| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| RTW INVESTMENTS, LP | 5,546,856 | 5,623,525 | +76,669 | 1.76 | 1.82 | +0.06 | buy |
| BlackRock, Inc. | 5,212,554 | 5,385,714 | +173,160 | 0.00 | 0.00 | +0.00 | buy |
| FMR LLC | 5,600,920 | 5,383,666 | -217,254 | 0.01 | 0.01 | +0.00 | sell |
| Lynx1 Capital Management LP | 5,404,674 | 4,763,673 | -641,001 | 34.73 | 24.51 | -10.21 | sell |
| Redmile Group, LLC | 4,034,070 | 4,164,120 | +130,050 | 9.43 | 8.98 | -0.45 | buy |
| MORGAN STANLEY | 3,546,158 | 3,423,280 | -122,878 | 0.01 | 0.01 | -0.00 | sell |
| BAKER BROS. ADVISORS LP | 3,336,697 | 3,336,697 | 0 | 0.62 | 0.62 | +0.00 | hold |
| TORONTO DOMINION BANK | 3,173,258 | 3,173,258 | 0 | 0.18 | 0.20 | +0.02 | hold |
| WELLINGTON MANAGEMENT GROUP LLP | 735,799 | 3,095,700 | +2,359,901 | 0.00 | 0.02 | +0.01 | buy |
| BVF INC/IL | 2,265,674 | 2,547,557 | +281,883 | 2.42 | 2.64 | +0.22 | buy |
| STATE STREET CORP | 2,498,049 | 2,276,512 | -221,537 | 0.00 | 0.00 | -0.00 | sell |
| Siren, L.L.C. | 2,247,347 | 1,995,347 | -252,000 | 2.13 | 1.80 | -0.33 | sell |
| PRICE T ROWE ASSOCIATES INC /MD/ | 372,334 | 1,934,171 | +1,561,837 | 0.00 | 0.01 | +0.01 | buy |
| DEERFIELD MANAGEMENT COMPANY, L.P. | 1,823,500 | 1,823,500 | 0 | 0.74 | 0.70 | -0.04 | hold |
| JANUS HENDERSON GROUP PLC | 1,450,933 | 1,612,781 | +161,848 | 0.02 | 0.03 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 1,166,145 | 1,322,260 | +156,115 | 0.00 | 0.00 | +0.00 | buy |
| Polar Capital Holdings Plc | 1,269,131 | 1,132,511 | -136,620 | 0.18 | 0.16 | -0.02 | sell |
| DIMENSIONAL FUND ADVISORS LP | 827,139 | 989,936 | +162,797 | 0.01 | 0.01 | +0.00 | buy |
| Assenagon Asset Management S.A. | 1,227,723 | 907,015 | -320,708 | 0.06 | 0.05 | -0.01 | sell |
| GOLDMAN SACHS GROUP INC | 1,142,737 | 830,702 | -312,035 | 0.01 | 0.00 | -0.00 | sell |
| MPM BioImpact LLC | 770,289 | 767,038 | -3,251 | 2.80 | 1.93 | -0.87 | sell |
| Opaleye Management Inc. | 695,000 | 700,000 | +5,000 | 2.91 | 3.00 | +0.09 | buy |
| Troluce Capital Advisors LLC | 0 | 652,800 | +652,800 | 0.00 | 2.25 | +2.25 | buy |
| BAILLIE GIFFORD & CO | 246,900 | 575,182 | +328,282 | 0.01 | 0.02 | +0.01 | buy |
| BANK OF AMERICA CORP /DE/ | 206,164 | 543,095 | +336,931 | 0.00 | 0.00 | +0.00 | buy |
| Candriam S.C.A. | 446,690 | 502,020 | +55,330 | 0.07 | 0.08 | +0.01 | buy |
| TANG CAPITAL MANAGEMENT LLC | 500,000 | 500,000 | 0 | 0.78 | 0.83 | +0.04 | hold |
| MILLENNIUM MANAGEMENT LLC | 0 | 472,141 | +472,141 | 0.00 | 0.01 | +0.01 | buy |
| Erste Asset Management GmbH | 396,000 | 446,000 | +50,000 | 0.11 | 0.13 | +0.03 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 410,906 | 437,175 | +26,269 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 403,168 | 431,630 | +28,462 | 0.00 | 0.00 | +0.00 | buy |
| Parkman Healthcare Partners LLC | 430,155 | 336,519 | -93,636 | 1.30 | 1.14 | -0.16 | sell |
| Granahan Investment Management, LLC | 191,397 | 335,586 | +144,189 | 0.26 | 0.53 | +0.27 | buy |
