| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Kynam Capital Management, LP | 2,210,125 | 5,854,766 | +3,644,641 | 3.58 | 3.90 | +0.31 | buy |
| MILLENNIUM MANAGEMENT LLC | 123,689 | 2,797,244 | +2,673,555 | 0.00 | 0.02 | +0.01 | buy |
| MORGAN STANLEY | 129,499 | 2,259,201 | +2,129,702 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 3,766,755 | 5,191,448 | +1,424,693 | 0.13 | 0.09 | -0.03 | buy |
| STATE STREET CORP | 2,967,635 | 4,150,615 | +1,182,980 | 0.00 | 0.00 | -0.00 | buy |
| Redmile Group, LLC | 2,053,333 | 2,914,022 | +860,689 | 0.95 | 0.61 | -0.34 | buy |
| FMR LLC | 4,569,781 | 5,302,854 | +733,073 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 120,000 | 790,484 | +670,484 | 0.01 | 0.05 | +0.04 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 3,053,300 | 3,710,539 | +657,239 | 1.61 | 1.00 | -0.61 | buy |
| CITADEL ADVISORS LLC | 60,605 | 640,771 | +580,166 | 0.00 | 0.00 | +0.00 | buy |
| Polar Asset Management Partners Inc. | 0 | 495,200 | +495,200 | 0.00 | 0.08 | +0.08 | buy |
| Frazier Life Sciences Management, L.P. | 1,501,383 | 1,995,267 | +493,884 | 0.97 | 0.63 | -0.35 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 651,372 | 966,748 | +315,376 | 2.37 | 1.75 | -0.61 | buy |
| ALGERT GLOBAL LLC | 103,075 | 355,570 | +252,495 | 0.05 | 0.08 | +0.04 | buy |
| SG Americas Securities, LLC | 104,722 | 317,409 | +212,687 | 0.01 | 0.02 | +0.01 | buy |
| VANGUARD GROUP INC | 4,373,311 | 4,534,655 | +161,344 | 0.00 | 0.00 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 21,335 | 179,415 | +158,080 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 79,074 | 227,407 | +148,333 | 0.00 | 0.00 | +0.00 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 135,000 | +135,000 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 127,444 | +127,444 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 110,912 | 229,205 | +118,293 | 0.00 | 0.00 | -0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 117,168 | +117,168 | 0.00 | 0.00 | +0.00 | buy |
| LANDSCAPE CAPITAL MANAGEMENT, L.L.C. | 0 | 102,730 | +102,730 | 0.00 | 0.05 | +0.05 | buy |
| Rafferty Asset Management, LLC | 191,777 | 288,671 | +96,894 | 0.01 | 0.01 | -0.00 | buy |
| HRT FINANCIAL LP | 0 | 90,215 | +90,215 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 10,281 | 96,014 | +85,733 | 0.01 | 0.05 | +0.04 | buy |
| XTX Topco Ltd | 0 | 83,424 | +83,424 | 0.00 | 0.11 | +0.11 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 2,150,000 | 2,232,968 | +82,968 | 0.38 | 0.21 | -0.16 | buy |
| HighVista Strategies LLC | 198,587 | 281,093 | +82,506 | 0.90 | 0.60 | -0.30 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,647,246 | 1,728,782 | +81,536 | 0.00 | 0.00 | -0.00 | buy |
| Nantahala Capital Management, LLC | 575,000 | 640,936 | +65,936 | 0.71 | 0.38 | -0.33 | buy |
| Atom Investors LP | 37,398 | 103,216 | +65,818 | 0.08 | 0.11 | +0.02 | buy |
| DIMENSIONAL FUND ADVISORS LP | 1,579,691 | 1,636,834 | +57,143 | 0.01 | 0.00 | -0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 32,228 | 87,748 | +55,520 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 266,534 | 320,316 | +53,782 | 0.06 | 0.04 | -0.02 | buy |
| GOLDMAN SACHS GROUP INC | 399,882 | 446,772 | +46,890 | 0.00 | 0.00 | -0.00 | buy |
| Nebula Research & Development LLC | 11,449 | 51,972 | +40,523 | 0.06 | 0.09 | +0.03 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 40,501 | +40,501 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 82,241 | 121,851 | +39,610 | 0.00 | 0.00 | -0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,917 | 39,856 | +36,939 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 41,108 | 77,402 | +36,294 | 0.01 | 0.01 | +0.00 | buy |
| CORNERCAP INVESTMENT COUNSEL INC | 0 | 34,328 | +34,328 | 0.00 | 0.03 | +0.03 | buy |
| Cubist Systematic Strategies, LLC | 0 | 33,974 | +33,974 | 0.00 | 0.00 | +0.00 | buy |
| Fisher Asset Management, LLC | 68,569 | 101,791 | +33,222 | 0.00 | 0.00 | -0.00 | buy |
| Graham Capital Management, L.P. | 0 | 27,742 | +27,742 | 0.00 | 0.01 | +0.01 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 26,268 | +26,268 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 25,018 | +25,018 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 237,530 | 260,955 | +23,425 | 0.02 | 0.01 | -0.01 | buy |
