| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Polar Capital Holdings Plc | 0 | 3,232,905 | +3,232,905 | 0.00 | 0.35 | +0.35 | buy |
| FMR LLC | 23,122,748 | 25,681,174 | +2,558,426 | 0.05 | 0.04 | -0.00 | buy |
| Sixth Street Partners Management Company, L.P. | 0 | 1,449,300 | +1,449,300 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 3,212,815 | 4,652,727 | +1,439,912 | 0.01 | 0.02 | +0.00 | buy |
| ORBIMED ADVISORS LLC | 322,100 | 1,681,300 | +1,359,200 | 0.27 | 1.23 | +0.96 | buy |
| BlackRock, Inc. | 16,045,014 | 17,352,646 | +1,307,632 | 0.01 | 0.01 | -0.00 | buy |
| STATE STREET CORP | 5,663,543 | 6,964,919 | +1,301,376 | 0.01 | 0.01 | +0.00 | buy |
| Assenagon Asset Management S.A. | 295,650 | 1,441,756 | +1,146,106 | 0.02 | 0.07 | +0.05 | buy |
| Woodline Partners LP | 1,509,557 | 2,603,162 | +1,093,605 | 0.22 | 0.31 | +0.09 | buy |
| Deep Track Capital, LP | 1,000,000 | 2,000,000 | +1,000,000 | 0.79 | 1.14 | +0.35 | buy |
| Logos Global Management LP | 0 | 900,000 | +900,000 | 0.00 | 1.50 | +1.50 | buy |
| UBS Group AG | 291,486 | 1,122,245 | +830,759 | 0.00 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,699,519 | 4,508,998 | +809,479 | 0.01 | 0.01 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 3,578,622 | 4,343,977 | +765,355 | 0.03 | 0.03 | +0.00 | buy |
| Pictet Asset Management Holding SA | 1,798,768 | 2,393,515 | +594,747 | 0.07 | 0.09 | +0.02 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 449,482 | 1,022,183 | +572,701 | 0.01 | 0.01 | +0.01 | buy |
| Candriam S.C.A. | 1,516,297 | 2,088,369 | +572,072 | 0.30 | 0.36 | +0.06 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 122,228 | 692,825 | +570,597 | 0.11 | 0.50 | +0.39 | buy |
| AMERICAN CENTURY COMPANIES INC | 890,568 | 1,432,957 | +542,389 | 0.02 | 0.02 | +0.01 | buy |
| Eversept Partners, LP | 0 | 490,235 | +490,235 | 0.00 | 1.03 | +1.03 | buy |
| SEGALL BRYANT & HAMILL, LLC | 0 | 421,207 | +421,207 | 0.00 | 0.19 | +0.19 | buy |
| ALLIANCEBERNSTEIN L.P. | 157,310 | 572,694 | +415,384 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 1,043,805 | 1,439,632 | +395,827 | 0.00 | 0.00 | +0.00 | buy |
| Neuberger Berman Group LLC | 6,061 | 384,296 | +378,235 | 0.00 | 0.01 | +0.01 | buy |
| Ikarian Capital, LLC | 0 | 370,084 | +370,084 | 0.00 | 2.34 | +2.34 | buy |
| TimesSquare Capital Management, LLC | 85,000 | 447,745 | +362,745 | 0.06 | 0.25 | +0.20 | buy |
| NORTHERN TRUST CORP | 1,245,751 | 1,557,830 | +312,079 | 0.01 | 0.01 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 369,715 | 673,676 | +303,961 | 0.00 | 0.01 | +0.00 | buy |
| MORGAN STANLEY | 642,679 | 941,725 | +299,046 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 706,268 | 996,168 | +289,900 | 0.04 | 0.05 | +0.01 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 664,146 | 952,757 | +288,611 | 0.03 | 0.03 | +0.01 | buy |
