| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Skorpios Trust | 14,443,681 | 14,443,681 | 0 | 99.80 | 99.92 | +0.12 | hold |
| Redmile Group, LLC | 2,625,506 | 5,073,049 | +2,447,543 | 0.49 | 2.51 | +2.02 | buy |
| RTW INVESTMENTS, LP | 4,131,045 | 4,224,838 | +93,793 | 0.34 | 0.84 | +0.50 | buy |
| MORGAN STANLEY | 3,370,362 | 4,025,002 | +654,640 | 0.00 | 0.00 | +0.00 | buy |
| Lynx1 Capital Management LP | 2,956,918 | 3,696,820 | +739,902 | 6.12 | 12.85 | +6.74 | buy |
| BAKER BROS. ADVISORS LP | 2,030,134 | 3,368,443 | +1,338,309 | 0.12 | 0.57 | +0.45 | buy |
| VANGUARD GROUP INC | 1,648,502 | 1,715,554 | +67,052 | 0.00 | 0.00 | +0.00 | buy |
| GOLDMAN SACHS GROUP INC | 1,391,431 | 1,404,055 | +12,624 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 0 | 1,058,300 | +1,058,300 | 0.00 | 0.00 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 615,724 | 639,807 | +24,083 | 0.00 | 0.00 | +0.00 | buy |
| STATE STREET CORP | 543,533 | 579,607 | +36,074 | 0.00 | 0.00 | +0.00 | buy |
| Granahan Investment Management, LLC | 1,137,887 | 475,463 | -662,424 | 0.20 | 0.23 | +0.03 | sell |
| Cormorant Asset Management, LP | 1,087,807 | 427,163 | -660,644 | 0.27 | 0.25 | -0.02 | sell |
| DEUTSCHE BANK AG\ | 412,778 | 412,240 | -538 | 0.00 | 0.00 | +0.00 | sell |
| FMR LLC | 5,000 | 375,481 | +370,481 | 0.00 | 0.00 | +0.00 | buy |
| Artal Group S.A. | 0 | 300,000 | +300,000 | 0.00 | 0.10 | +0.10 | buy |
| Eversept Partners, LP | 0 | 290,000 | +290,000 | 0.00 | 0.29 | +0.29 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 239,300 | 263,700 | +24,400 | 0.00 | 0.01 | +0.01 | buy |
| NORTHERN TRUST CORP | 257,592 | 260,891 | +3,299 | 0.00 | 0.00 | +0.00 | buy |
| Sio Capital Management, LLC | 0 | 225,496 | +225,496 | 0.00 | 1.06 | +1.06 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 205,242 | 223,038 | +17,796 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 215,294 | 219,765 | +4,471 | 0.00 | 0.00 | +0.00 | buy |
| Birchview Capital, LP | 210,000 | 210,000 | 0 | 0.86 | 2.31 | +1.45 | hold |
| D. E. Shaw & Co., Inc. | 142,711 | 193,760 | +51,049 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 0 | 178,586 | +178,586 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 0 | 145,000 | +145,000 | 0.00 | 0.45 | +0.45 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 0 | 143,351 | +143,351 | 0.00 | 0.00 | +0.00 | buy |
| Point72 Asset Management, L.P. | 0 | 142,458 | +142,458 | 0.00 | 0.01 | +0.01 | buy |
| Palo Alto Investors LP | 0 | 125,861 | +125,861 | 0.00 | 0.19 | +0.19 | buy |
| Woodline Partners LP | 56,904 | 106,904 | +50,000 | 0.00 | 0.01 | +0.01 | buy |
| Laurion Capital Management LP | 0 | 100,000 | +100,000 | 0.00 | 0.04 | +0.04 | buy |
| Maven Securities LTD | 0 | 100,000 | +100,000 | 0.00 | 0.08 | +0.08 | buy |
| GSA CAPITAL PARTNERS LLP | 102,107 | 97,508 | -4,599 | 0.05 | 0.10 | +0.06 | sell |
| Mirae Asset Global Investments Co., Ltd. | 0 | 90,663 | +90,663 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 98,328 | 89,904 | -8,424 | 0.00 | 0.00 | +0.00 | sell |
| GILDER GAGNON HOWE & CO LLC | 62,248 | 89,783 | +27,535 | 0.00 | 0.02 | +0.01 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 0 | 79,526 | +79,526 | 0.00 | 0.00 | +0.00 | buy |
| Fort Point Capital Partners LLC | 75,429 | 75,429 | 0 | 0.06 | 0.14 | +0.08 | hold |
| Monashee Investment Management LLC | 0 | 67,584 | +67,584 | 0.00 | 0.11 | +0.11 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 62,257 | 62,257 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Squarepoint Ops LLC | 19,096 | 51,097 | +32,001 | 0.00 | 0.00 | +0.00 | buy |
| NORGES BANK | 0 | 50,000 | +50,000 | 0.00 | 0.00 | +0.00 | buy |
| LMR Partners LLP | 0 | 50,000 | +50,000 | 0.00 | 0.02 | +0.02 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 86,600 | 48,200 | -38,400 | 0.00 | 0.00 | +0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 168,028 | 47,912 | -120,116 | 0.00 | 0.00 | -0.00 | sell |
| MILLENNIUM MANAGEMENT LLC | 23,914 | 45,984 | +22,070 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 0 | 45,845 | +45,845 | 0.00 | 0.10 | +0.10 | buy |
| Susquehanna Portfolio Strategies, LLC | 45,108 | 43,424 | -1,684 | 0.00 | 0.01 | +0.01 | sell |
