| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 22,408,263 | 23,086,967 | +678,704 | 0.02 | 0.04 | +0.03 | buy |
| BlackRock, Inc. | 10,369,535 | 12,974,591 | +2,605,056 | 0.00 | 0.01 | +0.01 | buy |
| VANGUARD GROUP INC | 7,757,662 | 11,514,326 | +3,756,664 | 0.00 | 0.01 | +0.00 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 9,053,118 | 9,043,903 | -9,215 | 1.99 | 4.12 | +2.13 | sell |
| Fairmount Funds Management LLC | 9,003,418 | 9,003,418 | 0 | 11.63 | 24.34 | +12.71 | hold |
| RTW INVESTMENTS, LP | 3,467,486 | 7,592,241 | +4,124,755 | 0.61 | 2.70 | +2.09 | buy |
| Kynam Capital Management, LP | 7,886,172 | 6,165,223 | -1,720,949 | 8.43 | 14.26 | +5.83 | sell |
| TCG Crossover Management, LLC | 6,798,162 | 5,868,162 | -930,000 | 4.80 | 6.90 | +2.10 | sell |
| Polar Capital Holdings Plc | 0 | 5,500,000 | +5,500,000 | 0.00 | 0.03 | +0.03 | buy |
| STATE STREET CORP | 4,775,419 | 4,940,300 | +164,881 | 0.00 | 0.01 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 3,178,043 | 4,537,408 | +1,359,365 | 0.02 | 0.07 | +0.05 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,274,155 | 3,514,562 | +240,407 | 0.00 | 0.01 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 406,899 | 2,712,336 | +2,305,437 | 0.00 | 0.02 | +0.02 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 89,716 | 2,564,062 | +2,474,346 | 0.00 | 0.01 | +0.01 | buy |
| Vivo Capital, LLC | 2,789,137 | 2,398,993 | -390,144 | 3.22 | 5.51 | +2.29 | sell |
| Octagon Capital Advisors LP | 2,874,111 | 2,350,000 | -524,111 | 6.44 | 10.45 | +4.01 | sell |
| D. E. Shaw & Co., Inc. | 1,530,925 | 2,247,804 | +716,879 | 0.02 | 0.06 | +0.04 | buy |
| Duquesne Family Office LLC | 1,059,580 | 2,214,470 | +1,154,890 | 0.39 | 1.86 | +1.48 | buy |
| Commodore Capital LP | 7,250,000 | 2,196,845 | -5,053,155 | 5.08 | 5.19 | +0.11 | sell |
| VR Adviser, LLC | 4,000,000 | 2,000,000 | -2,000,000 | 3.23 | 3.51 | +0.28 | sell |
| Sofinnova Investments, Inc. | 2,127,941 | 1,973,625 | -154,316 | 1.87 | 3.02 | +1.15 | sell |
| LORD, ABBETT & CO. LLC | 0 | 1,870,537 | +1,870,537 | 0.00 | 0.20 | +0.20 | buy |
| GOLDMAN SACHS GROUP INC | 1,659,677 | 1,705,144 | +45,467 | 0.00 | 0.01 | +0.01 | buy |
| MARSHALL WACE, LLP | 642,479 | 1,660,735 | +1,018,256 | 0.01 | 0.06 | +0.05 | buy |
| Siren, L.L.C. | 1,724,279 | 1,629,279 | -95,000 | 0.97 | 1.73 | +0.76 | sell |
| EMERALD ADVISERS, LLC | 1,579,496 | 1,583,346 | +3,850 | 0.73 | 1.73 | +1.01 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 2,670,486 | 1,440,318 | -1,230,168 | 0.08 | 0.10 | +0.02 | sell |
| CITADEL ADVISORS LLC | 1,667,807 | 1,438,994 | -228,813 | 0.02 | 0.03 | +0.02 | sell |
| Redmile Group, LLC | 2,209,118 | 1,437,918 | -771,200 | 3.09 | 3.76 | +0.67 | sell |
| Candriam S.C.A. | 954,209 | 1,296,475 | +342,266 | 0.07 | 0.23 | +0.16 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,190,645 | 1,280,779 | +90,134 | 0.00 | 0.01 | +0.00 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 815,075 | 1,245,254 | +430,179 | 1.69 | 6.40 | +4.71 | buy |
