| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| DEERFIELD MANAGEMENT COMPANY, L.P. | 2,640,215 | 9,053,118 | +6,412,903 | 0.34 | 1.99 | +1.65 | buy |
| FMR LLC | 17,078,468 | 22,408,263 | +5,329,795 | 0.01 | 0.02 | +0.01 | buy |
| Commodore Capital LP | 2,311,164 | 7,250,000 | +4,938,836 | 1.17 | 5.08 | +3.91 | buy |
| RTW INVESTMENTS, LP | 0 | 3,467,486 | +3,467,486 | 0.00 | 0.61 | +0.61 | buy |
| Fairmount Funds Management LLC | 6,225,641 | 9,003,418 | +2,777,777 | 5.79 | 11.63 | +5.84 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 0 | 2,670,486 | +2,670,486 | 0.00 | 0.08 | +0.08 | buy |
| BlackRock, Inc. | 8,626,581 | 10,369,535 | +1,742,954 | 0.00 | 0.00 | +0.00 | buy |
| Vivo Capital, LLC | 1,122,471 | 2,789,137 | +1,666,666 | 0.82 | 3.22 | +2.40 | buy |
| STATE STREET CORP | 3,371,912 | 4,775,419 | +1,403,507 | 0.00 | 0.00 | +0.00 | buy |
| D. E. Shaw & Co., Inc. | 273,535 | 1,530,925 | +1,257,390 | 0.00 | 0.02 | +0.02 | buy |
| VANGUARD GROUP INC | 6,522,951 | 7,757,662 | +1,234,711 | 0.00 | 0.00 | +0.00 | buy |
| Duquesne Family Office LLC | 0 | 1,059,580 | +1,059,580 | 0.00 | 0.39 | +0.39 | buy |
| CITADEL ADVISORS LLC | 621,235 | 1,667,807 | +1,046,572 | 0.00 | 0.02 | +0.02 | buy |
| BOONE CAPITAL MANAGEMENT LLC | 0 | 945,042 | +945,042 | 0.00 | 4.45 | +4.45 | buy |
| Siren, L.L.C. | 854,379 | 1,724,279 | +869,900 | 0.32 | 0.97 | +0.65 | buy |
| BANK OF AMERICA CORP /DE/ | 1,400,965 | 2,239,255 | +838,290 | 0.00 | 0.00 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 815,075 | +815,075 | 0.00 | 1.69 | +1.69 | buy |
| Redmile Group, LLC | 1,448,040 | 2,209,118 | +761,078 | 1.11 | 3.09 | +1.98 | buy |
| Nuveen, LLC | 230,112 | 939,620 | +709,508 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 642,479 | +642,479 | 0.00 | 0.01 | +0.01 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 2,672,113 | 3,274,155 | +602,042 | 0.00 | 0.00 | +0.00 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 0 | 562,000 | +562,000 | 0.00 | 0.01 | +0.01 | buy |
| Candriam S.C.A. | 427,342 | 954,209 | +526,867 | 0.02 | 0.07 | +0.05 | buy |
| Logos Global Management LP | 0 | 500,000 | +500,000 | 0.00 | 0.71 | +0.71 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 215,414 | 697,964 | +482,550 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 1,200,437 | 1,659,677 | +459,240 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 196,659 | 577,004 | +380,345 | 0.00 | 0.01 | +0.01 | buy |
| JANUS HENDERSON GROUP PLC | 2,873,053 | 3,178,043 | +304,990 | 0.01 | 0.02 | +0.01 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 886,987 | 1,190,645 | +303,658 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 0 | 289,397 | +289,397 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 0 | 272,460 | +272,460 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 113,060 | 372,270 | +259,210 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 934,495 | 1,181,665 | +247,170 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 232,968 | +232,968 | 0.00 | 0.00 | +0.00 | buy |
| Rock Springs Capital Management LP | 800,199 | 1,008,308 | +208,109 | 0.36 | 0.85 | +0.49 | buy |
| Burkehill Global Management, LP | 0 | 200,000 | +200,000 | 0.00 | 0.16 | +0.16 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 187,083 | +187,083 | 0.00 | 0.01 | +0.01 | buy |
| HighVista Strategies LLC | 283,186 | 462,405 | +179,219 | 0.75 | 1.63 | +0.88 | buy |
| MACQUARIE GROUP LTD | 230,000 | 398,830 | +168,830 | 0.00 | 0.01 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 148,401 | +148,401 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 95,720 | 229,755 | +134,035 | 0.02 | 0.05 | +0.04 | buy |
| EMERALD ADVISERS, LLC | 1,445,774 | 1,579,496 | +133,722 | 0.38 | 0.73 | +0.35 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 895,412 | 1,022,858 | +127,446 | 0.39 | 0.76 | +0.37 | buy |
| Holocene Advisors, LP | 0 | 117,916 | +117,916 | 0.00 | 0.00 | +0.00 | buy |
| Octagon Capital Advisors LP | 2,763,000 | 2,874,111 | +111,111 | 4.35 | 6.44 | +2.09 | buy |
| Cinctive Capital Management LP | 0 | 111,058 | +111,058 | 0.00 | 0.08 | +0.08 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 297,364 | 406,899 | +109,535 | 0.00 | 0.00 | +0.00 | buy |
| ACUTA CAPITAL PARTNERS, LLC | 0 | 102,907 | +102,907 | 0.00 | 1.53 | +1.53 | buy |
