| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Kynam Capital Management, LP | 2,210,125 | 5,854,766 | +3,644,641 | 3.58 | 3.90 | +0.31 | buy |
| Redmile Group, LLC | 2,053,333 | 2,914,022 | +860,689 | 0.95 | 0.61 | -0.34 | buy |
| Woodline Partners LP | 120,000 | 790,484 | +670,484 | 0.01 | 0.05 | +0.04 | buy |
| SUVRETTA CAPITAL MANAGEMENT, LLC | 3,053,300 | 3,710,539 | +657,239 | 1.61 | 0.99 | -0.62 | buy |
| Frazier Life Sciences Management, L.P. | 1,501,383 | 1,995,267 | +493,884 | 0.97 | 0.63 | -0.35 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 651,372 | 966,748 | +315,376 | 2.37 | 1.75 | -0.61 | buy |
| ALGERT GLOBAL LLC | 103,075 | 355,570 | +252,495 | 0.05 | 0.08 | 0.00 | buy |
| Rafferty Asset Management, LLC | 191,777 | 288,671 | +96,894 | 0.01 | 0.01 | -0.00 | buy |
| EVENTIDE ASSET MANAGEMENT, LLC | 2,150,000 | 2,232,968 | +82,968 | 0.38 | 0.21 | -0.16 | buy |
| HighVista Strategies LLC | 198,587 | 281,093 | +82,506 | 0.90 | 0.60 | -0.30 | buy |
| Nantahala Capital Management, LLC | 575,000 | 640,936 | +65,936 | 0.48 | 0.23 | -0.25 | buy |
| Atom Investors LP | 37,398 | 103,216 | +65,818 | 0.08 | 0.11 | +0.02 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 266,534 | 320,316 | +53,782 | 0.06 | 0.04 | -0.02 | buy |
| Nebula Research & Development LLC | 11,449 | 51,972 | +40,523 | 0.06 | 0.09 | +0.03 | buy |
| Fisher Asset Management, LLC | 68,569 | 101,791 | +33,222 | 0.00 | 0.00 | -0.00 | buy |
| PROFUND ADVISORS LLC | 33,203 | 47,569 | +14,366 | 0.02 | 0.01 | 0.00 | buy |
| VIRTUS ADVISERS, LLC | 7,700 | 18,666 | +10,966 | 0.05 | 0.07 | +0.02 | buy |
| China Universal Asset Management Co., Ltd. | 2,189 | 9,961 | +7,772 | 0.01 | 0.01 | +0.01 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 475,837 | 475,634 | -203 | 0.18 | 0.11 | -0.07 | sell |
| Sandia Investment Management LP | 10,000 | 5,980 | -4,020 | 0.03 | 0.02 | -0.00 | sell |
| Parkman Healthcare Partners LLC | 193,637 | 96,837 | -96,800 | 0.35 | 0.08 | -0.27 | sell |
| SPHERA FUNDS MANAGEMENT LTD. | 420,000 | 259,201 | -160,799 | 0.75 | 0.25 | -0.50 | sell |
| New Leaf Venture Partners, L.L.C. | 501,530 | 250,765 | -250,765 | 6.28 | 1.19 | -5.09 | sell |
| Candriam S.C.A. | 777,487 | 232,487 | -545,000 | 0.05 | 0.01 | -0.04 | sell |
| Saturn V Capital Management LP | 1,775,415 | 756,681 | -1,018,734 | 7.25 | 1.70 | -5.54 | sell |
| PERCEPTIVE ADVISORS LLC | 2,309,470 | 1,122,958 | -1,186,512 | 0.75 | 0.15 | -0.60 | sell |