| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Logos Global Management LP | 0 | 2,000,000 | +2,000,000 | 0.00 | 2.42 | +2.42 | buy |
| Octagon Capital Advisors LP | 0 | 1,305,000 | +1,305,000 | 0.00 | 2.26 | +2.26 | buy |
| Paradigm Biocapital Advisors LP | 3,624,342 | 4,609,762 | +985,420 | 1.17 | 1.74 | +0.57 | buy |
| FMR LLC | 7,693,668 | 8,319,411 | +625,743 | 0.00 | 0.01 | +0.00 | buy |
| Walleye Capital LLC | 0 | 557,326 | +557,326 | 0.00 | 0.06 | +0.06 | buy |
| VANGUARD GROUP INC | 5,259,879 | 5,714,405 | +454,526 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,231,857 | 1,613,616 | +381,759 | 0.01 | 0.02 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 513,747 | 878,037 | +364,290 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 163,966 | 494,078 | +330,112 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,980,731 | 2,280,793 | +300,062 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 287,610 | +287,610 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 298,711 | 457,228 | +158,517 | 0.00 | 0.01 | +0.00 | buy |
| Cinctive Capital Management LP | 172,450 | 330,419 | +157,969 | 0.08 | 0.20 | +0.13 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 686,697 | 825,793 | +139,096 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 719,452 | 847,298 | +127,846 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 78,143 | 175,684 | +97,541 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 406,317 | 501,412 | +95,095 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 73,905 | +73,905 | 0.00 | 0.00 | +0.00 | buy |
| NOMURA ASSET MANAGEMENT CO LTD | 0 | 45,206 | +45,206 | 0.00 | 0.00 | +0.00 | buy |
| LMR Partners LLP | 0 | 44,483 | +44,483 | 0.00 | 0.01 | +0.01 | buy |
| Hennion & Walsh Asset Management, Inc. | 127,712 | 171,999 | +44,287 | 0.06 | 0.09 | +0.03 | buy |
| ExodusPoint Capital Management, LP | 0 | 43,977 | +43,977 | 0.00 | 0.00 | +0.00 | buy |
| Crestline Management, LP | 326,070 | 369,763 | +43,693 | 0.22 | 0.23 | +0.01 | buy |
| Saturn V Capital Management LP | 1,673,919 | 1,712,899 | +38,980 | 5.33 | 6.61 | +1.28 | buy |
| SG Americas Securities, LLC | 0 | 32,533 | +32,533 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 39,330 | 68,416 | +29,086 | 0.00 | 0.00 | +0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 0 | 28,424 | +28,424 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 316,853 | 342,323 | +25,470 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 22,678 | +22,678 | 0.00 | 0.05 | +0.05 | buy |
| ALGERT GLOBAL LLC | 157,034 | 179,025 | +21,991 | 0.04 | 0.05 | +0.01 | buy |
| Mesirow Financial Investment Management, Inc. | 0 | 21,495 | +21,495 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,206,214 | 1,221,362 | +15,148 | 2.51 | 2.97 | +0.46 | buy |
| AlphaQuest LLC | 10,561 | 24,982 | +14,421 | 0.01 | 0.02 | +0.01 | buy |
| Pictet Asset Management Holding SA | 0 | 13,874 | +13,874 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 13,610 | +13,610 | 0.00 | 0.01 | +0.01 | buy |
| ALPS ADVISORS INC | 74,598 | 87,463 | +12,865 | 0.00 | 0.01 | +0.00 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 12,434 | +12,434 | 0.00 | 0.01 | +0.01 | buy |
| DARK FOREST CAPITAL MANAGEMENT LP | 0 | 12,382 | +12,382 | 0.00 | 0.02 | +0.02 | buy |
| AQR CAPITAL MANAGEMENT LLC | 0 | 11,712 | +11,712 | 0.00 | 0.00 | +0.00 | buy |
| Squarepoint Ops LLC | 0 | 10,860 | +10,860 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 0 | 10,492 | +10,492 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 72,200 | 82,060 | +9,860 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 11,232 | 21,051 | +9,819 | 0.01 | 0.03 | +0.01 | buy |
| CITADEL ADVISORS LLC | 0 | 9,647 | +9,647 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 0 | 9,259 | +9,259 | 0.00 | 0.00 | +0.00 | buy |
| nVerses Capital, LLC | 0 | 7,000 | +7,000 | 0.00 | 0.03 | +0.03 | buy |
| ProShare Advisors LLC | 17,028 | 23,807 | +6,779 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 600,764 | 607,208 | +6,444 | 0.01 | 0.01 | +0.00 | buy |