| F/m Investments LLC | 120,011 | 220,168 | +100,157 | 0.03 | 0.12 | +0.09 | buy |
| Alyeska Investment Group, L.P. | 0 | 100,000 | +100,000 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 18,902 | 113,658 | +94,756 | 0.00 | 0.00 | +0.00 | buy |
| FEDERATED HERMES, INC. | 2 | 93,225 | +93,223 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 45,081 | 116,841 | +71,760 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 291,791 | 363,016 | +71,225 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 501,043 | 566,372 | +65,329 | 0.04 | 0.08 | +0.04 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 520,127 | 583,885 | +63,758 | 0.09 | 0.19 | +0.10 | buy |
| Campbell & CO Investment Adviser LLC | 0 | 61,634 | +61,634 | 0.00 | 0.07 | +0.07 | buy |
| MORGAN STANLEY | 1,229,121 | 1,288,164 | +59,043 | 0.00 | 0.00 | +0.00 | buy |
| Aquatic Capital Management LLC | 0 | 57,357 | +57,357 | 0.00 | 0.02 | +0.02 | buy |
| Rafferty Asset Management, LLC | 91,662 | 148,801 | +57,139 | 0.00 | 0.01 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 124,728 | 179,733 | +55,005 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 0 | 50,202 | +50,202 | 0.00 | 0.00 | +0.00 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 49,692 | +49,692 | 0.00 | 0.03 | +0.03 | buy |
| PANAGORA ASSET MANAGEMENT INC | 0 | 44,042 | +44,042 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 82,060 | 124,620 | +42,560 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 40,475 | +40,475 | 0.00 | 0.01 | +0.01 | buy |
| BARCLAYS PLC | 320,565 | 359,830 | +39,265 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 57,730 | 96,127 | +38,397 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 6,000 | 41,500 | +35,500 | 0.00 | 0.00 | +0.00 | buy |
| Optimize Financial Inc | 0 | 32,552 | +32,552 | 0.00 | 0.24 | +0.24 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 29,344 | 61,623 | +32,279 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 93,219 | 120,945 | +27,726 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 0 | 25,905 | +25,905 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 55,934 | 81,004 | +25,070 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 38,915 | 63,598 | +24,683 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 20,918 | 44,719 | +23,801 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF MONTREAL /CAN/ | 0 | 23,524 | +23,524 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 139,100 | 162,200 | +23,100 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 58,649 | 80,733 | +22,084 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 156,517 | 176,712 | +20,195 | 0.00 | 0.00 | +0.00 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 20,120 | +20,120 | 0.00 | 0.00 | +0.00 | buy |
| Legal & General Group Plc | 80,045 | 98,814 | +18,769 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 73,152 | 89,716 | +16,564 | 0.00 | 0.00 | +0.00 | buy |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 0 | 16,098 | +16,098 | 0.00 | 0.34 | +0.34 | buy |
| Sandia Investment Management LP | 0 | 15,000 | +15,000 | 0.00 | 0.64 | +0.64 | buy |
| Creative Planning | 53,675 | 67,738 | +14,063 | 0.00 | 0.00 | +0.00 | buy |
| Graham Capital Management, L.P. | 11,328 | 24,480 | +13,152 | 0.00 | 0.01 | +0.01 | buy |
| PROFUND ADVISORS LLC | 20,157 | 33,083 | +12,926 | 0.01 | 0.02 | +0.01 | buy |
| Police & Firemen's Retirement System of New Jersey | 23,571 | 35,680 | +12,109 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 63,712 | 75,701 | +11,989 | 0.00 | 0.01 | +0.00 | buy |
| SEI INVESTMENTS CO | 0 | 11,324 | +11,324 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 23,102 | 33,902 | +10,800 | 0.00 | 0.00 | +0.00 | buy |
| XPONANCE, INC. | 0 | 10,142 | +10,142 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 90,272 | 96,486 | +6,214 | 0.01 | 0.02 | +0.01 | buy |
| Gordian Capital Singapore Pte Ltd | 3,200 | 9,000 | +5,800 | 0.03 | 0.17 | +0.14 | buy |
| JPMORGAN CHASE & CO | 69,279 | 74,812 | +5,533 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 62,642 | 68,000 | +5,358 | 0.00 | 0.00 | +0.00 | buy |
| Arizona State Retirement System | 21,578 | 24,702 | +3,124 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 13,024 | 15,760 | +2,736 | 0.03 | 0.06 | +0.03 | buy |
| PRUDENTIAL FINANCIAL INC | 12,905 | 15,395 | +2,490 | 0.00 | 0.00 | +0.00 | buy |