| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Redmile Group, LLC | 2,625,506 | 5,073,049 | +2,447,543 | 0.49 | 2.51 | +2.02 | buy |
| BAKER BROS. ADVISORS LP | 2,030,134 | 3,368,443 | +1,338,309 | 0.12 | 0.57 | +0.45 | buy |
| RTW INVESTMENTS, LP | 4,131,045 | 4,224,838 | +93,793 | 0.34 | 0.84 | +0.50 | buy |
| Woodline Partners LP | 56,904 | 106,904 | +50,000 | 0.00 | 0.01 | +0.01 | buy |
| GILDER GAGNON HOWE & CO LLC | 62,248 | 89,783 | +27,535 | 0.00 | 0.02 | +0.01 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 239,300 | 263,700 | +24,400 | 0.00 | 0.01 | +0.01 | buy |
| ZACKS INVESTMENT MANAGEMENT | 14,064 | 21,439 | +7,375 | 0.00 | 0.00 | +0.00 | buy |
| GSA CAPITAL PARTNERS LLP | 102,107 | 97,508 | +4,599 | 0.05 | 0.12 | 0.00 | sell |
| Susquehanna Portfolio Strategies, LLC | 45,108 | 43,424 | -1,684 | 0.00 | 0.01 | +0.01 | sell |
| Ikarian Capital, LLC | 12,116 | 6,816 | -5,300 | 0.02 | 0.03 | +0.01 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 168,028 | 47,912 | -120,116 | 0.00 | 0.00 | -0.00 | sell |
| Cormorant Asset Management, LP | 1,087,807 | 427,163 | -660,644 | 0.27 | 0.25 | -0.02 | sell |
| Granahan Investment Management, LLC | 1,137,887 | 475,463 | -662,424 | 0.20 | 0.23 | +0.03 | sell |