| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Octagon Capital Advisors LP | 1,305,000 | 2,763,000 | +1,458,000 | 2.26 | 3.67 | +1.41 | buy |
| Paradigm Biocapital Advisors LP | 4,609,762 | 4,917,412 | +307,650 | 1.74 | 1.33 | -0.41 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,066,034 | 4,300,000 | +233,966 | 0.08 | 0.06 | -0.02 | buy |
| ALGERT GLOBAL LLC | 179,025 | 344,235 | +165,210 | 0.05 | 0.06 | 0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 171,999 | 275,292 | +103,293 | 0.09 | 0.10 | +0.01 | buy |
| Nantahala Capital Management, LLC | 790,936 | 852,855 | +61,919 | 0.43 | 0.29 | -0.15 | buy |
| HighVista Strategies LLC | 225,633 | 279,673 | +54,040 | 0.84 | 0.81 | -0.03 | buy |
| Rafferty Asset Management, LLC | 113,686 | 160,873 | +47,187 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 31,565 | 75,037 | +43,472 | 0.02 | 0.04 | 0.00 | buy |
| Woodline Partners LP | 600,576 | 613,165 | +12,589 | 0.05 | 0.03 | -0.02 | buy |
| PROFUND ADVISORS LLC | 23,422 | 31,589 | +8,167 | 0.01 | 0.01 | 0.00 | buy |
| NEOS Investment Management LLC | 46,815 | 51,926 | +5,111 | 0.02 | 0.01 | -0.01 | buy |
| Forefront Analytics, LLC | 10,021 | 13,760 | +3,739 | 0.05 | 0.05 | -0.00 | buy |
| China Universal Asset Management Co., Ltd. | 21,051 | 23,422 | +2,371 | 0.03 | 0.02 | -0.01 | buy |
| VR Adviser, LLC | 5,684,167 | 5,684,411 | +244 | 3.22 | 3.04 | -0.17 | buy |
| Mesirow Financial Investment Management, Inc. | 21,495 | 21,736 | +241 | 0.00 | 0.00 | -0.00 | buy |
| VIRTUS ADVISERS, LLC | 10,266 | 8,524 | -1,742 | 0.05 | 0.03 | -0.02 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 462,188 | 457,048 | -5,140 | 0.11 | 0.08 | -0.03 | sell |
| SECTORAL ASSET MANAGEMENT INC | 84,400 | 73,800 | -10,600 | 0.54 | 0.38 | -0.15 | sell |
| FOX RUN MANAGEMENT, L.L.C. | 22,678 | 10,108 | -12,570 | 0.05 | 0.01 | -0.04 | sell |
| Fisher Asset Management, LLC | 129,415 | 110,908 | -18,507 | 0.00 | 0.00 | -0.00 | sell |
| PDT Partners, LLC | 53,716 | 23,724 | -29,992 | 0.05 | 0.02 | -0.04 | sell |
| Kynam Capital Management, LP | 9,239,731 | 9,105,000 | -134,731 | 7.73 | 4.68 | -3.05 | sell |
| Saturn V Capital Management LP | 1,712,899 | 1,498,425 | -214,474 | 6.61 | 4.58 | -2.04 | sell |
| Cinctive Capital Management LP | 330,419 | 40,643 | -289,776 | 0.20 | 0.02 | -0.19 | sell |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,221,362 | 921,137 | -300,225 | 2.97 | 1.61 | -1.37 | sell |
| Commodore Capital LP | 7,539,930 | 6,881,629 | -658,301 | 5.09 | 3.93 | -1.15 | sell |
| Avidity Partners Management LP | 1,001,000 | 287,104 | -713,896 | 0.55 | 0.22 | -0.33 | sell |
| Redmile Group, LLC | 4,484,380 | 3,554,836 | -929,544 | 2.85 | 1.93 | -0.92 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,744,263 | 2,631,000 | -1,113,263 | 0.60 | 0.39 | -0.22 | sell |
| Sofinnova Investments, Inc. | 2,265,230 | 823,160 | -1,442,070 | 1.94 | 0.47 | -1.47 | sell |