| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 8,319,411 | 16,569,256 | +8,249,845 | 0.01 | 0.01 | +0.00 | buy |
| Kynam Capital Management, LP | 9,239,731 | 9,105,000 | -134,731 | 7.73 | 4.68 | -3.05 | sell |
| BlackRock, Inc. | 7,991,587 | 8,339,222 | +347,635 | 0.00 | 0.00 | -0.00 | buy |
| TCG Crossover Management, LLC | 6,964,375 | 6,964,375 | 0 | 6.37 | 5.31 | -1.06 | hold |
| Commodore Capital LP | 7,539,930 | 6,881,629 | -658,301 | 5.09 | 3.93 | -1.15 | sell |
| Fairmount Funds Management LLC | 6,225,641 | 6,225,641 | 0 | 5.45 | 4.83 | -0.62 | hold |
| VANGUARD GROUP INC | 5,714,405 | 6,133,380 | +418,975 | 0.00 | 0.00 | -0.00 | buy |
| VR Adviser, LLC | 5,684,167 | 5,684,411 | +244 | 3.22 | 3.04 | -0.17 | buy |
| Point72 Asset Management, L.P. | 10,470,398 | 5,347,302 | -5,123,096 | 0.39 | 0.11 | -0.28 | sell |
| Paradigm Biocapital Advisors LP | 4,609,762 | 4,917,412 | +307,650 | 1.74 | 1.33 | -0.41 | buy |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 4,066,034 | 4,300,000 | +233,966 | 0.08 | 0.06 | -0.02 | buy |
| STATE STREET CORP | 3,231,462 | 3,918,130 | +686,668 | 0.00 | 0.00 | -0.00 | buy |
| Redmile Group, LLC | 4,484,380 | 3,554,836 | -929,544 | 2.85 | 1.93 | -0.92 | sell |
| Octagon Capital Advisors LP | 1,305,000 | 2,763,000 | +1,458,000 | 2.26 | 3.67 | +1.41 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 3,744,263 | 2,631,000 | -1,113,263 | 0.60 | 0.39 | -0.21 | sell |
| GEODE CAPITAL MANAGEMENT, LLC | 2,280,793 | 2,308,509 | +27,716 | 0.00 | 0.00 | -0.00 | buy |
| Saturn V Capital Management LP | 1,712,899 | 1,498,425 | -214,474 | 6.61 | 4.58 | -2.04 | sell |
| FRANKLIN RESOURCES INC | 1,000,167 | 1,283,673 | +283,506 | 0.00 | 0.00 | -0.00 | buy |
| Vivo Capital, LLC | 1,122,471 | 1,122,471 | 0 | 1.00 | 0.98 | -0.02 | hold |
| SG Americas Securities, LLC | 32,533 | 964,712 | +932,179 | 0.00 | 0.03 | +0.03 | buy |
| MORGAN STANLEY | 688,894 | 958,629 | +269,735 | 0.00 | 0.00 | -0.00 | buy |
| Walleye Capital LLC | 557,326 | 936,791 | +379,465 | 0.06 | 0.07 | +0.01 | buy |
| Frazier Life Sciences Management, L.P. | 936,576 | 936,576 | 0 | 0.41 | 0.30 | -0.10 | hold |
| SILVERARC CAPITAL MANAGEMENT, LLC | 1,221,362 | 921,137 | -300,225 | 2.97 | 1.61 | -1.37 | sell |
| NORTHERN TRUST CORP | 847,298 | 912,713 | +65,415 | 0.00 | 0.00 | -0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 0 | 910,865 | +910,865 | 0.00 | 6.24 | +6.24 | buy |
| GOLDMAN SACHS GROUP INC | 878,037 | 864,893 | -13,144 | 0.00 | 0.00 | -0.00 | sell |
| Nantahala Capital Management, LLC | 790,936 | 852,855 | +61,919 | 0.72 | 0.47 | -0.25 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 825,793 | 833,155 | +7,362 | 0.00 | 0.00 | -0.00 | buy |
| Sofinnova Investments, Inc. | 2,265,230 | 823,160 | -1,442,070 | 2.02 | 0.47 | -1.55 | sell |
| DIMENSIONAL FUND ADVISORS LP | 792,423 | 743,652 | -48,771 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 600,576 | 613,165 | +12,589 | 0.05 | 0.03 | -0.02 | buy |