| Saturn V Capital Management LP | 2,025,041 | 1,217,064 | -807,977 | 6.38 | 7.93 | +1.56 | sell |
| MILLENNIUM MANAGEMENT LLC | 414,966 | 1,208,228 | +793,262 | 0.00 | 0.03 | +0.03 | buy |
| NORTHERN TRUST CORP | 1,181,665 | 1,199,300 | +17,635 | 0.00 | 0.01 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 2,239,255 | 1,191,930 | -1,047,325 | 0.00 | 0.00 | +0.00 | sell |
| Holocene Advisors, LP | 117,916 | 1,178,208 | +1,060,292 | 0.00 | 0.09 | +0.08 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 1,102,181 | +1,102,181 | 0.00 | 0.15 | +0.15 | buy |
| EMERALD MUTUAL FUND ADVISERS TRUST | 1,022,858 | 1,038,494 | +15,636 | 0.76 | 1.80 | +1.04 | buy |
| Nuveen, LLC | 939,620 | 932,621 | -6,999 | 0.00 | 0.01 | +0.01 | sell |
| AMERICAN CENTURY COMPANIES INC | 0 | 892,920 | +892,920 | 0.00 | 0.02 | +0.02 | buy |
| Rock Springs Capital Management LP | 1,008,308 | 849,030 | -159,278 | 0.85 | 1.55 | +0.70 | sell |
| Point72 Asset Management, L.P. | 1,237,833 | 827,525 | -410,308 | 0.04 | 0.05 | +0.01 | sell |
| First Turn Management, LLC | 0 | 824,283 | +824,283 | 0.00 | 3.35 | +3.35 | buy |
| Woodline Partners LP | 513,397 | 818,782 | +305,385 | 0.03 | 0.11 | +0.08 | buy |
| MORGAN STANLEY | 1,288,164 | 726,777 | -561,387 | 0.00 | 0.00 | +0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 232,968 | 689,068 | +456,100 | 0.00 | 0.04 | +0.03 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 668,970 | +668,970 | 0.00 | 0.08 | +0.08 | buy |
| Invesco Ltd. | 372,270 | 585,765 | +213,495 | 0.00 | 0.00 | +0.00 | buy |
| Atika Capital Management LLC | 0 | 506,000 | +506,000 | 0.00 | 2.50 | +2.50 | buy |
| Alyeska Investment Group, L.P. | 100,000 | 493,934 | +393,934 | 0.00 | 0.05 | +0.05 | buy |
| Deep Track Capital, LP | 0 | 453,102 | +453,102 | 0.00 | 0.37 | +0.37 | buy |
| J. Goldman & Co LP | 0 | 439,269 | +439,269 | 0.00 | 0.61 | +0.61 | buy |
| FEDERATED HERMES, INC. | 93,225 | 426,782 | +333,557 | 0.00 | 0.03 | +0.02 | buy |
| Ensign Peak Advisors, Inc | 25,625 | 421,540 | +395,915 | 0.00 | 0.03 | +0.03 | buy |
| JPMORGAN CHASE & CO | 74,812 | 400,931 | +326,119 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 120,945 | 385,457 | +264,512 | 0.00 | 0.01 | +0.01 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 98,526 | 378,500 | +279,974 | 0.34 | 2.81 | +2.47 | buy |
| Bank of New York Mellon Corp | 363,016 | 376,296 | +13,280 | 0.00 | 0.00 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 289,397 | 375,919 | +86,522 | 0.00 | 0.00 | +0.00 | buy |
| Assenagon Asset Management S.A. | 577,004 | 375,626 | -201,378 | 0.01 | 0.02 | +0.01 | sell |
| ORBIMED ADVISORS LLC | 0 | 371,000 | +371,000 | 0.00 | 0.27 | +0.27 | buy |
| SUPERSTRING CAPITAL MANAGEMENT LP | 361,408 | 366,238 | +4,830 | 5.11 | 6.96 | +1.85 | buy |
| KENNEDY CAPITAL MANAGEMENT LLC | 583,885 | 352,387 | -231,498 | 0.19 | 0.27 | +0.08 | sell |
| Affinity Asset Advisors, LLC | 0 | 350,000 | +350,000 | 0.00 | 0.89 | +0.89 | buy |
| Hennion & Walsh Asset Management, Inc. | 300,127 | 338,065 | +37,938 | 0.16 | 0.41 | +0.26 | buy |