| Artisan Partners Limited Partnership | 0 | 315,492 | +315,492 | 0.00 | 0.02 | +0.02 | buy |
| JPMORGAN CHASE & CO | 277,930 | 265,473 | -12,457 | 0.00 | 0.00 | -0.00 | sell |
| T. Rowe Price Investment Management, Inc. | 0 | 250,913 | +250,913 | 0.00 | 0.01 | +0.01 | buy |
| Birchview Capital, LP | 260,000 | 210,000 | -50,000 | 4.83 | 3.89 | -0.94 | sell |
| FIRST TRUST ADVISORS LP | 162,679 | 163,459 | +780 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 169,713 | 158,304 | -11,409 | 0.00 | 0.00 | -0.00 | sell |
| Invesco Ltd. | 259,543 | 150,045 | -109,498 | 0.00 | 0.00 | -0.00 | sell |
| Bank of New York Mellon Corp | 140,802 | 143,407 | +2,605 | 0.00 | 0.00 | +0.00 | buy |
| FRANKLIN RESOURCES INC | 132,222 | 142,793 | +10,571 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 108,875 | 130,875 | +22,000 | 0.80 | 0.97 | +0.17 | buy |
| CITADEL ADVISORS LLC | 15,851 | 123,022 | +107,171 | 0.00 | 0.00 | +0.00 | buy |
| Susquehanna Portfolio Strategies, LLC | 126,350 | 119,226 | -7,124 | 0.06 | 0.06 | -0.00 | sell |
| GILDER GAGNON HOWE & CO LLC | 122,448 | 112,627 | -9,821 | 0.04 | 0.04 | +0.00 | sell |
| Nuveen, LLC | 104,261 | 108,617 | +4,356 | 0.00 | 0.00 | +0.00 | buy |
| EcoR1 Capital, LLC | 0 | 100,000 | +100,000 | 0.00 | 0.14 | +0.14 | buy |
| Palo Alto Investors LP | 72,022 | 84,631 | +12,609 | 0.32 | 0.42 | +0.10 | buy |
| HUSSMAN STRATEGIC ADVISORS, INC. | 63,000 | 84,000 | +21,000 | 0.48 | 0.59 | +0.11 | buy |
| Rhenman & Partners Asset Management AB | 216,000 | 83,000 | -133,000 | 0.64 | 0.33 | -0.31 | sell |
| Swiss National Bank | 75,700 | 79,100 | +3,400 | 0.00 | 0.00 | +0.00 | buy |
| Quantedge Capital Pte Ltd | 87,200 | 78,600 | -8,600 | 1.32 | 1.40 | +0.08 | sell |
| TD ASSET MANAGEMENT INC | 0 | 74,400 | +74,400 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 13,550 | 69,222 | +55,672 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 62,414 | 67,315 | +4,901 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 67,112 | 64,349 | -2,763 | 0.00 | 0.00 | -0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 70,282 | 63,933 | -6,349 | 0.00 | 0.00 | -0.00 | sell |
| Harvest Investment Services, LLC | 38,347 | 62,838 | +24,491 | 0.23 | 0.37 | +0.14 | buy |
| HighVista Strategies LLC | 115,539 | 62,617 | -52,922 | 0.94 | 0.56 | -0.38 | sell |
| Rafferty Asset Management, LLC | 90,193 | 59,898 | -30,295 | 0.01 | 0.01 | -0.00 | sell |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 57,212 | 58,185 | +973 | 0.00 | 0.00 | +0.00 | buy |
| SUSQUEHANNA INTERNATIONAL GROUP, LLP | 46,022 | 57,291 | +11,269 | 0.00 | 0.00 | +0.00 | buy |
| BNP PARIBAS FINANCIAL MARKETS | 4,257 | 56,128 | +51,871 | 0.00 | 0.00 | +0.00 | buy |
| Informed Momentum Co LLC | 117,823 | 52,000 | -65,823 | 0.42 | 0.20 | -0.22 | sell |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 37,127 | 51,606 | +14,479 | 0.00 | 0.00 | +0.00 | buy |
