| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 23,122,748 | 25,681,174 | +2,558,426 | 0.05 | 0.04 | -0.00 | buy |
| BlackRock, Inc. | 16,045,014 | 17,352,646 | +1,307,632 | 0.01 | 0.01 | -0.00 | buy |
| STATE STREET CORP | 5,663,543 | 6,964,919 | +1,301,376 | 0.01 | 0.01 | +0.00 | buy |
| Fairmount Funds Management LLC | 5,503,418 | 5,503,418 | 0 | 15.30 | 14.08 | -1.22 | hold |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 9,043,903 | 5,006,104 | -4,037,799 | 4.11 | 2.02 | -2.09 | sell |
| TCG Crossover Management, LLC | 4,946,894 | 4,854,436 | -92,458 | 5.45 | 4.52 | -0.93 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,212,815 | 4,652,727 | +1,439,912 | 0.01 | 0.02 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,699,519 | 4,508,998 | +809,479 | 0.01 | 0.01 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 3,578,622 | 4,343,977 | +765,355 | 0.03 | 0.03 | +0.00 | buy |
| Kynam Capital Management, LP | 4,037,331 | 3,667,097 | -370,234 | 9.86 | 7.84 | -2.02 | sell |
| LORD, ABBETT & CO. LLC | 3,181,270 | 3,431,030 | +249,760 | 0.40 | 0.38 | -0.02 | buy |
| Polar Capital Holdings Plc | 0 | 3,232,905 | +3,232,905 | 0.00 | 0.35 | +0.35 | buy |
| Commodore Capital LP | 2,888,007 | 3,050,000 | +161,993 | 6.43 | 7.03 | +0.60 | buy |
| Invesco Ltd. | 2,429,629 | 2,609,141 | +179,512 | 0.01 | 0.01 | -0.00 | buy |
| Woodline Partners LP | 1,509,557 | 2,603,162 | +1,093,605 | 0.22 | 0.31 | +0.09 | buy |
| Pictet Asset Management Holding SA | 1,798,768 | 2,393,515 | +594,747 | 0.07 | 0.09 | +0.02 | buy |
| Octagon Capital Advisors LP | 2,350,000 | 2,350,000 | 0 | 10.01 | 8.35 | -1.66 | hold |
| RTW INVESTMENTS, LP | 5,458,675 | 2,309,021 | -3,149,654 | 2.09 | 0.76 | -1.33 | sell |
| GOLDMAN SACHS GROUP INC | 4,434,054 | 2,288,633 | -2,145,421 | 0.02 | 0.01 | -0.01 | sell |
| Candriam S.C.A. | 1,516,297 | 2,088,369 | +572,072 | 0.30 | 0.36 | +0.06 | buy |
| Deep Track Capital, LP | 1,000,000 | 2,000,000 | +1,000,000 | 0.79 | 1.14 | +0.35 | buy |
| Siren, L.L.C. | 1,709,279 | 1,859,279 | +150,000 | 1.82 | 1.46 | -0.36 | buy |
| ORBIMED ADVISORS LLC | 322,100 | 1,681,300 | +1,359,200 | 0.27 | 1.23 | +0.96 | buy |
| VR Adviser, LLC | 2,000,000 | 1,642,166 | -357,834 | 2.87 | 1.93 | -0.95 | sell |
| EMERALD ADVISERS, LLC | 1,588,132 | 1,603,319 | +15,187 | 1.93 | 1.46 | -0.47 | buy |
| NORTHERN TRUST CORP | 1,245,751 | 1,557,830 | +312,079 | 0.01 | 0.01 | +0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 1,449,300 | +1,449,300 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,242,322 | 1,449,300 | +206,978 | 0.01 | 0.01 | +0.00 | buy |
| Assenagon Asset Management S.A. | 295,650 | 1,441,756 | +1,146,106 | 0.02 | 0.07 | +0.05 | buy |
| BANK OF AMERICA CORP /DE/ | 1,043,805 | 1,439,632 | +395,827 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 890,568 | 1,432,957 | +542,389 | 0.02 | 0.02 | +0.01 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,314,189 | 1,280,707 | -33,482 | 5.96 | 5.52 | -0.44 | sell |
| UBS Group AG | 291,486 | 1,122,245 | +830,759 | 0.00 | 0.01 | +0.00 | buy |