| RHUMBLINE ADVISERS | 40,971 | 41,870 | +899 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 29,773 | 39,415 | +9,642 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 37,340 | 37,340 | 0 | 0.00 | 0.00 | +0.00 | hold |
| TUDOR INVESTMENT CORP ET AL | 0 | 33,326 | +33,326 | 0.00 | 0.01 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 29,789 | 31,431 | +1,642 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 39,800 | 30,976 | -8,824 | 0.00 | 0.01 | +0.00 | sell |
| Ghisallo Capital Management LLC | 0 | 30,000 | +30,000 | 0.00 | 0.05 | +0.05 | buy |
| SEVEN GRAND MANAGERS, LLC | 0 | 30,000 | +30,000 | 0.00 | 0.20 | +0.20 | buy |
| AMERICAN CENTURY COMPANIES INC | 21,036 | 29,660 | +8,624 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 75,339 | 28,607 | -46,732 | 0.00 | 0.00 | -0.00 | sell |
| Belvedere Trading LLC | 0 | 23,665 | +23,665 | 0.00 | 0.02 | +0.02 | buy |
| ZACKS INVESTMENT MANAGEMENT | 14,064 | 21,439 | +7,375 | 0.00 | 0.00 | +0.00 | buy |
| PDT Partners, LLC | 0 | 21,426 | +21,426 | 0.00 | 0.03 | +0.03 | buy |
| CHASE INVESTMENT COUNSEL CORP | 0 | 20,738 | +20,738 | 0.00 | 0.10 | +0.10 | buy |
| BARCLAYS PLC | 39,271 | 20,624 | -18,647 | 0.00 | 0.00 | +0.00 | sell |
| Hudson Bay Capital Management LP | 0 | 20,000 | +20,000 | 0.00 | 0.00 | +0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 0 | 19,100 | +19,100 | 0.00 | 0.00 | +0.00 | buy |
| BRIDGEWAY CAPITAL MANAGEMENT, LLC | 17,100 | 17,100 | 0 | 0.00 | 0.00 | +0.00 | hold |
| XTX Topco Ltd | 0 | 16,308 | +16,308 | 0.00 | 0.03 | +0.03 | buy |
| TWO SIGMA INVESTMENTS, LP | 11,200 | 15,500 | +4,300 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 7,694 | 14,330 | +6,636 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN INTERNATIONAL GROUP, INC. | 13,711 | 13,738 | +27 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 11,916 | 11,970 | +54 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 18,133 | 10,944 | -7,189 | 0.00 | 0.00 | +0.00 | sell |
| Dorsey & Whitney Trust CO LLC | 10,815 | 10,815 | 0 | 0.00 | 0.01 | +0.01 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 10,642 | 10,583 | -59 | 0.00 | 0.00 | +0.00 | sell |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 10,473 | +10,473 | 0.00 | 0.00 | +0.00 | buy |
| PRINCIPAL FINANCIAL GROUP INC | 12,037 | 10,451 | -1,586 | 0.00 | 0.00 | +0.00 | sell |
| WELLS FARGO & COMPANY/MN | 8,500 | 9,852 | +1,352 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 15,101 | 9,658 | -5,443 | 0.00 | 0.00 | -0.00 | sell |
| Aquatic Capital Management LLC | 0 | 9,600 | +9,600 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 14,616 | 8,284 | -6,332 | 0.00 | 0.00 | +0.00 | sell |
| Ikarian Capital, LLC | 12,116 | 6,816 | -5,300 | 0.02 | 0.03 | +0.01 | sell |
| CITIGROUP INC | 3,972 | 5,466 | +1,494 | 0.00 | 0.00 | +0.00 | buy |
| LAZARD ASSET MANAGEMENT LLC | 5,779 | 3,710 | -2,069 | 0.00 | 0.00 | +0.00 | sell |
| ADAR1 Capital Management, LLC | 0 | 2,900 | +2,900 | 0.00 | 0.01 | +0.01 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 4,540 | 2,803 | -1,737 | 0.00 | 0.00 | +0.00 | sell |
| Tower Research Capital LLC (TRC) | 5,039 | 2,661 | -2,378 | 0.00 | 0.00 | +0.00 | sell |
| CANADA LIFE ASSURANCE Co | 2,110 | 2,436 | +326 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,278 | 2,278 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Legal & General Group Plc | 3,129 | 2,278 | -851 | 0.00 | 0.00 | +0.00 | sell |
| NISA INVESTMENT ADVISORS, LLC | 1,934 | 1,951 | +17 | 0.00 | 0.00 | +0.00 | buy |
| METROPOLITAN LIFE INSURANCE CO/NY | 1,515 | 1,625 | +110 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 7,979 | 1,156 | -6,823 | 0.00 | 0.00 | -0.00 | sell |
| AMALGAMATED BANK | 2,099 | 787 | -1,312 | 0.00 | 0.00 | +0.00 | sell |
| Stone House Investment Management, LLC | 0 | 500 | +500 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 0 | 117 | +117 | 0.00 | 0.00 | +0.00 | buy |
| Avior Wealth Management, LLC | 0 | 5 | +5 | 0.00 | 0.00 | +0.00 | buy |
| PUBLIC EMPLOYEES RETIREMENT SYSTEM OF OHIO | 17,283 | 0 | -17,283 | 0.00 | 0.00 | -0.00 | sell |
| VOYA INVESTMENT MANAGEMENT LLC | 11,175 | 0 | -11,175 | 0.00 | 0.00 | -0.00 | sell |
| ALGERT GLOBAL LLC | 12,540 | 0 | -12,540 | 0.00 | 0.00 | -0.00 | sell |
| CITADEL ADVISORS LLC | 15,577 | 0 | -15,577 | 0.00 | 0.00 | -0.00 | sell |