| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| WELLINGTON MANAGEMENT GROUP LLP | 735,799 | 3,095,700 | +2,359,901 | 0.00 | 0.02 | +0.01 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 372,334 | 1,934,171 | +1,561,837 | 0.00 | 0.01 | +0.01 | buy |
| Troluce Capital Advisors LLC | 0 | 652,800 | +652,800 | 0.00 | 2.25 | +2.25 | buy |
| MILLENNIUM MANAGEMENT LLC | 0 | 472,141 | +472,141 | 0.00 | 0.01 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 206,164 | 543,095 | +336,931 | 0.00 | 0.00 | +0.00 | buy |
| BAILLIE GIFFORD & CO | 246,900 | 575,182 | +328,282 | 0.01 | 0.02 | +0.01 | buy |
| Artisan Partners Limited Partnership | 0 | 315,492 | +315,492 | 0.00 | 0.02 | +0.02 | buy |
| BVF INC/IL | 2,265,674 | 2,547,557 | +281,883 | 2.42 | 2.64 | +0.22 | buy |
| T. Rowe Price Investment Management, Inc. | 0 | 250,913 | +250,913 | 0.00 | 0.01 | +0.01 | buy |
| BlackRock, Inc. | 5,212,554 | 5,385,714 | +173,160 | 0.00 | 0.00 | +0.00 | buy |
| DIMENSIONAL FUND ADVISORS LP | 827,139 | 989,936 | +162,797 | 0.01 | 0.01 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 1,450,933 | 1,612,781 | +161,848 | 0.02 | 0.03 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,166,145 | 1,322,260 | +156,115 | 0.00 | 0.00 | +0.00 | buy |
| Granahan Investment Management, LLC | 191,397 | 335,586 | +144,189 | 0.26 | 0.53 | +0.27 | buy |
| Redmile Group, LLC | 4,034,070 | 4,164,120 | +130,050 | 9.43 | 8.98 | -0.45 | buy |
| CITADEL ADVISORS LLC | 15,851 | 123,022 | +107,171 | 0.00 | 0.00 | +0.00 | buy |
| EcoR1 Capital, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.14 | +0.14 | buy |
| RTW INVESTMENTS, LP | 5,546,856 | 5,623,525 | +76,669 | 1.76 | 1.82 | +0.06 | buy |
| TD ASSET MANAGEMENT INC | 0 | 74,400 | +74,400 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 13,550 | 69,222 | +55,672 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 446,690 | 502,020 | +55,330 | 0.07 | 0.08 | +0.01 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 4,257 | 56,128 | +51,871 | 0.00 | 0.00 | +0.00 | buy |
| Erste Asset Management GmbH | 396,000 | 446,000 | +50,000 | 0.11 | 0.13 | +0.03 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 47,307 | +47,307 | 0.00 | 0.04 | +0.04 | buy |
| OMERS ADMINISTRATION Corp | 0 | 41,500 | +41,500 | 0.00 | 0.01 | +0.01 | buy |
| Moran Wealth Management, LLC | 0 | 40,552 | +40,552 | 0.00 | 0.04 | +0.04 | buy |
| LPL Financial LLC | 0 | 36,047 | +36,047 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 35,174 | +35,174 | 0.00 | 0.05 | +0.05 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 34,102 | +34,102 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 14,819 | 47,859 | +33,040 | 0.00 | 0.00 | +0.00 | buy |
| Blackstone Inc. | 0 | 30,579 | +30,579 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 403,168 | 431,630 | +28,462 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 410,906 | 437,175 | +26,269 | 0.00 | 0.00 | +0.00 | buy |
| Harvest Investment Services, LLC | 38,347 | 62,838 | +24,491 | 0.23 | 0.37 | +0.14 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 15,035 | 39,158 | +24,123 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 108,875 | 130,875 | +22,000 | 0.80 | 0.97 | +0.17 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 9,206 | 30,479 | +21,273 | 0.00 | 0.00 | +0.00 | buy |
| HUSSMAN STRATEGIC ADVISORS, INC. | 63,000 | 84,000 | +21,000 | 0.48 | 0.59 | +0.11 | buy |
| HSBC HOLDINGS PLC | 0 | 20,521 | +20,521 | 0.00 | 0.00 | +0.00 | buy |
| AQR CAPITAL MANAGEMENT LLC | 29,467 | 46,459 | +16,992 | 0.00 | 0.00 | +0.00 | buy |
| Jefferies Financial Group Inc. | 0 | 16,300 | +16,300 | 0.00 | 0.01 | +0.01 | buy |
| Universal- Beteiligungs- und Servicegesellschaft mbH | 0 | 16,206 | +16,206 | 0.00 | 0.00 | +0.00 | buy |
| BALYASNY ASSET MANAGEMENT L.P. | 9,340 | 23,878 | +14,538 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 37,127 | 51,606 | +14,479 | 0.00 | 0.00 | +0.00 | buy |
| CIM, LLC | 0 | 14,228 | +14,228 | 0.00 | 0.07 | +0.07 | buy |
| State of New Jersey Common Pension Fund D | 0 | 13,664 | +13,664 | 0.00 | 0.00 | +0.00 | buy |
| Palo Alto Investors LP | 72,022 | 84,631 | +12,609 | 0.32 | 0.42 | +0.10 | buy |
| CAPSTONE INVESTMENT ADVISORS, LLC | 0 | 12,230 | +12,230 | 0.00 | 0.00 | +0.00 | buy |
