| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| JANUS HENDERSON GROUP PLC | 29,073 | 2,873,053 | +2,843,980 | 0.00 | 0.01 | +0.01 | buy |
| EMERALD ADVISERS, LLC | 0 | 1,445,774 | +1,445,774 | 0.00 | 0.38 | +0.38 | buy |
| Paradigm Biocapital Advisors LP | 8,963,655 | 10,352,449 | +1,388,794 | 2.47 | 3.17 | +0.70 | buy |
| Ikarian Capital, LLC | 0 | 1,035,528 | +1,035,528 | 0.00 | 2.46 | +2.46 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 0 | 895,412 | +895,412 | 0.00 | 0.39 | +0.39 | buy |
| Siren, L.L.C. | 0 | 854,379 | +854,379 | 0.00 | 0.32 | +0.32 | buy |
| Saturn V Capital Management LP | 1,480,020 | 2,297,524 | +817,504 | 4.47 | 6.69 | +2.21 | buy |
| Nantahala Capital Management, LLC | 843,489 | 1,655,689 | +812,200 | 0.42 | 0.84 | +0.42 | buy |
| Rock Springs Capital Management LP | 0 | 800,199 | +800,199 | 0.00 | 0.36 | +0.36 | buy |
| Frazier Life Sciences Management, L.P. | 936,576 | 1,734,601 | +798,025 | 0.26 | 0.50 | +0.24 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 502,000 | +502,000 | 0.00 | 0.11 | +0.11 | buy |
| VANGUARD GROUP INC | 6,058,338 | 6,522,951 | +464,613 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 514,498 | 969,973 | +455,475 | 0.00 | 0.01 | +0.00 | buy |
| BlackRock, Inc. | 8,175,527 | 8,626,581 | +451,054 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 437,228 | +437,228 | 0.00 | 0.29 | +0.29 | buy |
| Candriam S.C.A. | 0 | 427,342 | +427,342 | 0.00 | 0.02 | +0.02 | buy |
| UBS Group AG | 3,104,130 | 3,518,671 | +414,541 | 0.00 | 0.01 | +0.00 | buy |
| ALGERT GLOBAL LLC | 528,262 | 864,066 | +335,804 | 0.08 | 0.13 | +0.05 | buy |
| BANK OF AMERICA CORP /DE/ | 1,071,258 | 1,400,965 | +329,707 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 183,821 | 501,043 | +317,222 | 0.01 | 0.04 | +0.03 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 136,742 | 406,118 | +269,376 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,415,854 | 2,672,113 | +256,259 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 988,962 | 1,200,437 | +211,475 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 6,187 | 215,414 | +209,227 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 189,708 | +189,708 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 774,721 | 962,951 | +188,230 | 5.54 | 8.61 | +3.08 | buy |
| ExodusPoint Capital Management, LP | 0 | 176,276 | +176,276 | 0.00 | 0.02 | +0.02 | buy |
| Sofinnova Investments, Inc. | 2,182,121 | 2,355,505 | +173,384 | 0.99 | 1.15 | +0.17 | buy |
| BARCLAYS PLC | 174,918 | 320,565 | +145,647 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 489,688 | 621,235 | +131,547 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 124,728 | +124,728 | 0.00 | 0.00 | +0.00 | buy |
| F/m Investments LLC | 0 | 120,011 | +120,011 | 0.00 | 0.03 | +0.03 | buy |
| Bollard Group LLC | 0 | 105,059 | +105,059 | 0.00 | 0.02 | +0.02 | buy |
| Squarepoint Ops LLC | 0 | 101,518 | +101,518 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 95,720 | +95,720 | 0.00 | 0.02 | +0.02 | buy |
| XTX Topco Ltd | 21,072 | 116,489 | +95,417 | 0.01 | 0.03 | +0.03 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 133,910 | 219,504 | +85,594 | 0.05 | 0.10 | +0.06 | buy |
| Vestal Point Capital, LP | 3,000,000 | 3,080,000 | +80,000 | 1.28 | 1.16 | -0.12 | buy |
| SIMPLEX TRADING, LLC | 12 | 79,361 | +79,349 | 0.00 | 0.02 | +0.02 | buy |
| Y-Intercept (Hong Kong) Ltd | 43,499 | 116,127 | +72,628 | 0.02 | 0.02 | +0.00 | buy |
| GROUP ONE TRADING LLC | 660 | 72,444 | +71,784 | 0.00 | 0.02 | +0.02 | buy |
| Engineers Gate Manager LP | 25,916 | 90,272 | +64,356 | 0.00 | 0.01 | +0.01 | buy |
| Russell Investments Group, Ltd. | 29,843 | 93,219 | +63,376 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 826,295 | 886,987 | +60,692 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 148,280 | 207,198 | +58,918 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 41,829 | 98,589 | +56,760 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 217,531 | 273,535 | +56,004 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 879,837 | 934,495 | +54,658 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 71,563 | 117,639 | +46,076 | 0.01 | 0.01 | +0.00 | buy |