| LORD, ABBETT & CO. LLC | 3,181,270 | 3,431,030 | +249,760 | 0.40 | 0.38 | -0.02 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 70,478 | 279,066 | +208,588 | 0.00 | 0.01 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,242,322 | 1,449,300 | +206,978 | 0.01 | 0.01 | +0.00 | buy |
| Invesco Ltd. | 2,429,629 | 2,609,141 | +179,512 | 0.01 | 0.01 | -0.00 | buy |
| DIADEMA PARTNERS LP | 322,764 | 493,664 | +170,900 | 5.13 | 6.75 | +1.62 | buy |
| AMERIPRISE FINANCIAL INC | 252,114 | 418,316 | +166,202 | 0.00 | 0.00 | +0.00 | buy |
| Commodore Capital LP | 2,888,007 | 3,050,000 | +161,993 | 6.43 | 7.03 | +0.60 | buy |
| Bank of New York Mellon Corp | 372,796 | 533,968 | +161,172 | 0.00 | 0.00 | +0.00 | buy |
| SILVERCREST ASSET MANAGEMENT GROUP LLC | 0 | 159,545 | +159,545 | 0.00 | 0.04 | +0.04 | buy |
| Parkman Healthcare Partners LLC | 100,126 | 253,365 | +153,239 | 0.40 | 1.01 | +0.61 | buy |
| Siren, L.L.C. | 1,709,279 | 1,859,279 | +150,000 | 1.82 | 1.46 | -0.36 | buy |
| CITIGROUP INC | 32,925 | 180,459 | +147,534 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 127,469 | 266,584 | +139,115 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 24,353 | 162,785 | +138,432 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 55,574 | 188,159 | +132,585 | 0.03 | 0.07 | +0.04 | buy |
| WELLS FARGO & COMPANY/MN | 106,660 | 228,426 | +121,766 | 0.00 | 0.00 | +0.00 | buy |
| Aberdeen Group plc | 272,707 | 393,234 | +120,527 | 0.02 | 0.02 | +0.00 | buy |
| Swedbank AB | 0 | 118,400 | +118,400 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 225,158 | 343,284 | +118,126 | 6.19 | 8.39 | +2.20 | buy |
| MUTUAL OF AMERICA CAPITAL MANAGEMENT LLC | 0 | 106,044 | +106,044 | 0.00 | 0.04 | +0.04 | buy |
| AQR CAPITAL MANAGEMENT LLC | 189,796 | 294,913 | +105,117 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 105,102 | +105,102 | 0.00 | 0.03 | +0.03 | buy |
| Russell Investments Group, Ltd. | 374,868 | 474,898 | +100,030 | 0.02 | 0.02 | +0.00 | buy |
| Bleichroeder LP | 0 | 100,000 | +100,000 | 0.00 | 0.69 | +0.69 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 856,598 | 954,843 | +98,245 | 0.06 | 0.07 | +0.00 | buy |
| Pier Capital, LLC | 101,304 | 188,951 | +87,647 | 0.64 | 0.97 | +0.33 | buy |
| Swiss National Bank | 165,400 | 246,400 | +81,000 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 15,939 | 85,339 | +69,400 | 0.00 | 0.01 | +0.01 | buy |
| TEMA ETFS LLC | 176,667 | 241,565 | +64,898 | 0.46 | 0.30 | -0.15 | buy |
| Brevan Howard Capital Management LP | 5,201 | 68,945 | +63,744 | 0.00 | 0.04 | +0.04 | buy |
| Schonfeld Strategic Advisors LLC | 112,463 | 169,113 | +56,650 | 0.04 | 0.03 | -0.00 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 50,156 | +50,156 | 0.00 | 0.01 | +0.01 | buy |
| Sculptor Capital LP | 0 | 50,000 | +50,000 | 0.00 | 0.02 | +0.02 | buy |
| BANK OF MONTREAL /CAN/ | 38,309 | 86,164 | +47,855 | 0.00 | 0.00 | +0.00 | buy |
| Persistent Asset Partners Ltd | 92,516 | 138,272 | +45,756 | 1.38 | 1.69 | +0.31 | buy |
