| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 17,078,468 | 22,408,263 | +5,329,795 | 0.01 | 0.02 | +0.01 | buy |
| BlackRock, Inc. | 8,626,581 | 10,369,535 | +1,742,954 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,640,215 | 9,053,118 | +6,412,903 | 0.34 | 1.99 | +1.65 | buy |
| Fairmount Funds Management LLC | 6,225,641 | 9,003,418 | +2,777,777 | 5.79 | 11.63 | +5.84 | buy |
| Kynam Capital Management, LP | 8,492,557 | 7,886,172 | -606,385 | 6.56 | 8.43 | +1.87 | sell |
| VANGUARD GROUP INC | 6,522,951 | 7,757,662 | +1,234,711 | 0.00 | 0.00 | +0.00 | buy |
| Commodore Capital LP | 2,311,164 | 7,250,000 | +4,938,836 | 1.17 | 5.08 | +3.91 | buy |
| TCG Crossover Management, LLC | 6,964,375 | 6,798,162 | -166,213 | 5.71 | 4.80 | -0.91 | sell |
| STATE STREET CORP | 3,371,912 | 4,775,419 | +1,403,507 | 0.00 | 0.00 | +0.00 | buy |
| VR Adviser, LLC | 4,755,411 | 4,000,000 | -755,411 | 2.56 | 3.23 | +0.67 | sell |
| RTW INVESTMENTS, LP | 0 | 3,467,486 | +3,467,486 | 0.00 | 0.61 | +0.61 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,672,113 | 3,274,155 | +602,042 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 2,873,053 | 3,178,043 | +304,990 | 0.01 | 0.02 | +0.01 | buy |
| Paradigm Biocapital Advisors LP | 10,352,449 | 3,156,398 | -7,196,051 | 3.17 | 1.34 | -1.83 | sell |
| Octagon Capital Advisors LP | 2,763,000 | 2,874,111 | +111,111 | 4.35 | 6.44 | +2.09 | buy |
| Vivo Capital, LLC | 1,122,471 | 2,789,137 | +1,666,666 | 0.82 | 3.22 | +2.40 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 2,670,486 | +2,670,486 | 0.00 | 0.08 | +0.08 | buy |
| BANK OF AMERICA CORP /DE/ | 1,400,965 | 2,239,255 | +838,290 | 0.00 | 0.00 | +0.00 | buy |
| Redmile Group, LLC | 1,448,040 | 2,209,118 | +761,078 | 1.11 | 3.09 | +1.98 | buy |
| Sofinnova Investments, Inc. | 2,355,505 | 2,127,941 | -227,564 | 1.15 | 1.87 | +0.72 | sell |
| Saturn V Capital Management LP | 2,297,524 | 2,025,041 | -272,483 | 6.69 | 6.38 | -0.31 | sell |
| UBS Group AG | 3,518,671 | 1,853,672 | -1,664,999 | 0.01 | 0.01 | -0.00 | sell |
| Siren, L.L.C. | 854,379 | 1,724,279 | +869,900 | 0.32 | 0.97 | +0.65 | buy |
| CITADEL ADVISORS LLC | 621,235 | 1,667,807 | +1,046,572 | 0.00 | 0.02 | +0.02 | buy |
| GOLDMAN SACHS GROUP INC | 1,200,437 | 1,659,677 | +459,240 | 0.00 | 0.00 | +0.00 | buy |
| EMERALD ADVISERS, LLC | 1,445,774 | 1,579,496 | +133,722 | 0.38 | 0.73 | +0.35 | buy |
| D. E. Shaw & Co., Inc. | 273,535 | 1,530,925 | +1,257,390 | 0.00 | 0.02 | +0.02 | buy |
| Nantahala Capital Management, LLC | 1,655,689 | 1,506,989 | -148,700 | 0.84 | 1.34 | +0.50 | sell |
| MORGAN STANLEY | 1,229,121 | 1,288,164 | +59,043 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 4,911,924 | 1,237,833 | -3,674,091 | 0.08 | 0.04 | -0.04 | sell |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 886,987 | 1,190,645 | +303,658 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 934,495 | 1,181,665 | +247,170 | 0.00 | 0.00 | +0.00 | buy |
| Duquesne Family Office LLC | 0 | 1,059,580 | +1,059,580 | 0.00 | 0.39 | +0.39 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 895,412 | 1,022,858 | +127,446 | 0.39 | 0.76 | +0.37 | buy |
| Rock Springs Capital Management LP | 800,199 | 1,008,308 | +208,109 | 0.36 | 0.85 | +0.49 | buy |
| Candriam S.C.A. | 427,342 | 954,209 | +526,867 | 0.02 | 0.07 | +0.05 | buy |
| BOONE CAPITAL MANAGEMENT LLC | 0 | 945,042 | +945,042 | 0.00 | 4.45 | +4.45 | buy |
| Nuveen, LLC | 230,112 | 939,620 | +709,508 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 815,075 | +815,075 | 0.00 | 1.69 | +1.69 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 215,414 | 697,964 | +482,550 | 0.00 | 0.01 | +0.01 | buy |
| MARSHALL WACE, LLP | 0 | 642,479 | +642,479 | 0.00 | 0.01 | +0.01 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 520,127 | 583,885 | +63,758 | 0.09 | 0.19 | +0.10 | buy |
| Assenagon Asset Management S.A. | 196,659 | 577,004 | +380,345 | 0.00 | 0.01 | +0.01 | buy |
| Trexquant Investment LP | 501,043 | 566,372 | +65,329 | 0.04 | 0.08 | +0.04 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 562,000 | +562,000 | 0.00 | 0.01 | +0.01 | buy |
| Woodline Partners LP | 1,000,611 | 513,397 | -487,214 | 0.04 | 0.03 | -0.00 | sell |
| Logos Global Management LP | 0 | 500,000 | +500,000 | 0.00 | 0.71 | +0.71 | buy |
| HighVista Strategies LLC | 283,186 | 462,405 | +179,219 | 0.75 | 1.63 | +0.88 | buy |
| Exome Asset Management LLC | 533,647 | 443,547 | -90,100 | 3.16 | 4.21 | +1.05 | sell |