| HighVista Strategies LLC | 462,405 | 336,667 | -125,738 | 1.63 | 3.08 | +1.45 | sell |
| Burkehill Global Management, LP | 200,000 | 325,000 | +125,000 | 0.16 | 0.76 | +0.60 | buy |
| BARCLAYS PLC | 359,830 | 321,606 | -38,224 | 0.00 | 0.00 | +0.00 | sell |
| Patient Square Capital LP | 0 | 317,372 | +317,372 | 0.00 | 2.41 | +2.41 | buy |
| Exome Asset Management LLC | 443,547 | 305,568 | -137,979 | 4.21 | 5.36 | +1.16 | sell |
| Man Group plc | 0 | 292,082 | +292,082 | 0.00 | 0.02 | +0.02 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 78,623 | 283,497 | +204,874 | 0.00 | 0.01 | +0.01 | buy |
| Qube Research & Technologies Ltd | 113,658 | 276,728 | +163,070 | 0.00 | 0.01 | +0.01 | buy |
| UBS Group AG | 1,853,672 | 264,047 | -1,589,625 | 0.01 | 0.00 | -0.00 | sell |
| SummitTX Capital, L.P. | 295,810 | 257,171 | -38,639 | 0.18 | 0.28 | +0.10 | sell |
| Nantahala Capital Management, LLC | 1,506,989 | 250,000 | -1,256,989 | 1.34 | 0.53 | -0.81 | sell |
| Evergreen Quality Fund GP, Ltd. | 0 | 250,000 | +250,000 | 0.00 | 0.18 | +0.18 | buy |
| NWI MANAGEMENT LP | 0 | 241,671 | +241,671 | 0.00 | 0.52 | +0.52 | buy |
| F/m Investments LLC | 220,168 | 235,804 | +15,636 | 0.12 | 0.32 | +0.20 | buy |
| Susquehanna Portfolio Strategies, LLC | 229,755 | 229,755 | 0 | 0.05 | 0.13 | +0.07 | hold |
| ALGERT GLOBAL LLC | 267,142 | 227,862 | -39,280 | 0.06 | 0.13 | +0.06 | sell |
| Cormorant Asset Management, LP | 0 | 225,000 | +225,000 | 0.00 | 0.45 | +0.45 | buy |
| Boxer Capital Management, LLC | 0 | 225,000 | +225,000 | 0.00 | 1.75 | +1.75 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 697,964 | 198,969 | -498,995 | 0.01 | 0.00 | -0.00 | sell |
| AMERIPRISE FINANCIAL INC | 0 | 188,349 | +188,349 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 176,712 | 180,176 | +3,464 | 0.00 | 0.01 | +0.00 | buy |
| SEI INVESTMENTS CO | 11,324 | 179,414 | +168,090 | 0.00 | 0.01 | +0.01 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 175,889 | +175,889 | 0.00 | 0.02 | +0.02 | buy |
| Swiss National Bank | 162,200 | 165,400 | +3,200 | 0.00 | 0.00 | +0.00 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 0 | 164,437 | +164,437 | 0.00 | 0.02 | +0.02 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 142,954 | 164,140 | +21,186 | 0.00 | 0.00 | +0.00 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 159,942 | +159,942 | 0.00 | 0.03 | +0.03 | buy |
| Squarepoint Ops LLC | 0 | 155,984 | +155,984 | 0.00 | 0.01 | +0.01 | buy |
| ALLIANCEBERNSTEIN L.P. | 124,620 | 155,510 | +30,890 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 81,004 | 153,625 | +72,621 | 0.00 | 0.00 | +0.00 | buy |
| Nicholas Investment Partners, LP | 0 | 151,066 | +151,066 | 0.00 | 0.39 | +0.39 | buy |
| Informed Momentum Co LLC | 0 | 134,295 | +134,295 | 0.00 | 0.53 | +0.53 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 61,623 | 133,214 | +71,591 | 0.00 | 0.00 | +0.00 | buy |
| DIADEMA PARTNERS LP | 97,813 | 131,852 | +34,039 | 0.98 | 2.79 | +1.81 | buy |