| Woodline Partners LP | 50,120 | 50,120 | 0 | 0.01 | 0.01 | +0.00 | hold |
| Privium Fund Management B.V. | 55,000 | 50,000 | -5,000 | 0.32 | 0.34 | +0.02 | sell |
| D. E. Shaw & Co., Inc. | 49,901 | 49,972 | +71 | 0.00 | 0.00 | +0.00 | buy |
| Schonfeld Strategic Advisors LLC | 63,109 | 49,302 | -13,807 | 0.01 | 0.01 | +0.00 | sell |
| Creative Planning | 41,712 | 48,108 | +6,396 | 0.00 | 0.00 | +0.00 | buy |
| STATE OF WISCONSIN INVESTMENT BOARD | 14,819 | 47,859 | +33,040 | 0.00 | 0.00 | +0.00 | buy |
| BOOTHBAY FUND MANAGEMENT, LLC | 0 | 47,307 | +47,307 | 0.00 | 0.04 | +0.04 | buy |
| ALPS ADVISORS INC | 66,502 | 46,498 | -20,004 | 0.01 | 0.01 | -0.01 | sell |
| AQR CAPITAL MANAGEMENT LLC | 29,467 | 46,459 | +16,992 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 40,630 | 41,830 | +1,200 | 0.00 | 0.00 | +0.00 | buy |
| OMERS ADMINISTRATION Corp | 0 | 41,500 | +41,500 | 0.00 | 0.01 | +0.01 | buy |
| PLATINUM INVESTMENT MANAGEMENT LTD | 40,815 | 40,815 | 0 | 0.30 | 0.33 | +0.04 | hold |
| DEUTSCHE BANK AG\ | 33,406 | 40,596 | +7,190 | 0.00 | 0.00 | +0.00 | buy |
| Moran Wealth Management, LLC | 0 | 40,552 | +40,552 | 0.00 | 0.04 | +0.04 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 15,035 | 39,158 | +24,123 | 0.00 | 0.00 | +0.00 | buy |
| LPL Financial LLC | 0 | 36,047 | +36,047 | 0.00 | 0.00 | +0.00 | buy |
| Caption Management, LLC | 0 | 35,174 | +35,174 | 0.00 | 0.05 | +0.05 | buy |
| SCHRODER INVESTMENT MANAGEMENT GROUP | 0 | 34,102 | +34,102 | 0.00 | 0.00 | +0.00 | buy |
| SG Americas Securities, LLC | 25,836 | 33,996 | +8,160 | 0.00 | 0.00 | +0.00 | buy |
| VICTORY CAPITAL MANAGEMENT INC | 41,140 | 33,890 | -7,250 | 0.00 | 0.00 | -0.00 | sell |
| MIRAE ASSET GLOBAL ETFS HOLDINGS Ltd. | 32,515 | 33,873 | +1,358 | 0.00 | 0.00 | -0.00 | buy |
| Legal & General Group Plc | 36,366 | 32,048 | -4,318 | 0.00 | 0.00 | -0.00 | sell |
| Blackstone Inc. | 0 | 30,579 | +30,579 | 0.00 | 0.00 | +0.00 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 9,206 | 30,479 | +21,273 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 33,388 | 26,985 | -6,403 | 0.03 | 0.03 | +0.00 | sell |
| NOMURA HOLDINGS INC | 44,352 | 26,891 | -17,461 | 0.00 | 0.01 | +0.00 | sell |
| CANADA PENSION PLAN INVESTMENT BOARD | 35,200 | 26,200 | -9,000 | 0.00 | 0.00 | -0.00 | sell |
| MetLife Investment Management, LLC | 25,320 | 26,106 | +786 | 0.00 | 0.00 | +0.00 | buy |
| Cresset Asset Management, LLC | 26,325 | 24,494 | -1,831 | 0.00 | 0.00 | -0.00 | sell |
| BALYASNY ASSET MANAGEMENT L.P. | 9,340 | 23,878 | +14,538 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 115,118 | 23,397 | -91,721 | 0.00 | 0.00 | -0.00 | sell |
| MASSACHUSETTS FINANCIAL SERVICES CO /MA/ | 19,101 | 22,645 | +3,544 | 0.00 | 0.00 | +0.00 | buy |
| Allspring Global Investments Holdings, LLC | 24,462 | 20,985 | -3,477 | 0.00 | 0.00 | -0.00 | sell |
| HSBC HOLDINGS PLC | 0 | 20,521 | +20,521 | 0.00 | 0.00 | +0.00 | buy |