| Fund | Previous Shares | Current Shares ▲▼ | Change in Shares ▲▼ | Previous Portfolio Weightage (%) | Current Portfolio Weightage (%) ▲▼ | Change in Weight (%) ▲▼ | Type |
|---|---|---|---|---|---|---|---|
| Lynx1 Capital Management LP | 3,696,820 | 5,185,191 | +1,488,371 | 12.85 | 25.32 | +12.46 | buy |
| Assenagon Asset Management S.A. | 0 | 1,468,202 | +1,468,202 | 0.00 | 0.05 | +0.05 | buy |
| HEALTHCARE OF ONTARIO PENSION PLAN TRUST FUND | 263,700 | 1,387,200 | +1,123,500 | 0.01 | 0.06 | +0.04 | buy |
| Logos Global Management LP | 0 | 1,050,000 | +1,050,000 | 0.00 | 1.63 | +1.63 | buy |
| STATE STREET CORP | 579,607 | 1,591,743 | +1,012,136 | 0.00 | 0.00 | +0.00 | buy |
| BAKER BROS. ADVISORS LP | 3,368,443 | 4,368,443 | +1,000,000 | 0.57 | 0.75 | +0.18 | buy |
| MARSHALL WACE, LLP | 178,586 | 1,161,037 | +982,451 | 0.00 | 0.02 | +0.02 | buy |
| VANGUARD GROUP INC | 1,715,554 | 2,687,658 | +972,104 | 0.00 | 0.00 | +0.00 | buy |
| Invesco Ltd. | 0 | 437,136 | +437,136 | 0.00 | 0.00 | +0.00 | buy |
| MILLENNIUM MANAGEMENT LLC | 45,984 | 289,067 | +243,083 | 0.00 | 0.00 | +0.00 | buy |
| VOLORIDGE INVESTMENT MANAGEMENT, LLC | 0 | 198,280 | +198,280 | 0.00 | 0.01 | +0.01 | buy |
| FRANKLIN RESOURCES INC | 1,058,300 | 1,216,200 | +157,900 | 0.00 | 0.01 | +0.00 | buy |
| GEODE CAPITAL MANAGEMENT, LLC | 639,807 | 794,170 | +154,363 | 0.00 | 0.00 | +0.00 | buy |
| Trexquant Investment LP | 30,976 | 179,613 | +148,637 | 0.01 | 0.04 | +0.03 | buy |
| SILVERARC CAPITAL MANAGEMENT, LLC | 0 | 141,518 | +141,518 | 0.00 | 0.47 | +0.47 | buy |
| Walleye Capital LLC | 0 | 126,830 | +126,830 | 0.00 | 0.02 | +0.02 | buy |
| Granahan Investment Management, LLC | 475,463 | 598,401 | +122,938 | 0.23 | 0.32 | +0.10 | buy |
| TWO SIGMA INVESTMENTS, LP | 15,500 | 114,905 | +99,405 | 0.00 | 0.00 | +0.00 | buy |
| Qube Research & Technologies Ltd | 0 | 97,798 | +97,798 | 0.00 | 0.00 | +0.00 | buy |
| Rafferty Asset Management, LLC | 0 | 79,885 | +79,885 | 0.00 | 0.00 | +0.00 | buy |
| UBS Group AG | 39,415 | 118,254 | +78,839 | 0.00 | 0.00 | +0.00 | buy |
| JANE STREET GROUP, LLC | 0 | 75,414 | +75,414 | 0.00 | 0.00 | +0.00 | buy |
| BANK OF AMERICA CORP /DE/ | 28,607 | 97,798 | +69,191 | 0.00 | 0.00 | +0.00 | buy |
| Swiss National Bank | 0 | 66,400 | +66,400 | 0.00 | 0.00 | +0.00 | buy |
| CHARLES SCHWAB INVESTMENT MANAGEMENT INC | 223,038 | 289,264 | +66,226 | 0.00 | 0.00 | +0.00 | buy |
| DAFNA Capital Management LLC | 145,000 | 207,427 | +62,427 | 0.45 | 0.67 | +0.22 | buy |
| SG Americas Securities, LLC | 9,658 | 68,601 | +58,943 | 0.00 | 0.01 | +0.01 | buy |
| UBS AM, a distinct business unit of UBS ASSET MANAGEMENT AMERICAS LLC | 0 | 57,399 | +57,399 | 0.00 | 0.00 | +0.00 | buy |
| Verition Fund Management LLC | 0 | 44,205 | +44,205 | 0.00 | 0.00 | +0.00 | buy |
| Jump Financial, LLC | 0 | 34,277 | +34,277 | 0.00 | 0.01 | +0.01 | buy |