| TEMA ETFS LLC | 71,563 | 117,639 | +46,076 | 0.13 | 0.22 | +0.10 | buy |
| Invesco Ltd. | 68,743 | 113,060 | +44,317 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 10,494 | 53,675 | +43,181 | 0.00 | 0.00 | +0.00 | buy |
| Brevan Howard Capital Management LP | 0 | 41,481 | +41,481 | 0.00 | 0.00 | +0.00 | buy |
| Birchview Capital, LP | 0 | 40,000 | +40,000 | 0.00 | 0.29 | +0.29 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 258,301 | 297,364 | +39,063 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 481,241 | 520,127 | +38,886 | 0.07 | 0.09 | +0.02 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 164,213 | 201,989 | +37,776 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 256,600 | 291,791 | +35,191 | 0.00 | 0.00 | +0.00 | buy |
| AIGEN INVESTMENT MANAGEMENT, LP | 0 | 33,784 | +33,784 | 0.00 | 0.03 | +0.03 | buy |
| Ensign Peak Advisors, Inc | 18,825 | 49,325 | +30,500 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 130,458 | 156,517 | +26,059 | 0.00 | 0.00 | +0.00 | buy |
| DRW Securities, LLC | 0 | 23,194 | +23,194 | 0.00 | 0.01 | +0.01 | buy |
| Qube Research & Technologies Ltd | 0 | 18,902 | +18,902 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 54,386 | 73,152 | +18,766 | 0.00 | 0.00 | +0.00 | buy |
| OXFORD ASSET MANAGEMENT LLP | 0 | 15,931 | +15,931 | 0.00 | 0.04 | +0.04 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 7,024 | 20,918 | +13,894 | 0.00 | 0.00 | +0.00 | buy |
| Belvedere Trading LLC | 0 | 13,727 | +13,727 | 0.00 | 0.01 | +0.01 | buy |
| SHERBROOKE PARK ADVISERS LLC | 0 | 13,038 | +13,038 | 0.00 | 0.04 | +0.04 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 12,905 | +12,905 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 5,192 | 17,805 | +12,613 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA SECURITIES, LLC | 0 | 11,428 | +11,428 | 0.00 | 0.01 | +0.01 | buy |
| WELLS FARGO & COMPANY/MN | 44,628 | 55,934 | +11,306 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 52,736 | 63,712 | +10,976 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 69,167 | 80,045 | +10,878 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 13,874 | 22,451 | +8,577 | 0.00 | 0.00 | +0.00 | buy |
| KLP KAPITALFORVALTNING AS | 11,300 | 18,900 | +7,600 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,633,862 | 2,640,215 | +6,353 | 0.31 | 0.34 | +0.03 | buy |
| Brooklyn Investment Group | 316 | 6,099 | +5,783 | 0.00 | 0.01 | +0.01 | buy |
| Police & Firemen's Retirement System of New Jersey | 18,485 | 23,571 | +5,086 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 33,885 | 38,915 | +5,030 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 25,428 | 29,344 | +3,916 | 0.00 | 0.00 | +0.00 | buy |
| HighVista Strategies LLC | 279,673 | 283,186 | +3,513 | 0.65 | 0.75 | +0.10 | buy |
| Gordian Capital Singapore Pte Ltd | 0 | 3,200 | +3,200 | 0.00 | 0.03 | +0.03 | buy |
| Hennion & Walsh Asset Management, Inc. | 302,481 | 305,615 | +3,134 | 0.08 | 0.09 | +0.01 | buy |
| SummitTX Capital, L.P. | 297,128 | 299,939 | +2,811 | 0.08 | 0.09 | +0.02 | buy |
| 49 WEALTH MANAGEMENT, LLC | 13,032 | 15,508 | +2,476 | 0.01 | 0.01 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 9,296 | 10,839 | +1,543 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 17,077,329 | 17,078,468 | +1,139 | 0.01 | 0.01 | +0.00 | buy |
| Corton Capital Inc. | 16,392 | 17,438 | +1,046 | 0.32 | 0.15 | -0.18 | buy |
| ProShare Advisors LLC | 25,001 | 26,021 | +1,020 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 20,567 | 21,578 | +1,011 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 19,217 | 19,858 | +641 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 3,810 | 4,398 | +588 | 0.00 | 0.00 | +0.00 | buy |
| NORTHWESTERN MUTUAL WEALTH MANAGEMENT CO | 0 | 400 | +400 | 0.00 | 0.00 | +0.00 | buy |
| Farther Finance Advisors, LLC | 352 | 747 | +395 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 62,275 | 62,642 | +367 | 0.00 | 0.00 | +0.00 | buy |
| Versant Capital Management, Inc | 0 | 170 | +170 | 0.00 | 0.00 | +0.00 | buy |
| Sterling Capital Management LLC | 198 | 353 | +155 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 326 | 463 | +137 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 155 | 275 | +120 | 0.00 | 0.00 | +0.00 | buy |