| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Checkpoint Capital L.P. | 305,387 | 730,717 | +425,330 | 1.71 | 2.67 | +0.95 | buy |
| Opaleye Management Inc. | 25,000 | 300,000 | +275,000 | 0.05 | 0.44 | +0.40 | buy |
| DAFNA Capital Management LLC | 171,097 | 443,998 | +272,901 | 0.48 | 0.84 | +0.36 | buy |
| Siren, L.L.C. | 2,000,000 | 2,247,347 | +247,347 | 0.97 | 0.84 | -0.13 | buy |
| TANG CAPITAL MANAGEMENT LLC | 300,000 | 500,000 | +200,000 | 0.22 | 0.18 | -0.03 | buy |
| Lynx1 Capital Management LP | 5,187,191 | 5,291,929 | +104,738 | 21.45 | 12.60 | -8.85 | buy |
| Granahan Investment Management, LLC | 567,689 | 660,430 | +92,741 | 0.26 | 0.22 | -0.04 | buy |
| GILDER GAGNON HOWE & CO LLC | 92,546 | 105,817 | +13,271 | 0.01 | 0.01 | -0.00 | buy |
| MPM BioImpact LLC | 685,826 | 693,988 | +8,162 | 1.07 | 0.79 | -0.28 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,112 | 1,355 | +243 | 0.00 | 0.00 | -0.00 | buy |
| Woodline Partners LP | 94,903 | 95,120 | +217 | 0.01 | 0.00 | -0.00 | buy |
| Birchview Capital, LP | 210,000 | 210,005 | +5 | 1.88 | 1.21 | -0.67 | buy |
| PROFUND ADVISORS LLC | 13,148 | 12,882 | -266 | 0.01 | 0.00 | -0.00 | sell |
| China Universal Asset Management Co., Ltd. | 11,231 | 10,624 | -607 | 0.01 | 0.01 | -0.01 | sell |
| ALPS ADVISORS INC | 42,830 | 39,890 | -2,940 | 0.00 | 0.00 | -0.00 | sell |
| Freestone Grove Partners LP | 18,049 | 14,776 | -3,273 | 0.00 | 0.00 | -0.00 | sell |
| Rafferty Asset Management, LLC | 67,227 | 61,706 | -5,521 | 0.00 | 0.00 | -0.00 | sell |
| Redmile Group, LLC | 4,593,629 | 4,485,981 | -107,648 | 3.53 | 2.82 | -0.71 | sell |