| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Point72 Asset Management, L.P. | 10,470,398 | 10,470,398 | 0 | 0.29 | 0.39 | +0.11 | hold |
| Kynam Capital Management, LP | 9,260,385 | 9,239,731 | -20,654 | 8.17 | 7.73 | -0.44 | sell |
| FMR LLC | 7,693,668 | 8,319,411 | +625,743 | 0.00 | 0.01 | +0.00 | buy |
| Commodore Capital LP | 9,738,000 | 7,539,930 | -2,198,070 | 5.60 | 5.09 | -0.51 | sell |
| TCG Crossover Management, LLC | 6,964,375 | 6,964,375 | 0 | 6.12 | 6.37 | +0.25 | hold |
| Fairmount Funds Management LLC | 6,225,641 | 6,225,641 | 0 | 5.93 | 5.45 | -0.48 | hold |
| VANGUARD GROUP INC | 5,259,879 | 5,714,405 | +454,526 | 0.00 | 0.00 | +0.00 | buy |
| VR Adviser, LLC | 5,684,167 | 5,684,167 | 0 | 3.05 | 3.22 | +0.16 | hold |
| Paradigm Biocapital Advisors LP | 3,624,342 | 4,609,762 | +985,420 | 1.17 | 1.74 | +0.57 | buy |
| Redmile Group, LLC | 4,799,973 | 4,484,380 | -315,593 | 2.45 | 2.85 | +0.41 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,248,888 | 4,066,034 | -182,854 | 0.07 | 0.08 | +0.01 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,744,263 | 3,744,263 | 0 | 0.53 | 0.60 | +0.08 | hold |
| STATE STREET CORP | 3,836,962 | 3,231,462 | -605,500 | 0.00 | 0.00 | +0.00 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 1,980,731 | 2,280,793 | +300,062 | 0.00 | 0.00 | +0.00 | buy |
| Sofinnova Investments, Inc. | 2,773,286 | 2,265,230 | -508,056 | 1.47 | 2.02 | +0.55 | sell |
| Logos Global Management LP | 0 | 2,000,000 | +2,000,000 | 0.00 | 2.42 | +2.42 | buy |
| Saturn V Capital Management LP | 1,673,919 | 1,712,899 | +38,980 | 5.33 | 6.61 | +1.28 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,231,857 | 1,613,616 | +381,759 | 0.01 | 0.02 | +0.01 | buy |
| Octagon Capital Advisors LP | 0 | 1,305,000 | +1,305,000 | 0.00 | 2.26 | +2.26 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,206,214 | 1,221,362 | +15,148 | 2.51 | 2.97 | +0.46 | buy |
| Vivo Capital, LLC | 2,244,941 | 1,122,471 | -1,122,470 | 1.75 | 1.00 | -0.74 | sell |
| Avidity Partners Management LP | 1,000,706 | 1,001,000 | +294 | 0.36 | 0.55 | +0.19 | buy |
| FRANKLIN RESOURCES INC | 1,000,116 | 1,000,167 | +51 | 0.00 | 0.00 | +0.00 | buy |
| Frazier Life Sciences Management, L.P. | 936,576 | 936,576 | 0 | 0.37 | 0.41 | +0.04 | hold |
| EVENTIDE ASSET MANAGEMENT, LLC | 1,398,992 | 919,635 | -479,357 | 0.20 | 0.17 | -0.03 | sell |
| GOLDMAN SACHS GROUP INC | 513,747 | 878,037 | +364,290 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 719,452 | 847,298 | +127,846 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 686,697 | 825,793 | +139,096 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 930,297 | 792,423 | -137,874 | 0.00 | 0.00 | +0.00 | sell |
| Nantahala Capital Management, LLC | 790,936 | 790,936 | 0 | 0.67 | 0.72 | +0.05 | hold |
| MORGAN STANLEY | 981,644 | 688,894 | -292,750 | 0.00 | 0.00 | -0.00 | sell |
| Assenagon Asset Management S.A. | 600,764 | 607,208 | +6,444 | 0.01 | 0.01 | +0.00 | buy |
| Woodline Partners LP | 600,098 | 600,576 | +478 | 0.05 | 0.05 | +0.01 | buy |
| 5AM Venture Management, LLC | 790,440 | 561,854 | -228,586 | 1.49 | 1.25 | -0.24 | sell |
| Walleye Capital LLC | 0 | 557,326 | +557,326 | 0.00 | 0.06 | +0.06 | buy |
| BANK OF AMERICA CORP /DE/ | 406,317 | 501,412 | +95,095 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 163,966 | 494,078 | +330,112 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 459,938 | 462,188 | +2,250 | 0.08 | 0.11 | +0.03 | buy |
| D. E. Shaw & Co., Inc. | 298,711 | 457,228 | +158,517 | 0.00 | 0.01 | +0.00 | buy |
| Prosight Management, LP | 500,000 | 410,830 | -89,170 | 1.26 | 1.13 | -0.13 | sell |
| Crestline Management, LP | 326,070 | 369,763 | +43,693 | 0.22 | 0.23 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 316,853 | 342,323 | +25,470 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 172,450 | 330,419 | +157,969 | 0.08 | 0.20 | +0.13 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 287,610 | +287,610 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 326,584 | 263,578 | -63,006 | 0.00 | 0.00 | +0.00 | sell |
| New Leaf Venture Partners, L.L.C. | 250,765 | 250,765 | 0 | 2.57 | 2.78 | +0.21 | hold |
| MACQUARIE GROUP LTD | 230,000 | 230,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| HighVista Strategies LLC | 281,093 | 225,633 | -55,460 | 0.87 | 0.84 | -0.03 | sell |
| ALGERT GLOBAL LLC | 157,034 | 179,025 | +21,991 | 0.04 | 0.05 | +0.01 | buy |
