| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| SUVRETTA CAPITAL MANAGEMENT, LLC | 2,219,693 | 3,053,300 | +833,607 | 1.41 | 1.61 | +0.20 | buy |
| Saturn V Capital Management LP | 1,143,368 | 1,775,415 | +632,047 | 7.51 | 7.25 | -0.26 | buy |
| Kynam Capital Management, LP | 1,617,391 | 2,210,125 | +592,734 | 2.93 | 3.58 | +0.65 | buy |
| Nantahala Capital Management, LLC | 64,132 | 575,000 | +510,868 | 0.09 | 0.71 | +0.62 | buy |
| JANUS HENDERSON GROUP PLC | 1,318,112 | 1,636,961 | +318,849 | 0.01 | 0.01 | 0.00 | buy |
| BAKER BROS. ADVISORS LP | 979,600 | 1,292,966 | +313,366 | 0.07 | 0.07 | +0.01 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 276,082 | 225,888 | +50,194 | 0.02 | 0.01 | -0.00 | sell |
| Walleye Capital LLC | 597,226 | 552,908 | +44,318 | 0.15 | 0.11 | 0.00 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 620,000 | 651,372 | +31,372 | 2.48 | 2.37 | -0.11 | buy |
| Atom Investors LP | 13,294 | 37,398 | +24,104 | 0.06 | 0.08 | +0.02 | buy |
| Parkman Healthcare Partners LLC | 185,782 | 193,637 | +7,855 | 0.38 | 0.35 | -0.04 | buy |
| Candriam S.C.A. | 772,487 | 777,487 | +5,000 | 0.07 | 0.05 | -0.01 | buy |
| China Universal Asset Management Co., Ltd. | 930 | 2,189 | +1,259 | 0.00 | 0.01 | +0.00 | buy |
| ALGERT GLOBAL LLC | 103,775 | 103,075 | +700 | 0.05 | 0.05 | 0.00 | sell |
| Nebula Research & Development LLC | 11,307 | 11,449 | +142 | 0.10 | 0.06 | -0.04 | buy |
| VR Adviser, LLC | 4,684,132 | 4,684,167 | +35 | 8.87 | 4.81 | -4.06 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 267,057 | 266,534 | -523 | 0.07 | 0.06 | -0.01 | sell |
| VIRTUS ADVISERS, LLC | 8,462 | 7,700 | -762 | 0.06 | 0.05 | -0.01 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 477,080 | 475,837 | -1,243 | 0.20 | 0.18 | -0.02 | sell |
| PROFUND ADVISORS LLC | 37,987 | 33,203 | -4,784 | 0.02 | 0.02 | -0.01 | sell |
| Values First Advisors, Inc. | 17,052 | 10,318 | -6,734 | 0.12 | 0.06 | -0.06 | sell |
| Rafferty Asset Management, LLC | 206,143 | 191,777 | -14,366 | 0.01 | 0.01 | -0.00 | sell |
| HighVista Strategies LLC | 216,130 | 198,587 | -17,543 | 1.17 | 0.90 | -0.27 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 1,136,069 | 1,036,069 | -100,000 | 0.03 | 0.02 | -0.01 | sell |
| PERCEPTIVE ADVISORS LLC | 2,659,470 | 2,309,470 | -350,000 | 0.91 | 0.76 | -0.16 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 3,440,796 | 2,150,000 | -1,290,796 | 0.69 | 0.38 | -0.31 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,366,345 | 1,089,345 | -2,277,000 | 0.85 | 0.23 | -0.62 | sell |