| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| FMR LLC | 165,196 | 2,541,937 | +2,376,741 | 0.00 | 0.00 | +0.00 | buy |
| MARSHALL WACE, LLP | 951,432 | 2,131,783 | +1,180,351 | 0.01 | 0.02 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 0 | 532,884 | +532,884 | 0.00 | 0.00 | +0.00 | buy |
| Checkpoint Capital L.P. | 305,387 | 730,717 | +425,330 | 1.71 | 2.67 | +0.95 | buy |
| Erste Asset Management GmbH | 0 | 396,000 | +396,000 | 0.00 | 0.03 | +0.03 | buy |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 0 | 357,248 | +357,248 | 0.00 | 0.01 | +0.01 | buy |
| GOLDMAN SACHS GROUP INC | 1,368,967 | 1,662,039 | +293,072 | 0.00 | 0.00 | -0.00 | buy |
| Opaleye Management Inc. | 25,000 | 300,000 | +275,000 | 0.05 | 0.44 | +0.40 | buy |
| DAFNA Capital Management LLC | 171,097 | 443,998 | +272,901 | 0.48 | 0.84 | +0.36 | buy |
| Siren, L.L.C. | 2,000,000 | 2,247,347 | +247,347 | 0.97 | 0.84 | -0.13 | buy |
| TANG CAPITAL MANAGEMENT LLC | 300,000 | 500,000 | +200,000 | 0.22 | 0.18 | -0.03 | buy |
| MORGAN STANLEY | 3,437,244 | 3,590,825 | +153,581 | 0.00 | 0.00 | -0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 538,900 | 664,735 | +125,835 | 0.00 | 0.00 | -0.00 | buy |
| Lynx1 Capital Management LP | 5,187,191 | 5,291,929 | +104,738 | 21.45 | 12.60 | -8.85 | buy |
| Granahan Investment Management, LLC | 567,689 | 660,430 | +92,741 | 0.26 | 0.22 | -0.04 | buy |
| VANGUARD GROUP INC | 2,731,198 | 2,784,202 | +53,004 | 0.00 | 0.00 | -0.00 | buy |
| RENAISSANCE TECHNOLOGIES LLC | 129,043 | 178,300 | +49,257 | 0.00 | 0.00 | -0.00 | buy |
| Schonfeld Strategic Advisors LLC | 291,795 | 335,360 | +43,565 | 0.02 | 0.01 | -0.01 | buy |
| Kennondale Capital Management LLC | 0 | 42,100 | +42,100 | 0.00 | 0.31 | +0.31 | buy |
| XTX Topco Ltd | 0 | 40,181 | +40,181 | 0.00 | 0.01 | +0.01 | buy |
| ADAR1 Capital Management, LLC | 0 | 30,085 | +30,085 | 0.00 | 0.04 | +0.04 | buy |
| Dauntless Investment Group, LLC | 0 | 28,600 | +28,600 | 0.00 | 0.70 | +0.70 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 877,095 | 901,986 | +24,891 | 0.00 | 0.00 | -0.00 | buy |
| Aquatic Capital Management LLC | 0 | 23,643 | +23,643 | 0.00 | 0.00 | +0.00 | buy |
| Net Worth Advisory Group | 0 | 20,741 | +20,741 | 0.00 | 0.04 | +0.04 | buy |
| Graham Capital Management, L.P. | 18,634 | 36,087 | +17,453 | 0.01 | 0.01 | +0.00 | buy |
| CITIGROUP INC | 58,133 | 74,620 | +16,487 | 0.00 | 0.00 | -0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 16,119 | +16,119 | 0.00 | 0.00 | +0.00 | buy |
| CITADEL ADVISORS LLC | 92,580 | 107,562 | +14,982 | 0.00 | 0.00 | -0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 0 | 14,750 | +14,750 | 0.00 | 0.04 | +0.04 | buy |
| AXQ CAPITAL, LP | 0 | 14,600 | +14,600 | 0.00 | 0.04 | +0.04 | buy |
| Invesco Ltd. | 12,065 | 26,183 | +14,118 | 0.00 | 0.00 | +0.00 | buy |