| FRED ALGER MANAGEMENT, LLC | 1,239,700 | 1,072,830 | -166,870 | 0.21 | 0.14 | -0.07 | sell |
| Sofinnova Investments, Inc. | 2,113,551 | 1,035,148 | -1,078,403 | 4.08 | 2.14 | -1.94 | sell |
| EMERALD MUTUAL FUND ADVISERS TRUST | 1,028,832 | 1,031,378 | +2,546 | 1.92 | 1.40 | -0.52 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 449,482 | 1,022,183 | +572,701 | 0.01 | 0.01 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 706,268 | 996,168 | +289,900 | 0.04 | 0.05 | +0.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 856,598 | 954,843 | +98,245 | 0.06 | 0.07 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 664,146 | 952,757 | +288,611 | 0.03 | 0.03 | +0.01 | buy |
| MORGAN STANLEY | 642,679 | 941,725 | +299,046 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 1,868,389 | 922,479 | -945,910 | 0.06 | 0.02 | -0.03 | sell |
| MILLENNIUM MANAGEMENT LLC | 1,192,406 | 907,712 | -284,694 | 0.03 | 0.02 | -0.01 | sell |
| Logos Global Management LP | 0 | 900,000 | +900,000 | 0.00 | 1.50 | +1.50 | buy |
| CITADEL ADVISORS LLC | 1,714,927 | 849,694 | -865,233 | 0.05 | 0.02 | -0.03 | sell |
| Point72 Asset Management, L.P. | 1,410,826 | 744,195 | -666,631 | 0.09 | 0.04 | -0.05 | sell |
| MARSHALL WACE, LLP | 1,600,168 | 706,153 | -894,015 | 0.07 | 0.02 | -0.04 | sell |
| BOOTHBAY FUND MANAGEMENT, LLC | 122,228 | 692,825 | +570,597 | 0.11 | 0.50 | +0.39 | buy |
| RAYMOND JAMES FINANCIAL INC | 369,715 | 673,676 | +303,961 | 0.00 | 0.01 | +0.00 | buy |
| Nuveen, LLC | 831,602 | 657,664 | -173,938 | 0.01 | 0.01 | -0.00 | sell |
| J. Goldman & Co LP | 779,570 | 637,994 | -141,576 | 1.39 | 0.87 | -0.52 | sell |
| First Turn Management, LLC | 947,339 | 602,281 | -345,058 | 4.07 | 2.49 | -1.58 | sell |
| ALLIANCEBERNSTEIN L.P. | 157,310 | 572,694 | +415,384 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 372,796 | 533,968 | +161,172 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 624,155 | 515,917 | -108,238 | 1.42 | 0.97 | -0.44 | sell |
| Fiera Capital Corp | 558,252 | 511,824 | -46,428 | 0.07 | 0.07 | -0.00 | sell |
| Redmile Group, LLC | 688,036 | 503,321 | -184,715 | 1.75 | 1.31 | -0.45 | sell |
| DIADEMA PARTNERS LP | 322,764 | 493,664 | +170,900 | 5.13 | 6.75 | +1.62 | buy |
| Eversept Partners, LP | 0 | 490,235 | +490,235 | 0.00 | 1.03 | +1.03 | buy |
| Russell Investments Group, Ltd. | 374,868 | 474,898 | +100,030 | 0.02 | 0.02 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 416,340 | 459,340 | +43,000 | 2.76 | 2.54 | -0.21 | buy |
| Ensign Peak Advisors, Inc | 572,872 | 457,302 | -115,570 | 0.04 | 0.03 | -0.01 | sell |
| Affinity Asset Advisors, LLC | 750,000 | 450,000 | -300,000 | 1.69 | 0.85 | -0.84 | sell |
| TimesSquare Capital Management, LLC | 85,000 | 447,745 | +362,745 | 0.06 | 0.25 | +0.20 | buy |
| Patient Square Capital LP | 596,000 | 425,000 | -171,000 | 4.07 | 2.55 | -1.52 | sell |
| SEGALL BRYANT & HAMILL, LLC | 0 | 421,207 | +421,207 | 0.00 | 0.19 | +0.19 | buy |