| JPMORGAN CHASE & CO | 59,108 | 64,828 | +5,720 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 49,228 | 54,751 | +5,523 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 40,617 | 44,157 | +3,540 | 0.00 | 0.00 | +0.00 | buy |
| ACADIAN ASSET MANAGEMENT LLC | 0 | 3,320 | +3,320 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 11,052 | 14,324 | +3,272 | 0.00 | 0.00 | +0.00 | buy |
| Values First Advisors, Inc. | 0 | 2,962 | +2,962 | 0.00 | 0.02 | +0.02 | buy |
| NEOS Investment Management LLC | 43,856 | 46,815 | +2,959 | 0.02 | 0.02 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 459,938 | 462,188 | +2,250 | 0.08 | 0.11 | +0.03 | buy |
| PUBLIC EMPLOYEES RETIREMENT ASSOCIATION OF COLORADO | 0 | 2,198 | +2,198 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 29,052 | 31,228 | +2,176 | 0.00 | 0.00 | +0.00 | buy |
| TEACHER RETIREMENT SYSTEM OF TEXAS | 13,650 | 15,587 | +1,937 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 8,129 | 9,296 | +1,167 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,855 | 3,959 | +1,104 | 0.00 | 0.00 | +0.00 | buy |
| LORING WOLCOTT & COOLIDGE FIDUCIARY ADVISORS LLP/MA | 0 | 1,000 | +1,000 | 0.00 | 0.00 | +0.00 | buy |
| GROUP ONE TRADING LLC | 3,896 | 4,856 | +960 | 0.00 | 0.00 | +0.00 | buy |
| Wilmington Savings Fund Society, FSB | 0 | 730 | +730 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 17,399 | 17,896 | +497 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 600,098 | 600,576 | +478 | 0.05 | 0.05 | +0.01 | buy |
| GAMMA Investing LLC | 122 | 574 | +452 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 67,300 | 67,630 | +330 | 0.00 | 0.00 | +0.00 | buy |
| Avidity Partners Management LP | 1,000,706 | 1,001,000 | +294 | 0.36 | 0.55 | +0.19 | buy |
| VIRTUS ADVISERS, LLC | 10,081 | 10,266 | +185 | 0.04 | 0.05 | +0.01 | buy |
| BESSEMER GROUP INC | 0 | 180 | +180 | 0.00 | 0.00 | +0.00 | buy |
| Daiwa Securities Group Inc. | 281 | 416 | +135 | 0.00 | 0.00 | +0.00 | buy |
| Cornerstone Planning Group LLC | 0 | 100 | +100 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 1,210 | 1,263 | +53 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 15 | 67 | +52 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 1,000,116 | 1,000,167 | +51 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 70 | 120 | +50 | 0.00 | 0.00 | +0.00 | buy |
| EARNED WEALTH ADVISORS, LLC | 0 | 37 | +37 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 12,005 | 12,040 | +35 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 1 | 3 | +2 | 0.00 | 0.00 | +0.00 | buy |
| NATIONAL BANK OF CANADA /FI/ | 0 | 1 | +1 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,744,263 | 3,744,263 | 0 | 0.53 | 0.60 | +0.08 | hold |
| PLATINUM INVESTMENT MANAGEMENT LTD | 157,851 | 157,851 | 0 | 0.05 | 0.08 | +0.02 | hold |
| JANUS HENDERSON GROUP PLC | 15,773 | 15,773 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 18,934 | 18,934 | 0 | 0.00 | 0.00 | +0.00 | hold |
| MACQUARIE GROUP LTD | 230,000 | 230,000 | 0 | 0.00 | 0.00 | +0.00 | hold |
| SIGNATUREFD, LLC | 120 | 120 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Nantahala Capital Management, LLC | 790,936 | 790,936 | 0 | 0.67 | 0.72 | +0.05 | hold |
| MetLife Investment Management, LLC | 53,368 | 53,368 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Allworth Financial LP | 60 | 60 | 0 | 0.00 | 0.00 | +0.00 | hold |
| PDT Partners, LLC | 53,716 | 53,716 | 0 | 0.04 | 0.05 | +0.01 | hold |
| Arax Advisory Partners | 28 | 28 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Point72 Asset Management, L.P. | 10,470,398 | 10,470,398 | 0 | 0.29 | 0.39 | +0.11 | hold |
| VR Adviser, LLC | 5,684,167 | 5,684,167 | 0 | 3.05 | 3.22 | +0.16 | hold |
| New Leaf Venture Partners, L.L.C. | 250,765 | 250,765 | 0 | 2.57 | 2.78 | +0.21 | hold |
| LGL PARTNERS, LLC | 14,500 | 14,500 | 0 | 0.02 | 0.02 | +0.00 | hold |
| Fairmount Funds Management LLC | 6,225,641 | 6,225,641 | 0 | 5.93 | 5.45 | -0.48 | hold |
| TCG Crossover Management, LLC | 6,964,375 | 6,964,375 | 0 | 6.12 | 6.37 | +0.25 | hold |
| SkyView Investment Advisors, LLC | 12,500 | 12,500 | 0 | 0.02 | 0.02 | +0.00 | hold |
| Frazier Life Sciences Management, L.P. | 936,576 | 936,576 | 0 | 0.37 | 0.41 | +0.04 | hold |