| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Polar Capital Holdings Plc | 0 | 5,500,000 | +5,500,000 | 0.00 | 0.03 | +0.03 | buy |
| RTW INVESTMENTS, LP | 3,467,486 | 7,592,241 | +4,124,755 | 0.61 | 2.70 | +2.09 | buy |
| VANGUARD GROUP INC | 7,757,662 | 11,514,326 | +3,756,664 | 0.00 | 0.01 | +0.00 | buy |
| BlackRock, Inc. | 10,369,535 | 12,974,591 | +2,605,056 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 89,716 | 2,564,062 | +2,474,346 | 0.00 | 0.01 | +0.01 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 406,899 | 2,712,336 | +2,305,437 | 0.00 | 0.02 | +0.02 | buy |
| LORD, ABBETT & CO. LLC | 0 | 1,870,537 | +1,870,537 | 0.00 | 0.20 | +0.20 | buy |
| JANUS HENDERSON GROUP PLC | 3,178,043 | 4,537,408 | +1,359,365 | 0.02 | 0.07 | +0.05 | buy |
| Duquesne Family Office LLC | 1,059,580 | 2,214,470 | +1,154,890 | 0.39 | 1.86 | +1.48 | buy |
| FRED ALGER MANAGEMENT, LLC | 0 | 1,102,181 | +1,102,181 | 0.00 | 0.15 | +0.15 | buy |
| Holocene Advisors, LP | 117,916 | 1,178,208 | +1,060,292 | 0.00 | 0.09 | +0.08 | buy |
| MARSHALL WACE, LLP | 642,479 | 1,660,735 | +1,018,256 | 0.01 | 0.06 | +0.05 | buy |
| AMERICAN CENTURY COMPANIES INC | 0 | 892,920 | +892,920 | 0.00 | 0.02 | +0.02 | buy |
| First Turn Management, LLC | 0 | 824,283 | +824,283 | 0.00 | 3.35 | +3.35 | buy |
| MILLENNIUM MANAGEMENT LLC | 414,966 | 1,208,228 | +793,262 | 0.00 | 0.03 | +0.03 | buy |
| D. E. Shaw & Co., Inc. | 1,530,925 | 2,247,804 | +716,879 | 0.02 | 0.06 | +0.04 | buy |
| FMR LLC | 22,408,263 | 23,086,967 | +678,704 | 0.02 | 0.04 | +0.03 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 668,970 | +668,970 | 0.00 | 0.08 | +0.08 | buy |
| Atika Capital Management LLC | 0 | 506,000 | +506,000 | 0.00 | 2.50 | +2.50 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 232,968 | 689,068 | +456,100 | 0.00 | 0.04 | +0.03 | buy |
| Deep Track Capital, LP | 0 | 453,102 | +453,102 | 0.00 | 0.37 | +0.37 | buy |
| J. Goldman & Co LP | 0 | 439,269 | +439,269 | 0.00 | 0.61 | +0.61 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 815,075 | 1,245,254 | +430,179 | 1.69 | 6.40 | +4.71 | buy |
| Ensign Peak Advisors, Inc | 25,625 | 421,540 | +395,915 | 0.00 | 0.03 | +0.03 | buy |
| Alyeska Investment Group, L.P. | 100,000 | 493,934 | +393,934 | 0.00 | 0.05 | +0.05 | buy |
| ORBIMED ADVISORS LLC | 0 | 371,000 | +371,000 | 0.00 | 0.27 | +0.27 | buy |
| Affinity Asset Advisors, LLC | 0 | 350,000 | +350,000 | 0.00 | 0.89 | +0.89 | buy |
| Candriam S.C.A. | 954,209 | 1,296,475 | +342,266 | 0.07 | 0.23 | +0.16 | buy |
| FEDERATED HERMES, INC. | 93,225 | 426,782 | +333,557 | 0.00 | 0.03 | +0.02 | buy |
| JPMORGAN CHASE & CO | 74,812 | 400,931 | +326,119 | 0.00 | 0.00 | +0.00 | buy |
| Patient Square Capital LP | 0 | 317,372 | +317,372 | 0.00 | 2.41 | +2.41 | buy |
| Woodline Partners LP | 513,397 | 818,782 | +305,385 | 0.03 | 0.11 | +0.08 | buy |