| AMERIPRISE FINANCIAL INC | 252,114 | 418,316 | +166,202 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 272,707 | 393,234 | +120,527 | 0.02 | 0.02 | +0.00 | buy |
| Neuberger Berman Group LLC | 6,061 | 384,296 | +378,235 | 0.00 | 0.01 | +0.01 | buy |
| Ikarian Capital, LLC | 0 | 370,084 | +370,084 | 0.00 | 2.34 | +2.34 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 360,490 | 353,790 | -6,700 | 0.29 | 0.24 | -0.05 | sell |
| SUPERSTRING CAPITAL MANAGEMENT LP | 225,158 | 343,284 | +118,126 | 6.19 | 8.39 | +2.20 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 343,082 | 332,334 | -10,748 | 0.01 | 0.01 | -0.00 | sell |
| Burkehill Global Management, LP | 675,000 | 325,000 | -350,000 | 1.29 | 0.45 | -0.83 | sell |
| AQR CAPITAL MANAGEMENT LLC | 189,796 | 294,913 | +105,117 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 285,661 | 282,979 | -2,682 | 0.02 | 0.02 | -0.00 | sell |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 70,478 | 279,066 | +208,588 | 0.00 | 0.01 | +0.01 | buy |
| Alyeska Investment Group, L.P. | 250,000 | 274,849 | +24,849 | 0.03 | 0.03 | +0.00 | buy |
| Atika Capital Management LLC | 293,200 | 272,000 | -21,200 | 1.78 | 1.04 | -0.74 | sell |
| DEUTSCHE BANK AG\ | 127,469 | 266,584 | +139,115 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 262,704 | 258,952 | -3,752 | 0.00 | 0.00 | -0.00 | sell |
| Parkman Healthcare Partners LLC | 100,126 | 253,365 | +153,239 | 0.40 | 1.01 | +0.61 | buy |
| Evergreen Quality Fund GP, Ltd. | 250,000 | 250,000 | 0 | 0.22 | 0.16 | -0.06 | hold |
| Swiss National Bank | 165,400 | 246,400 | +81,000 | 0.00 | 0.00 | +0.00 | buy |
| NWI MANAGEMENT LP | 241,671 | 241,671 | 0 | 0.57 | 0.60 | +0.03 | hold |
| Tidal Investments LLC | 231,569 | 241,565 | +9,996 | 0.03 | 0.02 | -0.01 | buy |
| TEMA ETFS LLC | 176,667 | 241,565 | +64,898 | 0.46 | 0.30 | -0.15 | buy |
| Susquehanna Portfolio Strategies, LLC | 229,755 | 229,755 | 0 | 0.13 | 0.14 | +0.01 | hold |
| F/m Investments LLC | 226,142 | 228,688 | +2,546 | 0.58 | 0.45 | -0.13 | buy |
| WELLS FARGO & COMPANY/MN | 106,660 | 228,426 | +121,766 | 0.00 | 0.00 | +0.00 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 201,959 | 226,350 | +24,391 | 0.29 | 0.28 | -0.00 | buy |
| Boxer Capital Management, LLC | 225,000 | 225,000 | 0 | 1.14 | 0.66 | -0.48 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 223,216 | 224,116 | +900 | 0.01 | 0.01 | -0.00 | buy |
| Exome Asset Management LLC | 278,533 | 210,523 | -68,010 | 6.31 | 5.03 | -1.28 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 165,510 | 209,402 | +43,892 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 175,276 | 207,609 | +32,333 | 0.01 | 0.01 | +0.00 | buy |
| Integral Health Asset Management, LLC | 350,000 | 200,000 | -150,000 | 0.71 | 0.32 | -0.40 | sell |
| Pier Capital, LLC | 101,304 | 188,951 | +87,647 | 0.64 | 0.97 | +0.33 | buy |
| HighVista Strategies LLC | 197,051 | 188,780 | -8,271 | 2.09 | 1.67 | -0.43 | sell |
| Jefferies Financial Group Inc. | 55,574 | 188,159 | +132,585 | 0.03 | 0.07 | +0.04 | buy |