| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 263,700 | 1,387,200 | +1,123,500 | 0.01 | 0.05 | +0.04 | buy |
| BAKER BROS. ADVISORS LP | 3,368,443 | 4,368,443 | +1,000,000 | 0.57 | 0.75 | +0.18 | buy |
| Granahan Investment Management, LLC | 475,463 | 598,401 | +122,938 | 0.23 | 0.32 | +0.10 | buy |
| DAFNA Capital Management LLC | 145,000 | 207,427 | +62,427 | 0.45 | 0.67 | +0.22 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 62,257 | 66,765 | +4,508 | 0.00 | 0.00 | 0.00 | buy |
| GILDER GAGNON HOWE & CO LLC | 89,783 | 88,577 | -1,206 | 0.02 | 0.01 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 47,912 | 46,059 | -1,853 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 106,904 | 100,182 | -6,722 | 0.01 | 0.01 | -0.00 | sell |
| PDT Partners, LLC | 21,426 | 14,039 | -7,387 | 0.03 | 0.02 | -0.01 | sell |
| Informed Momentum Co LLC | 45,845 | 37,637 | -8,208 | 0.10 | 0.08 | -0.01 | sell |
| Ghisallo Capital Management LLC | 30,000 | 15,000 | -15,000 | 0.05 | 0.02 | -0.03 | sell |
| Sio Capital Management, LLC | 225,496 | 175,301 | -50,195 | 0.91 | 0.64 | -0.27 | sell |
| Eversept Partners, LP | 290,000 | 61,277 | -228,723 | 0.26 | 0.06 | -0.20 | sell |
| Redmile Group, LLC | 5,073,049 | 4,721,054 | -351,995 | 2.51 | 3.86 | +1.34 | sell |
| Skorpios Trust | 14,443,681 | 10,843,681 | -3,600,000 | 99.92 | 99.89 | -0.02 | sell |