| Man Group plc | 0 | 292,082 | +292,082 | 0.00 | 0.02 | +0.02 | buy |
| SPHERA FUNDS MANAGEMENT LTD. | 98,526 | 378,500 | +279,974 | 0.34 | 2.81 | +2.47 | buy |
| Russell Investments Group, Ltd. | 120,945 | 385,457 | +264,512 | 0.00 | 0.01 | +0.01 | buy |
| Evergreen Quality Fund GP, Ltd. | 0 | 250,000 | +250,000 | 0.00 | 0.18 | +0.18 | buy |
| NWI MANAGEMENT LP | 0 | 241,671 | +241,671 | 0.00 | 0.52 | +0.52 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 3,274,155 | 3,514,562 | +240,407 | 0.00 | 0.01 | +0.00 | buy |
| Cormorant Asset Management, LP | 0 | 225,000 | +225,000 | 0.00 | 0.45 | +0.45 | buy |
| Boxer Capital Management, LLC | 0 | 225,000 | +225,000 | 0.00 | 1.75 | +1.75 | buy |
| Invesco Ltd. | 372,270 | 585,765 | +213,495 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 78,623 | 283,497 | +204,874 | 0.00 | 0.01 | +0.01 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 188,349 | +188,349 | 0.00 | 0.00 | +0.00 | buy |
| Connor, Clark & Lunn Investment Management Ltd. | 0 | 175,889 | +175,889 | 0.00 | 0.02 | +0.02 | buy |
| SEI INVESTMENTS CO | 11,324 | 179,414 | +168,090 | 0.00 | 0.01 | +0.01 | buy |
| STATE STREET CORP | 4,775,419 | 4,940,300 | +164,881 | 0.00 | 0.01 | +0.00 | buy |
| Skandinaviska Enskilda Banken AB (publ) | 0 | 164,437 | +164,437 | 0.00 | 0.02 | +0.02 | buy |
| Qube Research & Technologies Ltd | 113,658 | 276,728 | +163,070 | 0.00 | 0.01 | +0.01 | buy |
| TUDOR INVESTMENT CORP ET AL | 0 | 159,942 | +159,942 | 0.00 | 0.03 | +0.03 | buy |
| Squarepoint Ops LLC | 0 | 155,984 | +155,984 | 0.00 | 0.01 | +0.01 | buy |
| Nicholas Investment Partners, LP | 0 | 151,066 | +151,066 | 0.00 | 0.39 | +0.39 | buy |
| Informed Momentum Co LLC | 0 | 134,295 | +134,295 | 0.00 | 0.53 | +0.53 | buy |
| Burkehill Global Management, LP | 200,000 | 325,000 | +125,000 | 0.16 | 0.76 | +0.60 | buy |
| PERCEPTIVE ADVISORS LLC | 0 | 121,082 | +121,082 | 0.00 | 0.08 | +0.08 | buy |
| Soleus Capital Management, L.P. | 0 | 120,000 | +120,000 | 0.00 | 0.18 | +0.18 | buy |
| Walleye Capital LLC | 0 | 114,463 | +114,463 | 0.00 | 0.02 | +0.02 | buy |
| SONA ASSET MANAGEMENT (US) LLC | 0 | 105,000 | +105,000 | 0.00 | 0.12 | +0.12 | buy |
| PRUDENTIAL FINANCIAL INC | 15,395 | 120,175 | +104,780 | 0.00 | 0.01 | +0.00 | buy |
| Knott David M Jr | 0 | 102,000 | +102,000 | 0.00 | 1.68 | +1.68 | buy |
| Pictet Asset Management Holding SA | 13,874 | 112,476 | +98,602 | 0.00 | 0.00 | +0.00 | buy |
| Y-Intercept (Hong Kong) Ltd | 0 | 94,804 | +94,804 | 0.00 | 0.08 | +0.08 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 1,190,645 | 1,280,779 | +90,134 | 0.00 | 0.01 | +0.00 | buy |
| RAYMOND JAMES FINANCIAL INC | 289,397 | 375,919 | +86,522 | 0.00 | 0.00 | +0.00 | buy |
| Maven Securities LTD | 0 | 82,800 | +82,800 | 0.00 | 0.37 | +0.37 | buy |
| HRT FINANCIAL LP | 0 | 81,340 | +81,340 | 0.00 | 0.01 | +0.01 | buy |
| JTC Employer Solutions Trustee Ltd | 0 | 78,400 | +78,400 | 0.00 | 0.20 | +0.20 | buy |