| FOX RUN MANAGEMENT, L.L.C. | 0 | 13,780 | +13,780 | 0.00 | 0.01 | +0.01 | buy |
| Virtus Investment Advisers, LLC | 0 | 13,323 | +13,323 | 0.00 | 0.02 | +0.02 | buy |
| GILDER GAGNON HOWE & CO LLC | 92,546 | 105,817 | +13,271 | 0.01 | 0.01 | -0.00 | buy |
| Creative Planning | 0 | 12,598 | +12,598 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 114 | 11,222 | +11,108 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 0 | 10,832 | +10,832 | 0.00 | 0.01 | +0.01 | buy |
| MPM BioImpact LLC | 685,826 | 693,988 | +8,162 | 1.07 | 0.79 | -0.28 | buy |
| INTECH INVESTMENT MANAGEMENT LLC | 16,416 | 22,334 | +5,918 | 0.00 | 0.00 | -0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 31,716 | 37,606 | +5,890 | 0.00 | 0.00 | -0.00 | buy |
| Covestor Ltd | 0 | 2,417 | +2,417 | 0.00 | 0.01 | +0.01 | buy |
| JONES FINANCIAL COMPANIES LLLP | 1,050 | 2,950 | +1,900 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 37,455 | 39,098 | +1,643 | 0.00 | 0.00 | -0.00 | buy |
| CANADA LIFE ASSURANCE Co | 9,716 | 10,889 | +1,173 | 0.00 | 0.00 | -0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 23,018 | 24,167 | +1,149 | 0.00 | 0.00 | -0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 134,812 | 135,960 | +1,148 | 0.00 | 0.00 | -0.00 | buy |
| WELLS FARGO & COMPANY/MN | 16,786 | 17,680 | +894 | 0.00 | 0.00 | -0.00 | buy |
| SIMPLEX TRADING, LLC | 1,481 | 2,257 | +776 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 276 | 806 | +530 | 0.00 | 0.00 | +0.00 | buy |
| Stone House Investment Management, LLC | 0 | 500 | +500 | 0.00 | 0.00 | +0.00 | buy |
| MONTAG A & ASSOCIATES INC | 0 | 440 | +440 | 0.00 | 0.00 | +0.00 | buy |
| JPMORGAN CHASE & CO | 19,964 | 20,257 | +293 | 0.00 | 0.00 | -0.00 | buy |
| AMALGAMATED BANK | 979 | 1,240 | +261 | 0.00 | 0.00 | -0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,112 | 1,355 | +243 | 0.00 | 0.00 | -0.00 | buy |
| RHUMBLINE ADVISERS | 49,374 | 49,599 | +225 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 94,903 | 95,120 | +217 | 0.01 | 0.00 | -0.00 | buy |
| Banque Transatlantique SA | 0 | 162 | +162 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 2,704 | 2,760 | +56 | 0.00 | 0.00 | -0.00 | buy |
| COLDSTREAM CAPITAL MANAGEMENT INC | 0 | 55 | +55 | 0.00 | 0.00 | +0.00 | buy |
| Parkside Financial Bank & Trust | 0 | 50 | +50 | 0.00 | 0.00 | +0.00 | buy |
| Larson Financial Group LLC | 0 | 38 | +38 | 0.00 | 0.00 | +0.00 | buy |
| Parallel Advisors, LLC | 0 | 24 | +24 | 0.00 | 0.00 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 1,765 | 1,787 | +22 | 0.00 | 0.00 | -0.00 | buy |
| Brooklyn Investment Group | 0 | 7 | +7 | 0.00 | 0.00 | +0.00 | buy |
| Birchview Capital, LP | 210,000 | 210,005 | +5 | 1.88 | 1.21 | -0.67 | buy |
| Ameritas Investment Partners, Inc. | 3,484 | 3,484 | 0 | 0.00 | 0.00 | -0.00 | hold |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 32,068 | 32,068 | 0 | 0.00 | 0.00 | -0.00 | hold |