| State of Wyoming | 1,110 | 13,262 | +12,152 | 0.00 | 0.05 | +0.05 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 46,022 | 57,291 | +11,269 | 0.00 | 0.00 | +0.00 | buy |
| Virtu Financial LLC | 0 | 11,042 | +11,042 | 0.00 | 0.01 | +0.01 | buy |
| HARBOR CAPITAL ADVISORS, INC. | 0 | 10,876 | +10,876 | 0.00 | 0.03 | +0.03 | buy |
| FRANKLIN RESOURCES INC | 132,222 | 142,793 | +10,571 | 0.00 | 0.00 | +0.00 | buy |
| Quadrature Capital Ltd | 0 | 10,293 | +10,293 | 0.00 | 0.00 | +0.00 | buy |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 0 | 9,089 | +9,089 | 0.00 | 0.00 | +0.00 | buy |
| TEMA ETFS LLC | 0 | 8,540 | +8,540 | 0.00 | 0.02 | +0.02 | buy |
| SG Americas Securities, LLC | 25,836 | 33,996 | +8,160 | 0.00 | 0.00 | +0.00 | buy |
| XTX Topco Ltd | 0 | 8,054 | +8,054 | 0.00 | 0.00 | +0.00 | buy |
| PRUDENTIAL FINANCIAL INC | 0 | 7,640 | +7,640 | 0.00 | 0.00 | +0.00 | buy |
| Pictet Asset Management Holding SA | 0 | 7,581 | +7,581 | 0.00 | 0.00 | +0.00 | buy |
| E Fund Management Co., Ltd. | 0 | 7,530 | +7,530 | 0.00 | 0.01 | +0.01 | buy |
| DEUTSCHE BANK AG\ | 33,406 | 40,596 | +7,190 | 0.00 | 0.00 | +0.00 | buy |
| Creative Planning | 41,712 | 48,108 | +6,396 | 0.00 | 0.00 | +0.00 | buy |
| Caitong International Asset Management Co., Ltd | 0 | 5,662 | +5,662 | 0.00 | 0.03 | +0.03 | buy |
| Opaleye Management Inc. | 695,000 | 700,000 | +5,000 | 2.91 | 3.00 | +0.09 | buy |
| RHUMBLINE ADVISERS | 62,414 | 67,315 | +4,901 | 0.00 | 0.00 | +0.00 | buy |
| Generali Investments, Management Co LLC | 2,471 | 6,912 | +4,441 | 0.02 | 0.05 | +0.04 | buy |
| Nuveen, LLC | 104,261 | 108,617 | +4,356 | 0.00 | 0.00 | +0.00 | buy |
| VIRGINIA RETIREMENT SYSTEMS ET Al | 6,550 | 10,650 | +4,100 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 14,768 | 18,830 | +4,062 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 630 | 4,427 | +3,797 | 0.00 | 0.00 | +0.00 | buy |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 19,101 | 22,645 | +3,544 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 75,700 | 79,100 | +3,400 | 0.00 | 0.00 | +0.00 | buy |
| Bank of New York Mellon Corp | 140,802 | 143,407 | +2,605 | 0.00 | 0.00 | +0.00 | buy |
| China Universal Asset Management Co., Ltd. | 12,907 | 15,136 | +2,229 | 0.03 | 0.04 | +0.01 | buy |
| HARBOUR INVESTMENTS, INC. | 1,185 | 3,352 | +2,167 | 0.00 | 0.00 | +0.00 | buy |
| Campbell & CO Investment Adviser LLC | 12,995 | 15,049 | +2,054 | 0.02 | 0.03 | +0.01 | buy |
| Western Wealth Management, LLC | 0 | 1,700 | +1,700 | 0.00 | 0.00 | +0.00 | buy |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 32,515 | 33,873 | +1,358 | 0.00 | 0.00 | -0.00 | buy |
| EverSource Wealth Advisors, LLC | 622 | 1,837 | +1,215 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 40,630 | 41,830 | +1,200 | 0.00 | 0.00 | +0.00 | buy |
| KBC Group NV | 0 | 1,096 | +1,096 | 0.00 | 0.00 | +0.00 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 57,212 | 58,185 | +973 | 0.00 | 0.00 | +0.00 | buy |
| MetLife Investment Management, LLC | 25,320 | 26,106 | +786 | 0.00 | 0.00 | +0.00 | buy |
| FIRST TRUST ADVISORS LP | 162,679 | 163,459 | +780 | 0.00 | 0.00 | +0.00 | buy |
| KLP KAPITALFORVALTNING AS | 8,200 | 8,800 | +600 | 0.00 | 0.00 | +0.00 | buy |
| Kemnay Advisory Services Inc. | 0 | 471 | +471 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 9,129 | 9,582 | +453 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 7,761 | 8,205 | +444 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 2,436 | 2,838 | +402 | 0.00 | 0.00 | +0.00 | buy |
| Rockefeller Capital Management L.P. | 98 | 481 | +383 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 3,748 | 4,009 | +261 | 0.00 | 0.00 | +0.00 | buy |
| Virtus Investment Advisers, LLC | 8,214 | 8,418 | +204 | 0.07 | 0.08 | +0.00 | buy |
| Mirae Asset Global Investments Co., Ltd. | 2,776 | 2,979 | +203 | 0.00 | 0.00 | +0.00 | buy |
| J.Safra Asset Management Corp | 97 | 299 | +202 | 0.00 | 0.00 | +0.00 | buy |
| Tidal Investments LLC | 8,355 | 8,540 | +185 | 0.00 | 0.00 | -0.00 | buy |
| BNP Paribas Asset Management Holding S.A. | 476 | 648 | +172 | 0.00 | 0.00 | +0.00 | buy |
| GF FUND MANAGEMENT CO. LTD. | 1,121 | 1,283 | +162 | 0.00 | 0.00 | +0.00 | buy |
| LRI Investments, LLC | 0 | 146 | +146 | 0.00 | 0.00 | +0.00 | buy |
| Financial Life Planners | 0 | 144 | +144 | 0.00 | 0.00 | +0.00 | buy |