.46 | 0.24 | -0.22 | sell |
| Kynam Capital Management, LP | 9,105,000 | 8,492,557 | -612,443 | 4.67 | 6.56 | +1.90 | sell |
| Woodline Partners LP | 1,687,540 | 1,000,611 | -686,929 | 0.07 | 0.04 | -0.03 | sell |
| VR Adviser, LLC | 5,684,411 | 4,755,411 | -929,000 | 2.90 | 2.56 | -0.34 | sell |
| Redmile Group, LLC | 3,216,026 | 1,448,040 | -1,767,986 | 1.82 | 1.11 | -0.71 | sell |
| Commodore Capital LP | 8,892,816 | 2,311,164 | -6,581,652 | 3.93 | 1.17 | -2.75 | sell |