| READYSTATE ASSET MANAGEMENT LP | 0 | 520,000 | +520,000 | 0.00 | 0.17 | +0.17 | buy |
| Assenagon Asset Management S.A. | 607,208 | 473,693 | -133,515 | 0.01 | 0.01 | -0.01 | sell |
| ALLIANCEBERNSTEIN L.P. | 82,060 | 464,942 | +382,882 | 0.00 | 0.00 | +0.00 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 462,188 | 457,048 | -5,140 | 0.11 | 0.08 | -0.03 | sell |
| Crestline Management, LP | 369,763 | 369,763 | 0 | 0.23 | 0.10 | -0.13 | hold |
| ALGERT GLOBAL LLC | 179,025 | 344,235 | +165,210 | 0.05 | 0.06 | +0.01 | buy |
| D. E. Shaw & Co., Inc. | 457,228 | 339,988 | -117,240 | 0.01 | 0.00 | -0.00 | sell |
| Avidity Partners Management LP | 1,001,000 | 287,104 | -713,896 | 0.55 | 0.22 | -0.33 | sell |
| WELLINGTON MANAGEMENT GROUP LLP | 342,323 | 284,850 | -57,473 | 0.00 | 0.00 | -0.00 | sell |
| HighVista Strategies LLC | 225,633 | 279,673 | +54,040 | 0.84 | 0.81 | -0.03 | buy |
| Trexquant Investment LP | 97,565 | 277,523 | +179,958 | 0.01 | 0.03 | +0.01 | buy |
| Hennion & Walsh Asset Management, Inc. | 171,999 | 275,292 | +103,293 | 0.09 | 0.10 | +0.01 | buy |
| Bank of New York Mellon Corp | 263,578 | 258,766 | -4,812 | 0.00 | 0.00 | -0.00 | sell |
| New Leaf Venture Partners, L.L.C. | 250,765 | 250,765 | 0 | 2.78 | 2.61 | -0.17 | hold |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 242,929 | +242,929 | 0.00 | 0.00 | +0.00 | buy |
| MACQUARIE GROUP LTD | 230,000 | 230,000 | 0 | 0.00 | 0.00 | -0.00 | hold |
| UBS Group AG | 115,495 | 213,934 | +98,439 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 175,684 | 193,068 | +17,384 | 0.00 | 0.00 | -0.00 | buy |
| Rafferty Asset Management, LLC | 113,686 | 160,873 | +47,187 | 0.00 | 0.00 | +0.00 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 157,851 | 157,851 | 0 | 0.08 | 0.07 | -0.00 | hold |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 43,370 | 151,618 | +108,248 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 68,416 | 144,454 | +76,038 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 117,863 | 135,604 | +17,741 | 0.00 | 0.00 | -0.00 | buy |
| Squarepoint Ops LLC | 10,860 | 128,799 | +117,939 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 124,921 | 125,581 | +660 | 0.00 | 0.00 | -0.00 | buy |
| Cubist Systematic Strategies, LLC | 130,098 | 122,830 | -7,268 | 0.02 | 0.02 | -0.01 | sell |
| Swiss National Bank | 121,400 | 118,400 | -3,000 | 0.00 | 0.00 | -0.00 | sell |
| Caption Management, LLC | 0 | 112,100 | +112,100 | 0.00 | 0.04 | +0.04 | buy |
| Fisher Asset Management, LLC | 129,415 | 110,908 | -18,507 | 0.00 | 0.00 | -0.00 | sell |
| TWO SIGMA INVESTMENTS, LP | 106,623 | 101,990 | -4,633 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 9,647 | 97,663 | +88,016 | 0.00 | 0.00 | +0.00 | buy |
| DEUTSCHE BANK AG\ | 162,858 | 79,265 | -83,593 | 0.00 | 0.00 | -0.00 | sell |
| Y-Intercept (Hong Kong) Ltd | 31,565 | 75,037 | +43,472 | 0.02 | 0.04 | +0.02 | buy |
