| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| EcoR1 Capital, LLC | 100,000 | 735,000 | +635,000 | 0.14 | 1.17 | +1.03 | buy |
| Granahan Investment Management, LLC | 335,586 | 461,608 | +126,022 | 0.53 | 0.54 | +0.01 | buy |
| Artisan Partners Limited Partnership | 315,492 | 355,153 | +39,661 | 0.02 | 0.02 | +0.00 | buy |
| Generali Investments, Management Co LLC | 6,912 | 33,149 | +26,237 | 0.05 | 0.24 | +0.18 | buy |
| TEMA ETFS LLC | 8,540 | 9,917 | +1,377 | 0.02 | 0.01 | -0.01 | buy |
| CIM, LLC | 14,228 | 14,556 | +328 | 0.07 | 0.06 | -0.01 | buy |
| J.Safra Asset Management Corp | 299 | 247 | -52 | 0.00 | 0.00 | -0.00 | sell |
| HighVista Strategies LLC | 62,617 | 61,316 | -1,301 | 0.56 | 0.46 | -0.11 | sell |
| China Universal Asset Management Co., Ltd. | 15,136 | 10,112 | -5,024 | 0.04 | 0.02 | -0.02 | sell |
| OMERS ADMINISTRATION Corp | 41,500 | 30,000 | -11,500 | 0.01 | 0.01 | -0.00 | sell |
| Rhenman & Partners Asset Management AB | 83,000 | 64,500 | -18,500 | 0.33 | 0.20 | -0.13 | sell |
| Candriam S.C.A. | 502,020 | 480,136 | -21,884 | 0.08 | 0.07 | -0.01 | sell |
| Birchview Capital, LP | 210,000 | 178,110 | -31,890 | 3.89 | 2.73 | -1.17 | sell |
| MPM BioImpact LLC | 767,038 | 723,314 | -43,724 | 1.93 | 1.44 | -0.49 | sell |
| BAILLIE GIFFORD & CO | 575,182 | 517,275 | -57,907 | 0.02 | 0.02 | -0.00 | sell |
| TANG CAPITAL MANAGEMENT LLC | 500,000 | 300,000 | -200,000 | 0.83 | 0.45 | -0.38 | sell |
| Redmile Group, LLC | 4,164,120 | 3,945,920 | -218,200 | 8.98 | 8.67 | -0.31 | sell |