| MILLENNIUM MANAGEMENT LLC | 969,973 | 414,966 | -555,007 | 0.01 | 0.00 | -0.00 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 297,364 | 406,899 | +109,535 | 0.00 | 0.00 | +0.00 | buy |
| MACQUARIE GROUP LTD | 230,000 | 398,830 | +168,830 | 0.00 | 0.01 | +0.00 | buy |
| Invesco Ltd. | 113,060 | 372,270 | +259,210 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 291,791 | 363,016 | +71,225 | 0.00 | 0.00 | +0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 962,951 | 361,408 | -601,543 | 8.61 | 5.11 | -3.50 | sell |
| BARCLAYS PLC | 320,565 | 359,830 | +39,265 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 305,615 | 300,127 | -5,488 | 0.09 | 0.16 | +0.07 | sell |
| SummitTX Capital, L.P. | 299,939 | 295,810 | -4,129 | 0.09 | 0.18 | +0.08 | sell |
| RAYMOND JAMES FINANCIAL INC | 0 | 289,397 | +289,397 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 0 | 272,460 | +272,460 | 0.00 | 0.00 | +0.00 | buy |
| ALGERT GLOBAL LLC | 864,066 | 267,142 | -596,924 | 0.13 | 0.06 | -0.07 | sell |
| New Leaf Venture Partners, L.L.C. | 250,765 | 250,765 | 0 | 3.40 | 8.37 | +4.96 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 232,968 | +232,968 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 95,720 | 229,755 | +134,035 | 0.02 | 0.05 | +0.04 | buy |
| F/m Investments LLC | 120,011 | 220,168 | +100,157 | 0.03 | 0.12 | +0.09 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 219,504 | 219,504 | 0 | 0.10 | 0.20 | +0.10 | hold |
| Burkehill Global Management, LP | 0 | 200,000 | +200,000 | 0.00 | 0.16 | +0.16 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 502,000 | 192,770 | -309,230 | 0.11 | 0.07 | -0.04 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 187,083 | +187,083 | 0.00 | 0.01 | +0.01 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 124,728 | 179,733 | +55,005 | 0.00 | 0.00 | +0.00 | buy |
| ROYAL BANK OF CANADA | 189,708 | 179,718 | -9,990 | 0.00 | 0.00 | +0.00 | sell |
| RHUMBLINE ADVISERS | 156,517 | 176,712 | +20,195 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 437,228 | 176,064 | -261,164 | 0.29 | 0.15 | -0.14 | sell |
| Swiss National Bank | 139,100 | 162,200 | +23,100 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 91,662 | 148,801 | +57,139 | 0.00 | 0.01 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 148,401 | +148,401 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 207,198 | 142,954 | -64,244 | 0.00 | 0.00 | +0.00 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 163,181 | 137,281 | -25,900 | 0.11 | 0.15 | +0.04 | sell |
| ALLIANCEBERNSTEIN L.P. | 82,060 | 124,620 | +42,560 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 93,219 | 120,945 | +27,726 | 0.00 | 0.00 | +0.00 | buy |
| Holocene Advisors, LP | 0 | 117,916 | +117,916 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 45,081 | 116,841 | +71,760 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 18,902 | 113,658 | +94,756 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 0 | 111,058 | +111,058 | 0.00 | 0.08 | +0.08 | buy |
| Fisher Asset Management, LLC | 110,908 | 103,492 | -7,416 | 0.00 | 0.00 | +0.00 | sell |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 102,907 | +102,907 | 0.00 | 1.53 | +1.53 | buy |
| Alyeska Investment Group, L.P. | 0 | 100,000 | +100,000 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 80,045 | 98,814 | +18,769 | 0.00 | 0.00 | +0.00 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 143,693 | 98,526 | -45,167 | 0.27 | 0.34 | +0.07 | sell |
| DIADEMA PARTNERS LP | 392,213 | 97,813 | -294,400 | 1.75 | 0.98 | -0.77 | sell |
| Engineers Gate Manager LP | 90,272 | 96,486 | +6,214 | 0.01 | 0.02 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 57,730 | 96,127 | +38,397 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 201,989 | 95,893 | -106,096 | 0.00 | 0.00 | -0.00 | sell |
| FEDERATED HERMES, INC. | 2 | 93,225 | +93,223 | 0.00 | 0.00 | +0.00 | buy |
| NEOS Investment Management LLC | 117,639 | 89,923 | -27,716 | 0.01 | 0.01 | -0.00 | sell |
| TEMA ETFS LLC | 117,639 | 89,923 | -27,716 | 0.22 | 0.11 | -0.12 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 73,152 | 89,716 | +16,564 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 55,934 | 81,004 | +25,070 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 58,649 | 80,733 | +22,084 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 406,118 | 78,623 | -327,495 | 0.00 | 0.00 | -0.00 | sell |