| JANE STREET GROUP, LLC | 111,863 | 74,484 | -37,379 | 0.00 | 0.00 | -0.00 | sell |
| SECTORAL ASSET MANAGEMENT INC | 84,400 | 73,800 | -10,600 | 0.54 | 0.38 | -0.15 | sell |
| Legal & General Group Plc | 67,630 | 69,541 | +1,911 | 0.00 | 0.00 | -0.00 | buy |
| ExodusPoint Capital Management, LP | 43,977 | 67,381 | +23,404 | 0.00 | 0.01 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 0 | 66,784 | +66,784 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 31,228 | 63,524 | +32,296 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 47,710 | 63,037 | +15,327 | 0.00 | 0.00 | -0.00 | buy |
| JPMORGAN CHASE & CO | 64,828 | 61,460 | -3,368 | 0.00 | 0.00 | -0.00 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 60,905 | 58,649 | -2,256 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 54,751 | 58,582 | +3,831 | 0.00 | 0.00 | -0.00 | buy |
| XTX Topco Ltd | 0 | 58,560 | +58,560 | 0.00 | 0.04 | +0.04 | buy |
| HRT FINANCIAL LP | 0 | 57,056 | +57,056 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 53,368 | 56,750 | +3,382 | 0.00 | 0.00 | -0.00 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 28,424 | 56,657 | +28,233 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 1,613,616 | 56,512 | -1,557,104 | 0.02 | 0.00 | -0.01 | sell |
| EntryPoint Capital, LLC | 0 | 52,346 | +52,346 | 0.00 | 0.17 | +0.17 | buy |
| NEOS Investment Management LLC | 46,815 | 51,926 | +5,111 | 0.02 | 0.01 | -0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 44,157 | 49,643 | +5,486 | 0.00 | 0.00 | -0.00 | buy |
| Engineers Gate Manager LP | 0 | 46,934 | +46,934 | 0.00 | 0.01 | +0.01 | buy |
| SIMPLEX TRADING, LLC | 0 | 46,610 | +46,610 | 0.00 | 0.01 | +0.01 | buy |
| Corebridge Financial, Inc. | 49,064 | 45,621 | -3,443 | 0.00 | 0.00 | -0.00 | sell |
| WELLS FARGO & COMPANY/MN | 29,232 | 43,645 | +14,413 | 0.00 | 0.00 | +0.00 | buy |
| Cinctive Capital Management LP | 330,419 | 40,643 | -289,776 | 0.20 | 0.02 | -0.19 | sell |
| Invesco Ltd. | 494,078 | 38,641 | -455,437 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 34,937 | 34,273 | -664 | 0.00 | 0.00 | -0.00 | sell |
| PROFUND ADVISORS LLC | 23,422 | 31,589 | +8,167 | 0.01 | 0.01 | -0.00 | buy |
| ProShare Advisors LLC | 23,807 | 31,074 | +7,267 | 0.00 | 0.00 | -0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 30,300 | +30,300 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 15,773 | 29,073 | +13,300 | 0.00 | 0.00 | +0.00 | buy |
| Corton Capital Inc. | 0 | 28,761 | +28,761 | 0.00 | 0.13 | +0.13 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 30,232 | 27,899 | -2,333 | 0.00 | 0.00 | -0.00 | sell |
| AQR CAPITAL MANAGEMENT LLC | 11,712 | 27,593 | +15,881 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 53,716 | 23,724 | -29,992 | 0.05 | 0.02 | -0.04 | sell |
| China Universal Asset Management Co., Ltd. | 21,051 | 23,422 | +2,371 | 0.03 | 0.02 | -0.01 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 23,142 | 23,142 | 0 | 0.00 | 0.00 | -0.00 | hold |