| Legal & General Group Plc | 2,278 | 32,790 | +30,512 | 0.00 | 0.00 | +0.00 | buy |
| CALIFORNIA STATE TEACHERS RETIREMENT SYSTEM | 2,803 | 33,087 | +30,284 | 0.00 | 0.00 | +0.00 | buy |
| AMERICAN CENTURY COMPANIES INC | 29,660 | 59,149 | +29,489 | 0.00 | 0.00 | +0.00 | buy |
| Engineers Gate Manager LP | 0 | 27,924 | +27,924 | 0.00 | 0.01 | +0.01 | buy |
| Bank of New York Mellon Corp | 89,904 | 115,892 | +25,988 | 0.00 | 0.00 | +0.00 | buy |
| EntryPoint Capital, LLC | 0 | 25,926 | +25,926 | 0.00 | 0.16 | +0.16 | buy |
| FMR LLC | 375,481 | 398,019 | +22,538 | 0.00 | 0.00 | +0.00 | buy |
| NORTHERN TRUST CORP | 260,891 | 282,615 | +21,724 | 0.00 | 0.00 | +0.00 | buy |
| TWO SIGMA ADVISERS, LP | 0 | 19,700 | +19,700 | 0.00 | 0.00 | +0.00 | buy |
| JANUS HENDERSON GROUP PLC | 0 | 18,900 | +18,900 | 0.00 | 0.00 | +0.00 | buy |
| PROFUND ADVISORS LLC | 0 | 14,893 | +14,893 | 0.00 | 0.01 | +0.01 | buy |
| MetLife Investment Management, LLC | 8,284 | 20,805 | +12,521 | 0.00 | 0.00 | +0.00 | buy |
| VOYA INVESTMENT MANAGEMENT LLC | 0 | 11,932 | +11,932 | 0.00 | 0.00 | +0.00 | buy |
| BARCLAYS PLC | 20,624 | 32,501 | +11,877 | 0.00 | 0.00 | +0.00 | buy |
| AMERIPRISE FINANCIAL INC | 0 | 10,305 | +10,305 | 0.00 | 0.00 | +0.00 | buy |
| CITIGROUP INC | 5,466 | 15,144 | +9,678 | 0.00 | 0.00 | +0.00 | buy |
| Zurcher Kantonalbank (Zurich Cantonalbank) | 0 | 9,129 | +9,129 | 0.00 | 0.00 | +0.00 | buy |
| CANADA LIFE ASSURANCE Co | 2,436 | 10,043 | +7,607 | 0.00 | 0.00 | +0.00 | buy |
| RHUMBLINE ADVISERS | 41,870 | 47,860 | +5,990 | 0.00 | 0.00 | +0.00 | buy |
| VIRTUS ADVISERS, LLC | 0 | 5,167 | +5,167 | 0.00 | 0.03 | +0.03 | buy |
| LOS ANGELES CAPITAL MANAGEMENT LLC | 62,257 | 66,765 | +4,508 | 0.00 | 0.00 | +0.00 | buy |
| PRICE T ROWE ASSOCIATES INC /MD/ | 31,431 | 35,046 | +3,615 | 0.00 | 0.00 | +0.00 | buy |
| SIMPLEX TRADING, LLC | 1,156 | 4,727 | +3,571 | 0.00 | 0.00 | +0.00 | buy |
| ALLIANCEBERNSTEIN L.P. | 37,340 | 40,630 | +3,290 | 0.00 | 0.00 | +0.00 | buy |
| STRS OHIO | 0 | 2,300 | +2,300 | 0.00 | 0.00 | +0.00 | buy |
| AlphaQuest LLC | 0 | 2,110 | +2,110 | 0.00 | 0.00 | +0.00 | buy |
| MANUFACTURERS LIFE INSURANCE COMPANY, THE | 11,970 | 13,964 | +1,994 | 0.00 | 0.00 | +0.00 | buy |
| WELLS FARGO & COMPANY/MN | 9,852 | 11,387 | +1,535 | 0.00 | 0.00 | +0.00 | buy |
| Russell Investments Group, Ltd. | 0 | 1,527 | +1,527 | 0.00 | 0.00 | +0.00 | buy |
| Tower Research Capital LLC (TRC) | 2,661 | 4,018 | +1,357 | 0.00 | 0.00 | +0.00 | buy |
| Ameritas Investment Partners, Inc. | 2,278 | 3,484 | +1,206 | 0.00 | 0.00 | +0.00 | buy |
| NISA INVESTMENT ADVISORS, LLC | 1,951 | 2,989 | +1,038 | 0.00 | 0.00 | +0.00 | buy |
| Pacer Advisors, Inc. | 0 | 454 | +454 | 0.00 | 0.00 | +0.00 | buy |
| US BANCORP \DE\ | 0 | 396 | +396 | 0.00 | 0.00 | +0.00 | buy |
| WELLINGTON MANAGEMENT GROUP LLP | 143,351 | 143,636 | +285 | 0.00 | 0.00 | +0.00 | buy |
