| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 3,467,486 | 7,592,241 | +4,124,755 | 0.61 | 2.70 | +2.09 | buy |
| Duquesne Family Office LLC | 1,059,580 | 2,214,470 | +1,154,890 | 0.37 | 1.75 | +1.38 | buy |
| Holocene Advisors, LP | 117,916 | 1,178,208 | +1,060,292 | 0.00 | 0.09 | +0.08 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 815,075 | 1,245,254 | +430,179 | 1.69 | 6.40 | +4.71 | buy |
| Alyeska Investment Group, L.P. | 100,000 | 493,934 | +393,934 | 0.00 | 0.05 | +0.05 | buy |
| Candriam S.C.A. | 954,209 | 1,296,475 | +342,266 | 0.07 | 0.23 | +0.16 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 98,526 | 378,500 | +279,974 | 0.30 | 2.60 | +2.30 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 179,733 | 53,307 | +126,426 | 0.00 | 0.00 | -0.00 | sell |
| Burkehill Global Management, LP | 200,000 | 325,000 | +125,000 | 0.16 | 0.76 | +0.60 | buy |
| Hennion & Walsh Asset Management, Inc. | 300,127 | 338,065 | +37,938 | 0.16 | 0.41 | +0.26 | buy |
| DIADEMA PARTNERS LP | 97,813 | 131,852 | +34,039 | 0.98 | 2.79 | +1.81 | buy |
| Persistent Asset Partners Ltd | 22,486 | 47,499 | +25,013 | 0.23 | 0.81 | +0.58 | buy |
| NEOS Investment Management LLC | 89,923 | 107,924 | +18,001 | 0.01 | 0.02 | +0.01 | buy |
| TEMA ETFS LLC | 89,923 | 106,329 | +16,406 | 0.11 | 0.29 | +0.19 | buy |
| F/m Investments LLC | 220,168 | 235,804 | +15,636 | 0.12 | 0.32 | +0.20 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 1,022,858 | 1,038,494 | +15,636 | 0.76 | 1.80 | +1.04 | buy |
| PROFUND ADVISORS LLC | 33,083 | 42,749 | +9,666 | 0.02 | 0.05 | 0.00 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 361,408 | 366,238 | +4,830 | 5.11 | 6.96 | +1.85 | buy |
| EMERALD ADVISERS, LLC | 1,579,496 | 1,583,346 | +3,850 | 0.73 | 1.73 | +1.01 | buy |
| China Universal Asset Management Co., Ltd. | 24,487 | 25,014 | +527 | 0.03 | 0.07 | +0.04 | buy |
| Optimize Financial Inc | 32,552 | 33,024 | +472 | 0.24 | 0.59 | +0.35 | buy |
| GF FUND MANAGEMENT CO. LTD. | 3,006 | 3,016 | +10 | 0.00 | 0.00 | +0.00 | buy |
| J.Safra Asset Management Corp | 266 | 255 | -11 | 0.00 | 0.00 | +0.00 | sell |
| 49 WEALTH MANAGEMENT, LLC | 10,043 | 6,431 | -3,612 | 0.01 | 0.02 | +0.00 | sell |
| Gordian Capital Singapore Pte Ltd | 9,000 | 4,500 | -4,500 | 0.17 | 0.22 | +0.05 | sell |
| Arrowpoint Investment Partners (Singapore) Pte. Ltd. | 16,098 | 7,353 | -8,745 | 0.34 | 0.04 | -0.30 | sell |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 9,053,118 | 9,043,903 | -9,215 | 1.98 | 4.10 | +2.12 | sell |
| Virtus Investment Advisers, LLC | 15,760 | 6,317 | -9,443 | 0.06 | 0.06 | -0.00 | sell |
| STRS OHIO | 41,500 | 30,500 | -11,000 | 0.00 | 0.00 | +0.00 | sell |
| Sandia Investment Management LP | 15,000 | 1,000 | -14,000 | 0.64 | 0.09 | -0.55 | sell |
| Rafferty Asset Management, LLC | 148,801 | 111,094 | -37,707 | 0.01 | 0.01 | +0.01 | sell |
| SummitTX Capital, L.P. | 295,810 | 257,171 | -38,639 | 0.18 | 0.28 | +0.10 | sell |
| PRELUDE CAPITAL MANAGEMENT, LLC | 137,281 | 72,378 | -64,903 | 0.16 | 0.19 | +0.04 | sell |
| Cinctive Capital Management LP | 111,058 | 44,665 | -66,393 | 0.08 | 0.09 | +0.01 | sell |
| Siren, L.L.C. | 1,724,279 | 1,629,279 | -95,000 | 0.97 | 1.73 | +0.76 | sell |
| PLATINUM INVESTMENT MANAGEMENT LTD | 219,504 | 121,229 | -98,275 | 0.20 | 1.00 | +0.79 | sell |
| HighVista Strategies LLC | 462,405 | 336,667 | -125,738 | 1.63 | 3.08 | +1.45 | sell |
| Exome Asset Management LLC | 443,547 | 305,568 | -137,979 | 4.21 | 5.36 | +1.16 | sell |
| Sofinnova Investments, Inc. | 2,127,941 | 1,973,625 | -154,316 | 1.67 | 3.02 | +1.35 | sell |
| Rock Springs Capital Management LP | 1,008,308 | 849,030 | -159,278 | 0.85 | 1.55 | +0.70 | sell |
| KENNEDY CAPITAL MANAGEMENT LLC | 583,885 | 352,387 | -231,498 | 0.19 | 0.27 | +0.08 | sell |
| Vivo Capital, LLC | 2,789,137 | 2,398,993 | -390,144 | 3.22 | 5.51 | +2.29 | sell |
| ADAGE CAPITAL PARTNERS GP, L.L.C. | 562,000 | 100,000 | -462,000 | 0.01 | 0.01 | -0.01 | sell |
| Octagon Capital Advisors LP | 2,874,111 | 2,350,000 | -524,111 | 6.44 | 10.45 | +4.01 | sell |
| Redmile Group, LLC | 2,209,118 | 1,437,918 | -771,200 | 3.09 | 3.76 | +0.67 | sell |
| Saturn V Capital Management LP | 2,025,041 | 1,217,064 | -807,977 | 6.38 | 7.93 | +1.56 | sell |
| TCG Crossover Management, LLC | 6,798,162 | 5,868,162 | -930,000 | 4.80 | 6.90 | +2.10 | sell |
| Nantahala Capital Management, LLC | 1,506,989 | 250,000 | -1,256,989 | 0.75 | 0.29 | -0.46 | sell |
| Kynam Capital Management, LP | 7,886,172 | 6,165,223 | -1,720,949 | 8.43 | 14.26 | +5.83 | sell |
| VR Adviser, LLC | 4,000,000 | 2,000,000 | -2,000,000 | 3.23 | 3.51 | +0.28 | sell |
| Commodore Capital LP | 7,250,000 | 2,196,845 | -5,053,155 | 5.08 | 5.19 | +0.11 | sell |