| ALLIANCEBERNSTEIN L.P. | 40,630 | 40,630 | 0 | 0.00 | 0.00 | -0.00 | hold |
| BAKER BROS. ADVISORS LP | 4,633,838 | 4,633,838 | 0 | 0.55 | 0.34 | -0.20 | hold |
| JANUS HENDERSON GROUP PLC | 18,900 | 18,900 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Palo Alto Investors LP | 125,861 | 125,861 | 0 | 0.22 | 0.16 | -0.06 | hold |
| Sterling Capital Management LLC | 37 | 37 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 9,129 | 9,129 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Dorsey & Whitney Trust CO LLC | 10,815 | 10,815 | 0 | 0.01 | 0.00 | -0.00 | hold |
| Mesirow Financial Investment Management, Inc. | 15,779 | 15,779 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Daiwa Securities Group Inc. | 175 | 175 | 0 | 0.00 | 0.00 | -0.00 | hold |
| RTW INVESTMENTS, LP | 5,123,525 | 5,123,525 | 0 | 0.85 | 0.52 | -0.33 | hold |
| Swiss National Bank | 67,300 | 67,300 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Cormorant Asset Management, LP | 254,161 | 254,161 | 0 | 0.15 | 0.13 | -0.03 | hold |
| Fort Point Capital Partners LLC | 75,429 | 75,429 | 0 | 0.09 | 0.06 | -0.04 | hold |
| KLP KAPITALFORVALTNING AS | 5,700 | 5,700 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Versant Capital Management, Inc | 560 | 560 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Skorpios Trust | 6,906,181 | 6,906,181 | 0 | 99.80 | 99.70 | -0.10 | hold |
| Farther Finance Advisors, LLC | 7 | 7 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Police & Firemen's Retirement System of New Jersey | 7,174 | 7,174 | 0 | 0.00 | 0.00 | -0.00 | hold |
| FRANKLIN RESOURCES INC | 22,314 | 22,314 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Legal & General Group Plc | 35,347 | 35,347 | 0 | 0.00 | 0.00 | -0.00 | hold |
| VALLEY NATIONAL ADVISERS INC | 750 | 750 | 0 | 0.00 | 0.00 | -0.00 | hold |
| HARBOUR INVESTMENTS, INC. | 50 | 50 | 0 | 0.00 | 0.00 | -0.00 | hold |
| NEW YORK STATE COMMON RETIREMENT FUND | 10,635 | 10,635 | 0 | 0.00 | 0.00 | -0.00 | hold |
| Wilmington Savings Fund Society, FSB | 400 | 400 | 0 | 0.00 | 0.00 | -0.00 | hold |
| TORONTO DOMINION BANK | 3,173,258 | 3,173,258 | 0 | 0.07 | 0.05 | -0.01 | hold |
| EverSource Wealth Advisors, LLC | 3 | 0 | -3 | 0.00 | 0.00 | -0.00 | sell |
| SBI Securities Co., Ltd. | 9 | 4 | -5 | 0.00 | 0.00 | -0.00 | sell |
| IFP Advisors, Inc | 6 | 0 | -6 | 0.00 | 0.00 | -0.00 | sell |
| ROTHSCHILD INVESTMENT LLC | 50 | 25 | -25 | 0.00 | 0.00 | -0.00 | sell |
| LAZARD ASSET MANAGEMENT LLC | 58 | 0 | -58 | 0.00 | 0.00 | 0.00 | sell |
| Caitong International Asset Management Co., Ltd | 59 | 0 | -59 | 0.00 | 0.00 | -0.00 | sell |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 13,304 | 13,237 | -67 | 0.00 | 0.00 | -0.00 | sell |