| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Paradigm Biocapital Advisors LP | 3,624,342 | 4,609,762 | +985,420 | 1.17 | 1.74 | +0.57 | buy |
| Cinctive Capital Management LP | 172,450 | 330,419 | +157,969 | 0.08 | 0.20 | +0.13 | buy |
| Hennion & Walsh Asset Management, Inc. | 127,712 | 171,999 | +44,287 | 0.06 | 0.09 | +0.03 | buy |
| Crestline Management, LP | 326,070 | 369,763 | +43,693 | 0.21 | 0.21 | -0.01 | buy |
| Saturn V Capital Management LP | 1,673,919 | 1,712,899 | +38,980 | 5.33 | 6.61 | +1.28 | buy |
| ALGERT GLOBAL LLC | 157,034 | 179,025 | +21,991 | 0.05 | 0.05 | 0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,206,214 | 1,221,362 | +15,148 | 2.51 | 2.97 | +0.46 | buy |
| AlphaQuest LLC | 10,561 | 24,982 | +14,421 | 0.01 | 0.03 | 0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 44,859 | 31,565 | +13,294 | 0.02 | 0.02 | 0.00 | sell |
| ALPS ADVISORS INC | 74,598 | 87,463 | +12,865 | 0.00 | 0.01 | +0.00 | buy |
| PROFUND ADVISORS LLC | 34,494 | 23,422 | +11,072 | 0.01 | 0.01 | 0.00 | sell |
| China Universal Asset Management Co., Ltd. | 11,232 | 21,051 | +9,819 | 0.01 | 0.03 | +0.01 | buy |
| NEOS Investment Management LLC | 43,856 | 46,815 | +2,959 | 0.02 | 0.02 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 459,938 | 462,188 | +2,250 | 0.08 | 0.11 | +0.03 | buy |
| Woodline Partners LP | 600,098 | 600,576 | +478 | 0.05 | 0.05 | +0.01 | buy |
| Avidity Partners Management LP | 1,000,706 | 1,001,000 | +294 | 0.36 | 0.55 | +0.19 | buy |
| VIRTUS ADVISERS, LLC | 10,081 | 10,266 | +185 | 0.04 | 0.05 | +0.01 | buy |
| SECTORAL ASSET MANAGEMENT INC | 85,600 | 84,400 | -1,200 | 0.29 | 0.54 | +0.25 | sell |
| Forefront Analytics, LLC | 15,627 | 10,021 | -5,606 | 0.06 | 0.05 | -0.01 | sell |
| CORNERCAP INVESTMENT COUNSEL INC | 34,138 | 16,165 | -17,973 | 0.05 | 0.05 | +0.00 | sell |
| Fisher Asset Management, LLC | 149,045 | 129,415 | -19,630 | 0.00 | 0.00 | +0.00 | sell |
| Kynam Capital Management, LP | 9,260,385 | 9,239,731 | -20,654 | 8.17 | 7.73 | -0.44 | sell |
| HighVista Strategies LLC | 281,093 | 225,633 | -55,460 | 0.87 | 0.84 | -0.03 | sell |
| Rafferty Asset Management, LLC | 183,963 | 113,686 | -70,277 | 0.01 | 0.00 | -0.00 | sell |
| Prosight Management, LP | 500,000 | 410,830 | -89,170 | 1.26 | 1.09 | -0.17 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,248,888 | 4,066,034 | -182,854 | 0.07 | 0.08 | +0.01 | sell |
| 5AM Venture Management, LLC | 790,440 | 561,854 | -228,586 | 1.49 | 1.25 | -0.24 | sell |
| Redmile Group, LLC | 4,799,973 | 4,484,380 | -315,593 | 2.45 | 2.85 | +0.41 | sell |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,398,992 | 919,635 | -479,357 | 0.20 | 0.17 | -0.03 | sell |
| Sofinnova Investments, Inc. | 2,773,286 | 2,265,230 | -508,056 | 1.22 | 1.94 | +0.73 | sell |
| Vivo Capital, LLC | 2,244,941 | 1,122,471 | -1,122,470 | 1.75 | 1.00 | -0.74 | sell |
| Commodore Capital LP | 9,738,000 | 7,539,930 | -2,198,070 | 5.60 | 5.09 | -0.51 | sell |