| AMALGAMATED BANK | 787 | 979 | +192 | 0.00 | 0.00 | +0.00 | buy |
| Arax Advisory Partners | 0 | 173 | +173 | 0.00 | 0.00 | +0.00 | buy |
| GAMMA Investing LLC | 117 | 253 | +136 | 0.00 | 0.00 | +0.00 | buy |
| Quarry LP | 0 | 118 | +118 | 0.00 | 0.00 | +0.00 | buy |
| CWM, LLC | 0 | 110 | +110 | 0.00 | 0.00 | +0.00 | buy |
| NEW YORK STATE COMMON RETIREMENT FUND | 10,583 | 10,635 | +52 | 0.00 | 0.00 | -0.00 | buy |
| HARBOUR INVESTMENTS, INC. | 0 | 50 | +50 | 0.00 | 0.00 | +0.00 | buy |
| ROTHSCHILD INVESTMENT LLC | 0 | 30 | +30 | 0.00 | 0.00 | +0.00 | buy |
| Palo Alto Investors LP | 125,861 | 125,861 | 0 | 0.19 | 0.20 | +0.01 | hold |
| Dorsey & Whitney Trust CO LLC | 10,815 | 10,815 | 0 | 0.01 | 0.01 | +0.00 | hold |
| RTW INVESTMENTS, LP | 4,224,838 | 4,224,838 | 0 | 0.84 | 0.88 | +0.04 | hold |
| Cormorant Asset Management, LP | 427,163 | 427,163 | 0 | 0.25 | 0.34 | +0.08 | hold |
| Fort Point Capital Partners LLC | 75,429 | 75,429 | 0 | 0.14 | 0.13 | -0.01 | hold |
| Birchview Capital, LP | 210,000 | 210,000 | 0 | 2.31 | 2.62 | +0.31 | hold |
| Stone House Investment Management, LLC | 500 | 500 | 0 | 0.00 | 0.00 | +0.00 | hold |
| Ikarian Capital, LLC | 6,816 | 6,816 | 0 | 0.03 | 0.03 | +0.00 | hold |
| CHASE INVESTMENT COUNSEL CORP | 20,738 | 20,738 | 0 | 0.10 | 0.10 | -0.00 | hold |
| Susquehanna Portfolio Strategies, LLC | 43,424 | 43,424 | 0 | 0.01 | 0.02 | +0.01 | hold |
| Avior Wealth Management, LLC | 5 | 0 | -5 | 0.00 | 0.00 | -0.00 | sell |
| GILDER GAGNON HOWE & CO LLC | 89,783 | 88,577 | -1,206 | 0.02 | 0.01 | -0.00 | sell |
| METROPOLITAN LIFE INSURANCE CO/NY | 1,625 | 0 | -1,625 | 0.00 | 0.00 | -0.00 | sell |
| JACOBS LEVY EQUITY MANAGEMENT, INC | 47,912 | 46,059 | -1,853 | 0.00 | 0.00 | -0.00 | sell |
| ADAR1 Capital Management, LLC | 2,900 | 0 | -2,900 | 0.01 | 0.00 | -0.01 | sell |
| LAZARD ASSET MANAGEMENT LLC | 3,710 | 213 | -3,497 | 0.00 | 0.00 | -0.00 | sell |
| Woodline Partners LP | 106,904 | 100,182 | -6,722 | 0.01 | 0.01 | -0.00 | sell |
| PDT Partners, LLC | 21,426 | 14,039 | -7,387 | 0.03 | 0.02 | -0.01 | sell |
| STATE OF WISCONSIN INVESTMENT BOARD | 48,200 | 40,602 | -7,598 | 0.00 | 0.00 | -0.00 | sell |
| RENAISSANCE TECHNOLOGIES LLC | 19,100 | 11,200 | -7,900 | 0.00 | 0.00 | -0.00 | sell |
| Informed Momentum Co LLC | 45,845 | 37,637 | -8,208 | 0.10 | 0.08 | -0.01 | sell |
| Aquatic Capital Management LLC | 9,600 | 0 | -9,600 | 0.00 | 0.00 | -0.00 | sell |
| BNP PARIBAS FINANCIAL MARKETS | 14,330 | 4,507 | -9,823 | 0.00 | 0.00 | -0.00 | sell |
| PRINCIPAL FINANCIAL GROUP INC | 10,451 | 0 | -10,451 | 0.00 | 0.00 | -0.00 | sell |
| STATE BOARD OF ADMINISTRATION OF FLORIDA RETIREMENT SYSTEM | 10,473 | 0 | -10,473 | 0.00 | 0.00 | -0.00 | sell |
| JPMORGAN CHASE & CO | 10,944 | 0 | -10,944 | 0.00 | 0.00 | -0.00 | sell |
| AMERICAN INTERNATIONAL GROUP, INC. | 13,738 | 0 | -13,738 | 0.00 | 0.00 | -0.00 | sell |