| Jefferies Financial Group Inc. | 0 | 75,112 | +75,112 | 0.00 | 0.02 | +0.02 | buy |
| LPL Financial LLC | 50,202 | 124,238 | +74,036 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 81,004 | 153,625 | +72,621 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 61,623 | 133,214 | +71,591 | 0.00 | 0.00 | +0.00 | buy |
| TD ASSET MANAGEMENT INC | 0 | 56,342 | +56,342 | 0.00 | 0.00 | +0.00 | buy |
| LMR Partners LLP | 0 | 54,433 | +54,433 | 0.00 | 0.02 | +0.02 | buy |
| CITIGROUP INC | 14,408 | 68,653 | +54,245 | 0.00 | 0.00 | +0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 0 | 53,275 | +53,275 | 0.00 | 0.02 | +0.02 | buy |
| Aquatic Capital Management LLC | 57,357 | 106,246 | +48,889 | 0.02 | 0.11 | +0.09 | buy |
| Jain Global LLC | 0 | 48,079 | +48,079 | 0.00 | 0.02 | +0.02 | buy |
| Pier Capital, LLC | 0 | 46,260 | +46,260 | 0.00 | 0.26 | +0.26 | buy |
| GOLDMAN SACHS GROUP INC | 1,659,677 | 1,705,144 | +45,467 | 0.00 | 0.01 | +0.01 | buy |
| Verition Fund Management LLC | 17,114 | 59,456 | +42,342 | 0.00 | 0.01 | +0.01 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 12,954 | 51,586 | +38,632 | 0.00 | 0.00 | +0.00 | buy |
| Hennion & Walsh Asset Management, Inc. | 300,127 | 338,065 | +37,938 | 0.16 | 0.41 | +0.26 | buy |
| Virtu Financial LLC | 0 | 37,619 | +37,619 | 0.00 | 0.05 | +0.05 | buy |
| TEACHERS RETIREMENT SYSTEM OF THE STATE OF KENTUCKY | 0 | 37,445 | +37,445 | 0.00 | 0.01 | +0.01 | buy |
| SEVEN GRAND MANAGERS, LLC | 0 | 35,000 | +35,000 | 0.00 | 0.09 | +0.09 | buy |
| DIADEMA PARTNERS LP | 97,813 | 131,852 | +34,039 | 0.98 | 2.79 | +1.81 | buy |
| Legato Capital Management LLC | 0 | 32,740 | +32,740 | 0.00 | 0.10 | +0.10 | buy |
| SECTORAL ASSET MANAGEMENT INC | 0 | 32,685 | +32,685 | 0.00 | 0.93 | +0.93 | buy |
| Allianz Asset Management GmbH | 0 | 32,600 | +32,600 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 63,598 | 96,011 | +32,413 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 124,620 | 155,510 | +30,890 | 0.00 | 0.00 | +0.00 | buy |
| Harvest Investment Services, LLC | 0 | 30,738 | +30,738 | 0.00 | 0.21 | +0.21 | buy |
| TWINBEECH CAPITAL LP | 0 | 29,300 | +29,300 | 0.00 | 0.07 | +0.07 | buy |
| State of New Jersey Common Pension Fund D | 0 | 28,610 | +28,610 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF HAWAII | 0 | 26,142 | +26,142 | 0.00 | 0.05 | +0.05 | buy |
| Persistent Asset Partners Ltd | 22,486 | 47,499 | +25,013 | 0.23 | 0.81 | +0.58 | buy |
| DYMON ASIA CAPITAL (SINGAPORE) PTE. LTD. | 0 | 24,200 | +24,200 | 0.00 | 0.19 | +0.19 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 38,279 | 61,590 | +23,311 | 0.00 | 0.02 | +0.01 | buy |
| Creative Planning | 67,738 | 89,905 | +22,167 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 142,954 | 164,140 | +21,186 | 0.00 | 0.00 | +0.00 | buy |
| Atom Investors LP | 0 | 18,108 | +18,108 | 0.00 | 0.05 | +0.05 | buy |