| Handelsbanken Fonder AB | 0 | 44,600 | +44,600 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 165,510 | 209,402 | +43,892 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 416,340 | 459,340 | +43,000 | 2.76 | 2.54 | -0.21 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 112,066 | 154,220 | +42,154 | 1.09 | 1.47 | +0.38 | buy |
| Capricorn Fund Managers Ltd | 0 | 41,300 | +41,300 | 0.00 | 0.13 | +0.13 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 83,944 | 125,158 | +41,214 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 100,980 | 141,621 | +40,641 | 0.00 | 0.01 | +0.00 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 45,233 | 85,731 | +40,498 | 0.00 | 0.01 | +0.00 | buy |
| CASTLEARK MANAGEMENT LLC | 63,950 | 99,870 | +35,920 | 0.08 | 0.10 | +0.02 | buy |
| Calamos Advisors LLC | 0 | 35,546 | +35,546 | 0.00 | 0.00 | +0.00 | buy |
| Jain Global LLC | 0 | 35,014 | +35,014 | 0.00 | 0.02 | +0.02 | buy |
| CANTOR FITZGERALD, L. P. | 0 | 35,000 | +35,000 | 0.00 | 0.03 | +0.03 | buy |
| RHUMBLINE ADVISERS | 175,276 | 207,609 | +32,333 | 0.01 | 0.01 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 22,857 | 52,702 | +29,845 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 70,457 | 99,141 | +28,684 | 0.01 | 0.01 | +0.00 | buy |
| CAPITAL FUND MANAGEMENT S.A. | 0 | 27,630 | +27,630 | 0.00 | 0.01 | +0.01 | buy |
| Alyeska Investment Group, L.P. | 250,000 | 274,849 | +24,849 | 0.03 | 0.03 | +0.00 | buy |
| PEREGRINE CAPITAL MANAGEMENT LLC | 201,959 | 226,350 | +24,391 | 0.29 | 0.28 | -0.00 | buy |
| Pathstone Holdings, LLC | 0 | 24,349 | +24,349 | 0.00 | 0.00 | +0.00 | buy |
| OSTERWEIS CAPITAL MANAGEMENT INC | 150,810 | 172,085 | +21,275 | 0.30 | 0.31 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 109,419 | 129,925 | +20,506 | 0.00 | 0.00 | +0.00 | buy |
| Maven Securities LTD | 0 | 20,000 | +20,000 | 0.00 | 0.05 | +0.05 | buy |
| MetLife Investment Management, LLC | 78,621 | 96,979 | +18,358 | 0.02 | 0.02 | +0.00 | buy |
| Legal & General Group Plc | 81,243 | 98,820 | +17,577 | 0.00 | 0.00 | +0.00 | buy |
| Fisher Asset Management, LLC | 167,412 | 184,875 | +17,463 | 0.00 | 0.00 | -0.00 | buy |
| BARCLAYS PLC | 31,261 | 47,963 | +16,702 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 105,517 | 121,486 | +15,969 | 0.00 | 0.00 | +0.00 | buy |
| EMERALD ADVISERS, LLC | 1,588,132 | 1,603,319 | +15,187 | 1.93 | 1.46 | -0.47 | buy |
| LPL Financial LLC | 74,155 | 88,535 | +14,380 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 34,759 | 48,220 | +13,461 | 0.03 | 0.04 | +0.01 | buy |
| Aquatic Capital Management LLC | 0 | 13,328 | +13,328 | 0.00 | 0.02 | +0.02 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 5,798 | 19,072 | +13,274 | 0.04 | 0.12 | +0.09 | buy |
| ADAR1 Capital Management, LLC | 0 | 12,200 | +12,200 | 0.00 | 0.02 | +0.02 | buy |
| VIRTUS ADVISERS, LLC | 0 | 11,524 | +11,524 | 0.00 | 0.17 | +0.17 | buy |