| Forefront Analytics, LLC | 0 | 19,982 | +19,982 | 0.00 | 0.06 | +0.06 | buy |
| Point72 Middle East FZE | 0 | 18,201 | +18,201 | 0.00 | 0.01 | +0.01 | buy |
| Squarepoint Ops LLC | 0 | 16,277 | +16,277 | 0.00 | 0.00 | +0.00 | buy |
| 683 Capital Management, LLC | 0 | 15,694 | +15,694 | 0.00 | 0.01 | +0.01 | buy |
| E Fund Management Co., Ltd. | 0 | 15,411 | +15,411 | 0.00 | 0.01 | +0.01 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 14,618 | +14,618 | 0.00 | 0.01 | +0.01 | buy |
| PROFUND ADVISORS LLC | 33,203 | 47,569 | +14,366 | 0.02 | 0.01 | -0.01 | buy |
| ROYAL BANK OF CANADA | 11,759 | 25,956 | +14,197 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 592,492 | 606,029 | +13,537 | 0.00 | 0.00 | -0.00 | buy |
| NEOS Investment Management LLC | 0 | 12,936 | +12,936 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 288,207 | 300,899 | +12,692 | 0.00 | 0.00 | -0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 36,174 | 48,467 | +12,293 | 0.00 | 0.00 | -0.00 | buy |
| Dynamic Technology Lab Private Ltd | 0 | 11,888 | +11,888 | 0.00 | 0.01 | +0.01 | buy |
| Engineers Gate Manager LP | 0 | 11,460 | +11,460 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 46,971 | 58,031 | +11,060 | 0.01 | 0.00 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 7,700 | 18,666 | +10,966 | 0.05 | 0.07 | +0.02 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 51,657 | 59,557 | +7,900 | 0.00 | 0.00 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 2,189 | 9,961 | +7,772 | 0.01 | 0.01 | +0.01 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 11,328 | 18,934 | +7,606 | 0.00 | 0.00 | -0.00 | buy |
| JANE STREET GROUP, LLC | 29,647 | 34,671 | +5,024 | 0.00 | 0.00 | -0.00 | buy |
| ProShare Advisors LLC | 16,123 | 19,253 | +3,130 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 113,834 | 115,951 | +2,117 | 0.00 | 0.00 | -0.00 | buy |
| Invesco Ltd. | 32,674 | 34,740 | +2,066 | 0.00 | 0.00 | -0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 29,655 | 31,181 | +1,526 | 0.00 | 0.00 | -0.00 | buy |
| Virtu Financial LLC | 12,305 | 13,598 | +1,293 | 0.01 | 0.01 | -0.01 | buy |
| Quarry LP | 0 | 1,183 | +1,183 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 40,474 | 41,288 | +814 | 0.00 | 0.00 | -0.00 | buy |
| NORTHERN TRUST CORP | 712,862 | 713,587 | +725 | 0.00 | 0.00 | -0.00 | buy |
| AMALGAMATED BANK | 9,083 | 9,617 | +534 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 54,369 | 54,818 | +449 | 0.00 | 0.00 | -0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 32,349 | 32,796 | +447 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 2,649 | 2,994 | +345 | 0.00 | 0.00 | -0.00 | buy |
| SIGNATUREFD, LLC | 0 | 76 | +76 | 0.00 | 0.00 | +0.00 | buy |
| O'Dell Group, LLC | 0 | 35 | +35 | 0.00 | 0.00 | +0.00 | buy |
| Covestor Ltd | 7 | 15 | +8 | 0.00 | 0.00 | 0.00 | buy |
| Farther Finance Advisors, LLC | 0 | 6 | +6 | 0.00 | 0.00 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,089,345 | 1,089,345 | 0 | 0.23 | 0.12 | -0.12 | hold |
| Ameritas Investment Partners, Inc. | 8,129 | 8,129 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 72,200 | 72,200 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MACQUARIE GROUP LTD | 230,000 | 230,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Alyeska Investment Group, L.P. | 50,000 | 50,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 281 | 281 | 0 | 0.00 | 0.00 | -0.00 | hold |
| MetLife Investment Management, LLC | 42,855 | 42,855 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VR Adviser, LLC | 4,684,167 | 4,684,167 | 0 | 4.81 | 1.89 | -2.92 | hold |
| LGL PARTNERS, LLC | 14,500 | 14,500 | 0 | 0.02 | 0.01 | -0.01 | hold |
| Vivo Capital, LLC | 2,244,941 | 2,244,941 | 0 | 2.40 | 1.08 | -1.32 | hold |
| 5AM Venture Management, LLC | 790,440 | 790,440 | 0 | 2.22 | 1.23 | -0.98 | hold |
| Fairmount Funds Management LLC | 3,558,975 | 3,558,975 | 0 | 4.17 | 2.21 | -1.96 | hold |
| Commodore Capital LP | 5,566,026 | 5,566,026 | 0 | 6.34 | 2.86 | -3.48 | hold |
| TCG Crossover Management, LLC | 5,631,042 | 5,631,042 | 0 | 8.08 | 3.67 | -4.41 | hold |
| Red Tortoise LLC | 342 | 342 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CONCOURSE FINANCIAL GROUP SECURITIES, INC. | 0 | 0 | 0 | 0.00 | 0.00 | 0.00 | hold |