| BARCLAYS PLC | 78,143 | 175,684 | +97,541 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 127,712 | 171,999 | +44,287 | 0.06 | 0.09 | +0.03 | buy |
| DEUTSCHE BANK AG\ | 238,440 | 162,858 | -75,582 | 0.00 | 0.00 | -0.00 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 157,851 | 157,851 | 0 | 0.05 | 0.08 | +0.02 | hold |
| TWO SIGMA ADVISERS, LP | 173,790 | 156,090 | -17,700 | 0.00 | 0.00 | +0.00 | sell |
| Cubist Systematic Strategies, LLC | 134,660 | 130,098 | -4,562 | 0.02 | 0.02 | +0.00 | sell |
| Fisher Asset Management, LLC | 149,045 | 129,415 | -19,630 | 0.00 | 0.00 | +0.00 | sell |
| RHUMBLINE ADVISERS | 130,516 | 124,921 | -5,595 | 0.00 | 0.00 | +0.00 | sell |
| Swiss National Bank | 124,000 | 121,400 | -2,600 | 0.00 | 0.00 | +0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 126,217 | 117,863 | -8,354 | 0.00 | 0.00 | +0.00 | sell |
| UBS Group AG | 126,539 | 115,495 | -11,044 | 0.00 | 0.00 | +0.00 | sell |
| Rafferty Asset Management, LLC | 183,963 | 113,686 | -70,277 | 0.01 | 0.00 | -0.00 | sell |
| JANE STREET GROUP, LLC | 248,544 | 111,863 | -136,681 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 149,401 | 106,623 | -42,778 | 0.00 | 0.00 | -0.00 | sell |
| Trexquant Investment LP | 148,854 | 97,565 | -51,289 | 0.02 | 0.01 | -0.01 | sell |
| ALPS ADVISORS INC | 74,598 | 87,463 | +12,865 | 0.00 | 0.01 | +0.00 | buy |
| SECTORAL ASSET MANAGEMENT INC | 85,600 | 84,400 | -1,200 | 0.29 | 0.54 | +0.25 | sell |
| ALLIANCEBERNSTEIN L.P. | 72,200 | 82,060 | +9,860 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 73,905 | +73,905 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 39,330 | 68,416 | +29,086 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 67,300 | 67,630 | +330 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 59,108 | 64,828 | +5,720 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 62,945 | 60,905 | -2,040 | 0.00 | 0.00 | +0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 49,228 | 54,751 | +5,523 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 53,716 | 53,716 | 0 | 0.04 | 0.05 | +0.01 | hold |
| MetLife Investment Management, LLC | 53,368 | 53,368 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Corebridge Financial, Inc. | 49,367 | 49,064 | -303 | 0.00 | 0.00 | +0.00 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 59,395 | 47,710 | -11,685 | 0.00 | 0.00 | -0.00 | sell |
| NEOS Investment Management LLC | 43,856 | 46,815 | +2,959 | 0.02 | 0.02 | +0.00 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 45,206 | +45,206 | 0.00 | 0.00 | +0.00 | buy |
| LMR Partners LLP | 0 | 44,483 | +44,483 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 40,617 | 44,157 | +3,540 | 0.00 | 0.00 | +0.00 | buy |
| ExodusPoint Capital Management, LP | 0 | 43,977 | +43,977 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 103,200 | 43,370 | -59,830 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 35,752 | 34,937 | -815 | 0.00 | 0.00 | +0.00 | sell |
| SG Americas Securities, LLC | 0 | 32,533 | +32,533 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 44,859 | 31,565 | -13,294 | 0.02 | 0.02 | +0.00 | sell |
| Verition Fund Management LLC | 29,052 | 31,228 | +2,176 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 30,823 | 30,232 | -591 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 30,144 | 29,232 | -912 | 0.00 | 0.00 | +0.00 | sell |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 28,424 | +28,424 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 10,561 | 24,982 | +14,421 | 0.01 | 0.02 | +0.01 | buy |
| ProShare Advisors LLC | 17,028 | 23,807 | +6,779 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 34,494 | 23,422 | -11,072 | 0.01 | 0.01 | -0.00 | sell |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 23,142 | 23,142 | 0 | 0.00 | 0.00 | +0.00 | hold |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 22,678 | +22,678 | 0.00 | 0.05 | +0.05 | buy |
| Mesirow Financial Investment Management, Inc. | 0 | 21,495 | +21,495 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 11,232 | 21,051 | +9,819 | 0.01 | 0.03 | +0.01 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 29,902 | 20,902 | -9,000 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 44,441 | 19,118 | -25,323 | 0.00 | 0.00 | -0.00 | sell |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 18,934 | 18,934 | 0 | 0.00 | 0.00 | +0.00 | hold |